Development Level

Tbio 574 | 11,445
Tdark 134 | 6,588
Tchem 99 | 1,598
Tclin 26 | 613

Collection

RFA-RM-18-021 11 | 328
GPCR: IDG Consortium (Targets) 6 | 126
Kinase: IDG Consortium (Target... 4 | 125
GPCR: IDG Consortium (Complete... 2 | 25
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 49 | 979
preweaning lethality, incomple... 29 | 499
embryonic lethality prior to t... 13 | 278
abnormal bone structure 12 | 187
decreased total body fat amoun... 12 | 207
enlarged heart 11 | 210
increased lean body mass 11 | 172
increased startle reflex 11 | 112
increased heart weight 10 | 62
abnormal heart morphology 9 | 162
abnormal seminal vesicle morph... 9 | 114
increased total body fat amoun... 9 | 134
abnormal behavior 8 | 298
abnormal embryo size 8 | 220
decreased lean body mass 8 | 135
embryonic lethality prior to o... 8 | 239
hypoactivity 8 | 132
abnormal kidney morphology 7 | 65
decreased bone mineral density 7 | 126
decreased vertical activity 7 | 208
increased mean corpuscular hem... 7 | 96
prenatal lethality prior to he... 7 | 87
decreased body weight 6 | 161
decreased bone mineral content 6 | 151
increased circulating HDL chol... 6 | 80
abnormal skin morphology 5 | 50
abnormal sleep behavior 5 | 70
abnormal spleen morphology 5 | 55
cataract 5 | 92
decreased leukocyte cell numbe... 5 | 73
edema 5 | 59
hyperactivity 5 | 148
increased circulating alkaline... 5 | 122
increased or absent threshold ... 5 | 101
abnormal craniofacial morpholo... 4 | 33
abnormal gait 4 | 69
abnormal lens morphology 4 | 81
anophthalmia 4 | 33
decreased body length 4 | 101
decreased circulating free fat... 4 | 31
decreased circulating glucose ... 4 | 126
decreased startle reflex 4 | 75
embryonic growth retardation 4 | 106
impaired glucose tolerance 4 | 75
increased blood urea nitrogen ... 4 | 48
increased bone mineral density 4 | 72
increased circulating choleste... 4 | 66
increased circulating potassiu... 4 | 29
short tibia 4 | 97
small testis 4 | 58
abnormal coat-hair pigmentatio... 3 | 64
abnormal eye morphology 3 | 68
abnormal facial morphology 3 | 17
abnormal limb bud morphology 3 | 17
abnormal limb morphology 3 | 13
abnormal pericardium morpholog... 3 | 26
abnormal response to new envir... 3 | 10
abnormal testis morphology 3 | 43
cleft palate 3 | 8
decreased blood urea nitrogen ... 3 | 51
decreased circulating choleste... 3 | 93
decreased circulating iron lev... 3 | 32
decreased circulating triglyce... 3 | 79
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
decreased neutrophil cell numb... 3 | 42
decreased prepulse inhibition 3 | 82
enlarged kidney 3 | 14
increased body length 3 | 32
increased body weight 3 | 25
increased bone mineral content 3 | 108
increased circulating bilirubi... 3 | 16
increased circulating iron lev... 3 | 30
increased fasted circulating g... 3 | 76
increased hemoglobin content 3 | 45
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
male infertility 3 | 123
microphthalmia 3 | 26
pallor 3 | 34
prolonged PR interval 3 | 15
small superior vagus ganglion 3 | 74
syndactyly 3 | 23
thrombocytopenia 3 | 56
abnormal cornea morphology 2 | 31
abnormal retinal vasculature m... 2 | 27
absent startle reflex 2 | 24
cardiovascular system phenotyp... 2 | 36
decreased IgE level 2 | 6
decreased circulating HDL chol... 2 | 68
decreased circulating calcium ... 2 | 36
decreased circulating creatini... 2 | 39
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
increased circulating phosphat... 2 | 26
increased circulating serum al... 2 | 22
increased prepulse inhibition 2 | 32
thrombocytosis 2 | 27

Disease

Carcinoma 426 | 11,493
ovarian cancer 411 | 8,520
osteosarcoma 396 | 7,950
psoriasis 304 | 6,694
glioblastoma 275 | 5,792
medulloblastoma, large-cell 270 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 238 | 3,291
atypical teratoid / rhabdoid tumor 231 | 5,112
lung cancer 228 | 4,740
ependymoma 204 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 203 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 190 | 2,955
non-small cell lung cancer 176 | 2,890
Cancer 174 | 2,499
malignant mesothelioma 169 | 3,232
group 3 medulloblastoma 166 | 4,104
pancreatic cancer 165 | 2,398
adult high grade glioma 162 | 3,801
lung carcinoma 159 | 2,843
interstitial cystitis 156 | 2,312
lung adenocarcinoma 153 | 2,716
Astrocytoma, Pilocytic 150 | 3,081
Breast cancer 150 | 3,578
invasive ductal carcinoma 139 | 2,951
primitive neuroectodermal tumor 127 | 3,035
oligodendroglioma 115 | 2,850
tuberculosis 115 | 2,010
diabetes mellitus 113 | 1,728
subependymal giant cell astrocytoma 113 | 2,287
astrocytic glioma 100 | 2,597
ductal carcinoma in situ 98 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 98 | 1,962
ulcerative colitis 95 | 1,819
cystic fibrosis 90 | 1,696
pituitary cancer 88 | 1,972
Multiple myeloma 86 | 1,332
Kidney cancer 85 | 2,613
group 4 medulloblastoma 84 | 1,855
breast carcinoma 81 | 1,638
primary pancreatic ductal adenocarcinoma 80 | 1,109
Rheumatoid arthritis 76 | 1,191
adrenocortical carcinoma 76 | 1,428
Autosomal recessive predisposition 75 | 1,442
astrocytoma 74 | 1,146
active Crohn's disease 66 | 922
colon cancer 66 | 1,478
cutaneous lupus erythematosus 64 | 1,057
Pick disease 63 | 1,894
pediatric high grade glioma 60 | 1,064
Liver Cirrhosis, Experimental 57 | 769
Schizophrenia 55 | 1,160
active ulcerative colitis 53 | 764
dermatomyositis 51 | 966
juvenile dermatomyositis 50 | 1,187
esophageal adenocarcinoma 49 | 737
gastric carcinoma 48 | 807
spina bifida 48 | 1,074
acute quadriplegic myopathy 47 | 1,158
non primary Sjogren syndrome sicca 46 | 891
nasopharyngeal carcinoma 43 | 1,058
Waldenstrons macroglobulinemia 42 | 765
Intellectual disability 41 | 1,016
Epilepsy 40 | 792
primary Sjogren syndrome 38 | 735
Obesity 37 | 678
acute myeloid leukemia 36 | 783
progressive supranuclear palsy 35 | 676
Atopic dermatitis 33 | 952
Cognitive delay 32 | 608
Duchenne muscular dystrophy 32 | 601
Global developmental delay 32 | 608
Mental and motor retardation 32 | 608
Seizures 32 | 596
aldosterone-producing adenoma 32 | 665
mucosa-associated lymphoid tissue lymphoma 32 | 484
Bipolar Disorder 31 | 666
Alzheimer's disease 30 | 658
Breast Neoplasms 30 | 445
Mammary Neoplasms 29 | 425
medulloblastoma 29 | 720
Hypertension 28 | 396
Pancreatitis 28 | 123
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 510
Vascular disease 27 | 319
posterior fossa group A ependymoma 27 | 468
Down syndrome 26 | 499
fibroadenoma 26 | 559
sonic hedgehog group medulloblastoma 26 | 467
Dull intelligence 25 | 645
Low intelligence 25 | 645
Mental Retardation 25 | 645
Mental deficiency 25 | 645
Polycystic ovary syndrome 25 | 360
Poor school performance 25 | 645
Prostatic Neoplasms 25 | 495
pancreatic carcinoma 25 | 562
Atherosclerosis 24 | 291
Short stature 24 | 531
Stomach Neoplasms 24 | 300
gastric cancer 23 | 459

Tissue

Endocrine System 815 | 18,159
Digestive Tract 811 | 17,369
Skin and soft tissues 810 | 17,230
Female tissues 807 | 17,400
Liver and Pancreas 807 | 16,750
Blood and immune system 805 | 16,909
Male tissues 801 | 17,142
Urinary Tract 797 | 16,678
Respiratory system 793 | 16,393
Nervous System 789 | 16,725
Cardiovascular System 758 | 15,192

Target Family

Non-IDG 477 | 12,091
Enzyme 235 | 4,145
Transcription Factor 38 | 1,400
GPCR 23 | 408
Kinase 21 | 634
Transporter 20 | 473
Ion Channel 12 | 344
Epigenetic 4 | 242
Nuclear Receptor 3 | 48

Jensen-KB Tissue

Pancreas 833 | 833
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
Zona pellucida-binding protein 1 ZPBP Tdark Non-IDG -1.44041 27.1 43
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
LIM domain only protein 7 LMO7 Tbio Non-IDG -1.24771 19.7 80
Cytochrome c oxidase assembly factor 5 COA5 Tdark Enzyme -0.77512 6.90 3
Integral membrane protein GPR180 GPR180 Tbio Non-IDG -2.50178 313.6 132
Retinoid-binding protein 7 RBP7 Tbio Non-IDG -0.86335 6.26 89