Development Level

Tbio 527 | 10,625
Tdark 156 | 7,003
Tchem 120 | 1,890
Tclin 25 | 602

Collection

Eligible non-olfactory GPCR Proteins 6 | 143
Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 27 | 633
preweaning lethality, incomple... 17 | 260
decreased bone mineral content 11 | 157
decreased total body fat amoun... 11 | 186
decreased lean body mass 10 | 195
abnormal bone structure 9 | 131
decreased bone mineral density 8 | 126
abnormal bone mineralization 7 | 55
decreased body weight 7 | 174
embryonic lethality prior to t... 7 | 187
hypoactivity 7 | 89
increased circulating HDL chol... 7 | 63
increased lean body mass 7 | 107
abnormal behavior 6 | 226
abnormal lens morphology 6 | 73
increased body weight 6 | 42
increased heart weight 6 | 37
abnormal sleep behavior 5 | 63
embryonic lethality prior to o... 5 | 148
enlarged heart 5 | 111
increased bone mineral density 5 | 52
increased mean corpuscular hem... 5 | 93
increased or absent threshold ... 5 | 128
increased total body fat amoun... 5 | 57
abnormal embryo size 4 | 112
decreased circulating iron lev... 4 | 25
decreased erythrocyte cell num... 4 | 43
impaired glucose tolerance 4 | 52
increased blood urea nitrogen ... 4 | 44
increased circulating alkaline... 4 | 119
increased fasted circulating g... 4 | 68
increased grip strength 4 | 83
increased sacral vertebrae num... 4 | 62
polydactyly 4 | 22
prenatal lethality prior to he... 4 | 64
abnormal craniofacial morpholo... 3 | 12
abnormal limb bud morphology 3 | 15
abnormal retina morphology 3 | 100
abnormal testis morphology 3 | 30
decreased body length 3 | 108
decreased circulating free fat... 3 | 39
decreased circulating glucose ... 3 | 121
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular vol... 3 | 50
decreased prepulse inhibition 3 | 52
decreased startle reflex 3 | 48
edema 3 | 11
hyperactivity 3 | 108
increased bone mineral content 3 | 92
increased circulating choleste... 3 | 53
increased circulating iron lev... 3 | 25
increased circulating potassiu... 3 | 31
increased mean corpuscular vol... 3 | 91
increased startle reflex 3 | 38
male infertility 3 | 62
small testis 3 | 37
abnormal body wall morphology 2 | 7
abnormal coat/hair pigmentatio... 2 | 54
abnormal facial morphology 2 | 9
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal response to new envir... 2 | 8
abnormal retinal vasculature m... 2 | 15
abnormal rib morphology 2 | 28
abnormal seminal vesicle morph... 2 | 47
abnormal skin morphology 2 | 23
absent startle reflex 2 | 15
anophthalmia 2 | 20
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
cleft palate 2 | 6
decreased caudal vertebrae num... 2 | 49
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating fructosa... 2 | 31
decreased circulating glycerol... 2 | 19
decreased circulating magnesiu... 2 | 11
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
facial cleft 2 | 3
increased body length 2 | 20
increased caudal vertebrae num... 2 | 8
increased circulating bilirubi... 2 | 16
increased circulating glycerol... 2 | 11
increased effector memory CD4-... 2 | 15
increased heart rate 2 | 17
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 25
increased mean platelet volume 2 | 19
increased prepulse inhibition 2 | 21
increased vertical activity 2 | 18
microphthalmia 2 | 15
oligodactyly 2 | 14
pallor 2 | 13
short tibia 2 | 82
small superior vagus ganglion 2 | 20
thrombocytopenia 2 | 46
vertebral fusion 2 | 23

Disease

ovarian cancer 404 | 8,484
osteosarcoma 394 | 7,933
psoriasis 305 | 6,685
medulloblastoma, large-cell 267 | 6,234
glioblastoma 264 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 238 | 3,289
lung cancer 219 | 4,466
intraductal papillary-mucinous carcinoma (IPMC) 202 | 2,988
atypical teratoid / rhabdoid tumor 199 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 190 | 2,956
non-small cell lung cancer 171 | 2,798
malignant mesothelioma 167 | 3,162
pancreatic cancer 166 | 2,300
Cancer 161 | 2,346
lung carcinoma 158 | 2,844
interstitial cystitis 155 | 2,299
pilocytic astrocytoma 153 | 3,086
lung adenocarcinoma 152 | 2,713
invasive ductal carcinoma 138 | 2,950
pediatric high grade glioma 137 | 2,712
Breast cancer 127 | 3,094
primitive neuroectodermal tumor 127 | 3,031
ulcerative colitis 118 | 2,087
ependymoma 117 | 2,514
oligodendroglioma 114 | 2,849
subependymal giant cell astrocytoma 112 | 2,287
diabetes mellitus 103 | 1,663
ductal carcinoma in situ 98 | 1,745
tuberculosis 95 | 1,557
group 4 medulloblastoma 91 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 91 | 1,795
group 3 medulloblastoma 89 | 2,254
astrocytoma 88 | 1,493
primary pancreatic ductal adenocarcinoma 88 | 1,271
cystic fibrosis 87 | 1,665
Multiple myeloma 86 | 1,327
pituitary cancer 86 | 1,972
astrocytic glioma 83 | 2,241
adult high grade glioma 82 | 2,148
breast carcinoma 80 | 1,614
adrenocortical carcinoma 75 | 1,427
Rheumatoid Arthritis 71 | 1,160
colon cancer 66 | 1,475
medulloblastoma 66 | 1,524
active Crohn's disease 65 | 918
posterior fossa group A ependymoma 65 | 1,511
cutaneous lupus erythematosus 64 | 1,056
Pick disease 63 | 1,893
posterior fossa group B ependymoma 60 | 1,530
sonic hedgehog group medulloblastoma 55 | 1,482
Carcinoma 51 | 2,147
dermatomyositis 51 | 933
juvenile dermatomyositis 50 | 1,189
esophageal adenocarcinoma 49 | 737
gastric carcinoma 49 | 832
spina bifida 47 | 1,064
acute quadriplegic myopathy 45 | 1,157
atypical teratoid/rhabdoid tumor 45 | 1,095
nasopharyngeal carcinoma 43 | 1,056
Waldenstrons macroglobulinemia 42 | 765
non primary Sjogren syndrome sicca 42 | 840
Obesity 41 | 616
primary Sjogren syndrome 40 | 789
acute myeloid leukemia 37 | 780
progressive supranuclear palsy 34 | 674
Atopic dermatitis 33 | 944
active ulcerative colitis 32 | 477
mucosa-associated lymphoid tissue lymphoma 32 | 480
Duchenne muscular dystrophy 31 | 602
aldosterone-producing adenoma 31 | 664
Alzheimer's disease 29 | 644
Pancreatitis 28 | 97
tuberculosis and treatment for 6 months 28 | 686
Down syndrome 27 | 548
Mammary Neoplasms 27 | 410
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 499
fibroadenoma 26 | 557
Schizophrenia 25 | 501
pancreatic carcinoma 25 | 567
Prostatic Neoplasms 24 | 471
Stomach Neoplasms 24 | 282
Atherosclerosis 23 | 275
Intellectual disability 23 | 573
Vascular disease 23 | 281
interstitial lung disease 23 | 291
Endometriosis 22 | 535
gastric cancer 22 | 430
inflammatory breast cancer 22 | 404
nephrosclerosis 22 | 329
non-small cell lung carcinoma 22 | 413
Amyotrophic Lateral Sclerosis 21 | 431
Asthma 21 | 349
Hypertension 21 | 287
IGA Glomerulonephritis 20 | 454
Kidney disease 20 | 396
sarcoidosis 20 | 358
urothelial carcinoma 20 | 318
Multiple Sclerosis 19 | 498
Polycystic Ovary Syndrome 19 | 332
hepatocellular carcinoma 19 | 532

Tissue

Liver and Pancreas 815 | 18,136
Digestive Tract 812 | 18,473
Female tissues 812 | 18,647
Nervous System 811 | 18,561
Urinary Tract 811 | 18,444
Blood and immune system 810 | 17,995
Endocrine System 810 | 18,512
Male tissues 809 | 17,969
Cardiovascular System 805 | 17,958
Skin and soft tissues 804 | 18,115
Respiratory system 800 | 17,484

Target Family

Non-IDG 473 | 11,971
Enzyme 235 | 4,146
Transcription Factor 38 | 1,400
GPCR 23 | 406
Kinase 21 | 634
Transporter 20 | 473
Ion Channel 11 | 341
Epigenetic 4 | 242
Nuclear Receptor 3 | 48

Jensen-KB Tissue

Pancreas 828 | 828
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Small nuclear ribonucleoprotein G SNRPG Tdark Non-IDG 1.33 95
tRNA pseudouridine(38/39) synthase PUS3 Tbio Enzyme -1.19198 15.4 62
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.04569 136.6 321
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Calcium/calmodulin-dependent protein kinase type 1D CAMK1D Tchem Kinase -1.06137 12.5 282