Development Level

Tbio 142 | 11,178
Tchem 20 | 1,885
Tdark 19 | 6,569
Tclin 4 | 612

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 18 | 979
preweaning lethality, incomple... 8 | 499
abnormal behavior 7 | 298
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
enlarged heart 6 | 210
abnormal embryo size 5 | 220
decreased circulating calcium ... 4 | 36
decreased prepulse inhibition 4 | 82
decreased total body fat amoun... 4 | 207
hyperactivity 4 | 148
hypoactivity 4 | 132
abnormal embryo turning 3 | 31
abnormal heart morphology 3 | 162
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased lymphocyte cell numb... 3 | 83
embryonic growth retardation 3 | 106
increased bone mineral content 3 | 108
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
pallor 3 | 34
abnormal allantois morphology 2 | 8
abnormal bone structure 2 | 187
abnormal chorioallantoic fusio... 2 | 8
abnormal gait 2 | 69
abnormal optic disc morphology 2 | 10
abnormal retina morphology 2 | 71
abnormal retinal inner nuclear... 2 | 8
abnormal snout morphology 2 | 23
abnormal vertebrae morphology 2 | 18
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased total retina thickne... 2 | 17
decreased vertical activity 2 | 208
hydrometra 2 | 53
improved glucose tolerance 2 | 79
increased body temperature 2 | 9
increased bone mineral density 2 | 72
increased circulating chloride... 2 | 41
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased or absent threshold ... 2 | 101
prenatal lethality prior to he... 2 | 87
prolonged PR interval 2 | 15
short tibia 2 | 97
small superior vagus ganglion 2 | 74
unresponsive to tactile stimul... 2 | 8
abnormal blood vessel morpholo... 1 | 5
abnormal head morphology 1 | 10
abnormal limb bud morphology 1 | 17
abnormal liver morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
edema 1 | 59
impaired glucose tolerance 1 | 75
increased body weight 1 | 25
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
prenatal lethality 1 | 28
small testis 1 | 58
small thymus 1 | 16
thin ventricular wall 1 | 24
tremors 1 | 39
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 116 | 8,297
Carcinoma 113 | 11,192
osteosarcoma 99 | 7,766
psoriasis 73 | 6,514
medulloblastoma, large-cell 72 | 6,086
glioblastoma 63 | 5,635
lung cancer 62 | 4,607
atypical teratoid / rhabdoid tumor 54 | 4,971
ependymoma 54 | 4,559
Breast cancer 52 | 3,469
group 3 medulloblastoma 50 | 4,002
malignant mesothelioma 49 | 3,135
Multiple myeloma 39 | 1,296
Cancer 37 | 2,388
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,902
primitive neuroectodermal tumor 37 | 2,957
acute quadriplegic myopathy 36 | 1,133
oligodendroglioma 36 | 2,768
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,204
invasive ductal carcinoma 34 | 2,867
pancreatic cancer 34 | 2,322
non-small cell lung cancer 33 | 2,799
Kidney cancer 32 | 2,548
adult high grade glioma 31 | 3,701
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,872
Astrocytoma, Pilocytic 28 | 3,006
Pick disease 27 | 1,856
astrocytic glioma 27 | 2,530
group 4 medulloblastoma 27 | 1,806
lung adenocarcinoma 27 | 2,627
subependymal giant cell astrocytoma 27 | 2,230
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,911
Waldenstrons macroglobulinemia 25 | 742
breast carcinoma 25 | 1,589
astrocytoma 22 | 1,113
dermatomyositis 21 | 941
interstitial cystitis 20 | 2,237
lung carcinoma 20 | 2,755
pediatric high grade glioma 20 | 1,035
cystic fibrosis 19 | 1,629
juvenile dermatomyositis 18 | 1,147
primary pancreatic ductal adenocarcinoma 18 | 1,071
Autosomal recessive predisposition 17 | 1,407
Amyotrophic lateral sclerosis 16 | 437
adrenocortical carcinoma 16 | 1,385
diabetes mellitus 16 | 1,683
Intellectual disability 15 | 998
acute myeloid leukemia 15 | 760
nasopharyngeal carcinoma 15 | 1,024
tuberculosis 14 | 1,963
colon cancer 13 | 1,428
cutaneous lupus erythematosus 13 | 1,016
pituitary cancer 13 | 1,915
progressive supranuclear palsy 13 | 656
ulcerative colitis 13 | 1,765
gastric carcinoma 12 | 781
spina bifida 12 | 1,053
Atopic dermatitis 11 | 915
Breast Neoplasms 11 | 423
Mammary Neoplasms 11 | 403
ductal carcinoma in situ 11 | 1,686
Cleft Palate 10 | 265
Rheumatoid arthritis 10 | 1,156
aldosterone-producing adenoma 10 | 646
atypical teratoid/rhabdoid tumor 10 | 349
gastric cancer 10 | 445
non primary Sjogren syndrome sicca 10 | 861
primary Sjogren syndrome 10 | 710
Liver Cirrhosis, Experimental 9 | 733
active Crohn's disease 9 | 882
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 492
hepatocellular carcinoma 9 | 536
pancreatic carcinoma 9 | 555
tuberculosis and treatment for 6 months 9 | 399
Dull intelligence 8 | 634
Epilepsy 8 | 775
Hypoplastic mandible condyle 8 | 273
Low intelligence 8 | 634
Mandibular hypoplasia 8 | 273
Mental Retardation 8 | 634
Mental deficiency 8 | 634
Micrognathism 8 | 273
Poor school performance 8 | 634
Prostatic Neoplasms 8 | 472
Short stature 8 | 514
Small head 8 | 366
Stomach Neoplasms 8 | 287
Uranostaphyloschisis 8 | 162
active ulcerative colitis 8 | 736
posterior fossa group A ependymoma 8 | 456
Adenocarcinoma of lung 7 | 140
Cataract 7 | 290
Duchenne muscular dystrophy 7 | 587
Gaucher disease type 1 7 | 177
Hypotrophic malar bone 7 | 129
Malar flattening 7 | 129
Obesity 7 | 655
Schizophrenia 7 | 1,136
inflammatory breast cancer 7 | 272
sonic hedgehog group medulloblastoma 7 | 459

Tissue

Digestive Tract 183 | 17,369
Endocrine System 183 | 18,159
Female tissues 183 | 17,400
Liver and Pancreas 183 | 16,750
Male tissues 183 | 17,142
Nervous System 183 | 16,725
Skin and soft tissues 183 | 17,230
Blood and immune system 182 | 16,909
Respiratory system 182 | 16,393
Urinary Tract 182 | 16,678
Cardiovascular System 177 | 15,192

Target Family

Non-IDG 130 | 12,091
Enzyme 39 | 4,145
Transcription Factor 7 | 1,400
GPCR 3 | 408
Transporter 3 | 473
Epigenetic 2 | 242
Ion Channel 1 | 344

Jensen-KB Tissue

Ovary cancer cell 185 | 185
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 PLCB4 Tbio Enzyme -1.77110 57.7 19
Plectin PLEC Tbio Non-IDG -2.50749 337.2 130
Keratin, type II cytoskeletal 7 KRT7 Tbio Non-IDG -3.15812 1370.2 1288
Dynein light chain roadblock-type 2 DYNLRB2 Tbio Non-IDG -0.65444 2.59 77
Zinc finger CCCH-type antiviral protein 1-like ZC3HAV1L Tdark Non-IDG 0.30 0.50 66
Heterogeneous nuclear ribonucleoprotein D0 HNRNPD Tbio Non-IDG -2.21226 168.2 325
Splicing factor 3B subunit 4 SF3B4 Tbio Non-IDG -1.44416 28.7 222
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 SMCHD1 Tbio Non-IDG -1.44184 33.6 39
Polyglutamine-binding protein 1 PQBP1 Tbio Non-IDG -1.68270 53.0 101