Development Level

Tbio 462 | 11,445
Tdark 154 | 6,588
Tchem 52 | 1,598
Tclin 23 | 613

Collection

RFA-RM-18-021 8 | 328
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 33 | 979
preweaning lethality, incomple... 18 | 499
embryonic lethality prior to t... 16 | 278
abnormal embryo size 14 | 220
embryonic lethality prior to o... 13 | 239
abnormal behavior 11 | 298
decreased vertical activity 10 | 208
embryonic growth retardation 10 | 106
decreased lean body mass 9 | 135
decreased body weight 8 | 161
decreased bone mineral content 8 | 151
abnormal heart morphology 7 | 162
abnormal neural tube closure 7 | 46
decreased circulating triglyce... 7 | 79
enlarged heart 7 | 210
hyperactivity 7 | 148
decreased bone mineral density 6 | 126
decreased circulating glucose ... 6 | 126
increased lean body mass 6 | 172
increased or absent threshold ... 6 | 101
pallor 6 | 34
impaired glucose tolerance 5 | 75
improved glucose tolerance 5 | 79
increased total body fat amoun... 5 | 134
prenatal lethality prior to he... 5 | 87
abnormal bone structure 4 | 187
abnormal hindbrain development 4 | 16
abnormal midbrain development 4 | 20
abnormal seminal vesicle morph... 4 | 114
decreased body length 4 | 101
decreased total body fat amoun... 4 | 207
female infertility 4 | 60
increased mean corpuscular hem... 4 | 96
increased startle reflex 4 | 112
male infertility 4 | 123
small testis 4 | 58
abnormal craniofacial morpholo... 3 | 33
abnormal embryo turning 3 | 31
abnormal eye morphology 3 | 68
abnormal forebrain development 3 | 20
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal limb bud morphology 3 | 17
abnormal pericardium morpholog... 3 | 26
abnormal sleep behavior 3 | 70
abnormal tail bud morphology 3 | 8
absent startle reflex 3 | 24
decreased blood urea nitrogen ... 3 | 51
decreased circulating total pr... 3 | 49
decreased erythrocyte cell num... 3 | 62
decreased hemoglobin content 3 | 68
decreased lymphocyte cell numb... 3 | 83
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
enlarged spleen 3 | 41
hydrometra 3 | 53
increased bone mineral density 3 | 72
increased circulating alkaline... 3 | 122
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular vol... 3 | 92
pale yolk sac 3 | 25
small superior vagus ganglion 3 | 74
thrombocytopenia 3 | 56
abnormal behavioral response t... 2 | 66
abnormal cornea morphology 2 | 31
abnormal locomotor activation 2 | 16
abnormal locomotor behavior 2 | 24
abnormal neural tube morpholog... 2 | 12
abnormal retina morphology 2 | 71
abnormal retinal inner nuclear... 2 | 8
abnormal spleen morphology 2 | 55
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased IgG1 level 2 | 8
decreased circulating LDL chol... 2 | 38
decreased circulating chloride... 2 | 30
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased neutrophil cell numb... 2 | 42
edema 2 | 59
increased anti-nuclear antigen... 2 | 19
increased body length 2 | 32
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased circulating choleste... 2 | 66
increased circulating iron lev... 2 | 30
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased heart rate 2 | 23
increased monocyte cell number 2 | 63
long tibia 2 | 25
prenatal lethality 2 | 28
short tibia 2 | 97
shortened RR interval 2 | 17
small thymus 2 | 16

Disease

Carcinoma 397 | 11,493
ovarian cancer 395 | 8,520
osteosarcoma 326 | 7,950
psoriasis 244 | 6,694
medulloblastoma, large-cell 238 | 6,241
glioblastoma 224 | 5,792
lung cancer 195 | 4,740
atypical teratoid / rhabdoid tumor 193 | 5,112
ependymoma 186 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 150 | 3,291
Breast cancer 148 | 3,578
malignant mesothelioma 145 | 3,232
group 3 medulloblastoma 143 | 4,104
invasive ductal carcinoma 142 | 2,951
adult high grade glioma 140 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 130 | 2,989
non-small cell lung cancer 127 | 2,890
lung adenocarcinoma 123 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 118 | 2,955
oligodendroglioma 118 | 2,850
pancreatic cancer 117 | 2,398
primitive neuroectodermal tumor 114 | 3,035
Astrocytoma, Pilocytic 112 | 3,081
Cancer 100 | 2,499
astrocytic glioma 99 | 2,597
ductal carcinoma in situ 87 | 1,745
lung carcinoma 87 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 86 | 1,962
subependymal giant cell astrocytoma 85 | 2,287
interstitial cystitis 84 | 2,312
breast carcinoma 82 | 1,638
group 4 medulloblastoma 80 | 1,855
cystic fibrosis 75 | 1,696
pituitary cancer 75 | 1,972
tuberculosis 74 | 2,010
Pick disease 71 | 1,894
diabetes mellitus 71 | 1,728
Multiple myeloma 70 | 1,332
Kidney cancer 66 | 2,613
colon cancer 58 | 1,478
ulcerative colitis 58 | 1,819
primary pancreatic ductal adenocarcinoma 56 | 1,109
Rheumatoid arthritis 54 | 1,191
pediatric high grade glioma 53 | 1,064
astrocytoma 52 | 1,146
Autosomal recessive predisposition 51 | 1,442
acute quadriplegic myopathy 51 | 1,158
adrenocortical carcinoma 46 | 1,428
cutaneous lupus erythematosus 44 | 1,057
juvenile dermatomyositis 42 | 1,187
gastric carcinoma 40 | 807
Atopic dermatitis 39 | 952
esophageal adenocarcinoma 39 | 737
nasopharyngeal carcinoma 38 | 1,058
non primary Sjogren syndrome sicca 38 | 891
spina bifida 38 | 1,074
Duchenne muscular dystrophy 35 | 601
Liver Cirrhosis, Experimental 35 | 769
Intellectual disability 34 | 1,016
fibroadenoma 34 | 559
Waldenstrons macroglobulinemia 33 | 765
dermatomyositis 33 | 966
medulloblastoma 33 | 720
Schizophrenia 32 | 1,160
Alzheimer's disease 31 | 658
aldosterone-producing adenoma 29 | 665
Down syndrome 28 | 499
active Crohn's disease 27 | 922
acute myeloid leukemia 27 | 783
Epilepsy 26 | 792
Bipolar Disorder 25 | 666
Prostatic Neoplasms 25 | 495
active ulcerative colitis 25 | 764
sonic hedgehog group medulloblastoma 25 | 467
autosomal dominant Emery-Dreifuss muscular dystrophy 24 | 510
pancreatic carcinoma 23 | 562
Breast Neoplasms 22 | 445
posterior fossa group A ependymoma 22 | 468
Endometriosis 21 | 540
Mammary Neoplasms 21 | 425
Neurodegenerative disease 21 | 414
Obesity 21 | 678
Short stature 21 | 531
progressive supranuclear palsy 21 | 676
Cerebellar Ataxia 20 | 304
Dull intelligence 20 | 645
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
Osteoporosis 19 | 363
chronic rhinosinusitis 19 | 512
interstitial lung disease 19 | 298
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Liver cancer 18 | 604
Mammary Neoplasms, Experimental 18 | 154
Mental and motor retardation 18 | 608
Polycystic ovary syndrome 18 | 360
Muscle hypotonia 17 | 571

Tissue

Digestive Tract 677 | 17,369
Female tissues 676 | 17,400
Endocrine System 675 | 18,159
Skin and soft tissues 674 | 17,230
Male tissues 673 | 17,142
Urinary Tract 669 | 16,678
Blood and immune system 668 | 16,909
Liver and Pancreas 667 | 16,750
Respiratory system 665 | 16,393
Nervous System 661 | 16,725
Cardiovascular System 643 | 15,192

Target Family

Non-IDG 403 | 12,091
Enzyme 178 | 4,145
Transcription Factor 44 | 1,400
Kinase 22 | 634
Transporter 16 | 473
GPCR 11 | 408
Ion Channel 7 | 344
Epigenetic 6 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

Jensen-KB Tissue

Ovary 691 | 691
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Heterogeneous nuclear ribonucleoprotein H3 HNRNPH3 Tbio Non-IDG -1.80776 63.4 80
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Transportin-3 TNPO3 Tbio Non-IDG -1.74707 55.2 105
Phosphate carrier protein, mitochondrial SLC25A3 Tbio Transporter -2.85426 703.4 33
PCNA-interacting partner PARPBP Tbio Non-IDG -2.15213 141.3 72
Protein FAM118A FAM118A Tdark Non-IDG -0.04589 1.09 32
KN motif and ankyrin repeat domain-containing protein 2 KANK2 Tbio Non-IDG -0.97803 8.39 131
Fatty acyl-CoA reductase 1 FAR1 Tbio Enzyme -1.65427 43.8 27