Development Level

Tbio 528 | 11,651
Tdark 110 | 6,593
Tchem 58 | 1,388
Tclin 29 | 612

Collection

Kinase: IDG Consortium (Target... 8 | 125
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 76 | 979
preweaning lethality, incomple... 29 | 499
embryonic lethality prior to t... 23 | 278
abnormal behavior 21 | 298
decreased total body fat amoun... 18 | 207
abnormal bone structure 15 | 187
abnormal embryo size 15 | 220
embryonic lethality prior to o... 15 | 239
decreased lean body mass 14 | 135
decreased vertical activity 12 | 208
hypoactivity 12 | 132
hyperactivity 11 | 148
decreased body weight 10 | 161
embryonic growth retardation 10 | 106
cataract 9 | 92
decreased body length 9 | 101
decreased circulating glucose ... 9 | 126
decreased circulating serum al... 9 | 82
enlarged heart 9 | 210
increased lean body mass 9 | 172
decreased bone mineral content 8 | 151
decreased bone mineral density 8 | 126
increased circulating HDL chol... 8 | 80
increased circulating alkaline... 8 | 122
increased heart weight 8 | 62
increased mean corpuscular vol... 8 | 92
increased startle reflex 8 | 112
increased total body fat amoun... 8 | 134
abnormal heart morphology 7 | 162
abnormal lens morphology 7 | 81
abnormal retina morphology 7 | 71
decreased caudal vertebrae num... 7 | 53
improved glucose tolerance 7 | 79
increased circulating choleste... 7 | 66
increased mean platelet volume 7 | 45
abnormal coat-hair pigmentatio... 6 | 64
anophthalmia 6 | 33
decreased circulating choleste... 6 | 93
decreased mean corpuscular hem... 6 | 31
edema 6 | 59
increased circulating calcium ... 6 | 34
increased mean corpuscular hem... 6 | 96
male infertility 6 | 123
prenatal lethality prior to he... 6 | 87
short tibia 6 | 97
abnormal eye morphology 5 | 68
abnormal joint morphology 5 | 23
abnormal sleep behavior 5 | 70
decreased circulating alkaline... 5 | 46
decreased circulating total pr... 5 | 49
decreased erythrocyte cell num... 5 | 62
decreased grip strength 5 | 116
decreased mean corpuscular vol... 5 | 79
decreased prepulse inhibition 5 | 82
decreased startle reflex 5 | 75
impaired glucose tolerance 5 | 75
increased bone mineral content 5 | 108
increased or absent threshold ... 5 | 101
pallor 5 | 34
abnormal neural tube closure 4 | 46
abnormal placenta size 4 | 20
decreased blood urea nitrogen ... 4 | 51
decreased circulating HDL chol... 4 | 68
decreased circulating amylase ... 4 | 28
decreased circulating calcium ... 4 | 36
decreased circulating triglyce... 4 | 79
decreased hemoglobin content 4 | 68
decreased leukocyte cell numbe... 4 | 73
female infertility 4 | 60
hemorrhage 4 | 23
increased blood urea nitrogen ... 4 | 48
increased circulating phosphat... 4 | 26
increased circulating serum al... 4 | 22
increased circulating sodium l... 4 | 71
microphthalmia 4 | 26
abnormal behavioral response t... 3 | 66
abnormal craniofacial morpholo... 3 | 33
abnormal cranium morphology 3 | 36
abnormal embryo turning 3 | 31
abnormal kidney morphology 3 | 65
abnormal retinal blood vessel ... 3 | 26
abnormal seminal vesicle morph... 3 | 114
abnormal vertebrae morphology 3 | 18
brachydactyly 3 | 19
decreased circulating LDL chol... 3 | 38
decreased circulating insulin ... 3 | 76
decreased fasted circulating g... 3 | 65
decreased mean platelet volume 3 | 25
decreased neutrophil cell numb... 3 | 42
decreased red blood cell distr... 3 | 41
decreased total retina thickne... 3 | 17
increased circulating creatini... 3 | 38
increased circulating glycerol... 3 | 9
increased circulating total pr... 3 | 28
increased fasted circulating g... 3 | 76
increased red blood cell distr... 3 | 34
prenatal lethality 3 | 28
small superior vagus ganglion 3 | 74
syndactyly 3 | 23
thrombocytosis 3 | 27

Disease

Carcinoma 451 | 11,493
ovarian cancer 422 | 8,520
osteosarcoma 331 | 7,950
medulloblastoma, large-cell 282 | 6,241
psoriasis 268 | 6,694
glioblastoma 245 | 5,792
atypical teratoid / rhabdoid tumor 240 | 5,112
lung cancer 238 | 4,740
group 3 medulloblastoma 179 | 4,104
ependymoma 170 | 4,679
Breast cancer 155 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 154 | 3,291
malignant mesothelioma 153 | 3,232
adult high grade glioma 147 | 3,801
invasive ductal carcinoma 137 | 2,951
non-small cell lung cancer 137 | 2,890
Cancer 130 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 129 | 2,989
lung adenocarcinoma 118 | 2,716
primitive neuroectodermal tumor 118 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 114 | 2,955
oligodendroglioma 113 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 105 | 1,962
Multiple myeloma 104 | 1,332
pancreatic cancer 104 | 2,398
Astrocytoma, Pilocytic 101 | 3,081
astrocytic glioma 97 | 2,597
Kidney cancer 95 | 2,613
breast carcinoma 85 | 1,638
ductal carcinoma in situ 83 | 1,745
subependymal giant cell astrocytoma 82 | 2,287
diabetes mellitus 80 | 1,728
Pick disease 77 | 1,894
group 4 medulloblastoma 75 | 1,855
colon cancer 71 | 1,478
adrenocortical carcinoma 70 | 1,428
lung carcinoma 70 | 2,843
Autosomal recessive predisposition 69 | 1,442
ulcerative colitis 65 | 1,819
cystic fibrosis 64 | 1,696
interstitial cystitis 63 | 2,312
pituitary cancer 63 | 1,972
Intellectual disability 61 | 1,016
tuberculosis 61 | 2,010
juvenile dermatomyositis 60 | 1,187
acute quadriplegic myopathy 58 | 1,158
Waldenstrons macroglobulinemia 55 | 765
dermatomyositis 55 | 966
pediatric high grade glioma 52 | 1,064
astrocytoma 50 | 1,146
nasopharyngeal carcinoma 44 | 1,058
primary pancreatic ductal adenocarcinoma 44 | 1,109
Atopic dermatitis 42 | 952
Muscle hypotonia 42 | 571
Schizophrenia 41 | 1,160
non primary Sjogren syndrome sicca 40 | 891
spina bifida 40 | 1,074
Cognitive delay 37 | 608
Duchenne muscular dystrophy 37 | 601
Global developmental delay 37 | 608
Mental and motor retardation 37 | 608
cutaneous lupus erythematosus 36 | 1,057
Prostatic Neoplasms 35 | 495
esophageal adenocarcinoma 35 | 737
acute myeloid leukemia 34 | 783
Rheumatoid arthritis 33 | 1,191
Alzheimer's disease 32 | 658
Dull intelligence 32 | 645
Low intelligence 32 | 645
Mental Retardation 32 | 645
Mental deficiency 32 | 645
Poor school performance 32 | 645
Down syndrome 31 | 499
Obesity 31 | 678
active Crohn's disease 31 | 922
medulloblastoma 31 | 720
Epilepsy 30 | 792
aldosterone-producing adenoma 30 | 665
fibroadenoma 30 | 559
Endometriosis 29 | 540
gastric carcinoma 29 | 807
Liver Cirrhosis, Experimental 28 | 769
Short stature 28 | 531
Polycystic ovary syndrome 27 | 360
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 510
posterior fossa group A ependymoma 27 | 468
Acquired scoliosis 26 | 281
Amyotrophic lateral sclerosis 26 | 451
Curvature of spine 26 | 282
Melanoma 25 | 711
progressive supranuclear palsy 25 | 676
sonic hedgehog group medulloblastoma 25 | 467
Breast Neoplasms 24 | 445
Seizures 24 | 596
Stomach Neoplasms 24 | 300
primary Sjogren syndrome 24 | 735
tuberculosis and treatment for 6 months 24 | 409
Mammary Neoplasms 23 | 425
Liver cancer 22 | 604
Myopathy 22 | 185

Tissue

Digestive Tract 711 | 17,369
Endocrine System 711 | 18,159
Male tissues 711 | 17,142
Skin and soft tissues 710 | 17,230
Female tissues 709 | 17,400
Blood and immune system 707 | 16,909
Nervous System 707 | 16,725
Liver and Pancreas 705 | 16,750
Urinary Tract 705 | 16,678
Respiratory system 696 | 16,393
Cardiovascular System 691 | 15,192

Target Family

Non-IDG 422 | 12,091
Enzyme 179 | 4,145
Transcription Factor 58 | 1,400
Kinase 37 | 634
Transporter 12 | 473
Epigenetic 8 | 242
Ion Channel 6 | 344
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Muscle 725 | 725
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Proteasome assembly chaperone 1 PSMG1 Tbio Non-IDG -0.90381 8.14 122
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Heterogeneous nuclear ribonucleoprotein A0 HNRNPA0 Tbio Non-IDG -0.86935 6.45 110
ATP-dependent 6-phosphofructokinase, liver type PFKL Tbio Kinase -2.07015 107.6 240
Fatty acid desaturase 3 FADS3 Tbio Enzyme -1.15488 15.8 117
Zinc transporter ZIP1 SLC39A1 Tbio Transporter -1.89903 75.9 61
Cilia- and flagella-associated protein 20 CFAP20 Tbio Non-IDG -1.78803 43.9 88