Development Level

Tbio 256 | 10,625
Tdark 92 | 7,003
Tchem 54 | 1,890
Tclin 13 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 21 | 633
preweaning lethality, incomple... 10 | 260
decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
increased mean corpuscular hem... 5 | 93
abnormal behavior 4 | 226
abnormal embryo size 4 | 112
decreased body weight 4 | 174
decreased bone mineral content 4 | 157
decreased fasted circulating g... 4 | 49
embryonic lethality prior to t... 4 | 187
enlarged heart 4 | 111
increased or absent threshold ... 4 | 128
tremors 4 | 34
abnormal bone mineralization 3 | 55
abnormal coat/hair pigmentatio... 3 | 54
abnormal lens morphology 3 | 73
abnormal limb morphology 3 | 7
anophthalmia 3 | 20
cataract 3 | 26
decreased caudal vertebrae num... 3 | 49
decreased circulating LDL chol... 3 | 37
decreased circulating glucose ... 3 | 121
decreased circulating serum al... 3 | 79
edema 3 | 11
increased bone mineral content 3 | 92
increased circulating alkaline... 3 | 119
increased mean corpuscular vol... 3 | 91
prenatal lethality prior to he... 3 | 64
abnormal body wall morphology 2 | 7
abnormal craniofacial morpholo... 2 | 12
abnormal epididymis morphology 2 | 31
abnormal eye morphology 2 | 38
abnormal facial morphology 2 | 9
abnormal iris morphology 2 | 12
abnormal limb bud morphology 2 | 15
abnormal retinal pigmentation 2 | 61
abnormal snout morphology 2 | 18
cleft palate 2 | 6
decreased KLRG1-positive NK ce... 2 | 9
decreased body length 2 | 108
decreased circulating choleste... 2 | 85
decreased circulating insulin ... 2 | 75
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased mean corpuscular vol... 2 | 50
embryonic lethality prior to o... 2 | 148
enlarged epididymis 2 | 27
facial cleft 2 | 3
hyperactivity 2 | 108
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased circulating phosphat... 2 | 24
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased lean body mass 2 | 107
persistence of hyaloid vascula... 2 | 22
polydactyly 2 | 22
short tibia 2 | 82
thrombocytopenia 2 | 46
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal retina morphology 1 | 100
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
decreased NK cell number 1 | 16
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased effector memory CD8-... 1 | 24
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
decreased thoracic vertebrae n... 1 | 7
embryonic growth retardation 1 | 28
female infertility 1 | 34
impaired righting response 1 | 19
increased NK cell number 1 | 19
increased body length 1 | 20
increased circulating aspartat... 1 | 17
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 25
increased sacral vertebrae num... 1 | 62
prenatal lethality 1 | 16

Disease

ovarian cancer 224 | 8,492
osteosarcoma 191 | 7,933
psoriasis 169 | 6,685
medulloblastoma, large-cell 133 | 6,234
lung cancer 132 | 4,473
glioblastoma 122 | 5,572
atypical teratoid / rhabdoid tumor 109 | 4,369
Breast cancer 99 | 3,099
intraductal papillary-mucinous neoplasm (IPMN) 96 | 3,289
invasive ductal carcinoma 93 | 2,950
malignant mesothelioma 90 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 87 | 2,988
Cancer 85 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 82 | 2,956
interstitial cystitis 72 | 2,299
non-small cell lung cancer 71 | 2,798
lung adenocarcinoma 70 | 2,714
pancreatic cancer 69 | 2,300
primitive neuroectodermal tumor 67 | 3,031
ductal carcinoma in situ 62 | 1,745
pilocytic astrocytoma 61 | 3,086
pediatric high grade glioma 59 | 2,712
lung carcinoma 57 | 2,844
breast carcinoma 55 | 1,614
ulcerative colitis 55 | 2,087
ependymoma 53 | 2,514
oligodendroglioma 52 | 2,849
group 3 medulloblastoma 51 | 2,254
pituitary cancer 51 | 1,972
astrocytic glioma 50 | 2,241
adult high grade glioma 49 | 2,148
subependymal giant cell astrocytoma 49 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,795
tuberculosis 48 | 1,563
colon cancer 45 | 1,475
Pick disease 43 | 1,893
Carcinoma 41 | 2,147
diabetes mellitus 41 | 1,663
medulloblastoma 39 | 1,524
astrocytoma 38 | 1,493
posterior fossa group A ependymoma 38 | 1,511
cystic fibrosis 37 | 1,670
Multiple myeloma 36 | 1,328
primary pancreatic ductal adenocarcinoma 35 | 1,271
group 4 medulloblastoma 34 | 1,875
non primary Sjogren syndrome sicca 34 | 840
cutaneous lupus erythematosus 32 | 1,056
spina bifida 32 | 1,064
juvenile dermatomyositis 31 | 1,189
adrenocortical carcinoma 29 | 1,427
sonic hedgehog group medulloblastoma 29 | 1,482
acute quadriplegic myopathy 28 | 1,157
nasopharyngeal carcinoma 28 | 1,056
Rheumatoid Arthritis 27 | 1,171
esophageal adenocarcinoma 27 | 737
posterior fossa group B ependymoma 25 | 1,530
Atopic dermatitis 24 | 944
Mammary Neoplasms 24 | 410
Waldenstrons macroglobulinemia 24 | 765
Prostatic Neoplasms 23 | 471
dermatomyositis 23 | 967
gastric carcinoma 22 | 832
Endometriosis 19 | 535
atypical teratoid/rhabdoid tumor 19 | 1,095
fibroadenoma 19 | 557
pancreatic carcinoma 18 | 567
Alzheimer's disease 17 | 644
Polycystic Ovary Syndrome 17 | 335
active Crohn's disease 16 | 918
Obesity 15 | 616
gastric cancer 15 | 436
hepatocellular carcinoma 15 | 550
Down syndrome 14 | 548
primary Sjogren syndrome 14 | 789
tuberculosis and treatment for 6 months 14 | 686
active ulcerative colitis 13 | 477
acute myeloid leukemia 13 | 785
mucosa-associated lymphoid tissue lymphoma 13 | 480
progressive supranuclear palsy 13 | 674
Duchenne muscular dystrophy 12 | 602
aldosterone-producing adenoma 12 | 664
chronic rhinosinusitis 12 | 512
inflammatory breast cancer 12 | 404
Amyotrophic Lateral Sclerosis 11 | 432
Intellectual disability 11 | 573
Mammary Neoplasms, Experimental 11 | 150
Stomach Neoplasms 11 | 282
urothelial carcinoma 11 | 318
Animal Mammary Neoplasms 10 | 136
Atherosclerosis 10 | 275
IGA Glomerulonephritis 10 | 454
Osteoporosis 10 | 259
Schizophrenia 10 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
non-small cell lung carcinoma 10 | 413
Coronary artery disease 9 | 240
Crohn's disease 9 | 304
Kidney disease 9 | 397
Liver carcinoma 9 | 217
glioblastoma multiforme 9 | 347

Tissue

Female tissues 410 | 18,647
Endocrine System 409 | 18,512
Cardiovascular System 408 | 17,958
Digestive Tract 408 | 18,473
Liver and Pancreas 408 | 18,136
Nervous System 408 | 18,561
Blood and immune system 407 | 17,995
Urinary Tract 406 | 18,444
Male tissues 405 | 17,969
Respiratory system 404 | 17,484
Skin and soft tissues 403 | 18,115

Target Family

Non-IDG 238 | 11,969
Enzyme 99 | 4,146
Transcription Factor 26 | 1,400
Kinase 22 | 634
Transporter 13 | 473
Ion Channel 6 | 341
GPCR 4 | 408
Nuclear Receptor 4 | 48
Epigenetic 2 | 242
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Mammary gland 415 | 415
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome P450 4Z1 CYP4Z1 Tbio Non-IDG -0.62300 6.27 55
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.67656 3.42 165
Inter-alpha-trypsin inhibitor heavy chain H5 ITIH5 Tbio Non-IDG -1.02640 12.8 0
Transcription factor Ovo-like 2 OVOL2 Tbio Transcription Factor -1.12872 15.5 91
Soluble calcium-activated nucleotidase 1 CANT1 Tbio Enzyme -1.42022 25.3 175
Coiled-coil domain-containing protein 107 CCDC107 Tdark Non-IDG 0.00000 50
Short-chain dehydrogenase/reductase family 42E member 1 SDR42E1 Tdark Enzyme 0.00000 11
Activin receptor type-2A ACVR2A Tchem Kinase -2.04309 96.6 269
Signal recognition particle subunit SRP68 SRP68 Tbio Non-IDG -1.13992 12.9 73
Serine/threonine-protein kinase SIK3 SIK3 Tchem Kinase -1.08957 15.1 0