Development Level

Tbio 392 | 11,445
Tdark 95 | 6,588
Tchem 61 | 1,598
Tclin 15 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 52 | 979
preweaning lethality, incomple... 13 | 499
abnormal behavior 11 | 298
embryonic lethality prior to o... 11 | 239
increased circulating alkaline... 10 | 122
abnormal embryo size 9 | 220
embryonic lethality prior to t... 9 | 278
decreased circulating choleste... 8 | 93
increased or absent threshold ... 8 | 101
abnormal bone structure 7 | 187
decreased body weight 7 | 161
decreased bone mineral density 7 | 126
increased total body fat amoun... 7 | 134
decreased circulating glucose ... 6 | 126
decreased erythrocyte cell num... 6 | 62
decreased grip strength 6 | 116
decreased vertical activity 6 | 208
embryonic growth retardation 6 | 106
increased fasted circulating g... 6 | 76
abnormal bone mineralization 5 | 38
decreased body length 5 | 101
decreased bone mineral content 5 | 151
decreased circulating HDL chol... 5 | 68
decreased lean body mass 5 | 135
decreased total body fat amoun... 5 | 207
hyperactivity 5 | 148
increased circulating choleste... 5 | 66
increased circulating sodium l... 5 | 71
abnormal coat-hair pigmentatio... 4 | 64
abnormal lens morphology 4 | 81
abnormal sleep behavior 4 | 70
cataract 4 | 92
decreased basophil cell number 4 | 16
decreased circulating LDL chol... 4 | 38
decreased circulating fructosa... 4 | 30
decreased circulating triglyce... 4 | 79
decreased hemoglobin content 4 | 68
decreased prepulse inhibition 4 | 82
enlarged heart 4 | 210
impaired glucose tolerance 4 | 75
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
increased neutrophil cell numb... 4 | 46
male infertility 4 | 123
prolonged QT interval 4 | 38
abnormal heart morphology 3 | 162
abnormal retina morphology 3 | 71
cardiovascular system phenotyp... 3 | 36
decreased blood urea nitrogen ... 3 | 51
decreased circulating insulin ... 3 | 76
decreased circulating serum al... 3 | 82
decreased hematocrit 3 | 46
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
decreased startle reflex 3 | 75
hypoactivity 3 | 132
increased T cell number 3 | 6
increased circulating HDL chol... 3 | 80
increased circulating iron lev... 3 | 30
increased erythrocyte cell num... 3 | 39
increased grip strength 3 | 41
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
increased startle reflex 3 | 112
prolonged ST segment 3 | 36
short tibia 3 | 97
thrombocytopenia 3 | 56
thrombocytosis 3 | 27
abnormal blood vessel morpholo... 2 | 5
abnormal liver morphology 2 | 17
abnormal neural tube closure 2 | 46
abnormal spleen morphology 2 | 55
absent startle reflex 2 | 24
decreased T cell number 2 | 15
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating chloride... 2 | 30
decreased circulating free fat... 2 | 31
decreased circulating phosphat... 2 | 27
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased red blood cell distr... 2 | 41
decreased total retina thickne... 2 | 17
edema 2 | 59
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased circulating amylase ... 2 | 25
increased circulating creatini... 2 | 38
increased circulating serum al... 2 | 22
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 32
increased red blood cell distr... 2 | 34
small testis 2 | 58
trunk curl 2 | 16

Disease

Carcinoma 373 | 11,493
ovarian cancer 325 | 8,520
osteosarcoma 307 | 7,950
psoriasis 212 | 6,694
glioblastoma 199 | 5,792
medulloblastoma, large-cell 190 | 6,241
lung cancer 180 | 4,740
atypical teratoid / rhabdoid tumor 153 | 5,112
group 3 medulloblastoma 126 | 4,104
adult high grade glioma 117 | 3,801
malignant mesothelioma 116 | 3,232
ependymoma 113 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 111 | 3,291
non-small cell lung cancer 107 | 2,890
Breast cancer 105 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 105 | 2,989
invasive ductal carcinoma 105 | 2,951
Cancer 98 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 93 | 2,955
subependymal giant cell astrocytoma 91 | 2,287
interstitial cystitis 90 | 2,312
Astrocytoma, Pilocytic 89 | 3,081
oligodendroglioma 89 | 2,850
Kidney cancer 85 | 2,613
Multiple myeloma 84 | 1,332
primitive neuroectodermal tumor 84 | 3,035
lung adenocarcinoma 83 | 2,716
ulcerative colitis 79 | 1,819
lung carcinoma 75 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 68 | 1,962
pancreatic cancer 67 | 2,398
astrocytic glioma 66 | 2,597
primary Sjogren syndrome 66 | 735
tuberculosis 66 | 2,010
astrocytoma 64 | 1,146
diabetes mellitus 61 | 1,728
Pick disease 59 | 1,894
group 4 medulloblastoma 59 | 1,855
ductal carcinoma in situ 58 | 1,745
adrenocortical carcinoma 57 | 1,428
cutaneous lupus erythematosus 56 | 1,057
Waldenstrons macroglobulinemia 55 | 765
colon cancer 54 | 1,478
juvenile dermatomyositis 52 | 1,187
Rheumatoid arthritis 50 | 1,191
breast carcinoma 47 | 1,638
acute quadriplegic myopathy 46 | 1,158
Atopic dermatitis 44 | 952
Autosomal recessive predisposition 44 | 1,442
dermatomyositis 44 | 966
pediatric high grade glioma 44 | 1,064
pituitary cancer 43 | 1,972
nasopharyngeal carcinoma 40 | 1,058
Intellectual disability 39 | 1,016
cystic fibrosis 36 | 1,696
spina bifida 33 | 1,074
active Crohn's disease 32 | 922
non primary Sjogren syndrome sicca 32 | 891
Schizophrenia 31 | 1,160
Liver Cirrhosis, Experimental 30 | 769
primary pancreatic ductal adenocarcinoma 29 | 1,109
acute myeloid leukemia 26 | 783
Cognitive delay 25 | 608
Global developmental delay 25 | 608
Mental and motor retardation 25 | 608
Alzheimer's disease 23 | 658
Obesity 22 | 678
pancreatic carcinoma 22 | 562
Multiple Sclerosis 21 | 540
aldosterone-producing adenoma 21 | 665
Dull intelligence 20 | 645
Endometriosis 20 | 540
Epilepsy 20 | 792
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
esophageal adenocarcinoma 20 | 737
hepatocellular carcinoma 20 | 547
progressive supranuclear palsy 20 | 676
tuberculosis and treatment for 6 months 20 | 409
Amyotrophic lateral sclerosis 19 | 451
Bipolar Disorder 19 | 666
Muscle hypotonia 19 | 571
Neurodegenerative disease 19 | 414
Short stature 19 | 531
active ulcerative colitis 19 | 764
gastric carcinoma 19 | 807
periodontitis 19 | 293
posterior fossa group A ependymoma 18 | 468
Chronic Lymphocytic Leukemia 17 | 262
Seizures 17 | 596
sarcoidosis 17 | 370
Duchenne muscular dystrophy 16 | 601
medulloblastoma 16 | 720
Asthma 15 | 385
Crohn's disease 15 | 321
Prostatic Neoplasms 15 | 495
gastric cancer 15 | 459
sonic hedgehog group medulloblastoma 15 | 467

Tissue

Endocrine System 551 | 18,159
Blood and immune system 549 | 16,909
Digestive Tract 549 | 17,369
Male tissues 549 | 17,142
Female tissues 548 | 17,400
Liver and Pancreas 547 | 16,750
Respiratory system 547 | 16,393
Urinary Tract 547 | 16,678
Skin and soft tissues 546 | 17,230
Cardiovascular System 541 | 15,192
Nervous System 540 | 16,725

Target Family

Non-IDG 330 | 12,091
Enzyme 130 | 4,145
Transcription Factor 40 | 1,400
Kinase 27 | 634
Transporter 12 | 473
Epigenetic 11 | 242
Ion Channel 6 | 344
GPCR 4 | 408
TF/Epigenetic 3 | 38

Jensen-KB Tissue

Lymph 563 | 563
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Calcium homeostasis modulator protein 3 CALHM3 Tdark Ion Channel -0.10646 0.35 86
BTB/POZ domain-containing protein KCTD5 KCTD5 Tbio Non-IDG -1.70628 50.2 52
Multiple myeloma tumor-associated protein 2 C1orf35 Tdark Non-IDG 0.00000 1.00 39
Transmembrane protein 243 TMEM243 Tdark Non-IDG -0.18799 1.32 16
Exosome component 10 EXOSC10 Tbio Non-IDG -2.45249 279.1 123
Uncharacterized protein C1orf50 C1orf50 Tdark Non-IDG 0.00000 86
F-box/LRR-repeat protein 12 FBXL12 Tdark Non-IDG -0.43169 3.45 132
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.90516 156.1 254
Protein ABHD14A ABHD14A Tdark Enzyme 0.23 0.52 90