Development Level

Tbio 1,466 | 10,625
Tdark 449 | 7,003
Tchem 279 | 1,890
Tclin 88 | 602

Collection

Eligible Ion Channel Proteins 11 | 117
Eligible Kinase Proteins 10 | 134
Eligible non-olfactory GPCR Proteins 9 | 143

IMPC Term

preweaning lethality, complete... 108 | 633
embryonic lethality prior to t... 39 | 187
preweaning lethality, incomple... 38 | 260
decreased lean body mass 28 | 195
decreased body weight 26 | 174
enlarged heart 25 | 111
abnormal behavior 24 | 226
abnormal embryo size 24 | 112
embryonic lethality prior to o... 24 | 148
decreased total body fat amoun... 23 | 186
decreased bone mineral content 18 | 157
increased circulating alkaline... 17 | 119
abnormal bone structure 15 | 131
increased mean corpuscular vol... 15 | 91
increased or absent threshold ... 15 | 128
increased grip strength 14 | 83
increased mean corpuscular hem... 14 | 93
abnormal retina morphology 13 | 100
decreased circulating glucose ... 13 | 121
decreased circulating insulin ... 13 | 75
hyperactivity 13 | 108
increased lean body mass 13 | 107
decreased fasted circulating g... 12 | 49
increased bone mineral content 12 | 92
increased circulating sodium l... 12 | 71
abnormal heart morphology 11 | 51
decreased circulating serum al... 11 | 79
decreased lumbar vertebrae num... 11 | 62
impaired glucose tolerance 11 | 52
increased fasted circulating g... 11 | 68
abnormal lens morphology 10 | 73
decreased body length 10 | 108
decreased circulating HDL chol... 10 | 77
abnormal gait 9 | 51
abnormal neural tube closure 9 | 37
abnormal sleep behavior 9 | 63
decreased bone mineral density 9 | 126
decreased grip strength 9 | 123
decreased hemoglobin content 9 | 53
abnormal coat/hair pigmentatio... 8 | 54
decreased circulating LDL chol... 8 | 37
decreased circulating fructosa... 8 | 31
decreased circulating iron lev... 8 | 25
decreased circulating total pr... 8 | 41
decreased mean corpuscular vol... 8 | 50
decreased prepulse inhibition 8 | 52
decreased rib number 8 | 59
increased blood urea nitrogen ... 8 | 44
increased circulating HDL chol... 8 | 63
increased exploration in new e... 8 | 56
increased sacral vertebrae num... 8 | 62
limb grasping 8 | 35
male infertility 8 | 62
thrombocytopenia 8 | 46
abnormal bone mineralization 7 | 55
abnormal eye morphology 7 | 38
abnormal hindbrain development 7 | 24
abnormal locomotor activation 7 | 26
decreased Ly6C high monocyte n... 7 | 18
decreased circulating alanine ... 7 | 53
decreased circulating choleste... 7 | 85
decreased circulating free fat... 7 | 39
decreased circulating triglyce... 7 | 83
decreased startle reflex 7 | 48
improved glucose tolerance 7 | 56
increased bone mineral density 7 | 52
increased circulating amylase ... 7 | 13
increased circulating chloride... 7 | 43
increased total body fat amoun... 7 | 57
short tibia 7 | 82
shortened RR interval 7 | 19
abnormal cranium morphology 6 | 32
abnormal forebrain development 6 | 18
abnormal midbrain development 6 | 22
abnormal retinal pigmentation 6 | 61
abnormal testis morphology 6 | 30
anophthalmia 6 | 20
decreased circulating calcium ... 6 | 33
decreased erythrocyte cell num... 6 | 43
decreased leukocyte cell numbe... 6 | 54
decreased mean corpuscular hem... 6 | 34
decreased monocyte cell number 6 | 28
decreased neutrophil cell numb... 6 | 37
decreased threshold for audito... 6 | 32
immune system phenotype 6 | 17
increased body weight 6 | 42
increased hematocrit 6 | 36
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 37
prenatal lethality prior to he... 6 | 64
small testis 6 | 37
tremors 6 | 34
abnormal behavioral response t... 5 | 52
abnormal seminal vesicle morph... 5 | 47
abnormal spleen morphology 5 | 36
cardiovascular system phenotyp... 5 | 35
decreased heart weight 5 | 44
embryonic growth retardation 5 | 28
increased circulating choleste... 5 | 53
prenatal lethality 5 | 16

Disease

ovarian cancer 1,216 | 8,484
osteosarcoma 1,051 | 7,933
psoriasis 822 | 6,685
medulloblastoma, large-cell 764 | 6,234
glioblastoma 719 | 5,572
lung cancer 716 | 4,466
atypical teratoid / rhabdoid tumor 495 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 486 | 3,289
malignant mesothelioma 474 | 3,162
lung adenocarcinoma 473 | 2,713
non-small cell lung cancer 468 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 448 | 2,988
invasive ductal carcinoma 441 | 2,950
lung carcinoma 438 | 2,844
Breast cancer 417 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 409 | 2,956
Cancer 392 | 2,346
pancreatic cancer 356 | 2,300
primitive neuroectodermal tumor 341 | 3,031
pilocytic astrocytoma 340 | 3,086
oligodendroglioma 332 | 2,849
interstitial cystitis 326 | 2,299
pediatric high grade glioma 320 | 2,712
ependymoma 300 | 2,514
ulcerative colitis 297 | 2,087
group 3 medulloblastoma 285 | 2,254
subependymal giant cell astrocytoma 285 | 2,287
astrocytic glioma 269 | 2,241
adult high grade glioma 261 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 257 | 1,795
pituitary cancer 254 | 1,972
Multiple myeloma 252 | 1,327
ductal carcinoma in situ 247 | 1,745
group 4 medulloblastoma 238 | 1,875
breast carcinoma 237 | 1,614
colon cancer 236 | 1,475
Pick disease 233 | 1,893
cystic fibrosis 230 | 1,665
primary pancreatic ductal adenocarcinoma 223 | 1,271
tuberculosis 222 | 1,557
astrocytoma 221 | 1,493
adrenocortical carcinoma 220 | 1,427
diabetes mellitus 220 | 1,663
sonic hedgehog group medulloblastoma 209 | 1,482
acute quadriplegic myopathy 193 | 1,157
posterior fossa group A ependymoma 191 | 1,511
posterior fossa group B ependymoma 184 | 1,530
Carcinoma 173 | 2,147
nasopharyngeal carcinoma 173 | 1,056
juvenile dermatomyositis 169 | 1,189
Rheumatoid Arthritis 157 | 1,160
Waldenstrons macroglobulinemia 155 | 765
medulloblastoma 153 | 1,524
spina bifida 145 | 1,064
dermatomyositis 144 | 933
cutaneous lupus erythematosus 140 | 1,056
atypical teratoid/rhabdoid tumor 135 | 1,095
Atopic dermatitis 131 | 944
non primary Sjogren syndrome sicca 129 | 840
esophageal adenocarcinoma 126 | 737
active Crohn's disease 120 | 918
acute myeloid leukemia 111 | 780
gastric carcinoma 110 | 832
tuberculosis and treatment for 6 months 109 | 686
Endometriosis 94 | 535
primary Sjogren syndrome 92 | 789
Duchenne muscular dystrophy 91 | 602
Prostatic Neoplasms 91 | 471
Alzheimer's disease 89 | 644
progressive supranuclear palsy 86 | 674
aldosterone-producing adenoma 84 | 664
fibroadenoma 82 | 557
pancreatic carcinoma 79 | 567
Mammary Neoplasms 78 | 410
chronic rhinosinusitis 78 | 512
Obesity 77 | 616
Down syndrome 76 | 548
hepatocellular carcinoma 76 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 75 | 499
Intellectual disability 73 | 573
mucosa-associated lymphoid tissue lymphoma 73 | 480
non-small cell lung carcinoma 73 | 413
active ulcerative colitis 70 | 477
inflammatory breast cancer 69 | 404
Stomach Neoplasms 66 | 282
IGA Glomerulonephritis 65 | 454
Asthma 64 | 349
Schizophrenia 62 | 501
Neurodegenerative disease 61 | 383
Atherosclerosis 58 | 275
nephrosclerosis 54 | 329
Polycystic Ovary Syndrome 53 | 332
sarcoidosis 53 | 358
tuberculosis and treatment for 3 months 53 | 327
Kidney disease 52 | 396
Vascular disease 52 | 281
Multiple Sclerosis 51 | 498
gastric cancer 51 | 430
Amyotrophic Lateral Sclerosis 50 | 431
urothelial carcinoma 48 | 318

Tissue

Digestive Tract 2,253 | 18,473
Nervous System 2,253 | 18,561
Female tissues 2,252 | 18,647
Liver and Pancreas 2,248 | 18,136
Male tissues 2,242 | 17,969
Blood and immune system 2,240 | 17,995
Endocrine System 2,240 | 18,512
Urinary Tract 2,240 | 18,444
Cardiovascular System 2,235 | 17,958
Respiratory system 2,228 | 17,484
Skin and soft tissues 2,227 | 18,115

Target Family

Non-IDG 1,292 | 11,971
Enzyme 599 | 4,146
Transcription Factor 156 | 1,400
Kinase 69 | 634
GPCR 53 | 406
Transporter 46 | 473
Ion Channel 32 | 341
Epigenetic 26 | 242
TF/Epigenetic 4 | 38
Nuclear Receptor 3 | 48
oGPCR 2 | 421

Jensen-KB Tissue

Lung 2,282 | 2,282
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345