Development Level

Tbio 1,632 | 11,651
Tdark 377 | 6,593
Tchem 189 | 1,388
Tclin 88 | 612

Collection

RFA-RM-18-021 30 | 328
Ion Channel: IDG Consortium (T... 12 | 99
GPCR: IDG Consortium (Targets) 10 | 126
Kinase: IDG Consortium (Target... 8 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 157 | 979
preweaning lethality, incomple... 66 | 499
embryonic lethality prior to t... 58 | 278
embryonic lethality prior to o... 40 | 239
abnormal embryo size 37 | 220
enlarged heart 33 | 210
abnormal behavior 32 | 298
decreased vertical activity 24 | 208
decreased total body fat amoun... 23 | 207
abnormal heart morphology 22 | 162
increased lean body mass 22 | 172
decreased body weight 21 | 161
embryonic growth retardation 20 | 106
hyperactivity 19 | 148
abnormal bone structure 18 | 187
decreased lean body mass 18 | 135
increased total body fat amoun... 18 | 134
abnormal eye morphology 17 | 68
increased mean corpuscular vol... 17 | 92
increased startle reflex 17 | 112
male infertility 16 | 123
abnormal seminal vesicle morph... 15 | 114
decreased bone mineral content 15 | 151
decreased circulating glucose ... 15 | 126
decreased circulating choleste... 14 | 93
increased bone mineral content 14 | 108
increased circulating HDL chol... 14 | 80
increased circulating alkaline... 14 | 122
increased mean corpuscular hem... 14 | 96
decreased grip strength 13 | 116
abnormal retina morphology 12 | 71
decreased circulating serum al... 12 | 82
abnormal gait 11 | 69
cataract 11 | 92
decreased bone mineral density 11 | 126
decreased fasted circulating g... 11 | 65
decreased mean corpuscular vol... 11 | 79
decreased prepulse inhibition 11 | 82
impaired glucose tolerance 11 | 75
increased or absent threshold ... 11 | 101
short tibia 11 | 97
small superior vagus ganglion 11 | 74
abnormal coat-hair pigmentatio... 10 | 64
abnormal craniofacial morpholo... 10 | 33
abnormal lens morphology 10 | 81
decreased circulating HDL chol... 10 | 68
decreased circulating insulin ... 10 | 76
decreased erythrocyte cell num... 10 | 62
increased bone mineral density 10 | 72
increased circulating sodium l... 10 | 71
increased mean platelet volume 10 | 45
prenatal lethality prior to he... 10 | 87
decreased caudal vertebrae num... 9 | 53
decreased circulating total pr... 9 | 49
decreased hemoglobin content 9 | 68
decreased lymphocyte cell numb... 9 | 83
decreased red blood cell distr... 9 | 41
hypoactivity 9 | 132
improved glucose tolerance 9 | 79
increased fasted circulating g... 9 | 76
thrombocytopenia 9 | 56
tremors 9 | 39
abnormal behavioral response t... 8 | 66
abnormal neural tube closure 8 | 46
abnormal sleep behavior 8 | 70
anophthalmia 8 | 33
decreased circulating LDL chol... 8 | 38
decreased circulating calcium ... 8 | 36
decreased circulating iron lev... 8 | 32
decreased leukocyte cell numbe... 8 | 73
decreased mean corpuscular hem... 8 | 50
edema 8 | 59
female infertility 8 | 60
increased blood urea nitrogen ... 8 | 48
increased leukocyte cell numbe... 8 | 47
limb grasping 8 | 41
decreased blood urea nitrogen ... 7 | 51
decreased body length 7 | 101
decreased circulating free fat... 7 | 31
decreased circulating fructosa... 7 | 30
decreased hematocrit 7 | 46
decreased startle reflex 7 | 75
hydrometra 7 | 53
increased body length 7 | 32
increased circulating amylase ... 7 | 25
increased circulating chloride... 7 | 41
increased circulating choleste... 7 | 66
long tibia 7 | 25
pallor 7 | 34
small testis 7 | 58
abnormal epididymis morphology 6 | 42
abnormal skin morphology 6 | 50
abnormal spleen morphology 6 | 55
corneal opacity 6 | 32
decreased circulating alanine ... 6 | 47
decreased circulating alkaline... 6 | 46
decreased mean corpuscular hem... 6 | 31
increased heart weight 6 | 62
increased hematocrit 6 | 46
increased hemoglobin content 6 | 45

Disease

Carcinoma 1,285 | 11,493
ovarian cancer 1,221 | 8,520
osteosarcoma 1,054 | 7,950
psoriasis 821 | 6,694
medulloblastoma, large-cell 767 | 6,241
glioblastoma 753 | 5,792
lung cancer 741 | 4,740
atypical teratoid / rhabdoid tumor 597 | 5,112
ependymoma 590 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 489 | 3,291
group 3 medulloblastoma 488 | 4,104
non-small cell lung cancer 485 | 2,890
malignant mesothelioma 483 | 3,232
Breast cancer 477 | 3,578
lung adenocarcinoma 475 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 450 | 2,989
adult high grade glioma 448 | 3,801
invasive ductal carcinoma 443 | 2,951
lung carcinoma 439 | 2,843
Cancer 423 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 410 | 2,955
pancreatic cancer 365 | 2,398
primitive neuroectodermal tumor 344 | 3,035
Astrocytoma, Pilocytic 340 | 3,081
oligodendroglioma 333 | 2,850
interstitial cystitis 328 | 2,312
astrocytic glioma 314 | 2,597
tuberculosis 298 | 2,010
subependymal giant cell astrocytoma 287 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 281 | 1,962
ulcerative colitis 259 | 1,819
pituitary cancer 252 | 1,972
Multiple myeloma 249 | 1,332
ductal carcinoma in situ 248 | 1,745
breast carcinoma 244 | 1,638
cystic fibrosis 239 | 1,696
group 4 medulloblastoma 239 | 1,855
colon cancer 236 | 1,478
Pick disease 233 | 1,894
Kidney cancer 223 | 2,613
adrenocortical carcinoma 223 | 1,428
diabetes mellitus 222 | 1,728
primary pancreatic ductal adenocarcinoma 201 | 1,109
Autosomal recessive predisposition 200 | 1,442
acute quadriplegic myopathy 194 | 1,158
astrocytoma 180 | 1,146
nasopharyngeal carcinoma 172 | 1,058
juvenile dermatomyositis 169 | 1,187
Rheumatoid arthritis 160 | 1,191
Waldenstrons macroglobulinemia 154 | 765
spina bifida 150 | 1,074
Schizophrenia 144 | 1,160
dermatomyositis 144 | 966
cutaneous lupus erythematosus 139 | 1,057
pediatric high grade glioma 136 | 1,064
non primary Sjogren syndrome sicca 131 | 891
Atopic dermatitis 130 | 952
esophageal adenocarcinoma 126 | 737
Intellectual disability 124 | 1,016
active Crohn's disease 122 | 922
Liver Cirrhosis, Experimental 117 | 769
acute myeloid leukemia 112 | 783
active ulcerative colitis 111 | 764
gastric carcinoma 106 | 807
Epilepsy 102 | 792
Prostatic Neoplasms 96 | 495
Endometriosis 95 | 540
Cognitive delay 93 | 608
Global developmental delay 93 | 608
Mental and motor retardation 93 | 608
Seizures 92 | 596
Duchenne muscular dystrophy 91 | 601
primary Sjogren syndrome 89 | 735
medulloblastoma 88 | 720
progressive supranuclear palsy 86 | 676
Alzheimer's disease 85 | 658
Dull intelligence 84 | 645
Low intelligence 84 | 645
Mental Retardation 84 | 645
Mental deficiency 84 | 645
Poor school performance 84 | 645
aldosterone-producing adenoma 84 | 665
Muscle hypotonia 83 | 571
Breast Neoplasms 82 | 445
fibroadenoma 82 | 559
Mammary Neoplasms 81 | 425
Bipolar Disorder 79 | 666
Obesity 79 | 678
hepatocellular carcinoma 79 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 78 | 510
chronic rhinosinusitis 78 | 512
pancreatic carcinoma 77 | 562
sonic hedgehog group medulloblastoma 75 | 467
mucosa-associated lymphoid tissue lymphoma 74 | 484
Down syndrome 73 | 499
Short stature 71 | 531
Melanoma 69 | 711
Asthma 68 | 385
Stomach Neoplasms 68 | 300
Small head 66 | 374

Tissue

Endocrine System 2,240 | 18,159
Female tissues 2,235 | 17,400
Digestive Tract 2,234 | 17,369
Skin and soft tissues 2,224 | 17,230
Male tissues 2,221 | 17,142
Respiratory system 2,215 | 16,393
Blood and immune system 2,212 | 16,909
Urinary Tract 2,210 | 16,678
Liver and Pancreas 2,205 | 16,750
Nervous System 2,183 | 16,725
Cardiovascular System 2,105 | 15,192

Target Family

Non-IDG 1,296 | 12,091
Enzyme 599 | 4,145
Transcription Factor 156 | 1,400
Kinase 69 | 634
GPCR 53 | 408
Transporter 46 | 473
Ion Channel 32 | 344
Epigenetic 26 | 242
TF/Epigenetic 4 | 38
Nuclear Receptor 3 | 48
oGPCR 2 | 421

Jensen-KB Tissue

Lung 2,286 | 2,286
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275