Development Level

Tbio 828 | 10,625
Tdark 226 | 7,003
Tchem 177 | 1,890
Tclin 62 | 602

Collection

Eligible Ion Channel Proteins 11 | 117
Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 3 | 143

IMPC Term

preweaning lethality, complete... 65 | 633
decreased lean body mass 26 | 195
abnormal behavior 21 | 226
preweaning lethality, incomple... 21 | 260
decreased total body fat amoun... 19 | 186
decreased body weight 16 | 174
decreased bone mineral content 16 | 157
decreased bone mineral density 15 | 126
embryonic lethality prior to t... 15 | 187
increased lean body mass 15 | 107
abnormal bone structure 14 | 131
decreased grip strength 14 | 123
embryonic lethality prior to o... 14 | 148
abnormal embryo size 13 | 112
decreased circulating triglyce... 12 | 83
increased mean corpuscular vol... 12 | 91
abnormal retina morphology 11 | 100
decreased circulating HDL chol... 11 | 77
decreased circulating choleste... 11 | 85
decreased circulating glucose ... 11 | 121
hypoactivity 11 | 89
abnormal lens morphology 10 | 73
decreased body length 10 | 108
decreased circulating insulin ... 10 | 75
increased bone mineral content 10 | 92
decreased hemoglobin content 9 | 53
hyperactivity 9 | 108
increased circulating alkaline... 9 | 119
increased or absent threshold ... 9 | 128
decreased prepulse inhibition 8 | 52
enlarged heart 8 | 111
increased grip strength 8 | 83
increased mean corpuscular hem... 8 | 93
increased total body fat amoun... 8 | 57
short tibia 8 | 82
decreased circulating serum al... 7 | 79
decreased leukocyte cell numbe... 7 | 54
impaired glucose tolerance 7 | 52
increased bone mineral density 7 | 52
increased circulating HDL chol... 7 | 63
prenatal lethality prior to he... 7 | 64
abnormal bone mineralization 6 | 55
increased blood urea nitrogen ... 6 | 44
increased circulating chloride... 6 | 43
increased exploration in new e... 6 | 56
increased fasted circulating g... 6 | 68
male infertility 6 | 62
thrombocytopenia 6 | 46
tremors 6 | 34
abnormal epididymis morphology 5 | 31
abnormal kidney morphology 5 | 30
abnormal neural tube closure 5 | 37
abnormal retinal pigmentation 5 | 61
abnormal seminal vesicle morph... 5 | 47
abnormal skin morphology 5 | 23
abnormal startle reflex 5 | 14
decreased blood urea nitrogen ... 5 | 31
decreased circulating alanine ... 5 | 53
decreased circulating alkaline... 5 | 41
decreased heart weight 5 | 44
decreased mean corpuscular vol... 5 | 50
decreased startle reflex 5 | 48
improved glucose tolerance 5 | 56
increased B cell number 5 | 23
increased circulating sodium l... 5 | 71
increased sacral vertebrae num... 5 | 62
abnormal behavioral response t... 4 | 52
abnormal body wall morphology 4 | 7
abnormal coat/hair pigmentatio... 4 | 54
abnormal gait 4 | 51
abnormal response to tactile s... 4 | 16
abnormal rib morphology 4 | 28
abnormal sleep behavior 4 | 63
decreased B cell number 4 | 30
decreased circulating chloride... 4 | 32
decreased circulating fructosa... 4 | 31
decreased circulating sodium l... 4 | 18
decreased circulating total pr... 4 | 41
decreased erythrocyte cell num... 4 | 43
decreased lumbar vertebrae num... 4 | 62
decreased mean corpuscular hem... 4 | 34
decreased neutrophil cell numb... 4 | 37
decreased rib number 4 | 59
increased circulating choleste... 4 | 53
increased circulating creatini... 4 | 29
increased hematocrit 4 | 36
small testis 4 | 37
straub tail 4 | 26
abnormal cornea morphology 3 | 24
abnormal lung morphology 3 | 15
decreased circulating potassiu... 3 | 17
decreased fasted circulating g... 3 | 49
enlarged spleen 3 | 26
increased body weight 3 | 42
increased circulating bilirubi... 3 | 16
increased circulating calcium ... 3 | 32
increased circulating serum al... 3 | 25
increased circulating total pr... 3 | 20
increased heart weight 3 | 37
increased respiratory quotient 3 | 12

Disease

ovarian cancer 690 | 8,484
osteosarcoma 587 | 7,933
psoriasis 487 | 6,685
medulloblastoma, large-cell 465 | 6,234
glioblastoma 418 | 5,572
lung cancer 356 | 4,466
atypical teratoid / rhabdoid tumor 330 | 4,369
malignant mesothelioma 276 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 273 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 257 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 253 | 2,988
invasive ductal carcinoma 246 | 2,950
Breast cancer 237 | 3,094
non-small cell lung cancer 229 | 2,798
oligodendroglioma 224 | 2,849
lung adenocarcinoma 220 | 2,713
pilocytic astrocytoma 215 | 3,086
primitive neuroectodermal tumor 212 | 3,031
lung carcinoma 211 | 2,844
pediatric high grade glioma 210 | 2,712
pancreatic cancer 206 | 2,300
Cancer 188 | 2,346
ependymoma 187 | 2,514
ulcerative colitis 187 | 2,087
interstitial cystitis 181 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 181 | 1,795
subependymal giant cell astrocytoma 176 | 2,287
ductal carcinoma in situ 162 | 1,745
astrocytic glioma 160 | 2,241
group 3 medulloblastoma 159 | 2,254
Pick disease 158 | 1,893
pituitary cancer 157 | 1,972
cystic fibrosis 149 | 1,665
adult high grade glioma 144 | 2,148
group 4 medulloblastoma 140 | 1,875
breast carcinoma 133 | 1,614
Carcinoma 132 | 2,147
astrocytoma 130 | 1,493
Multiple myeloma 126 | 1,327
adrenocortical carcinoma 119 | 1,427
primary pancreatic ductal adenocarcinoma 117 | 1,271
colon cancer 114 | 1,475
diabetes mellitus 114 | 1,663
posterior fossa group A ependymoma 114 | 1,511
tuberculosis 113 | 1,557
sonic hedgehog group medulloblastoma 106 | 1,482
medulloblastoma 105 | 1,524
posterior fossa group B ependymoma 102 | 1,530
juvenile dermatomyositis 87 | 1,189
acute quadriplegic myopathy 85 | 1,157
spina bifida 84 | 1,064
dermatomyositis 81 | 933
gastric carcinoma 81 | 832
Kidney disease 80 | 396
nephrosclerosis 77 | 329
Rheumatoid Arthritis 74 | 1,160
atypical teratoid/rhabdoid tumor 72 | 1,095
cutaneous lupus erythematosus 70 | 1,056
active Crohn's disease 69 | 918
esophageal adenocarcinoma 68 | 737
non primary Sjogren syndrome sicca 64 | 840
Atopic dermatitis 62 | 944
Waldenstrons macroglobulinemia 61 | 765
tuberculosis and treatment for 6 months 61 | 686
nasopharyngeal carcinoma 58 | 1,056
Hypertension 57 | 287
pancreatic carcinoma 57 | 567
progressive supranuclear palsy 54 | 674
Down syndrome 53 | 548
Prostatic Neoplasms 52 | 471
acute myeloid leukemia 52 | 780
fibroadenoma 52 | 557
Duchenne muscular dystrophy 49 | 602
primary Sjogren syndrome 48 | 789
Intellectual disability 46 | 573
active ulcerative colitis 46 | 477
Endometriosis 45 | 535
aldosterone-producing adenoma 45 | 664
mucosa-associated lymphoid tissue lymphoma 42 | 480
Alzheimer's disease 41 | 644
Obesity 41 | 616
Multiple Sclerosis 40 | 498
Mammary Neoplasms 39 | 410
autosomal dominant Emery-Dreifuss muscular dystrophy 39 | 499
urothelial carcinoma 37 | 318
hepatocellular carcinoma 36 | 532
inflammatory breast cancer 36 | 404
Neurodegenerative disease 34 | 383
Asthma 33 | 349
Atherosclerosis 33 | 275
chronic rhinosinusitis 33 | 512
gastric cancer 33 | 430
Amyotrophic Lateral Sclerosis 32 | 431
IGA Glomerulonephritis 32 | 454
glioblastoma multiforme 32 | 347
non-small cell lung carcinoma 32 | 413
Acquired metabolic disease 31 | 267
Crohn's disease 29 | 304
Osteoporosis 29 | 257
Schizophrenia 29 | 501

Tissue

Nervous System 1,277 | 18,561
Urinary Tract 1,277 | 18,444
Digestive Tract 1,276 | 18,473
Endocrine System 1,276 | 18,512
Female tissues 1,275 | 18,647
Liver and Pancreas 1,273 | 18,136
Skin and soft tissues 1,269 | 18,115
Blood and immune system 1,267 | 17,995
Cardiovascular System 1,267 | 17,958
Male tissues 1,265 | 17,969
Respiratory system 1,250 | 17,484

Target Family

Non-IDG 656 | 11,971
Enzyme 369 | 4,146
Transporter 86 | 473
Transcription Factor 58 | 1,400
Kinase 44 | 634
Ion Channel 34 | 341
GPCR 21 | 406
Nuclear Receptor 14 | 48
Epigenetic 9 | 242
TF/Epigenetic 2 | 38

Jensen-KB Tissue

Kidney 1,293 | 1,293
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
HEAT repeat-containing protein 6 HEATR6 Tdark Non-IDG -1.48236 11.6 38
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18
Equilibrative nucleoside transporter 4 SLC29A4 Tbio Transporter -1.79381 73.1 189
Xaa-Pro aminopeptidase 2 XPNPEP2 Tchem Enzyme -1.55651 32.2 97
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161