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Target Filters...

Development Level

Tbio 88 | 10,625
Tdark 19 | 7,003
Tchem 11 | 1,890
Tclin 10 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

abnormal behavior 4 | 226
decreased lean body mass 4 | 195
preweaning lethality, complete... 4 | 633
decreased bone mineral content 3 | 157
increased or absent threshold ... 3 | 128
preweaning lethality, incomple... 3 | 260
abnormal heart morphology 2 | 51
decreased body length 2 | 108
decreased caudal vertebrae num... 2 | 49
decreased circulating choleste... 2 | 85
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
decreased vertical activity 2 | 22
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
long tibia 2 | 13
male infertility 2 | 62
short tibia 2 | 82
thrombocytosis 2 | 23
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal coat/ hair morphology 1 | 18
abnormal lung morphology 1 | 15
abnormal pancreas morphology 1 | 6
abnormal respiratory quotient 1 | 9
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
cardiovascular system phenotyp... 1 | 35
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased follicular B cell nu... 1 | 4
decreased heart weight 1 | 44
decreased lactate dehydrogenas... 1 | 14
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean platelet volume 1 | 12
decreased red blood cell distr... 1 | 11
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
hydrometra 1 | 13
increased KLRG1-positive NK ce... 1 | 9
increased circulating glycerol... 1 | 11
increased fasted circulating g... 1 | 68
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased marginal zone B cell... 1 | 3
increased mean corpuscular hem... 1 | 25
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
small heart 1 | 8
small superior vagus ganglion 1 | 20
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 79 | 8,492
osteosarcoma 52 | 7,933
medulloblastoma, large-cell 46 | 6,234
psoriasis 45 | 6,685
lung cancer 43 | 4,473
glioblastoma 36 | 5,572
Multiple myeloma 31 | 1,328
atypical teratoid / rhabdoid tumor 31 | 4,369
Breast cancer 29 | 3,099
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
oligodendroglioma 25 | 2,849
pituitary cancer 22 | 1,972
ependymoma 21 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
lung adenocarcinoma 20 | 2,714
pediatric high grade glioma 20 | 2,712
astrocytic glioma 19 | 2,241
pancreatic cancer 19 | 2,300
primitive neuroectodermal tumor 19 | 3,031
Cancer 18 | 2,346
lung carcinoma 18 | 2,844
Pick disease 17 | 1,893
colon cancer 17 | 1,475
malignant mesothelioma 17 | 3,163
non-small cell lung cancer 17 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
pilocytic astrocytoma 16 | 3,086
subependymal giant cell astrocytoma 16 | 2,287
diabetes mellitus 15 | 1,663
Waldenstrons macroglobulinemia 14 | 765
breast carcinoma 14 | 1,614
invasive ductal carcinoma 14 | 2,950
sonic hedgehog group medulloblastoma 14 | 1,482
Carcinoma 13 | 2,147
ductal carcinoma in situ 13 | 1,745
posterior fossa group A ependymoma 13 | 1,511
ulcerative colitis 13 | 2,087
adrenocortical carcinoma 12 | 1,427
primary pancreatic ductal adenocarcinoma 12 | 1,271
Osteoporosis 11 | 259
astrocytoma 11 | 1,493
medulloblastoma 11 | 1,524
posterior fossa group B ependymoma 11 | 1,530
Neurodegenerative disease 10 | 383
cystic fibrosis 10 | 1,670
juvenile dermatomyositis 10 | 1,189
adult high grade glioma 9 | 2,148
group 4 medulloblastoma 9 | 1,875
spina bifida 9 | 1,064
Alzheimer's disease 8 | 644
Obesity 8 | 616
Prostatic Neoplasms 8 | 471
dermatomyositis 8 | 967
group 3 medulloblastoma 8 | 2,254
interstitial cystitis 8 | 2,299
Atopic dermatitis 7 | 944
Duchenne muscular dystrophy 7 | 602
Hypothyroidism 7 | 89
acute quadriplegic myopathy 7 | 1,157
tuberculosis 7 | 1,563
Adenoma 6 | 165
Bipolar Disorder 6 | 266
Epilepsy 6 | 346
Polycystic Ovary Syndrome 6 | 335
aldosterone-producing adenoma 6 | 664
gastric carcinoma 6 | 832
pancreatic carcinoma 6 | 567
Endometriosis 5 | 535
Hypertension 5 | 293
Hypopituitarism 5 | 36
Major Depressive Disorder 5 | 106
Mammary Neoplasms 5 | 410
Pneumonia 5 | 133
Rheumatoid Arthritis 5 | 1,171
Schizophrenia 5 | 503
active Crohn's disease 5 | 918
acute myeloid leukemia 5 | 785
adrenocortical adenoma 5 | 134
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
tuberculosis and treatment for 6 months 5 | 686
Amyotrophic Lateral Sclerosis 4 | 432
Asthma 4 | 349
Becker muscular dystrophy 4 | 187
Down syndrome 4 | 548
Hypertensive disease 4 | 193
Pituitary adenoma 4 | 35
atypical teratoid/rhabdoid tumor 4 | 1,095
esophageal adenocarcinoma 4 | 737
hepatocellular carcinoma 4 | 550
inflammatory breast cancer 4 | 404
non primary Sjogren syndrome sicca 4 | 840
post-traumatic stress disorder 4 | 45
sarcoidosis 4 | 368
Contact Dermatitis 3 | 80
Vascular disease 3 | 281
fibroadenoma 3 | 557
nasopharyngeal carcinoma 3 | 1,056
nephrosclerosis 3 | 329
progressive supranuclear palsy 3 | 674

Tissue

Cardiovascular System 125 | 17,958
Endocrine System 125 | 18,512
Nervous System 125 | 18,561
Blood and immune system 124 | 17,995
Digestive Tract 124 | 18,473
Female tissues 124 | 18,647
Liver and Pancreas 124 | 18,136
Skin and soft tissues 124 | 18,115
Urinary Tract 124 | 18,444
Male tissues 122 | 17,969
Respiratory system 122 | 17,484

Target Family

Non-IDG 75 | 11,969
Enzyme 26 | 4,146
GPCR 9 | 408
Transcription Factor 6 | 1,400
Kinase 4 | 634
Epigenetic 3 | 242
Ion Channel 3 | 341
Nuclear Receptor 1 | 48
Transporter 1 | 473

Jensen-KB Tissue

Hypophysis 128 | 128
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylyl cyclase-associated protein 1 CAP1 Tbio Enzyme -0.87211 7.62 129
Sec1 family domain-containing protein 1 SCFD1 Tbio Non-IDG -1.46179 31.8 115
Lambda-crystallin homolog CRYL1 Tbio Enzyme -1.48253 26.6 35
Tetraspanin-13 TSPAN13 Tbio Non-IDG -0.42090 2.84 62
Probable G-protein coupled receptor 179 GPR179 Tdark GPCR -0.86734 8.78 0
Pro-opiomelanocortin POMC Tbio Non-IDG -4.55455 36028.8 1100
COP9 signalosome complex subunit 4 COPS4 Tbio Non-IDG -0.91181 6.31 78
DNA-directed RNA polymerase III subunit RPC8 POLR3H Tbio Enzyme -1.29994 19.0 87
Gonadotropin-releasing hormone receptor GNRHR Tclin GPCR -2.61137 425.1 280
Nuclear receptor corepressor 2 NCOR2 Tchem Transcription Factor -2.78439 578.1 198