Development Level

Tbio 407 | 11,651
Tdark 77 | 6,593
Tchem 57 | 1,388
Tclin 42 | 612

Collection

RFA-RM-18-021 13 | 328
Ion Channel: IDG Consortium (T... 9 | 99
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 31 | 979
preweaning lethality, incomple... 13 | 499
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 11 | 278
enlarged heart 11 | 210
decreased vertical activity 10 | 208
abnormal embryo size 9 | 220
abnormal heart morphology 9 | 162
increased lean body mass 8 | 172
decreased grip strength 7 | 116
decreased total body fat amoun... 7 | 207
abnormal behavior 6 | 298
abnormal seminal vesicle morph... 6 | 114
decreased circulating choleste... 6 | 93
hyperactivity 6 | 148
male infertility 6 | 123
abnormal skin morphology 5 | 50
impaired glucose tolerance 5 | 75
abnormal coat-hair pigmentatio... 4 | 64
abnormal neural tube closure 4 | 46
cardiovascular system phenotyp... 4 | 36
cataract 4 | 92
decreased body weight 4 | 161
decreased circulating HDL chol... 4 | 68
decreased fasted circulating g... 4 | 65
decreased lymphocyte cell numb... 4 | 83
embryonic growth retardation 4 | 106
hydrometra 4 | 53
increased circulating alkaline... 4 | 122
increased circulating chloride... 4 | 41
increased or absent threshold ... 4 | 101
increased prepulse inhibition 4 | 32
limb grasping 4 | 41
pallor 4 | 34
short tibia 4 | 97
small superior vagus ganglion 4 | 74
abnormal behavioral response t... 3 | 66
abnormal bone structure 3 | 187
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal skin coloration 3 | 25
abnormal sleep behavior 3 | 70
decreased blood urea nitrogen ... 3 | 51
decreased body length 3 | 101
decreased circulating alkaline... 3 | 46
decreased circulating glucose ... 3 | 126
decreased circulating insulin ... 3 | 76
decreased circulating iron lev... 3 | 32
decreased erythrocyte cell num... 3 | 62
decreased heart rate variabili... 3 | 13
decreased lean body mass 3 | 135
enlarged spleen 3 | 41
enlarged uterus 3 | 11
hypoactivity 3 | 132
increased bone mineral density 3 | 72
increased circulating choleste... 3 | 66
increased circulating glucose ... 3 | 24
increased heart weight 3 | 62
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
increased red blood cell distr... 3 | 34
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
prenatal lethality 3 | 28
small testis 3 | 58
abnormal cornea morphology 2 | 31
abnormal embryo turning 2 | 31
abnormal limb bud morphology 2 | 17
abnormal locomotor behavior 2 | 24
abnormal placenta size 2 | 20
abnormal spleen morphology 2 | 55
absent pinna reflex 2 | 23
brachydactyly 2 | 19
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating amylase ... 2 | 28
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased prepulse inhibition 2 | 82
decreased pulmonary respirator... 2 | 5
enlarged lymph nodes 2 | 37
enlarged stomach 2 | 2
increased body length 2 | 32
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating amylase ... 2 | 25
increased circulating magnesiu... 2 | 10
increased circulating sodium l... 2 | 71
long tibia 2 | 25
pale yolk sac 2 | 25
persistence of hyaloid vascula... 2 | 33
shortened RR interval 2 | 17
small thymus 2 | 16
syndactyly 2 | 23
thrombocytosis 2 | 27
tremors 2 | 39

Disease

Carcinoma 371 | 11,493
ovarian cancer 299 | 8,520
osteosarcoma 241 | 7,950
psoriasis 234 | 6,694
medulloblastoma, large-cell 216 | 6,241
glioblastoma 210 | 5,792
atypical teratoid / rhabdoid tumor 180 | 5,112
lung cancer 170 | 4,740
ependymoma 169 | 4,679
Breast cancer 152 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 134 | 2,955
adult high grade glioma 131 | 3,801
malignant mesothelioma 131 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 128 | 3,291
group 3 medulloblastoma 124 | 4,104
invasive ductal carcinoma 124 | 2,951
lung adenocarcinoma 122 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 119 | 2,989
Kidney cancer 113 | 2,613
astrocytic glioma 109 | 2,597
primitive neuroectodermal tumor 109 | 3,035
oligodendroglioma 107 | 2,850
Astrocytoma, Pilocytic 106 | 3,081
lung carcinoma 103 | 2,843
non-small cell lung cancer 96 | 2,890
pancreatic cancer 94 | 2,398
Cancer 90 | 2,499
colon cancer 87 | 1,478
subependymal giant cell astrocytoma 86 | 2,287
Autosomal recessive predisposition 75 | 1,442
breast carcinoma 75 | 1,638
interstitial cystitis 75 | 2,312
Pick disease 74 | 1,894
pituitary cancer 73 | 1,972
ductal carcinoma in situ 72 | 1,745
tuberculosis 70 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 69 | 1,962
cystic fibrosis 67 | 1,696
ulcerative colitis 67 | 1,819
adrenocortical carcinoma 66 | 1,428
diabetes mellitus 63 | 1,728
group 4 medulloblastoma 63 | 1,855
acute quadriplegic myopathy 61 | 1,158
Multiple myeloma 60 | 1,332
primary pancreatic ductal adenocarcinoma 53 | 1,109
Schizophrenia 51 | 1,160
dermatomyositis 45 | 966
juvenile dermatomyositis 45 | 1,187
Heart disease 41 | 306
Obesity 41 | 678
Atopic dermatitis 39 | 952
astrocytoma 39 | 1,146
gastric carcinoma 39 | 807
Rheumatoid arthritis 38 | 1,191
non primary Sjogren syndrome sicca 38 | 891
Duchenne muscular dystrophy 37 | 601
Intellectual disability 37 | 1,016
active Crohn's disease 37 | 922
medulloblastoma 37 | 720
fibroadenoma 36 | 559
pediatric high grade glioma 36 | 1,064
Alzheimer's disease 35 | 658
Liver Cirrhosis, Experimental 35 | 769
Epilepsy 34 | 792
Waldenstrons macroglobulinemia 34 | 765
active ulcerative colitis 33 | 764
aldosterone-producing adenoma 33 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 510
spina bifida 30 | 1,074
Cognitive delay 29 | 608
Down syndrome 29 | 499
Global developmental delay 29 | 608
Mental and motor retardation 29 | 608
Muscle hypotonia 29 | 571
Bipolar Disorder 28 | 666
Hypertension 28 | 396
Liver cancer 28 | 604
cutaneous lupus erythematosus 28 | 1,057
Atrial Fibrillation 27 | 124
sonic hedgehog group medulloblastoma 27 | 467
Amyotrophic lateral sclerosis 25 | 451
Melanoma 25 | 711
acute myeloid leukemia 25 | 783
hepatocellular carcinoma 25 | 547
nasopharyngeal carcinoma 24 | 1,058
Seizures 23 | 596
pancreatic carcinoma 23 | 562
Cardiomyopathy 22 | 116
Endometriosis 22 | 540
Multiple Sclerosis 22 | 540
esophageal adenocarcinoma 22 | 737
Heart failure 21 | 162
mucosa-associated lymphoid tissue lymphoma 21 | 484
progressive supranuclear palsy 21 | 676
Depressive disorder 20 | 409
Vascular disease 20 | 319
Low intelligence 19 | 645
Mental Retardation 19 | 645
Mental deficiency 19 | 645
Poor school performance 19 | 645

Tissue

Digestive Tract 567 | 17,369
Endocrine System 566 | 18,159
Female tissues 566 | 17,400
Skin and soft tissues 564 | 17,230
Male tissues 560 | 17,142
Liver and Pancreas 558 | 16,750
Urinary Tract 554 | 16,678
Blood and immune system 552 | 16,909
Cardiovascular System 552 | 15,192
Nervous System 546 | 16,725
Respiratory system 546 | 16,393

Target Family

Non-IDG 299 | 12,091
Enzyme 145 | 4,145
Transcription Factor 37 | 1,400
Ion Channel 33 | 344
Kinase 21 | 634
Transporter 20 | 473
GPCR 13 | 408
Nuclear Receptor 8 | 48
Epigenetic 7 | 242

Jensen-KB Tissue

Heart 583 | 583
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A INPP5J Tbio Enzyme -1.87182 73.3 126
Acyl-coenzyme A thioesterase 11 ACOT11 Tbio Enzyme -2.32299 204.5 165
Basic leucine zipper and W2 domain-containing protein 2 BZW2 Tbio Non-IDG -0.20261 1.21 83
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 CHCHD7 Tdark Non-IDG -1.37776 18.2 39
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -2.00780 91.4 120
Glucocorticoid modulatory element-binding protein 1 GMEB1 Tbio Transcription Factor -0.75841 7.65 104
Cdc42 effector protein 3 CDC42EP3 Tbio Non-IDG -1.57638 37.5 124
Angiopoietin-related protein 2 ANGPTL2 Tbio Non-IDG -1.79753 80.1 185