Development Level

Tbio 3,150 | 11,445
Tdark 628 | 6,588
Tchem 439 | 1,598
Tclin 83 | 613

Collection

RFA-RM-18-021 53 | 328
Kinase: IDG Consortium (Target... 47 | 125
Kinase: IDG Consortium (Comple... 16 | 37
Ion Channel: IDG Consortium (T... 5 | 99
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 438 | 979
preweaning lethality, incomple... 152 | 499
embryonic lethality prior to t... 115 | 278
embryonic lethality prior to o... 109 | 239
abnormal embryo size 86 | 220
abnormal behavior 83 | 298
decreased body weight 69 | 161
decreased total body fat amoun... 69 | 207
increased lean body mass 60 | 172
enlarged heart 47 | 210
abnormal bone structure 46 | 187
increased startle reflex 45 | 112
embryonic growth retardation 44 | 106
decreased circulating glucose ... 43 | 126
prenatal lethality prior to he... 43 | 87
decreased bone mineral content 40 | 151
decreased lean body mass 40 | 135
increased circulating alkaline... 40 | 122
hyperactivity 39 | 148
abnormal heart morphology 37 | 162
decreased vertical activity 37 | 208
increased mean corpuscular hem... 37 | 96
male infertility 37 | 123
decreased circulating choleste... 36 | 93
increased bone mineral content 36 | 108
increased total body fat amoun... 36 | 134
decreased grip strength 34 | 116
hypoactivity 34 | 132
decreased bone mineral density 33 | 126
decreased circulating triglyce... 32 | 79
increased mean corpuscular vol... 32 | 92
abnormal retina morphology 31 | 71
decreased body length 31 | 101
increased or absent threshold ... 31 | 101
cataract 29 | 92
short tibia 29 | 97
decreased hemoglobin content 28 | 68
decreased leukocyte cell numbe... 28 | 73
increased bone mineral density 28 | 72
abnormal lens morphology 27 | 81
decreased prepulse inhibition 27 | 82
increased fasted circulating g... 27 | 76
decreased circulating serum al... 26 | 82
decreased mean corpuscular vol... 26 | 79
decreased circulating HDL chol... 24 | 68
impaired glucose tolerance 24 | 75
increased circulating HDL chol... 24 | 80
abnormal eye morphology 23 | 68
decreased lymphocyte cell numb... 23 | 83
edema 23 | 59
improved glucose tolerance 23 | 79
increased mean platelet volume 23 | 45
decreased caudal vertebrae num... 22 | 53
abnormal coat-hair pigmentatio... 21 | 64
decreased circulating total pr... 21 | 49
decreased mean corpuscular hem... 21 | 50
decreased startle reflex 21 | 75
small superior vagus ganglion 21 | 74
decreased circulating LDL chol... 20 | 38
decreased circulating alanine ... 20 | 47
thrombocytopenia 20 | 56
decreased erythrocyte cell num... 19 | 62
increased grip strength 19 | 41
increased hematocrit 19 | 46
small testis 19 | 58
decreased blood urea nitrogen ... 18 | 51
decreased circulating insulin ... 18 | 76
decreased neutrophil cell numb... 18 | 42
abnormal kidney morphology 17 | 65
abnormal seminal vesicle morph... 17 | 114
decreased hematocrit 17 | 46
decreased red blood cell distr... 17 | 41
increased monocyte cell number 17 | 63
abnormal behavioral response t... 16 | 66
abnormal gait 16 | 69
increased circulating choleste... 16 | 66
increased heart weight 16 | 62
abnormal cornea morphology 15 | 31
abnormal neural tube closure 15 | 46
hydrometra 15 | 53
increased red blood cell distr... 15 | 34
prolonged QT interval 15 | 38
abnormal craniofacial morpholo... 14 | 33
abnormal cranium morphology 14 | 36
abnormal sleep behavior 14 | 70
abnormal spleen morphology 14 | 55
decreased circulating aspartat... 14 | 34
decreased fasted circulating g... 14 | 65
hemorrhage 14 | 23
increased hemoglobin content 14 | 45
increased mean corpuscular hem... 14 | 36
increased neutrophil cell numb... 14 | 46
abnormal bone mineralization 13 | 38
anophthalmia 13 | 33
corneal opacity 13 | 32
decreased circulating alkaline... 13 | 46
decreased circulating calcium ... 13 | 36
decreased circulating iron lev... 13 | 32
increased circulating chloride... 13 | 41
tremors 13 | 39

Disease

Carcinoma 3,129 | 11,493
ovarian cancer 2,698 | 8,520
osteosarcoma 2,389 | 7,950
medulloblastoma, large-cell 1,728 | 6,241
psoriasis 1,582 | 6,694
glioblastoma 1,580 | 5,792
lung cancer 1,420 | 4,740
atypical teratoid / rhabdoid tumor 1,401 | 5,112
group 3 medulloblastoma 1,235 | 4,104
ependymoma 1,160 | 4,679
Breast cancer 959 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 898 | 3,291
malignant mesothelioma 890 | 3,232
Kidney cancer 889 | 2,613
adult high grade glioma 881 | 3,801
primitive neuroectodermal tumor 853 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 791 | 2,989
Cancer 761 | 2,499
oligodendroglioma 744 | 2,850
invasive ductal carcinoma 734 | 2,951
non-small cell lung cancer 721 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 696 | 2,955
astrocytic glioma 653 | 2,597
lung adenocarcinoma 640 | 2,716
Pick disease 594 | 1,894
subependymal giant cell astrocytoma 584 | 2,287
Astrocytoma, Pilocytic 581 | 3,081
Multiple myeloma 576 | 1,332
pancreatic cancer 562 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 544 | 1,962
tuberculosis 506 | 2,010
group 4 medulloblastoma 487 | 1,855
acute quadriplegic myopathy 460 | 1,158
astrocytoma 419 | 1,146
lung carcinoma 419 | 2,843
juvenile dermatomyositis 415 | 1,187
diabetes mellitus 410 | 1,728
Rheumatoid arthritis 407 | 1,191
dermatomyositis 405 | 966
ulcerative colitis 397 | 1,819
ductal carcinoma in situ 396 | 1,745
breast carcinoma 388 | 1,638
colon cancer 386 | 1,478
Intellectual disability 374 | 1,016
adrenocortical carcinoma 369 | 1,428
pituitary cancer 369 | 1,972
Waldenstrons macroglobulinemia 368 | 765
interstitial cystitis 339 | 2,312
spina bifida 331 | 1,074
pediatric high grade glioma 326 | 1,064
Autosomal recessive predisposition 321 | 1,442
primary pancreatic ductal adenocarcinoma 293 | 1,109
acute myeloid leukemia 276 | 783
Schizophrenia 260 | 1,160
progressive supranuclear palsy 254 | 676
cystic fibrosis 247 | 1,696
nasopharyngeal carcinoma 231 | 1,058
Dull intelligence 225 | 645
Low intelligence 225 | 645
Mental Retardation 225 | 645
Mental deficiency 225 | 645
Poor school performance 225 | 645
non primary Sjogren syndrome sicca 225 | 891
Cognitive delay 208 | 608
Global developmental delay 208 | 608
Mental and motor retardation 208 | 608
Epilepsy 201 | 792
aldosterone-producing adenoma 195 | 665
primary Sjogren syndrome 190 | 735
Atopic dermatitis 189 | 952
Liver cancer 188 | 604
Muscle hypotonia 187 | 571
medulloblastoma 185 | 720
Short stature 182 | 531
active Crohn's disease 176 | 922
gastric carcinoma 173 | 807
Alzheimer's disease 172 | 658
tuberculosis and treatment for 6 months 171 | 409
Amyotrophic lateral sclerosis 169 | 451
hepatocellular carcinoma 168 | 547
cutaneous lupus erythematosus 167 | 1,057
Small head 166 | 374
Seizures 161 | 596
esophageal adenocarcinoma 151 | 737
Liver Cirrhosis, Experimental 149 | 769
pancreatic carcinoma 148 | 562
Breast Neoplasms 144 | 445
Down syndrome 139 | 499
Obesity 136 | 678
Prostatic Neoplasms 136 | 495
Endometriosis 134 | 540
Mammary Neoplasms 134 | 425
Bipolar Disorder 133 | 666
Neurodegenerative disease 132 | 414
autosomal dominant Emery-Dreifuss muscular dystrophy 132 | 510
hereditary spastic paraplegia 132 | 318
gastric cancer 129 | 459
sonic hedgehog group medulloblastoma 125 | 467
active ulcerative colitis 119 | 764
Polycystic ovary syndrome 114 | 360

Tissue

Endocrine System 4,247 | 18,159
Skin and soft tissues 4,237 | 17,230
Female tissues 4,236 | 17,400
Male tissues 4,236 | 17,142
Digestive Tract 4,232 | 17,369
Blood and immune system 4,229 | 16,909
Nervous System 4,228 | 16,725
Liver and Pancreas 4,224 | 16,750
Urinary Tract 4,222 | 16,678
Respiratory system 4,221 | 16,393
Cardiovascular System 4,178 | 15,192

Target Family

Non-IDG 2,545 | 12,091
Enzyme 931 | 4,145
Transcription Factor 291 | 1,400
Kinase 255 | 634
Epigenetic 149 | 242
Transporter 80 | 473
TF/Epigenetic 21 | 38
Ion Channel 19 | 344
Nuclear Receptor 5 | 48
GPCR 4 | 408

Jensen-KB Tissue

Erythroleukemia cell 4,300 | 4,300
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Heterogeneous nuclear ribonucleoprotein H3 HNRNPH3 Tbio Non-IDG -1.80776 63.4 80
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127
Nck-associated protein 5-like NCKAP5L Tdark Non-IDG -0.22123 2.83 11
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Transmembrane protein 184C TMEM184C Tbio Non-IDG -0.23045 1.81 39