Development Level

Tbio 2,961 | 10,625
Tdark 713 | 7,003
Tchem 517 | 1,890
Tclin 83 | 602

Collection

Eligible Kinase Proteins 50 | 134
Eligible Ion Channel Proteins 4 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 278 | 633
preweaning lethality, incomple... 81 | 260
decreased body weight 77 | 174
embryonic lethality prior to t... 77 | 187
decreased lean body mass 71 | 195
embryonic lethality prior to o... 69 | 148
decreased total body fat amoun... 66 | 186
abnormal behavior 59 | 226
decreased body length 44 | 108
decreased bone mineral content 44 | 157
abnormal embryo size 42 | 112
abnormal retina morphology 42 | 100
increased or absent threshold ... 39 | 128
decreased circulating glucose ... 37 | 121
decreased bone mineral density 36 | 126
increased circulating alkaline... 36 | 119
decreased grip strength 35 | 123
increased lean body mass 33 | 107
abnormal bone structure 32 | 131
decreased circulating choleste... 32 | 85
prenatal lethality prior to he... 32 | 64
increased bone mineral content 31 | 92
increased mean corpuscular hem... 31 | 93
increased grip strength 29 | 83
short tibia 28 | 82
abnormal lens morphology 27 | 73
abnormal retinal pigmentation 27 | 61
increased mean corpuscular vol... 27 | 91
decreased circulating triglyce... 26 | 83
hyperactivity 26 | 108
decreased circulating HDL chol... 25 | 77
decreased circulating serum al... 24 | 79
decreased leukocyte cell numbe... 23 | 54
increased fasted circulating g... 23 | 68
decreased caudal vertebrae num... 21 | 49
decreased circulating LDL chol... 20 | 37
decreased circulating total pr... 20 | 41
enlarged heart 20 | 111
increased sacral vertebrae num... 20 | 62
abnormal bone mineralization 19 | 55
decreased lumbar vertebrae num... 19 | 62
hypoactivity 19 | 89
increased bone mineral density 19 | 52
decreased circulating alanine ... 18 | 53
decreased hemoglobin content 18 | 53
decreased mean corpuscular vol... 18 | 50
male infertility 18 | 62
decreased circulating insulin ... 17 | 75
improved glucose tolerance 17 | 56
increased circulating HDL chol... 17 | 63
increased circulating choleste... 17 | 53
abnormal coat/hair pigmentatio... 15 | 54
decreased circulating calcium ... 15 | 33
decreased prepulse inhibition 15 | 52
decreased rib number 15 | 59
thrombocytopenia 15 | 46
decreased mean corpuscular hem... 14 | 34
decreased neutrophil cell numb... 14 | 37
increased body weight 14 | 42
abnormal cranium morphology 13 | 32
decreased circulating free fat... 13 | 39
impaired glucose tolerance 13 | 52
increased circulating chloride... 13 | 43
increased circulating sodium l... 13 | 71
increased hematocrit 13 | 36
abnormal neural tube closure 12 | 37
decreased circulating aspartat... 12 | 27
decreased circulating iron lev... 12 | 25
decreased fasted circulating g... 12 | 49
decreased startle reflex 12 | 48
increased leukocyte cell numbe... 12 | 37
abnormal behavioral response t... 11 | 52
abnormal cornea morphology 11 | 24
abnormal eye morphology 11 | 38
abnormal sleep behavior 11 | 63
decreased circulating alkaline... 11 | 41
decreased eosinophil cell numb... 11 | 41
decreased erythrocyte cell num... 11 | 43
increased startle reflex 11 | 38
abnormal gait 10 | 51
abnormal rib morphology 10 | 28
decreased CD4-positive, CD25-p... 10 | 24
decreased NK cell number 10 | 16
decreased T cell number 10 | 31
decreased blood urea nitrogen ... 10 | 31
decreased circulating fructosa... 10 | 31
decreased heart weight 10 | 44
decreased hematocrit 10 | 25
decreased total retina thickne... 10 | 20
increased blood urea nitrogen ... 10 | 44
increased circulating creatini... 10 | 29
increased circulating iron lev... 10 | 25
increased hemoglobin content 10 | 45
increased mean corpuscular hem... 10 | 25
increased rib number 10 | 41
increased total body fat amoun... 10 | 57
tremors 10 | 34
abnormal locomotor activation 9 | 26
cardiovascular system phenotyp... 9 | 35
increased NK cell number 9 | 19

Disease

ovarian cancer 2,676 | 8,484
osteosarcoma 2,371 | 7,933
medulloblastoma, large-cell 1,721 | 6,234
psoriasis 1,579 | 6,685
glioblastoma 1,521 | 5,572
lung cancer 1,361 | 4,466
atypical teratoid / rhabdoid tumor 1,194 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 892 | 3,289
malignant mesothelioma 865 | 3,162
Breast cancer 850 | 3,094
primitive neuroectodermal tumor 846 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 787 | 2,988
ependymoma 755 | 2,514
group 3 medulloblastoma 742 | 2,254
pediatric high grade glioma 742 | 2,712
oligodendroglioma 741 | 2,849
invasive ductal carcinoma 730 | 2,950
Cancer 720 | 2,346
non-small cell lung cancer 711 | 2,798
Carcinoma 694 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 693 | 2,956
lung adenocarcinoma 635 | 2,713
Pick disease 592 | 1,893
pilocytic astrocytoma 586 | 3,086
subependymal giant cell astrocytoma 581 | 2,287
Multiple myeloma 577 | 1,327
astrocytic glioma 554 | 2,241
pancreatic cancer 538 | 2,300
astrocytoma 511 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 500 | 1,795
group 4 medulloblastoma 477 | 1,875
acute quadriplegic myopathy 458 | 1,157
adult high grade glioma 458 | 2,148
ulcerative colitis 438 | 2,087
lung carcinoma 416 | 2,844
juvenile dermatomyositis 413 | 1,189
medulloblastoma 413 | 1,524
Rheumatoid Arthritis 404 | 1,160
dermatomyositis 404 | 933
diabetes mellitus 401 | 1,663
ductal carcinoma in situ 391 | 1,745
tuberculosis 390 | 1,557
colon cancer 386 | 1,475
sonic hedgehog group medulloblastoma 382 | 1,482
breast carcinoma 375 | 1,614
Waldenstrons macroglobulinemia 369 | 765
adrenocortical carcinoma 369 | 1,427
pituitary cancer 366 | 1,972
interstitial cystitis 337 | 2,299
primary pancreatic ductal adenocarcinoma 333 | 1,271
spina bifida 324 | 1,064
posterior fossa group A ependymoma 311 | 1,511
atypical teratoid/rhabdoid tumor 294 | 1,095
acute myeloid leukemia 274 | 780
tuberculosis and treatment for 6 months 273 | 686
posterior fossa group B ependymoma 262 | 1,530
progressive supranuclear palsy 255 | 674
cystic fibrosis 241 | 1,665
nasopharyngeal carcinoma 230 | 1,056
Intellectual disability 221 | 573
non primary Sjogren syndrome sicca 218 | 840
primary Sjogren syndrome 199 | 789
aldosterone-producing adenoma 196 | 664
Atopic dermatitis 187 | 944
gastric carcinoma 180 | 832
active Crohn's disease 174 | 918
IGA Glomerulonephritis 170 | 454
Alzheimer's disease 169 | 644
cutaneous lupus erythematosus 168 | 1,056
hepatocellular carcinoma 166 | 532
Amyotrophic Lateral Sclerosis 159 | 431
esophageal adenocarcinoma 153 | 737
pancreatic carcinoma 152 | 567
Down syndrome 148 | 548
Endometriosis 134 | 535
Mammary Neoplasms 132 | 410
hereditary spastic paraplegia 129 | 313
autosomal dominant Emery-Dreifuss muscular dystrophy 128 | 499
Prostatic Neoplasms 125 | 471
Neurodegenerative disease 123 | 383
gastric cancer 119 | 430
Obesity 113 | 616
Duchenne muscular dystrophy 111 | 602
Schizophrenia 110 | 501
Polycystic Ovary Syndrome 109 | 332
Gaucher disease type 1 101 | 171
inflammatory breast cancer 97 | 404
Crohn's disease 95 | 304
Parkinson's disease 95 | 364
fibroadenoma 85 | 557
Microcephaly 81 | 149
Peripheral Neuropathy 81 | 303
interstitial lung disease 81 | 291
chronic rhinosinusitis 79 | 512
active ulcerative colitis 77 | 477
Multiple Sclerosis 75 | 498
glioblastoma multiforme 72 | 347
mucosa-associated lymphoid tissue lymphoma 72 | 480
Stomach Neoplasms 71 | 282
tuberculosis and treatment for 3 months 71 | 327

Tissue

Blood and immune system 4,234 | 17,995
Female tissues 4,234 | 18,647
Male tissues 4,233 | 17,969
Nervous System 4,233 | 18,561
Digestive Tract 4,231 | 18,473
Liver and Pancreas 4,229 | 18,136
Cardiovascular System 4,226 | 17,958
Endocrine System 4,225 | 18,512
Urinary Tract 4,221 | 18,444
Respiratory system 4,202 | 17,484
Skin and soft tissues 4,197 | 18,115

Target Family

Non-IDG 2,523 | 11,971
Enzyme 931 | 4,146
Transcription Factor 291 | 1,400
Kinase 255 | 634
Epigenetic 146 | 242
Transporter 80 | 473
TF/Epigenetic 21 | 38
Ion Channel 18 | 341
Nuclear Receptor 5 | 48
GPCR 4 | 406

Jensen-KB Tissue

Erythroleukemia cell 4,274 | 4,274
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
HEAT repeat-containing protein 6 HEATR6 Tdark Non-IDG -1.48236 11.6 38
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Nuclear cap-binding protein subunit 3 NCBP3 Tbio Non-IDG -1.68208 49.3 22
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121