Development Level

Tbio 726 | 11,651
Tdark 211 | 6,593
Tchem 97 | 1,388
Tclin 29 | 612

Collection

RFA-RM-18-021 14 | 328
Kinase: IDG Consortium (Target... 8 | 125
Ion Channel: IDG Consortium (T... 4 | 99
GPCR: IDG Consortium (Targets) 2 | 126
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 68 | 979
preweaning lethality, incomple... 31 | 499
embryonic lethality prior to t... 25 | 278
embryonic lethality prior to o... 22 | 239
abnormal embryo size 16 | 220
decreased total body fat amoun... 16 | 207
abnormal behavior 15 | 298
decreased vertical activity 13 | 208
enlarged heart 12 | 210
increased lean body mass 11 | 172
abnormal bone structure 10 | 187
abnormal heart morphology 10 | 162
decreased lean body mass 10 | 135
decreased circulating glucose ... 9 | 126
embryonic growth retardation 9 | 106
increased mean corpuscular vol... 9 | 92
increased or absent threshold ... 9 | 101
decreased bone mineral content 8 | 151
decreased bone mineral density 8 | 126
decreased grip strength 8 | 116
improved glucose tolerance 8 | 79
increased bone mineral content 8 | 108
increased startle reflex 8 | 112
increased total body fat amoun... 8 | 134
abnormal kidney morphology 7 | 65
decreased body length 7 | 101
decreased body weight 7 | 161
decreased circulating insulin ... 7 | 76
hyperactivity 7 | 148
increased circulating alkaline... 7 | 122
abnormal behavioral response t... 6 | 66
abnormal eye morphology 6 | 68
abnormal gait 6 | 69
abnormal lens morphology 6 | 81
decreased fasted circulating g... 6 | 65
edema 6 | 59
hypoactivity 6 | 132
abnormal sleep behavior 5 | 70
corneal opacity 5 | 32
increased circulating sodium l... 5 | 71
increased mean platelet volume 5 | 45
limb grasping 5 | 41
male infertility 5 | 123
abnormal neural tube closure 4 | 46
abnormal retina morphology 4 | 71
abnormal seminal vesicle morph... 4 | 114
abnormal tail morphology 4 | 25
abnormal vibrissa morphology 4 | 25
absent vibrissae 4 | 12
decreased circulating serum al... 4 | 82
decreased circulating triglyce... 4 | 79
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular vol... 4 | 79
enlarged spleen 4 | 41
pallor 4 | 34
small superior vagus ganglion 4 | 74
small testis 4 | 58
abnormal cornea morphology 3 | 31
abnormal forebrain development 3 | 20
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased blood urea nitrogen ... 3 | 51
decreased circulating alanine ... 3 | 47
decreased circulating choleste... 3 | 93
decreased circulating phosphat... 3 | 27
decreased circulating total pr... 3 | 49
decreased food intake 3 | 13
decreased leukocyte cell numbe... 3 | 73
decreased monocyte cell number 3 | 8
decreased red blood cell distr... 3 | 41
hydrometra 3 | 53
impaired righting response 3 | 26
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating aspartat... 3 | 15
increased grip strength 3 | 41
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
increased prepulse inhibition 3 | 32
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
small spleen 3 | 19
thrombocytopenia 3 | 56
abnormal heart left ventricle ... 2 | 16
abnormal lung morphology 2 | 26
abnormal retinal vasculature m... 2 | 27
decreased circulating iron lev... 2 | 32
decreased circulating potassiu... 2 | 20
decreased heart rate variabili... 2 | 13
increased cardiac muscle contr... 2 | 8
increased circulating amylase ... 2 | 25
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 41
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased fasted circulating g... 2 | 76
increased hemoglobin content 2 | 45
microphthalmia 2 | 26
thrombocytosis 2 | 27

Disease

Carcinoma 665 | 11,493
ovarian cancer 556 | 8,520
osteosarcoma 475 | 7,950
psoriasis 412 | 6,694
medulloblastoma, large-cell 366 | 6,241
glioblastoma 359 | 5,792
lung cancer 308 | 4,740
atypical teratoid / rhabdoid tumor 299 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 259 | 3,291
ependymoma 243 | 4,679
group 3 medulloblastoma 242 | 4,104
malignant mesothelioma 238 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 225 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 217 | 2,955
Breast cancer 213 | 3,578
invasive ductal carcinoma 205 | 2,951
lung adenocarcinoma 196 | 2,716
adult high grade glioma 191 | 3,801
non-small cell lung cancer 191 | 2,890
pancreatic cancer 188 | 2,398
Cancer 181 | 2,499
primitive neuroectodermal tumor 172 | 3,035
interstitial cystitis 170 | 2,312
Astrocytoma, Pilocytic 168 | 3,081
lung carcinoma 164 | 2,843
oligodendroglioma 159 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 157 | 1,962
astrocytic glioma 139 | 2,597
colon cancer 138 | 1,478
pituitary cancer 131 | 1,972
ductal carcinoma in situ 130 | 1,745
subependymal giant cell astrocytoma 126 | 2,287
ulcerative colitis 126 | 1,819
breast carcinoma 123 | 1,638
cystic fibrosis 117 | 1,696
Kidney cancer 115 | 2,613
Pick disease 115 | 1,894
tuberculosis 114 | 2,010
Multiple myeloma 109 | 1,332
diabetes mellitus 104 | 1,728
group 4 medulloblastoma 101 | 1,855
Autosomal recessive predisposition 94 | 1,442
adrenocortical carcinoma 92 | 1,428
primary pancreatic ductal adenocarcinoma 89 | 1,109
spina bifida 87 | 1,074
esophageal adenocarcinoma 83 | 737
active ulcerative colitis 81 | 764
juvenile dermatomyositis 80 | 1,187
astrocytoma 78 | 1,146
acute quadriplegic myopathy 76 | 1,158
active Crohn's disease 75 | 922
dermatomyositis 75 | 966
nasopharyngeal carcinoma 75 | 1,058
pediatric high grade glioma 73 | 1,064
Rheumatoid arthritis 71 | 1,191
cutaneous lupus erythematosus 69 | 1,057
Schizophrenia 64 | 1,160
Intellectual disability 59 | 1,016
Liver Cirrhosis, Experimental 58 | 769
gastric carcinoma 58 | 807
Waldenstrons macroglobulinemia 56 | 765
Atopic dermatitis 55 | 952
non primary Sjogren syndrome sicca 53 | 891
aldosterone-producing adenoma 51 | 665
Prostatic Neoplasms 49 | 495
Duchenne muscular dystrophy 48 | 601
Epilepsy 47 | 792
Endometriosis 43 | 540
Dull intelligence 42 | 645
Low intelligence 42 | 645
Mental Retardation 42 | 645
Mental deficiency 42 | 645
Poor school performance 42 | 645
acute myeloid leukemia 41 | 783
Obesity 40 | 678
fibroadenoma 40 | 559
progressive supranuclear palsy 40 | 676
primary Sjogren syndrome 39 | 735
chronic rhinosinusitis 38 | 512
pancreatic carcinoma 38 | 562
Neurodegenerative disease 37 | 414
medulloblastoma 37 | 720
nephrosclerosis 36 | 333
posterior fossa group A ependymoma 36 | 468
Hypertension 35 | 396
Melanoma 35 | 711
Barrett's esophagus 34 | 182
Cognitive delay 34 | 608
Global developmental delay 34 | 608
Mental and motor retardation 34 | 608
Seizures 34 | 596
Kidney disease 33 | 430
urothelial carcinoma 33 | 318
sonic hedgehog group medulloblastoma 32 | 467
gastric cancer 31 | 459
hepatocellular carcinoma 31 | 547
Amyotrophic lateral sclerosis 30 | 451
Bipolar Disorder 30 | 666
Polycystic ovary syndrome 30 | 360
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 510

Tissue

Digestive Tract 1,044 | 17,369
Endocrine System 1,037 | 18,159
Urinary Tract 1,035 | 16,678
Female tissues 1,033 | 17,400
Skin and soft tissues 1,033 | 17,230
Male tissues 1,030 | 17,142
Liver and Pancreas 1,027 | 16,750
Blood and immune system 1,023 | 16,909
Nervous System 1,013 | 16,725
Respiratory system 1,004 | 16,393
Cardiovascular System 938 | 15,192

Target Family

Non-IDG 582 | 12,091
Enzyme 291 | 4,145
Transcription Factor 59 | 1,400
Transporter 54 | 473
Kinase 30 | 634
Epigenetic 19 | 242
Ion Channel 12 | 344
GPCR 10 | 408
Nuclear Receptor 4 | 48
TF/Epigenetic 2 | 38

Jensen-KB Tissue

Colon 1,063 | 1,063
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242
Galectin-2 LGALS2 Tbio Non-IDG -1.12300 13.4 172
Zinc finger protein 561 ZNF561 Tdark Transcription Factor 0.00000 36
Protein phosphatase 1 regulatory subunit 26 PPP1R26 Tdark Enzyme -0.60309 4.64 9
Fatty-acid amide hydrolase 2 FAAH2 Tbio Enzyme -0.82593 5.68 104
Keratinocyte-associated protein 2 KRTCAP2 Tbio Non-IDG -0.67158 5.41 59
Inactive serine protease PAMR1 PAMR1 Tdark Enzyme -0.86262 5.98 22