Development Level

Tbio 655 | 10,625
Tdark 244 | 7,003
Tchem 135 | 1,890
Tclin 27 | 602

Collection

Eligible Kinase Proteins 9 | 134
Eligible Ion Channel Proteins 4 | 117
Eligible non-olfactory GPCR Proteins 3 | 143

IMPC Term

preweaning lethality, complete... 49 | 633
decreased total body fat amoun... 14 | 186
embryonic lethality prior to t... 14 | 187
embryonic lethality prior to o... 13 | 148
preweaning lethality, incomple... 13 | 260
increased or absent threshold ... 12 | 128
decreased lean body mass 11 | 195
abnormal behavior 9 | 226
decreased body weight 8 | 174
decreased circulating glucose ... 8 | 121
increased grip strength 8 | 83
decreased circulating choleste... 7 | 85
decreased circulating insulin ... 7 | 75
decreased grip strength 7 | 123
hyperactivity 7 | 108
increased bone mineral content 7 | 92
increased lean body mass 7 | 107
decreased bone mineral content 6 | 157
decreased bone mineral density 6 | 126
decreased circulating serum al... 6 | 79
improved glucose tolerance 6 | 56
increased circulating sodium l... 6 | 71
increased mean corpuscular vol... 6 | 91
increased total body fat amoun... 6 | 57
abnormal embryo size 5 | 112
abnormal retina morphology 5 | 100
absent vibrissae 5 | 14
decreased body length 5 | 108
decreased circulating triglyce... 5 | 83
hypoactivity 5 | 89
increased circulating alkaline... 5 | 119
limb grasping 5 | 35
abnormal behavioral response t... 4 | 52
abnormal gait 4 | 51
abnormal lens morphology 4 | 73
abnormal sleep behavior 4 | 63
corneal opacity 4 | 25
decreased circulating HDL chol... 4 | 77
decreased circulating fructosa... 4 | 31
enlarged spleen 4 | 26
increased B cell number 4 | 23
increased circulating HDL chol... 4 | 63
increased circulating aspartat... 4 | 17
increased circulating choleste... 4 | 53
increased exploration in new e... 4 | 56
increased hemoglobin content 4 | 45
increased mean corpuscular hem... 4 | 93
increased startle reflex 4 | 38
abnormal neural tube closure 3 | 37
abnormal rib morphology 3 | 28
cardiovascular system phenotyp... 3 | 35
decreased NK T cell number 3 | 28
decreased T cell number 3 | 31
decreased circulating alanine ... 3 | 53
decreased eosinophil cell numb... 3 | 41
decreased granulocyte number 3 | 8
decreased lumbar vertebrae num... 3 | 62
enlarged heart 3 | 111
increased circulating LDL chol... 3 | 15
increased circulating amylase ... 3 | 13
increased circulating chloride... 3 | 43
increased heart weight 3 | 37
increased red blood cell distr... 3 | 21
increased respiratory quotient 3 | 12
increased rib number 3 | 41
increased sacral vertebrae num... 3 | 62
increased vertical activity 3 | 18
polydactyly 3 | 22
short tibia 3 | 82
thrombocytopenia 3 | 46
abnormal cornea morphology 2 | 24
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal retinal pigmentation 2 | 61
abnormal testis morphology 2 | 30
abnormal thoracic vertebrae mo... 2 | 16
abnormal vibrissa morphology 2 | 17
decreased NK cell number 2 | 16
decreased circulating bilirubi... 2 | 14
decreased circulating iron lev... 2 | 25
decreased circulating potassiu... 2 | 17
decreased fasted circulating g... 2 | 49
decreased heart rate variabili... 2 | 11
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased vertical activity 2 | 22
female infertility 2 | 34
impaired glucose tolerance 2 | 52
impaired righting response 2 | 19
increased body weight 2 | 42
increased circulating bilirubi... 2 | 16
increased circulating serum al... 2 | 25
increased circulating total pr... 2 | 20
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
prenatal lethality prior to he... 2 | 64
small testis 2 | 37
small thymus 2 | 11
straub tail 2 | 26

Disease

ovarian cancer 558 | 8,484
osteosarcoma 473 | 7,933
psoriasis 410 | 6,685
medulloblastoma, large-cell 365 | 6,234
glioblastoma 343 | 5,572
lung cancer 298 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 258 | 3,289
atypical teratoid / rhabdoid tumor 246 | 4,369
malignant mesothelioma 230 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 224 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 217 | 2,956
invasive ductal carcinoma 205 | 2,950
lung adenocarcinoma 198 | 2,713
Breast cancer 192 | 3,094
pancreatic cancer 187 | 2,300
non-small cell lung cancer 186 | 2,798
interstitial cystitis 171 | 2,299
primitive neuroectodermal tumor 171 | 3,031
Cancer 170 | 2,346
pilocytic astrocytoma 166 | 3,086
lung carcinoma 165 | 2,844
oligodendroglioma 159 | 2,849
ulcerative colitis 156 | 2,087
pediatric high grade glioma 149 | 2,712
pancreatic ductal adenocarcinoma liver metastasis 144 | 1,795
colon cancer 138 | 1,475
group 3 medulloblastoma 138 | 2,254
pituitary cancer 131 | 1,972
ductal carcinoma in situ 130 | 1,745
ependymoma 129 | 2,514
subependymal giant cell astrocytoma 126 | 2,287
astrocytic glioma 124 | 2,241
breast carcinoma 120 | 1,614
Pick disease 114 | 1,893
adult high grade glioma 114 | 2,148
cystic fibrosis 113 | 1,665
Multiple myeloma 111 | 1,327
primary pancreatic ductal adenocarcinoma 101 | 1,271
diabetes mellitus 100 | 1,663
group 4 medulloblastoma 99 | 1,875
posterior fossa group A ependymoma 95 | 1,511
adrenocortical carcinoma 93 | 1,427
astrocytoma 92 | 1,493
Carcinoma 91 | 2,147
sonic hedgehog group medulloblastoma 90 | 1,482
tuberculosis 88 | 1,557
spina bifida 87 | 1,064
medulloblastoma 84 | 1,524
esophageal adenocarcinoma 83 | 737
juvenile dermatomyositis 80 | 1,189
acute quadriplegic myopathy 76 | 1,157
active Crohn's disease 75 | 918
dermatomyositis 75 | 933
atypical teratoid/rhabdoid tumor 73 | 1,095
nasopharyngeal carcinoma 73 | 1,056
posterior fossa group B ependymoma 73 | 1,530
Rheumatoid Arthritis 71 | 1,160
cutaneous lupus erythematosus 70 | 1,056
gastric carcinoma 62 | 832
Waldenstrons macroglobulinemia 56 | 765
Atopic dermatitis 55 | 944
aldosterone-producing adenoma 52 | 664
active ulcerative colitis 51 | 477
non primary Sjogren syndrome sicca 51 | 840
Duchenne muscular dystrophy 49 | 602
Prostatic Neoplasms 48 | 471
primary Sjogren syndrome 43 | 789
Endometriosis 42 | 535
acute myeloid leukemia 41 | 780
fibroadenoma 40 | 557
pancreatic carcinoma 39 | 567
progressive supranuclear palsy 39 | 674
chronic rhinosinusitis 38 | 512
Obesity 37 | 616
nephrosclerosis 36 | 329
Barrett's esophagus 35 | 183
Neurodegenerative disease 35 | 383
urothelial carcinoma 33 | 318
tuberculosis and treatment for 6 months 32 | 686
Amyotrophic Lateral Sclerosis 31 | 431
Kidney disease 31 | 396
Down syndrome 30 | 548
Intellectual disability 30 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 30 | 499
hepatocellular carcinoma 30 | 532
non-small cell lung carcinoma 30 | 413
Alzheimer's disease 29 | 644
Polycystic Ovary Syndrome 29 | 332
Schizophrenia 28 | 501
inflammatory breast cancer 28 | 404
gastric cancer 27 | 430
Mammary Neoplasms 26 | 410
glioblastoma multiforme 26 | 347
mucosa-associated lymphoid tissue lymphoma 26 | 480
Stomach Neoplasms 25 | 282
Crohn's disease 24 | 304
IGA Glomerulonephritis 24 | 454
sarcoidosis 24 | 358
tuberculosis and treatment for 3 months 24 | 327
Asthma 23 | 349

Tissue

Digestive Tract 1,050 | 18,473
Nervous System 1,046 | 18,561
Liver and Pancreas 1,045 | 18,136
Female tissues 1,043 | 18,647
Endocrine System 1,042 | 18,512
Male tissues 1,042 | 17,969
Urinary Tract 1,042 | 18,444
Blood and immune system 1,039 | 17,995
Cardiovascular System 1,039 | 17,958
Skin and soft tissues 1,037 | 18,115
Respiratory system 1,028 | 17,484

Target Family

Non-IDG 581 | 11,971
Enzyme 292 | 4,146
Transcription Factor 58 | 1,400
Transporter 54 | 473
Kinase 30 | 634
Epigenetic 18 | 242
Ion Channel 12 | 341
GPCR 10 | 406
Nuclear Receptor 4 | 48
TF/Epigenetic 2 | 38

Jensen-KB Tissue

Colon 1,061 | 1,061
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
HEAT repeat-containing protein 6 HEATR6 Tdark Non-IDG -1.48236 11.6 38
Nuclear cap-binding protein subunit 3 NCBP3 Tbio Non-IDG -1.68208 49.3 22
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Plasma kallikrein KLKB1 Tclin Enzyme -2.88472 708.0 231
Xaa-Pro aminopeptidase 2 XPNPEP2 Tchem Enzyme -1.55651 32.2 97
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Solute carrier family 2, facilitated glucose transporter member 4 SLC2A4 Tchem Transporter -3.30074 2066.8 474
Small nuclear ribonucleoprotein F SNRPF Tdark Non-IDG -0.25254 1.81 65