Development Level

Tbio 3,624 | 11,445
Tdark 721 | 6,588
Tchem 508 | 1,598
Tclin 91 | 613

Collection

Kinase: IDG Consortium (Target... 53 | 125
Kinase: IDG Consortium (Comple... 21 | 37
Ion Channel: IDG Consortium (T... 7 | 99
GPCR: IDG Consortium (Targets) 6 | 126
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 473 | 979
preweaning lethality, incomple... 189 | 499
embryonic lethality prior to t... 138 | 278
embryonic lethality prior to o... 123 | 239
abnormal embryo size 104 | 220
abnormal behavior 96 | 298
decreased total body fat amoun... 74 | 207
decreased body weight 73 | 161
increased lean body mass 61 | 172
abnormal bone structure 59 | 187
enlarged heart 54 | 210
embryonic growth retardation 53 | 106
increased circulating alkaline... 52 | 122
increased startle reflex 52 | 112
prenatal lethality prior to he... 51 | 87
decreased lean body mass 49 | 135
decreased circulating glucose ... 48 | 126
hyperactivity 47 | 148
decreased bone mineral content 45 | 151
increased total body fat amoun... 44 | 134
abnormal heart morphology 43 | 162
decreased vertical activity 43 | 208
hypoactivity 41 | 132
decreased body length 39 | 101
decreased bone mineral density 39 | 126
decreased circulating choleste... 39 | 93
decreased grip strength 38 | 116
increased bone mineral content 37 | 108
increased mean corpuscular hem... 37 | 96
increased mean corpuscular vol... 36 | 92
male infertility 35 | 123
short tibia 33 | 97
edema 32 | 59
abnormal retina morphology 31 | 71
decreased prepulse inhibition 31 | 82
increased bone mineral density 31 | 72
decreased circulating triglyce... 30 | 79
cataract 29 | 92
decreased circulating HDL chol... 29 | 68
increased circulating HDL chol... 29 | 80
increased or absent threshold ... 29 | 101
abnormal eye morphology 28 | 68
decreased mean corpuscular vol... 28 | 79
abnormal lens morphology 27 | 81
decreased circulating serum al... 27 | 82
decreased leukocyte cell numbe... 26 | 73
abnormal coat-hair pigmentatio... 25 | 64
abnormal seminal vesicle morph... 25 | 114
decreased caudal vertebrae num... 25 | 53
increased fasted circulating g... 25 | 76
increased heart weight 25 | 62
small testis 25 | 58
decreased hemoglobin content 24 | 68
decreased startle reflex 24 | 75
decreased lymphocyte cell numb... 23 | 83
improved glucose tolerance 23 | 79
decreased circulating insulin ... 22 | 76
impaired glucose tolerance 22 | 75
decreased circulating total pr... 21 | 49
decreased erythrocyte cell num... 21 | 62
increased hematocrit 21 | 46
thrombocytopenia 21 | 56
abnormal behavioral response t... 20 | 66
abnormal spleen morphology 20 | 55
decreased mean corpuscular hem... 20 | 50
increased circulating choleste... 20 | 66
increased mean platelet volume 20 | 45
small superior vagus ganglion 20 | 74
abnormal neural tube closure 19 | 46
abnormal sleep behavior 19 | 70
anophthalmia 19 | 33
decreased circulating alanine ... 19 | 47
increased body length 19 | 32
increased monocyte cell number 19 | 63
abnormal cornea morphology 18 | 31
abnormal craniofacial morpholo... 18 | 33
abnormal embryo turning 18 | 31
decreased circulating LDL chol... 18 | 38
hydrometra 18 | 53
increased grip strength 18 | 41
decreased fasted circulating g... 17 | 65
decreased neutrophil cell numb... 17 | 42
abnormal gait 16 | 69
abnormal kidney morphology 16 | 65
decreased blood urea nitrogen ... 16 | 51
decreased circulating alkaline... 16 | 46
decreased red blood cell distr... 16 | 41
increased erythrocyte cell num... 16 | 39
decreased heart left ventricle... 15 | 28
decreased hematocrit 15 | 46
female infertility 15 | 60
increased neutrophil cell numb... 15 | 46
pallor 15 | 34
abnormal cranium morphology 14 | 36
abnormal testis morphology 14 | 43
corneal opacity 14 | 32
decreased circulating aspartat... 14 | 34
decreased mean corpuscular hem... 14 | 31
enlarged spleen 14 | 41
abnormal bone mineralization 13 | 38

Disease

Carcinoma 3,604 | 11,493
ovarian cancer 3,130 | 8,520
osteosarcoma 2,692 | 7,950
medulloblastoma, large-cell 2,018 | 6,241
glioblastoma 1,872 | 5,792
psoriasis 1,864 | 6,694
atypical teratoid / rhabdoid tumor 1,679 | 5,112
lung cancer 1,628 | 4,740
group 3 medulloblastoma 1,428 | 4,104
ependymoma 1,381 | 4,679
Breast cancer 1,169 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,086 | 3,291
malignant mesothelioma 1,084 | 3,232
adult high grade glioma 1,078 | 3,801
Kidney cancer 1,042 | 2,613
primitive neuroectodermal tumor 1,034 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 984 | 2,989
Cancer 917 | 2,499
invasive ductal carcinoma 898 | 2,951
oligodendroglioma 892 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 886 | 2,955
non-small cell lung cancer 848 | 2,890
lung adenocarcinoma 779 | 2,716
astrocytic glioma 770 | 2,597
pancreatic cancer 747 | 2,398
Astrocytoma, Pilocytic 739 | 3,081
subependymal giant cell astrocytoma 702 | 2,287
Pick disease 699 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 638 | 1,962
Multiple myeloma 610 | 1,332
tuberculosis 610 | 2,010
group 4 medulloblastoma 575 | 1,855
lung carcinoma 543 | 2,843
acute quadriplegic myopathy 534 | 1,158
ductal carcinoma in situ 517 | 1,745
juvenile dermatomyositis 498 | 1,187
pituitary cancer 497 | 1,972
diabetes mellitus 496 | 1,728
astrocytoma 494 | 1,146
breast carcinoma 487 | 1,638
ulcerative colitis 484 | 1,819
adrenocortical carcinoma 474 | 1,428
colon cancer 466 | 1,478
dermatomyositis 463 | 966
Rheumatoid arthritis 445 | 1,191
interstitial cystitis 435 | 2,312
spina bifida 418 | 1,074
Intellectual disability 400 | 1,016
Waldenstrons macroglobulinemia 384 | 765
primary pancreatic ductal adenocarcinoma 382 | 1,109
pediatric high grade glioma 378 | 1,064
Autosomal recessive predisposition 358 | 1,442
cystic fibrosis 350 | 1,696
acute myeloid leukemia 308 | 783
Schizophrenia 292 | 1,160
nasopharyngeal carcinoma 291 | 1,058
progressive supranuclear palsy 279 | 676
non primary Sjogren syndrome sicca 261 | 891
Dull intelligence 248 | 645
Low intelligence 248 | 645
Mental Retardation 248 | 645
Mental deficiency 248 | 645
Poor school performance 248 | 645
Atopic dermatitis 240 | 952
active Crohn's disease 238 | 922
Liver cancer 225 | 604
aldosterone-producing adenoma 224 | 665
Cognitive delay 221 | 608
Global developmental delay 221 | 608
Mental and motor retardation 221 | 608
gastric carcinoma 220 | 807
Epilepsy 217 | 792
medulloblastoma 215 | 720
Alzheimer's disease 213 | 658
Short stature 210 | 531
esophageal adenocarcinoma 199 | 737
cutaneous lupus erythematosus 198 | 1,057
Amyotrophic lateral sclerosis 197 | 451
primary Sjogren syndrome 193 | 735
Muscle hypotonia 190 | 571
autosomal dominant Emery-Dreifuss muscular dystrophy 184 | 510
hepatocellular carcinoma 184 | 547
Down syndrome 182 | 499
Seizures 181 | 596
tuberculosis and treatment for 6 months 181 | 409
Small head 177 | 374
active ulcerative colitis 175 | 764
Duchenne muscular dystrophy 173 | 601
Liver Cirrhosis, Experimental 172 | 769
pancreatic carcinoma 172 | 562
Endometriosis 169 | 540
Breast Neoplasms 166 | 445
Neurodegenerative disease 163 | 414
Prostatic Neoplasms 162 | 495
Melanoma 157 | 711
Mammary Neoplasms 156 | 425
sonic hedgehog group medulloblastoma 155 | 467
Obesity 150 | 678
Bipolar Disorder 148 | 666
hereditary spastic paraplegia 145 | 318

Tissue

Endocrine System 4,854 | 18,159
Female tissues 4,847 | 17,400
Skin and soft tissues 4,843 | 17,230
Digestive Tract 4,842 | 17,369
Male tissues 4,840 | 17,142
Blood and immune system 4,832 | 16,909
Urinary Tract 4,828 | 16,678
Liver and Pancreas 4,825 | 16,750
Nervous System 4,824 | 16,725
Respiratory system 4,822 | 16,393
Cardiovascular System 4,745 | 15,192

Target Family

Non-IDG 2,985 | 12,091
Enzyme 986 | 4,145
Transcription Factor 341 | 1,400
Kinase 304 | 634
Epigenetic 155 | 242
Transporter 104 | 473
Ion Channel 23 | 344
TF/Epigenetic 19 | 38
GPCR 18 | 408
Nuclear Receptor 9 | 48

Jensen-KB Tissue

Cervical carcinoma cell 4,944 | 4,944
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Heme-binding protein 2 HEBP2 Tbio Non-IDG -1.05941 10.8 114
Protein FAM171A2 FAM171A2 Tdark Non-IDG 0.00000 20
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Caskin-2 CASKIN2 Tdark Non-IDG -0.21450 1.97 118
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408