Development Level

Tbio 3,416 | 10,625
Tdark 816 | 7,003
Tchem 592 | 1,890
Tclin 91 | 602

Collection

Eligible Kinase Proteins 55 | 134
Eligible Ion Channel Proteins 7 | 117
Eligible non-olfactory GPCR Proteins 7 | 143

IMPC Term

preweaning lethality, complete... 303 | 633
preweaning lethality, incomple... 100 | 260
embryonic lethality prior to t... 91 | 187
decreased lean body mass 84 | 195
decreased body weight 76 | 174
embryonic lethality prior to o... 74 | 148
decreased total body fat amoun... 73 | 186
abnormal behavior 68 | 226
decreased bone mineral content 50 | 157
increased or absent threshold ... 50 | 128
abnormal embryo size 49 | 112
decreased body length 48 | 108
abnormal bone structure 45 | 131
abnormal retina morphology 45 | 100
increased circulating alkaline... 43 | 119
decreased circulating glucose ... 42 | 121
decreased bone mineral density 39 | 126
prenatal lethality prior to he... 38 | 64
hyperactivity 37 | 108
decreased grip strength 36 | 123
increased bone mineral content 36 | 92
increased lean body mass 36 | 107
decreased circulating choleste... 35 | 85
increased mean corpuscular hem... 35 | 93
decreased circulating HDL chol... 32 | 77
increased grip strength 32 | 83
increased mean corpuscular vol... 32 | 91
abnormal lens morphology 29 | 73
decreased circulating triglyce... 28 | 83
enlarged heart 28 | 111
short tibia 27 | 82
abnormal bone mineralization 26 | 55
abnormal retinal pigmentation 26 | 61
decreased circulating serum al... 26 | 79
hypoactivity 26 | 89
increased sacral vertebrae num... 26 | 62
decreased lumbar vertebrae num... 25 | 62
decreased mean corpuscular vol... 24 | 50
decreased rib number 23 | 59
decreased leukocyte cell numbe... 22 | 54
decreased prepulse inhibition 22 | 52
decreased circulating insulin ... 21 | 75
decreased circulating total pr... 21 | 41
increased bone mineral density 21 | 52
decreased caudal vertebrae num... 20 | 49
decreased hemoglobin content 20 | 53
increased fasted circulating g... 20 | 68
abnormal coat/hair pigmentatio... 19 | 54
decreased circulating LDL chol... 19 | 37
abnormal sleep behavior 18 | 63
decreased startle reflex 18 | 48
increased circulating HDL chol... 18 | 63
decreased circulating alanine ... 17 | 53
improved glucose tolerance 17 | 56
increased circulating choleste... 17 | 53
abnormal neural tube closure 16 | 37
decreased eosinophil cell numb... 16 | 41
male infertility 16 | 62
abnormal behavioral response t... 15 | 52
abnormal eye morphology 15 | 38
decreased erythrocyte cell num... 15 | 43
decreased neutrophil cell numb... 15 | 37
impaired glucose tolerance 15 | 52
increased heart weight 15 | 37
abnormal cornea morphology 14 | 24
abnormal spleen morphology 14 | 36
decreased circulating alkaline... 14 | 41
decreased heart weight 14 | 44
decreased mean corpuscular hem... 14 | 34
increased hematocrit 14 | 36
increased hemoglobin content 14 | 45
increased total body fat amoun... 14 | 57
cardiovascular system phenotyp... 13 | 35
decreased hematocrit 13 | 25
increased leukocyte cell numbe... 13 | 37
thrombocytopenia 13 | 46
abnormal heart morphology 12 | 51
abnormal hindbrain development 12 | 24
anophthalmia 12 | 20
decreased CD4-positive, CD25-p... 12 | 24
decreased circulating calcium ... 12 | 33
decreased circulating chloride... 12 | 32
decreased circulating free fat... 12 | 39
decreased circulating iron lev... 12 | 25
decreased fasted circulating g... 12 | 49
hydrops fetalis 12 | 22
increased body weight 12 | 42
increased circulating chloride... 12 | 43
increased circulating sodium l... 12 | 71
abnormal cranium morphology 11 | 32
abnormal rib morphology 11 | 28
decreased monocyte cell number 11 | 28
decreased threshold for audito... 11 | 32
enlarged spleen 11 | 26
increased erythrocyte cell num... 11 | 26
increased mean corpuscular hem... 11 | 25
increased startle reflex 11 | 38
small testis 11 | 37
thrombocytosis 11 | 23
tremors 11 | 34

Disease

ovarian cancer 3,101 | 8,484
osteosarcoma 2,674 | 7,933
medulloblastoma, large-cell 2,012 | 6,234
psoriasis 1,863 | 6,685
glioblastoma 1,801 | 5,572
lung cancer 1,561 | 4,466
atypical teratoid / rhabdoid tumor 1,435 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,080 | 3,289
malignant mesothelioma 1,053 | 3,162
primitive neuroectodermal tumor 1,026 | 3,031
Breast cancer 1,022 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 981 | 2,988
invasive ductal carcinoma 893 | 2,950
oligodendroglioma 888 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 885 | 2,956
pediatric high grade glioma 880 | 2,712
Cancer 866 | 2,346
ependymoma 864 | 2,514
group 3 medulloblastoma 831 | 2,254
non-small cell lung cancer 831 | 2,798
Carcinoma 824 | 2,147
lung adenocarcinoma 774 | 2,713
pilocytic astrocytoma 746 | 3,086
pancreatic cancer 717 | 2,300
subependymal giant cell astrocytoma 701 | 2,287
Pick disease 698 | 1,893
astrocytic glioma 656 | 2,241
Multiple myeloma 610 | 1,327
group 4 medulloblastoma 602 | 1,875
astrocytoma 600 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 574 | 1,795
adult high grade glioma 566 | 2,148
ulcerative colitis 545 | 2,087
lung carcinoma 541 | 2,844
acute quadriplegic myopathy 534 | 1,157
ductal carcinoma in situ 514 | 1,745
juvenile dermatomyositis 497 | 1,189
pituitary cancer 495 | 1,972
diabetes mellitus 481 | 1,663
breast carcinoma 476 | 1,614
adrenocortical carcinoma 471 | 1,427
colon cancer 466 | 1,475
dermatomyositis 465 | 933
sonic hedgehog group medulloblastoma 463 | 1,482
medulloblastoma 459 | 1,524
tuberculosis 442 | 1,557
primary pancreatic ductal adenocarcinoma 441 | 1,271
Rheumatoid Arthritis 436 | 1,160
interstitial cystitis 430 | 2,299
posterior fossa group A ependymoma 422 | 1,511
spina bifida 410 | 1,064
Waldenstrons macroglobulinemia 384 | 765
atypical teratoid/rhabdoid tumor 346 | 1,095
cystic fibrosis 341 | 1,665
posterior fossa group B ependymoma 315 | 1,530
acute myeloid leukemia 306 | 780
tuberculosis and treatment for 6 months 292 | 686
nasopharyngeal carcinoma 290 | 1,056
progressive supranuclear palsy 280 | 674
non primary Sjogren syndrome sicca 250 | 840
Intellectual disability 248 | 573
Atopic dermatitis 238 | 944
active Crohn's disease 235 | 918
gastric carcinoma 226 | 832
aldosterone-producing adenoma 225 | 664
Alzheimer's disease 215 | 644
primary Sjogren syndrome 204 | 789
cutaneous lupus erythematosus 199 | 1,056
esophageal adenocarcinoma 199 | 737
Down syndrome 194 | 548
Amyotrophic Lateral Sclerosis 188 | 431
autosomal dominant Emery-Dreifuss muscular dystrophy 181 | 499
IGA Glomerulonephritis 180 | 454
hepatocellular carcinoma 178 | 532
pancreatic carcinoma 173 | 567
Duchenne muscular dystrophy 172 | 602
Endometriosis 167 | 535
Neurodegenerative disease 153 | 383
Mammary Neoplasms 151 | 410
Prostatic Neoplasms 148 | 471
hereditary spastic paraplegia 144 | 313
gastric cancer 132 | 430
Obesity 128 | 616
Polycystic Ovary Syndrome 121 | 332
Schizophrenia 116 | 501
chronic rhinosinusitis 116 | 512
Gaucher disease type 1 115 | 171
Multiple Sclerosis 114 | 498
fibroadenoma 114 | 557
inflammatory breast cancer 114 | 404
interstitial lung disease 106 | 291
active ulcerative colitis 105 | 477
mucosa-associated lymphoid tissue lymphoma 105 | 480
tuberculosis and treatment for 3 months 103 | 327
Parkinson's disease 102 | 364
Kidney disease 95 | 396
Stomach Neoplasms 93 | 282
glioblastoma multiforme 92 | 347
Crohn's disease 89 | 304
Peripheral Neuropathy 88 | 303

Tissue

Nervous System 4,849 | 18,561
Blood and immune system 4,847 | 17,995
Liver and Pancreas 4,847 | 18,136
Female tissues 4,846 | 18,647
Male tissues 4,845 | 17,969
Digestive Tract 4,844 | 18,473
Endocrine System 4,839 | 18,512
Cardiovascular System 4,838 | 17,958
Urinary Tract 4,833 | 18,444
Respiratory system 4,812 | 17,484
Skin and soft tissues 4,800 | 18,115

Target Family

Non-IDG 2,961 | 11,971
Enzyme 986 | 4,146
Transcription Factor 341 | 1,400
Kinase 303 | 634
Epigenetic 152 | 242
Transporter 104 | 473
Ion Channel 22 | 341
TF/Epigenetic 19 | 38
GPCR 18 | 406
Nuclear Receptor 9 | 48

Jensen-KB Tissue

Cervical carcinoma cell 4,915 | 4,915
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
HEAT repeat-containing protein 6 HEATR6 Tdark Non-IDG -1.48236 11.6 38
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345