Development Level

Tbio 459 | 11,445
Tdark 142 | 6,588
Tchem 65 | 1,598
Tclin 32 | 613

Collection

RFA-RM-18-021 16 | 328
Kinase: IDG Consortium (Target... 8 | 125
Ion Channel: IDG Consortium (T... 5 | 99
GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 46 | 979
preweaning lethality, incomple... 20 | 499
abnormal behavior 15 | 298
decreased total body fat amoun... 14 | 207
embryonic lethality prior to t... 13 | 278
embryonic lethality prior to o... 11 | 239
decreased vertical activity 10 | 208
hypoactivity 9 | 132
increased or absent threshold ... 9 | 101
decreased body weight 8 | 161
enlarged heart 8 | 210
increased bone mineral content 8 | 108
abnormal embryo size 7 | 220
decreased bone mineral content 7 | 151
increased lean body mass 7 | 172
increased mean corpuscular vol... 7 | 92
increased total body fat amoun... 7 | 134
abnormal behavioral response t... 6 | 66
decreased circulating HDL chol... 6 | 68
decreased circulating LDL chol... 6 | 38
decreased grip strength 6 | 116
decreased lean body mass 6 | 135
decreased mean corpuscular vol... 6 | 79
decreased neutrophil cell numb... 6 | 42
hyperactivity 6 | 148
improved glucose tolerance 6 | 79
increased circulating alkaline... 6 | 122
increased startle reflex 6 | 112
male infertility 6 | 123
abnormal bone structure 5 | 187
abnormal gait 5 | 69
abnormal retina morphology 5 | 71
decreased circulating alanine ... 5 | 47
decreased circulating choleste... 5 | 93
abnormal heart morphology 4 | 162
cataract 4 | 92
decreased circulating alkaline... 4 | 46
decreased lymphocyte cell numb... 4 | 83
embryonic growth retardation 4 | 106
increased fasted circulating g... 4 | 76
increased lymphocyte cell numb... 4 | 32
increased mean corpuscular hem... 4 | 96
increased mean platelet volume 4 | 45
increased monocyte cell number 4 | 63
limb grasping 4 | 41
short tibia 4 | 97
tremors 4 | 39
abnormal coat appearance 3 | 31
abnormal locomotor behavior 3 | 24
abnormal tooth morphology 3 | 24
absent startle reflex 3 | 24
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 53
decreased circulating aspartat... 3 | 34
decreased circulating serum al... 3 | 82
decreased erythrocyte cell num... 3 | 62
decreased hemoglobin content 3 | 68
decreased lactate dehydrogenas... 3 | 16
decreased startle reflex 3 | 75
enlarged lymph nodes 3 | 37
increased blood urea nitrogen ... 3 | 48
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased circulating sodium l... 3 | 71
increased eosinophil cell numb... 3 | 11
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 36
prenatal lethality prior to he... 3 | 87
small superior vagus ganglion 3 | 74
small testis 3 | 58
syndactyly 3 | 23
abnormal coat-hair pigmentatio... 2 | 64
abnormal craniofacial morpholo... 2 | 33
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
abnormal tail movements 2 | 12
abnormal vocalization 2 | 21
anophthalmia 2 | 33
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating free fat... 2 | 31
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased hematocrit 2 | 46
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
enlarged spleen 2 | 41
impaired glucose tolerance 2 | 75
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating free fat... 2 | 20
increased circulating phosphat... 2 | 26
increased heart weight 2 | 62
long tibia 2 | 25
microphthalmia 2 | 26
prenatal lethality 2 | 28

Disease

Carcinoma 436 | 11,493
ovarian cancer 346 | 8,520
medulloblastoma, large-cell 303 | 6,241
osteosarcoma 301 | 7,950
glioblastoma 287 | 5,792
ependymoma 261 | 4,679
atypical teratoid / rhabdoid tumor 259 | 5,112
psoriasis 240 | 6,694
group 3 medulloblastoma 215 | 4,104
adult high grade glioma 208 | 3,801
oligodendroglioma 184 | 2,850
lung cancer 181 | 4,740
astrocytic glioma 178 | 2,597
Astrocytoma, Pilocytic 174 | 3,081
primitive neuroectodermal tumor 166 | 3,035
subependymal giant cell astrocytoma 157 | 2,287
Breast cancer 148 | 3,578
malignant mesothelioma 143 | 3,232
Pick disease 133 | 1,894
lung carcinoma 131 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 123 | 3,291
Kidney cancer 121 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 109 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 105 | 2,955
invasive ductal carcinoma 101 | 2,951
pituitary cancer 95 | 1,972
non-small cell lung cancer 94 | 2,890
group 4 medulloblastoma 92 | 1,855
Cancer 87 | 2,499
lung adenocarcinoma 87 | 2,716
pancreatic cancer 83 | 2,398
interstitial cystitis 79 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 74 | 1,962
cystic fibrosis 71 | 1,696
tuberculosis 69 | 2,010
Multiple myeloma 67 | 1,332
Schizophrenia 65 | 1,160
adrenocortical carcinoma 65 | 1,428
colon cancer 65 | 1,478
diabetes mellitus 65 | 1,728
ulcerative colitis 65 | 1,819
breast carcinoma 63 | 1,638
Epilepsy 61 | 792
Intellectual disability 59 | 1,016
Autosomal recessive predisposition 58 | 1,442
juvenile dermatomyositis 57 | 1,187
Bipolar Disorder 56 | 666
acute quadriplegic myopathy 53 | 1,158
Rheumatoid arthritis 51 | 1,191
dermatomyositis 48 | 966
astrocytoma 47 | 1,146
pediatric high grade glioma 47 | 1,064
Alzheimer's disease 46 | 658
ductal carcinoma in situ 45 | 1,745
nasopharyngeal carcinoma 43 | 1,058
non primary Sjogren syndrome sicca 42 | 891
Seizures 41 | 596
primary pancreatic ductal adenocarcinoma 40 | 1,109
Waldenstrons macroglobulinemia 38 | 765
Neurodegenerative disease 36 | 414
medulloblastoma 36 | 720
Liver Cirrhosis, Experimental 35 | 769
Muscle hypotonia 35 | 571
cutaneous lupus erythematosus 35 | 1,057
Dull intelligence 34 | 645
Liver cancer 34 | 604
Low intelligence 34 | 645
Mental Retardation 34 | 645
Mental deficiency 34 | 645
Poor school performance 34 | 645
active Crohn's disease 34 | 922
active ulcerative colitis 34 | 764
Down syndrome 33 | 499
aldosterone-producing adenoma 33 | 665
progressive supranuclear palsy 33 | 676
Atopic dermatitis 31 | 952
Duchenne muscular dystrophy 31 | 601
Melanoma 30 | 711
Cognitive delay 29 | 608
Global developmental delay 29 | 608
Mental and motor retardation 29 | 608
acute myeloid leukemia 29 | 783
Cerebellar Ataxia 28 | 304
esophageal adenocarcinoma 28 | 737
Amyotrophic lateral sclerosis 26 | 451
Depressive disorder 26 | 409
Obesity 26 | 678
Parkinson's disease 26 | 392
autosomal dominant Emery-Dreifuss muscular dystrophy 26 | 510
spina bifida 25 | 1,074
posterior fossa group A ependymoma 24 | 468
Skin cancer 23 | 469
atypical teratoid/rhabdoid tumor 23 | 357
gastric carcinoma 23 | 807
Autistic Disorder 22 | 364
Short stature 22 | 531
pancreatic carcinoma 22 | 562
sonic hedgehog group medulloblastoma 22 | 467
Nystagmus 21 | 317
primary Sjogren syndrome 21 | 735

Tissue

Endocrine System 679 | 18,159
Nervous System 673 | 16,725
Digestive Tract 672 | 17,369
Female tissues 663 | 17,400
Skin and soft tissues 663 | 17,230
Male tissues 659 | 17,142
Blood and immune system 651 | 16,909
Liver and Pancreas 650 | 16,750
Respiratory system 644 | 16,393
Urinary Tract 643 | 16,678
Cardiovascular System 603 | 15,192

Target Family

Non-IDG 389 | 12,091
Enzyme 165 | 4,145
Transcription Factor 40 | 1,400
Ion Channel 28 | 344
Kinase 28 | 634
Transporter 24 | 473
GPCR 11 | 408
Epigenetic 10 | 242
oGPCR 2 | 421
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Cerebellum 698 | 698
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinesin-like protein KIF25 KIF25 Tbio Non-IDG -0.75019 5.59 191
Cadherin-18 CDH18 Tdark Non-IDG -0.64897 4.11 125
Zinc finger protein 638 ZNF638 Tbio Non-IDG -0.68946 6.04 67
Proline-rich transmembrane protein 1 PRRT1 Tbio Non-IDG -1.33375 18.2 68
Hypoxia-inducible lipid droplet-associated protein HILPDA Tbio Non-IDG -1.24205 21.6 18
Exonuclease mut-7 homolog, isoform 5 EXD3 Tdark Enzyme -0.45611 3.91 0
RNA binding protein fox-1 homolog 3 RBFOX3 Tbio Non-IDG -3.23341 1462.9 208
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150
Calbindin CALB1 Tbio Non-IDG -3.31956 2149.9 287
Pleckstrin homology-like domain family A member 3 PHLDA3 Tbio Non-IDG -0.83900 8.89 101