Development Level

Tbio 422 | 10,625
Tdark 159 | 7,003
Tchem 79 | 1,890
Tclin 33 | 602

Collection

Eligible Kinase Proteins 8 | 134
Eligible Ion Channel Proteins 7 | 117
Eligible non-olfactory GPCR Proteins 3 | 143

IMPC Term

preweaning lethality, complete... 34 | 633
decreased total body fat amoun... 16 | 186
preweaning lethality, incomple... 13 | 260
embryonic lethality prior to t... 12 | 187
abnormal behavior 11 | 226
decreased lean body mass 10 | 195
decreased body weight 9 | 174
decreased grip strength 9 | 123
increased bone mineral content 9 | 92
abnormal behavioral response t... 7 | 52
decreased body length 7 | 108
decreased bone mineral content 7 | 157
decreased circulating alanine ... 7 | 53
embryonic lethality prior to o... 7 | 148
hyperactivity 7 | 108
hypoactivity 7 | 89
increased lean body mass 7 | 107
decreased circulating HDL chol... 6 | 77
decreased circulating choleste... 6 | 85
enlarged heart 6 | 111
increased circulating alkaline... 6 | 119
increased startle reflex 6 | 38
improved glucose tolerance 5 | 56
increased mean corpuscular vol... 5 | 91
increased or absent threshold ... 5 | 128
short tibia 5 | 82
abnormal bone structure 4 | 131
abnormal embryo size 4 | 112
abnormal gait 4 | 51
abnormal neural tube closure 4 | 37
abnormal retina morphology 4 | 100
decreased bone mineral density 4 | 126
decreased circulating LDL chol... 4 | 37
increased fasted circulating g... 4 | 68
increased grip strength 4 | 83
increased hemoglobin content 4 | 45
limb grasping 4 | 35
tremors 4 | 34
abnormal coat appearance 3 | 25
abnormal hindbrain development 3 | 24
abnormal retinal pigmentation 3 | 61
abnormal tooth morphology 3 | 24
decreased circulating alkaline... 3 | 41
decreased circulating aspartat... 3 | 27
decreased circulating bilirubi... 3 | 14
decreased circulating serum al... 3 | 79
decreased eosinophil cell numb... 3 | 41
decreased lactate dehydrogenas... 3 | 14
decreased mean corpuscular vol... 3 | 50
decreased neutrophil cell numb... 3 | 37
decreased rib number 3 | 59
decreased startle reflex 3 | 48
increased blood urea nitrogen ... 3 | 44
increased circulating LDL chol... 3 | 15
increased heart weight 3 | 37
increased mean corpuscular hem... 3 | 93
male infertility 3 | 62
prenatal lethality prior to he... 3 | 64
abnormal QRS complex 2 | 25
abnormal coat/hair pigmentatio... 2 | 54
abnormal heart morphology 2 | 51
abnormal kidney morphology 2 | 30
abnormal midbrain development 2 | 22
abnormal seminal vesicle morph... 2 | 47
abnormal tail movements 2 | 12
abnormal testis morphology 2 | 30
abnormal vocalization 2 | 21
cardiovascular system phenotyp... 2 | 35
decreased CD11b-low dendritic ... 2 | 3
decreased NK T cell number 2 | 28
decreased NK cell number 2 | 16
decreased T cell number 2 | 31
decreased blood urea nitrogen ... 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating calcium ... 2 | 33
decreased circulating creatini... 2 | 31
decreased circulating free fat... 2 | 39
decreased circulating glucose ... 2 | 121
decreased circulating glycerol... 2 | 19
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased erythrocyte cell num... 2 | 43
decreased exploration in new e... 2 | 9
decreased hemoglobin content 2 | 53
decreased mean corpuscular hem... 2 | 34
enlarged lymph nodes 2 | 27
enlarged spleen 2 | 26
increased circulating HDL chol... 2 | 63
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating free fat... 2 | 17
increased circulating potassiu... 2 | 31
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
increased mean corpuscular hem... 2 | 25
increased total body fat amoun... 2 | 57
small testis 2 | 37
straub tail 2 | 26
thrombocytopenia 2 | 46

Disease

ovarian cancer 343 | 8,484
medulloblastoma, large-cell 304 | 6,234
osteosarcoma 298 | 7,933
glioblastoma 278 | 5,572
psoriasis 238 | 6,685
atypical teratoid / rhabdoid tumor 223 | 4,369
oligodendroglioma 186 | 2,849
pilocytic astrocytoma 177 | 3,086
lung cancer 174 | 4,466
primitive neuroectodermal tumor 168 | 3,031
subependymal giant cell astrocytoma 158 | 2,287
pediatric high grade glioma 154 | 2,712
ependymoma 151 | 2,514
astrocytic glioma 146 | 2,241
malignant mesothelioma 137 | 3,162
Pick disease 132 | 1,893
lung carcinoma 132 | 2,844
Breast cancer 122 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 122 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 110 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 106 | 2,956
group 3 medulloblastoma 104 | 2,254
Carcinoma 103 | 2,147
adult high grade glioma 101 | 2,148
invasive ductal carcinoma 100 | 2,950
medulloblastoma 98 | 1,524
pituitary cancer 94 | 1,972
group 4 medulloblastoma 89 | 1,875
non-small cell lung cancer 88 | 2,798
lung adenocarcinoma 86 | 2,713
posterior fossa group A ependymoma 86 | 1,511
interstitial cystitis 80 | 2,299
pancreatic cancer 80 | 2,300
Cancer 79 | 2,346
astrocytoma 78 | 1,493
sonic hedgehog group medulloblastoma 74 | 1,482
ulcerative colitis 73 | 2,087
cystic fibrosis 70 | 1,665
Multiple myeloma 68 | 1,327
pancreatic ductal adenocarcinoma liver metastasis 67 | 1,795
adrenocortical carcinoma 65 | 1,427
colon cancer 65 | 1,475
diabetes mellitus 63 | 1,663
breast carcinoma 61 | 1,614
atypical teratoid/rhabdoid tumor 59 | 1,095
posterior fossa group B ependymoma 59 | 1,530
tuberculosis 59 | 1,557
juvenile dermatomyositis 57 | 1,189
acute quadriplegic myopathy 52 | 1,157
dermatomyositis 50 | 933
Rheumatoid Arthritis 47 | 1,160
primary pancreatic ductal adenocarcinoma 47 | 1,271
ductal carcinoma in situ 44 | 1,745
non primary Sjogren syndrome sicca 42 | 840
nasopharyngeal carcinoma 41 | 1,056
Waldenstrons macroglobulinemia 39 | 765
Intellectual disability 37 | 573
Alzheimer's disease 36 | 644
Schizophrenia 36 | 501
Down syndrome 35 | 548
Neurodegenerative disease 35 | 383
cutaneous lupus erythematosus 35 | 1,056
Epilepsy 34 | 346
active Crohn's disease 34 | 918
aldosterone-producing adenoma 33 | 664
progressive supranuclear palsy 32 | 674
Duchenne muscular dystrophy 31 | 602
Atopic dermatitis 29 | 944
acute myeloid leukemia 29 | 780
esophageal adenocarcinoma 28 | 737
Bipolar Disorder 27 | 266
Obesity 27 | 616
active ulcerative colitis 26 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 26 | 499
spina bifida 26 | 1,064
Autistic Disorder 25 | 320
gastric carcinoma 25 | 832
Amyotrophic Lateral Sclerosis 24 | 431
Parkinson's disease 24 | 364
tuberculosis and treatment for 6 months 24 | 686
pancreatic carcinoma 22 | 567
primary Sjogren syndrome 22 | 789
glioblastoma multiforme 19 | 347
Prostatic Neoplasms 18 | 471
hepatocellular carcinoma 18 | 532
Endometriosis 17 | 535
Toxic encephalopathy 17 | 131
Heart disease 16 | 279
Multiple Sclerosis 16 | 498
Vascular disease 16 | 281
non-small cell lung carcinoma 16 | 413
sarcoidosis 16 | 358
Mammary Neoplasms 15 | 410
chronic rhinosinusitis 15 | 512
Asthma 14 | 349
Dementia 14 | 129
IGA Glomerulonephritis 14 | 454
Stomach Neoplasms 14 | 282
fibroadenoma 14 | 557
Attention deficit hyperactivity disorder 13 | 156

Tissue

Nervous System 684 | 18,561
Female tissues 682 | 18,647
Urinary Tract 681 | 18,444
Cardiovascular System 680 | 17,958
Digestive Tract 680 | 18,473
Endocrine System 680 | 18,512
Blood and immune system 677 | 17,995
Male tissues 677 | 17,969
Liver and Pancreas 675 | 18,136
Skin and soft tissues 674 | 18,115
Respiratory system 667 | 17,484

Target Family

Non-IDG 383 | 11,971
Enzyme 165 | 4,146
Transcription Factor 40 | 1,400
Ion Channel 28 | 341
Kinase 27 | 634
Transporter 24 | 473
GPCR 13 | 406
Epigenetic 10 | 242
oGPCR 2 | 421
TF/Epigenetic 1 | 38

Jensen-KB Tissue

Cerebellum 693 | 693
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Blood platelet 539 | 539
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Transmembrane protein 229B TMEM229B Tdark Non-IDG 1.34 0.03 3
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Seizure protein 6 homolog SEZ6 Tdark Non-IDG -0.87986 8.64 27
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase MGAT3 Tchem Enzyme -1.22408 15.8 139
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Interleukin-15 IL15 Tbio Non-IDG -3.01964 1248.2 612
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120