Development Level

Tbio 4,894 | 11,651
Tdark 1,609 | 6,593
Tchem 580 | 1,388
Tclin 263 | 612

Collection

RFA-RM-18-021 145 | 328
Ion Channel: IDG Consortium (T... 55 | 99
Kinase: IDG Consortium (Target... 54 | 125
GPCR: IDG Consortium (Targets) 44 | 126
Kinase: IDG Consortium (Comple... 19 | 37
GPCR: IDG Consortium (Complete... 14 | 25

IMPC Phenotype

preweaning lethality, complete... 441 | 979
preweaning lethality, incomple... 243 | 499
abnormal behavior 154 | 298
embryonic lethality prior to t... 120 | 278
decreased total body fat amoun... 104 | 207
abnormal bone structure 98 | 187
embryonic lethality prior to o... 98 | 239
abnormal embryo size 88 | 220
increased lean body mass 87 | 172
decreased vertical activity 86 | 208
hyperactivity 80 | 148
enlarged heart 77 | 210
decreased body weight 76 | 161
decreased bone mineral content 76 | 151
decreased lean body mass 73 | 135
increased total body fat amoun... 66 | 134
increased circulating alkaline... 63 | 122
decreased grip strength 58 | 116
hypoactivity 57 | 132
decreased bone mineral density 55 | 126
abnormal heart morphology 52 | 162
male infertility 52 | 123
increased bone mineral content 51 | 108
increased or absent threshold ... 51 | 101
increased startle reflex 51 | 112
decreased circulating glucose ... 50 | 126
short tibia 50 | 97
abnormal seminal vesicle morph... 49 | 114
decreased body length 49 | 101
decreased circulating choleste... 48 | 93
decreased circulating serum al... 47 | 82
decreased lymphocyte cell numb... 47 | 83
increased mean corpuscular hem... 46 | 96
increased mean corpuscular vol... 46 | 92
decreased prepulse inhibition 43 | 82
cataract 42 | 92
embryonic growth retardation 41 | 106
decreased startle reflex 39 | 75
impaired glucose tolerance 39 | 75
improved glucose tolerance 39 | 79
increased fasted circulating g... 39 | 76
abnormal lens morphology 37 | 81
decreased leukocyte cell numbe... 37 | 73
abnormal coat-hair pigmentatio... 36 | 64
prenatal lethality prior to he... 36 | 87
small superior vagus ganglion 36 | 74
decreased circulating insulin ... 35 | 76
decreased circulating triglyce... 35 | 79
decreased hemoglobin content 35 | 68
abnormal retina morphology 34 | 71
edema 34 | 59
abnormal behavioral response t... 33 | 66
decreased circulating HDL chol... 33 | 68
decreased mean corpuscular vol... 33 | 79
increased bone mineral density 33 | 72
increased circulating sodium l... 33 | 71
abnormal eye morphology 32 | 68
decreased fasted circulating g... 32 | 65
increased monocyte cell number 32 | 63
abnormal gait 31 | 69
abnormal sleep behavior 31 | 70
increased circulating HDL chol... 30 | 80
increased circulating choleste... 30 | 66
increased heart weight 30 | 62
thrombocytopenia 30 | 56
decreased circulating LDL chol... 29 | 38
decreased circulating total pr... 29 | 49
abnormal kidney morphology 27 | 65
decreased mean corpuscular hem... 27 | 50
female infertility 27 | 60
decreased caudal vertebrae num... 26 | 53
abnormal spleen morphology 25 | 55
increased circulating chloride... 25 | 41
increased leukocyte cell numbe... 25 | 47
increased mean platelet volume 25 | 45
small testis 25 | 58
abnormal epididymis morphology 24 | 42
decreased circulating alkaline... 24 | 46
decreased erythrocyte cell num... 24 | 62
decreased red blood cell distr... 24 | 41
increased blood urea nitrogen ... 24 | 48
increased neutrophil cell numb... 24 | 46
increased hematocrit 23 | 46
tremors 23 | 39
abnormal cranium morphology 22 | 36
corneal opacity 22 | 32
decreased circulating alanine ... 22 | 47
hydrometra 22 | 53
limb grasping 21 | 41
decreased hematocrit 20 | 46
decreased neutrophil cell numb... 20 | 42
increased erythrocyte cell num... 20 | 39
increased red blood cell distr... 20 | 34
persistence of hyaloid vascula... 20 | 33
anophthalmia 19 | 33
decreased circulating calcium ... 19 | 36
decreased mean corpuscular hem... 19 | 31
enlarged spleen 19 | 41
increased hemoglobin content 19 | 45
prolonged QT interval 19 | 38

Disease

Carcinoma 4,989 | 11,493
ovarian cancer 3,802 | 8,520
osteosarcoma 3,449 | 7,950
medulloblastoma, large-cell 3,115 | 6,241
glioblastoma 2,903 | 5,792
atypical teratoid / rhabdoid tumor 2,677 | 5,112
psoriasis 2,661 | 6,694
ependymoma 2,451 | 4,679
group 3 medulloblastoma 2,059 | 4,104
lung cancer 2,041 | 4,740
adult high grade glioma 1,985 | 3,801
Astrocytoma, Pilocytic 1,642 | 3,081
oligodendroglioma 1,642 | 2,850
primitive neuroectodermal tumor 1,627 | 3,035
Breast cancer 1,565 | 3,578
astrocytic glioma 1,489 | 2,597
malignant mesothelioma 1,415 | 3,232
Kidney cancer 1,398 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 1,330 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 1,278 | 2,989
lung carcinoma 1,265 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 1,263 | 2,955
invasive ductal carcinoma 1,225 | 2,951
subependymal giant cell astrocytoma 1,189 | 2,287
non-small cell lung cancer 1,154 | 2,890
Pick disease 1,143 | 1,894
lung adenocarcinoma 1,075 | 2,716
pancreatic cancer 964 | 2,398
pituitary cancer 949 | 1,972
group 4 medulloblastoma 946 | 1,855
Cancer 897 | 2,499
interstitial cystitis 869 | 2,312
tuberculosis 772 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 763 | 1,962
cystic fibrosis 727 | 1,696
ulcerative colitis 711 | 1,819
breast carcinoma 689 | 1,638
ductal carcinoma in situ 680 | 1,745
colon cancer 621 | 1,478
Schizophrenia 619 | 1,160
Multiple myeloma 607 | 1,332
adrenocortical carcinoma 606 | 1,428
astrocytoma 573 | 1,146
Autosomal recessive predisposition 549 | 1,442
Intellectual disability 537 | 1,016
juvenile dermatomyositis 537 | 1,187
diabetes mellitus 529 | 1,728
acute quadriplegic myopathy 524 | 1,158
Rheumatoid arthritis 495 | 1,191
primary pancreatic ductal adenocarcinoma 477 | 1,109
pediatric high grade glioma 474 | 1,064
dermatomyositis 437 | 966
spina bifida 435 | 1,074
Epilepsy 433 | 792
cutaneous lupus erythematosus 388 | 1,057
Alzheimer's disease 381 | 658
progressive supranuclear palsy 359 | 676
non primary Sjogren syndrome sicca 355 | 891
active Crohn's disease 354 | 922
Bipolar Disorder 353 | 666
nasopharyngeal carcinoma 352 | 1,058
Waldenstrons macroglobulinemia 347 | 765
Liver cancer 345 | 604
medulloblastoma 343 | 720
gastric carcinoma 341 | 807
acute myeloid leukemia 332 | 783
Seizures 325 | 596
Dull intelligence 322 | 645
Low intelligence 322 | 645
Mental Retardation 322 | 645
Mental deficiency 322 | 645
Poor school performance 322 | 645
aldosterone-producing adenoma 320 | 665
Atopic dermatitis 314 | 952
Cognitive delay 304 | 608
Global developmental delay 304 | 608
Mental and motor retardation 304 | 608
Melanoma 302 | 711
Liver Cirrhosis, Experimental 298 | 769
Muscle hypotonia 285 | 571
active ulcerative colitis 281 | 764
primary Sjogren syndrome 267 | 735
Duchenne muscular dystrophy 263 | 601
Obesity 262 | 678
esophageal adenocarcinoma 262 | 737
Down syndrome 260 | 499
Neurodegenerative disease 247 | 414
Amyotrophic lateral sclerosis 245 | 451
autosomal dominant Emery-Dreifuss muscular dystrophy 242 | 510
Parkinson's disease 236 | 392
Depressive disorder 232 | 409
pancreatic carcinoma 230 | 562
Short stature 222 | 531
fibroadenoma 217 | 559
Skin cancer 215 | 469
hepatocellular carcinoma 215 | 547
sonic hedgehog group medulloblastoma 210 | 467
chronic rhinosinusitis 205 | 512
Autistic Disorder 202 | 364
tuberculosis and treatment for 6 months 199 | 409

Tissue

Endocrine System 7,204 | 18,159
Nervous System 7,082 | 16,725
Digestive Tract 7,077 | 17,369
Female tissues 7,075 | 17,400
Skin and soft tissues 7,032 | 17,230
Male tissues 7,028 | 17,142
Blood and immune system 6,937 | 16,909
Liver and Pancreas 6,925 | 16,750
Urinary Tract 6,910 | 16,678
Respiratory system 6,829 | 16,393
Cardiovascular System 6,509 | 15,192

Target Family

Non-IDG 4,107 | 12,091
Enzyme 1,724 | 4,145
Transcription Factor 519 | 1,400
Kinase 297 | 634
Transporter 186 | 473
Ion Channel 180 | 344
GPCR 163 | 408
Epigenetic 124 | 242
Nuclear Receptor 16 | 48
TF/Epigenetic 15 | 38
oGPCR 15 | 421

Jensen-KB Tissue

Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
tRNA-specific adenosine deaminase 1 ADAT1 Tbio Enzyme -1.08814 11.8 136