Development Level

Tbio 391 | 10,625
Tchem 92 | 1,890
Tdark 33 | 7,003
Tclin 23 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 29 | 633
preweaning lethality, incomple... 14 | 260
decreased body weight 10 | 174
decreased body length 8 | 108
decreased lean body mass 8 | 195
abnormal lens morphology 7 | 73
decreased total body fat amoun... 7 | 186
embryonic lethality prior to t... 7 | 187
abnormal behavior 6 | 226
decreased circulating total pr... 6 | 41
enlarged heart 6 | 111
abnormal embryo size 5 | 112
cardiovascular system phenotyp... 5 | 35
decreased circulating choleste... 5 | 85
increased circulating alkaline... 5 | 119
short tibia 5 | 82
abnormal bone structure 4 | 131
decreased bone mineral content 4 | 157
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 77
decreased circulating LDL chol... 4 | 37
decreased circulating serum al... 4 | 79
decreased grip strength 4 | 123
decreased lumbar vertebrae num... 4 | 62
decreased mean corpuscular vol... 4 | 50
decreased rib number 4 | 59
hyperactivity 4 | 108
increased blood urea nitrogen ... 4 | 44
increased red blood cell distr... 4 | 21
male infertility 4 | 62
abnormal femur morphology 3 | 14
abnormal rib morphology 3 | 28
abnormal seminal vesicle morph... 3 | 47
decreased circulating alanine ... 3 | 53
decreased circulating fructosa... 3 | 31
decreased erythrocyte cell num... 3 | 43
decreased fasted circulating g... 3 | 49
decreased hemoglobin content 3 | 53
embryonic lethality prior to o... 3 | 148
enlarged lymph nodes 3 | 27
increased circulating chloride... 3 | 43
increased exploration in new e... 3 | 56
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased lean body mass 3 | 107
increased leukocyte cell numbe... 3 | 37
increased mean corpuscular hem... 3 | 93
increased mean platelet volume 3 | 19
increased or absent threshold ... 3 | 128
increased sacral vertebrae num... 3 | 62
shortened RR interval 3 | 19
abnormal QRS complex 2 | 25
abnormal coat/hair pigmentatio... 2 | 54
abnormal limb bud morphology 2 | 15
abnormal locomotor activation 2 | 26
abnormal neural tube closure 2 | 37
abnormal pelvic girdle bone mo... 2 | 11
abnormal retina morphology 2 | 100
abnormal retinal blood vessel ... 2 | 18
abnormal snout morphology 2 | 18
anophthalmia 2 | 20
cyanosis 2 | 6
decreased basophil cell number 2 | 11
decreased circulating aspartat... 2 | 27
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating glucose ... 2 | 121
decreased circulating glycerol... 2 | 19
decreased circulating insulin ... 2 | 75
decreased circulating iron lev... 2 | 25
decreased circulating potassiu... 2 | 17
decreased eosinophil cell numb... 2 | 41
decreased heart weight 2 | 44
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular hem... 2 | 19
decreased prepulse inhibition 2 | 52
enlarged spleen 2 | 26
hemorrhage 2 | 12
hydrometra 2 | 13
hydrops fetalis 2 | 22
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating free fat... 2 | 17
increased circulating serum al... 2 | 25
increased circulating sodium l... 2 | 71
increased heart rate 2 | 17
increased heart weight 2 | 37
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 25
increased mean corpuscular vol... 2 | 91
increased respiratory quotient 2 | 12
premature death 2 | 5
prenatal lethality prior to he... 2 | 64
straub tail 2 | 26
thrombocytopenia 2 | 46
vertebral fusion 2 | 23

Disease

ovarian cancer 334 | 8,484
osteosarcoma 303 | 7,933
glioblastoma 221 | 5,572
medulloblastoma, large-cell 218 | 6,234
psoriasis 213 | 6,685
lung cancer 181 | 4,466
atypical teratoid / rhabdoid tumor 154 | 4,369
Cancer 153 | 2,346
pancreatic cancer 129 | 2,300
pilocytic astrocytoma 126 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 124 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 119 | 2,956
Breast cancer 116 | 3,094
invasive ductal carcinoma 116 | 2,950
diabetes mellitus 115 | 1,663
pediatric high grade glioma 115 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 110 | 2,988
lung carcinoma 107 | 2,844
subependymal giant cell astrocytoma 107 | 2,287
non-small cell lung cancer 105 | 2,798
lung adenocarcinoma 103 | 2,713
ependymoma 101 | 2,514
malignant mesothelioma 100 | 3,162
oligodendroglioma 92 | 2,849
primitive neuroectodermal tumor 91 | 3,031
Multiple myeloma 90 | 1,327
ulcerative colitis 89 | 2,087
astrocytoma 88 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 81 | 1,795
group 4 medulloblastoma 79 | 1,875
interstitial cystitis 78 | 2,299
primary pancreatic ductal adenocarcinoma 78 | 1,271
tuberculosis 73 | 1,557
acute quadriplegic myopathy 70 | 1,157
adult high grade glioma 68 | 2,148
juvenile dermatomyositis 68 | 1,189
Carcinoma 66 | 2,147
Pick disease 66 | 1,893
colon cancer 65 | 1,475
Rheumatoid Arthritis 64 | 1,160
astrocytic glioma 64 | 2,241
cystic fibrosis 59 | 1,665
dermatomyositis 58 | 933
Waldenstrons macroglobulinemia 56 | 765
ductal carcinoma in situ 54 | 1,745
breast carcinoma 53 | 1,614
group 3 medulloblastoma 53 | 2,254
medulloblastoma 51 | 1,524
Kidney disease 50 | 396
adrenocortical carcinoma 47 | 1,427
spina bifida 47 | 1,064
gastric carcinoma 46 | 832
pancreatic carcinoma 46 | 567
sonic hedgehog group medulloblastoma 45 | 1,482
esophageal adenocarcinoma 42 | 737
posterior fossa group A ependymoma 42 | 1,511
Duchenne muscular dystrophy 40 | 602
atypical teratoid/rhabdoid tumor 40 | 1,095
pituitary cancer 40 | 1,972
Down syndrome 39 | 548
Alzheimer's disease 37 | 644
mucosa-associated lymphoid tissue lymphoma 37 | 480
posterior fossa group B ependymoma 37 | 1,530
autosomal dominant Emery-Dreifuss muscular dystrophy 36 | 499
acute myeloid leukemia 35 | 780
cutaneous lupus erythematosus 34 | 1,056
Arthritis 33 | 248
aldosterone-producing adenoma 33 | 664
Liver disease 32 | 219
Multiple Sclerosis 32 | 498
Anemia 31 | 252
IGA Glomerulonephritis 31 | 454
primary Sjogren syndrome 31 | 789
Hypersensitivity reaction type II disease 30 | 235
tuberculosis and treatment for 6 months 29 | 686
Acquired immunodeficiency syndrome 28 | 164
Neurodegenerative disease 28 | 383
Prostatic Neoplasms 28 | 471
non primary Sjogren syndrome sicca 28 | 840
Atopic dermatitis 26 | 944
Hepatitis B 26 | 103
Leprosy 26 | 77
Skin disease 26 | 65
Hypertension 25 | 287
Amyotrophic Lateral Sclerosis 24 | 431
Atherosclerosis 24 | 275
Juvenile rheumatoid arthritis 24 | 104
Parkinson's disease 24 | 364
nasopharyngeal carcinoma 24 | 1,056
progressive supranuclear palsy 24 | 674
Ankylosing spondylitis 23 | 138
Asthma 23 | 349
Cerebrovascular disease 23 | 231
Heart disease 23 | 279
Osteoporosis 23 | 257
Vascular disease 23 | 281
Crohn's disease 22 | 304
Obesity 22 | 616
active Crohn's disease 22 | 918
gastric cancer 22 | 430

Tissue

Blood and immune system 516 | 17,995
Liver and Pancreas 516 | 18,136
Endocrine System 515 | 18,512
Female tissues 515 | 18,647
Urinary Tract 515 | 18,444
Cardiovascular System 514 | 17,958
Digestive Tract 514 | 18,473
Male tissues 513 | 17,969
Nervous System 513 | 18,561
Respiratory system 513 | 17,484
Skin and soft tissues 508 | 18,115

Target Family

Non-IDG 350 | 11,971
Enzyme 128 | 4,146
Kinase 37 | 634
Transporter 8 | 473
Transcription Factor 5 | 1,400
GPCR 4 | 406
Ion Channel 4 | 341
Epigenetic 3 | 242

Jensen-KB Tissue

Blood platelet 539 | 539
Brain 7,308 | 7,308
Liver 4,988 | 4,988
Cervical carcinoma cell 4,915 | 4,915
Erythroleukemia cell 4,274 | 4,274
Testis 3,862 | 3,862
Placenta 3,062 | 3,062
T-cell chronic lymphocytic leu... 2,337 | 2,337
Lung 2,282 | 2,282
Skin 1,548 | 1,548
Uterus 1,472 | 1,472
Kidney 1,293 | 1,293
Colon 1,061 | 1,061
Eye 852 | 852
Pancreas 828 | 828
Muscle 721 | 721
Pronephros 715 | 715
Cerebellum 693 | 693
Ovary 690 | 690
Bone marrow 633 | 633
Amygdala 622 | 622
Spleen 617 | 617
Teratocarcinoma cell 600 | 600
Heart 582 | 582
Blood 570 | 570
Colonic cancer cell 562 | 562
Lymph 562 | 562
Skeletal muscle 543 | 543
Hippocampus 528 | 528
Trachea 519 | 519
Tongue 466 | 466
Prostate gland epithelium 456 | 456
Thymus 425 | 425
Mammary gland 415 | 415
Uterine cervix 414 | 414
Melanoma cell line 363 | 363
BTO:0000379 353 | 353
Umbilical cord blood 343 | 343
Retina 334 | 334
Thalamus 330 | 330
Small intestine 327 | 327
Plasma cell 286 | 286
T-lymphocyte 284 | 284
B-lymphocyte cell line 273 | 273
Hepatoma cell 242 | 242
Urinary bladder 226 | 226
Breast cancer cell 219 | 219
Brain cortex cell line 216 | 216
Leukocyte 205 | 205
CL-48 cell 198 | 198
Interstitial cell of Cajal 193 | 193
Neuroblastoma cell 187 | 187
Peripheral nervous system 183 | 183
Ovary cancer cell 181 | 181
Stomach 179 | 179
Adrenal gland 176 | 176
Cerebral cortex 159 | 159
Lymph node 148 | 148
Synovium 147 | 147
Thyroid gland 144 | 144
Keratinocyte 140 | 140
Fibroblast 139 | 139
Adipose tissue 136 | 136
Duodenum 135 | 135
Peripheral blood 135 | 135
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 116 | 116
Subthalamic nucleus 111 | 111
Caudate nucleus 109 | 109
Lung cancer cell 104 | 104
Prostate cancer cell line 90 | 90
Lymphocyte 86 | 86
Aorta 84 | 84
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 76 | 76
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 73 | 73
Renal cell carcinoma cell 72 | 72
Substantia nigra 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Hair root 55 | 55
Colonic mucosa 54 | 54
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Inositol-trisphosphate 3-kinase B ITPKB Tbio Kinase -1.40405 29.1 141
Calumenin CALU Tbio Non-IDG -1.76431 61.4 157
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Emerin EMD Tbio Non-IDG -2.77469 617.6 238
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288