Development Level

Tbio 207 | 11,651
Tdark 28 | 6,593
Tchem 27 | 1,388
Tclin 10 | 612

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 19 | 979
abnormal bone structure 6 | 187
decreased lean body mass 6 | 135
embryonic lethality prior to t... 6 | 278
decreased bone mineral content 5 | 151
increased lean body mass 5 | 172
preweaning lethality, incomple... 5 | 499
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased circulating alkaline... 3 | 46
decreased circulating glucose ... 3 | 126
decreased mean corpuscular vol... 3 | 79
embryonic lethality prior to o... 3 | 239
increased body length 3 | 32
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal vocalization 2 | 21
decreased body length 2 | 101
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating free fat... 2 | 31
decreased circulating serum al... 2 | 82
decreased mean corpuscular hem... 2 | 50
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
enlarged spleen 2 | 41
hemorrhage 2 | 23
increased bone mineral content 2 | 108
increased circulating sodium l... 2 | 71
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 36
increased neutrophil cell numb... 2 | 46
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal esophagus morphology 1 | 5
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal pancreas morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal tooth morphology 1 | 24
cataract 1 | 92
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased food intake 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
long tibia 1 | 25
male infertility 1 | 123
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
tremors 1 | 39
vertebral fusion 1 | 23

Disease

ovarian cancer 148 | 8,520
osteosarcoma 144 | 7,950
Carcinoma 142 | 11,493
medulloblastoma, large-cell 92 | 6,241
psoriasis 92 | 6,694
lung cancer 88 | 4,740
glioblastoma 83 | 5,792
atypical teratoid / rhabdoid tumor 69 | 5,112
interstitial cystitis 61 | 2,312
group 3 medulloblastoma 58 | 4,104
Cancer 56 | 2,499
adult high grade glioma 55 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 55 | 3,291
Breast cancer 53 | 3,578
invasive ductal carcinoma 53 | 2,951
malignant mesothelioma 53 | 3,232
ependymoma 50 | 4,679
ulcerative colitis 48 | 1,819
non-small cell lung cancer 46 | 2,890
cutaneous lupus erythematosus 45 | 1,057
tuberculosis 45 | 2,010
lung carcinoma 44 | 2,843
subependymal giant cell astrocytoma 44 | 2,287
Multiple myeloma 43 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,989
lung adenocarcinoma 42 | 2,716
Waldenstrons macroglobulinemia 40 | 765
primary Sjogren syndrome 40 | 735
Astrocytoma, Pilocytic 39 | 3,081
Rheumatoid arthritis 38 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
Autosomal recessive predisposition 34 | 1,442
primitive neuroectodermal tumor 33 | 3,035
diabetes mellitus 32 | 1,728
ductal carcinoma in situ 31 | 1,745
group 4 medulloblastoma 31 | 1,855
pancreatic cancer 29 | 2,398
astrocytoma 27 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
Multiple Sclerosis 26 | 540
oligodendroglioma 26 | 2,850
astrocytic glioma 25 | 2,597
Schizophrenia 24 | 1,160
breast carcinoma 23 | 1,638
colon cancer 23 | 1,478
cystic fibrosis 23 | 1,696
Liver Cirrhosis, Experimental 22 | 769
Kidney cancer 20 | 2,613
active Crohn's disease 20 | 922
juvenile dermatomyositis 20 | 1,187
Chronic Lymphocytic Leukemia 19 | 262
Intellectual disability 19 | 1,016
acute myeloid leukemia 19 | 783
adrenocortical carcinoma 19 | 1,428
dermatomyositis 17 | 966
nasopharyngeal carcinoma 17 | 1,058
Failure to gain weight 16 | 365
Pediatric failure to thrive 16 | 365
acute quadriplegic myopathy 16 | 1,158
esophageal adenocarcinoma 16 | 737
pediatric high grade glioma 16 | 1,064
pituitary cancer 16 | 1,972
Pick disease 15 | 1,894
hepatocellular carcinoma 15 | 547
primary pancreatic ductal adenocarcinoma 15 | 1,109
Atopic dermatitis 14 | 952
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
Short stature 14 | 531
active ulcerative colitis 14 | 764
gastric carcinoma 14 | 807
periodontitis 14 | 293
Cognitive delay 13 | 608
Epilepsy 13 | 792
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Splenomegaly 13 | 190
sarcoidosis 13 | 370
spina bifida 13 | 1,074
Alzheimer's disease 12 | 658
Anemia 12 | 365
Crohn's disease 12 | 321
Hypersensitivity reaction type II disease 12 | 253
mucosa-associated lymphoid tissue lymphoma 12 | 484
Asthma 11 | 385
Diarrhea 11 | 253
Down syndrome 11 | 499
Fatigue 11 | 182
Pneumonia 11 | 174
Small head 11 | 374
Systemic lupus erythematosus 11 | 194
Hepatomegaly 10 | 285
Vascular disease 10 | 319
non primary Sjogren syndrome sicca 10 | 891
pancreatic carcinoma 10 | 562
progressive supranuclear palsy 10 | 676
tuberculosis and treatment for 6 months 10 | 409

Tissue

Male tissues 269 | 17,142
Digestive Tract 266 | 17,369
Endocrine System 266 | 18,159
Female tissues 265 | 17,400
Urinary Tract 265 | 16,678
Blood and immune system 264 | 16,909
Liver and Pancreas 264 | 16,750
Skin and soft tissues 264 | 17,230
Respiratory system 263 | 16,393
Nervous System 259 | 16,725
Cardiovascular System 258 | 15,192

Target Family

Non-IDG 171 | 12,091
Enzyme 55 | 4,145
Transcription Factor 30 | 1,400
Kinase 8 | 634
Epigenetic 4 | 242
GPCR 2 | 408
Ion Channel 1 | 344
Transporter 1 | 473

Jensen-KB Tissue

B-lymphocyte cell line 272 | 272
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Amygdala 627 | 627
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Poly [ADP-ribose] polymerase 3 PARP3 Tclin Enzyme -1.66230 41.9 193
AP-4 complex subunit sigma-1 AP4S1 Tdark Non-IDG -0.68049 4.42 25
Reticulon-4-interacting protein 1, mitochondrial RTN4IP1 Tbio Enzyme -1.69878 47.3 145
Plasma alpha-L-fucosidase FUCA2 Tchem Enzyme -1.52925 32.6 227
Arylsulfatase A ARSA Tbio Enzyme -2.50334 319.0 337
Phosphatidylcholine transfer protein PCTP Tbio Non-IDG -1.72354 56.3 156
Serine/threonine-protein kinase 17B STK17B Tchem Kinase -1.26923 26.6 344
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766