Development Level

Tbio 425 | 11,445
Tdark 148 | 6,588
Tchem 44 | 1,598
Tclin 10 | 613

Collection

RFA-RM-18-021 17 | 328
Kinase: IDG Consortium (Target... 9 | 125
Ion Channel: IDG Consortium (T... 7 | 99
GPCR: IDG Consortium (Complete... 2 | 25
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 45 | 979
preweaning lethality, incomple... 24 | 499
embryonic lethality prior to t... 17 | 278
abnormal behavior 16 | 298
embryonic lethality prior to o... 14 | 239
decreased bone mineral content 12 | 151
abnormal bone structure 11 | 187
abnormal heart morphology 11 | 162
decreased total body fat amoun... 10 | 207
enlarged heart 10 | 210
increased bone mineral content 10 | 108
decreased grip strength 9 | 116
hyperactivity 9 | 148
abnormal embryo size 8 | 220
decreased lean body mass 8 | 135
abnormal behavioral response t... 7 | 66
decreased prepulse inhibition 7 | 82
increased fasted circulating g... 7 | 76
increased total body fat amoun... 7 | 134
abnormal sleep behavior 6 | 70
decreased body weight 6 | 161
decreased bone mineral density 6 | 126
decreased vertical activity 6 | 208
increased lean body mass 6 | 172
increased or absent threshold ... 6 | 101
increased startle reflex 6 | 112
small testis 6 | 58
abnormal gait 5 | 69
abnormal seminal vesicle morph... 5 | 114
decreased mean corpuscular hem... 5 | 50
increased bone mineral density 5 | 72
increased circulating alkaline... 5 | 122
short tibia 5 | 97
abnormal retinal vasculature m... 4 | 27
abnormal testis morphology 4 | 43
cataract 4 | 92
decreased circulating glucose ... 4 | 126
decreased lymphocyte cell numb... 4 | 83
improved glucose tolerance 4 | 79
increased circulating calcium ... 4 | 34
increased mean corpuscular hem... 4 | 96
abnormal coat- hair morphology 3 | 19
abnormal eye morphology 3 | 68
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal neural tube closure 3 | 46
abnormal spleen morphology 3 | 55
cardiovascular system phenotyp... 3 | 36
decreased circulating bilirubi... 3 | 19
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased circulating serum al... 3 | 82
decreased startle reflex 3 | 75
embryonic growth retardation 3 | 106
hypoactivity 3 | 132
increased circulating phosphat... 3 | 26
increased heart weight 3 | 62
increased leukocyte cell numbe... 3 | 47
increased monocyte cell number 3 | 63
increased prepulse inhibition 3 | 32
prenatal lethality prior to he... 3 | 87
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal lung morphology 2 | 26
abnormal optic disc morphology 2 | 10
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal skin morphology 2 | 50
abnormal tail movements 2 | 12
anophthalmia 2 | 33
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating magnesiu... 2 | 13
decreased circulating phosphat... 2 | 27
decreased circulating triglyce... 2 | 79
decreased food intake 2 | 13
decreased hemoglobin content 2 | 68
decreased lactate dehydrogenas... 2 | 16
decreased mean corpuscular hem... 2 | 31
enlarged spleen 2 | 41
hydrometra 2 | 53
increased blood urea nitrogen ... 2 | 48
increased body length 2 | 32
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
increased circulating potassiu... 2 | 29
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
pale yolk sac 2 | 25
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small kidney 2 | 16

Disease

Carcinoma 472 | 11,493
ovarian cancer 351 | 8,520
medulloblastoma, large-cell 329 | 6,241
osteosarcoma 320 | 7,950
glioblastoma 307 | 5,792
atypical teratoid / rhabdoid tumor 288 | 5,112
ependymoma 258 | 4,679
adult high grade glioma 221 | 3,801
psoriasis 209 | 6,694
group 3 medulloblastoma 205 | 4,104
oligodendroglioma 199 | 2,850
Astrocytoma, Pilocytic 187 | 3,081
primitive neuroectodermal tumor 187 | 3,035
lung cancer 185 | 4,740
astrocytic glioma 177 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 161 | 3,291
Breast cancer 156 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 142 | 2,955
Pick disease 140 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 130 | 2,989
Kidney cancer 122 | 2,613
malignant mesothelioma 121 | 3,232
subependymal giant cell astrocytoma 119 | 2,287
lung carcinoma 118 | 2,843
non-small cell lung cancer 112 | 2,890
invasive ductal carcinoma 110 | 2,951
group 4 medulloblastoma 96 | 1,855
lung adenocarcinoma 95 | 2,716
interstitial cystitis 94 | 2,312
pituitary cancer 90 | 1,972
pancreatic cancer 87 | 2,398
Cancer 72 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 68 | 1,962
ductal carcinoma in situ 67 | 1,745
juvenile dermatomyositis 66 | 1,187
tuberculosis 64 | 2,010
breast carcinoma 63 | 1,638
cystic fibrosis 62 | 1,696
ulcerative colitis 62 | 1,819
adrenocortical carcinoma 60 | 1,428
Multiple myeloma 56 | 1,332
acute quadriplegic myopathy 50 | 1,158
progressive supranuclear palsy 50 | 676
astrocytoma 47 | 1,146
Intellectual disability 44 | 1,016
colon cancer 44 | 1,478
primary pancreatic ductal adenocarcinoma 44 | 1,109
diabetes mellitus 43 | 1,728
spina bifida 42 | 1,074
active Crohn's disease 40 | 922
pediatric high grade glioma 40 | 1,064
Rheumatoid arthritis 39 | 1,191
Schizophrenia 39 | 1,160
cutaneous lupus erythematosus 37 | 1,057
medulloblastoma 36 | 720
Liver cancer 35 | 604
Epilepsy 34 | 792
dermatomyositis 34 | 966
nasopharyngeal carcinoma 34 | 1,058
Alzheimer's disease 33 | 658
Autosomal recessive predisposition 33 | 1,442
Atopic dermatitis 31 | 952
aldosterone-producing adenoma 31 | 665
gastric cancer 29 | 459
Bipolar Disorder 28 | 666
Cognitive delay 27 | 608
Global developmental delay 27 | 608
Mental and motor retardation 27 | 608
hepatocellular carcinoma 27 | 547
Melanoma 26 | 711
Muscle hypotonia 26 | 571
acute myeloid leukemia 26 | 783
Dull intelligence 25 | 645
Low intelligence 25 | 645
Mental Retardation 25 | 645
Mental deficiency 25 | 645
Parkinson's disease 25 | 392
Poor school performance 25 | 645
chronic rhinosinusitis 25 | 512
primary Sjogren syndrome 25 | 735
Seizures 24 | 596
pancreatic carcinoma 24 | 562
Down syndrome 23 | 499
active ulcerative colitis 23 | 764
non primary Sjogren syndrome sicca 23 | 891
Acquired metabolic disease 22 | 336
Autistic Disorder 22 | 364
gastric carcinoma 22 | 807
Duchenne muscular dystrophy 21 | 601
Neurodegenerative disease 21 | 414
Waldenstrons macroglobulinemia 21 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 21 | 510
esophageal adenocarcinoma 21 | 737
Multiple Sclerosis 20 | 540
Skin cancer 20 | 469
hereditary spastic paraplegia 20 | 318
Cerebellar Ataxia 19 | 304
Amyotrophic lateral sclerosis 18 | 451
fibroadenoma 18 | 559
Obesity 17 | 678

Tissue

Nervous System 616 | 16,725
Endocrine System 613 | 18,159
Digestive Tract 609 | 17,369
Female tissues 608 | 17,400
Male tissues 607 | 17,142
Skin and soft tissues 605 | 17,230
Liver and Pancreas 600 | 16,750
Blood and immune system 598 | 16,909
Urinary Tract 597 | 16,678
Respiratory system 592 | 16,393
Cardiovascular System 573 | 15,192

Target Family

Non-IDG 347 | 12,091
Enzyme 149 | 4,145
Transcription Factor 36 | 1,400
Kinase 29 | 634
Transporter 20 | 473
Epigenetic 17 | 242
Ion Channel 16 | 344
GPCR 9 | 408
TF/Epigenetic 3 | 38
Nuclear Receptor 1 | 48

Jensen-KB Tissue

Amygdala 627 | 627
Brain 7,346 | 7,346
Liver 5,008 | 5,008
Cervical carcinoma cell 4,944 | 4,944
Erythroleukemia cell 4,300 | 4,300
Testis 3,897 | 3,897
Placenta 3,079 | 3,079
T-cell chronic lymphocytic leu... 2,346 | 2,346
Lung 2,286 | 2,286
Skin 1,556 | 1,556
Uterus 1,493 | 1,493
Kidney 1,299 | 1,299
Colon 1,063 | 1,063
Eye 856 | 856
Pancreas 833 | 833
Muscle 725 | 725
Pronephros 717 | 717
Cerebellum 698 | 698
Ovary 691 | 691
Bone marrow 636 | 636
Spleen 620 | 620
Teratocarcinoma cell 604 | 604
Heart 583 | 583
Blood 567 | 567
Lymph 563 | 563
Colonic cancer cell 562 | 562
Skeletal muscle 549 | 549
Blood platelet 538 | 538
Hippocampus 531 | 531
Trachea 525 | 525
Tongue 470 | 470
Prostate gland epithelium 457 | 457
Thymus 427 | 427
Uterine cervix 418 | 418
Mammary gland 415 | 415
Melanoma cell line 364 | 364
BTO:0000379 352 | 352
Umbilical cord blood 344 | 344
Retina 337 | 337
Thalamus 331 | 331
Small intestine 330 | 330
T-lymphocyte 286 | 286
Plasma cell 284 | 284
B-lymphocyte cell line 272 | 272
Hepatoma cell 244 | 244
Urinary bladder 228 | 228
Breast cancer cell 221 | 221
Brain cortex cell line 215 | 215
Leukocyte 206 | 206
CL-48 cell 200 | 200
Interstitial cell of Cajal 192 | 192
Neuroblastoma cell 187 | 187
Ovary cancer cell 185 | 185
Peripheral nervous system 184 | 184
Stomach 182 | 182
Adrenal gland 177 | 177
Cerebral cortex 159 | 159
Lymph node 151 | 151
Synovium 148 | 148
Thyroid gland 144 | 144
Fibroblast 139 | 139
Keratinocyte 139 | 139
Adipose tissue 136 | 136
Duodenum 136 | 136
Peripheral blood 134 | 134
B-cell lymphoma cell 130 | 130
Hypophysis 128 | 128
Uterine endometrium 122 | 122
Hypothalamus 117 | 117
Subthalamic nucleus 114 | 114
Caudate nucleus 109 | 109
Lung cancer cell 103 | 103
Prostate cancer cell line 91 | 91
Aorta 86 | 86
Lymphocyte 86 | 86
Retinoblastoma cell 84 | 84
Colonic adenocarcinoma cell 81 | 81
Monocyte 78 | 78
Dendritic cell 77 | 77
Lymphoblast 74 | 74
Salivary gland 74 | 74
Spinal cord 74 | 74
Substantia nigra 73 | 73
Renal cell carcinoma cell 72 | 72
Leukemia cell 69 | 69
Corpus callosum 67 | 67
Esophagus 65 | 65
Lymphoid tissue 60 | 60
Scalp 59 | 59
Endothelial cell 57 | 57
Saliva 56 | 56
Colonic mucosa 55 | 55
Hair root 55 | 55
Lymphoma cell 53 | 53
Gastric mucosa 52 | 52
Bone 51 | 51
Pericardium 50 | 50
Prepuce 50 | 50
Umbilical vein endothelial cel... 49 | 49
Uterine endometrial cancer cel... 49 | 49

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Importin-9 IPO9 Tbio Non-IDG -1.14983 12.2 108
Potassium voltage-gated channel subfamily E member 4 KCNE4 Tbio Ion Channel -1.17671 15.9 99
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Cysteine sulfinic acid decarboxylase CSAD Tbio Enzyme -2.16604 143.8 134
MAP7 domain-containing protein 1 MAP7D1 Tdark Non-IDG 0.27 0.84 52
Potassium voltage-gated channel subfamily C member 2 KCNC2 Tclin Ion Channel -1.45272 28.7 178
Putative postmeiotic segregation increased 2-like protein 11 PMS2P11 Tdark Enzyme -2.19299 339.5 0
Serine/threonine-protein phosphatase 4 regulatory subunit 3B PPP4R3B Tbio Enzyme -1.46618 28.8 121