Development Level

Tbio 6 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

unresponsive to tactile stimul... 8 | 8
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

glioblastoma 7 | 5,792
osteosarcoma 7 | 7,950
ovarian cancer 6 | 8,520
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
Astrocytoma, Pilocytic 4 | 3,081
Breast cancer 4 | 3,578
Carcinoma 4 | 11,493
medulloblastoma, large-cell 4 | 6,241
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
cystic fibrosis 3 | 1,696
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
psoriasis 3 | 6,694
Pick disease 2 | 1,894
adult high grade glioma 2 | 3,801
astrocytoma 2 | 1,146
ductal carcinoma in situ 2 | 1,745
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primitive neuroectodermal tumor 2 | 3,035
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 3 months 2 | 179
ulcerative colitis 2 | 1,819
Abnormality of the fingernails 1 | 51
Alzheimer's disease 1 | 658
Amyotrophic lateral sclerosis 1 | 451
Astigmatism 1 | 54
Barrett's esophagus 1 | 182
Big calvaria 1 | 147
Brachydactyly 1 | 156
Brain cancer 1 | 30
COPD 1 | 118
Cancer 1 | 2,499
Cornea plana 1 | 12
Craniofacial Abnormalities 1 | 151
Decreased projection of midface 1 | 105
Endometriosis 1 | 540
Fibular hypoplasia 1 | 9
Gastrointestinal Stromal Tumors 1 | 48
Hooked clavicle 1 | 5
Hyperopia 1 | 70
Hypotrophic malar bone 1 | 129
Hypotrophic midface 1 | 105
Increased fibular diameter 1 | 4
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of skull 1 | 147
Inflammatory Bowel Diseases 1 | 35
Liver Cirrhosis, Experimental 1 | 769
Long narrow head 1 | 75
Lymphatic obstruction 1 | 21
Lymphedema 1 | 42
Malar flattening 1 | 129
Micromelia 1 | 58
Midface retrusion 1 | 105
Myopia 1 | 176
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Narrow thorax 1 | 53
Onset of lymphedema around puberty 1 | 21
Polyhydramnios 1 | 108
Primary ciliary dyskinesia 1 | 76
Short limb dwarfism, disproportionate 1 | 22
Short ribs 1 | 30
Situs Inversus 1 | 65
Situs ambiguus 1 | 25
Small midface 1 | 105
Stillbirth 1 | 17
Substance-Related Disorders 1 | 115
Thrombophlebitis 1 | 19
Turridolichocephaly 1 | 75
Waldenstrons macroglobulinemia 1 | 765
active ulcerative colitis 1 | 764
aldosterone-producing adenoma 1 | 665
breast carcinoma 1 | 1,638
chronic rhinosinusitis 1 | 512
colon cancer 1 | 1,478
fascioscapulohumeral muscular dystrophy 1 | 100
hepatocellular carcinoma 1 | 547
hereditary spastic paraplegia 1 | 318
medulloblastoma 1 | 720
pancreatic carcinoma 1 | 562
permanent atrial fibrillation 1 | 45
primary pancreatic ductal adenocarcinoma 1 | 1,109
progressive supranuclear palsy 1 | 676
spina bifida 1 | 1,074
tuberculosis 1 | 2,010

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Enzyme 3 | 4,145
Non-IDG 3 | 12,091
Kinase 1 | 634
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoside diphosphate kinase 7 NME7 Tbio Enzyme -0.83479 6.29 113
FLYWCH-type zinc finger-containing protein 1 FLYWCH1 Tdark Non-IDG -0.17609 0.83 42
Serine/threonine-protein kinase SBK1 SBK1 Tchem Kinase -1.79211 61.1 17
Ras GTPase-activating protein-binding protein 1 G3BP1 Tbio Enzyme -2.01627 111.4 426
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter SLC35D1 Tbio Transporter -0.77614 5.86 105
Leucine-rich repeat flightless-interacting protein 1 LRRFIP1 Tbio Non-IDG -1.60708 41.5 237
Integrin beta-8 ITGB8 Tbio Non-IDG -1.47947 27.7 99
Gamma-secretase subunit APH-1A APH1A Tbio Enzyme -1.87175 70.7 290