Development Level

Tbio 12 | 11,445
Tdark 3 | 6,588
Tclin 1 | 613

IMPC Phenotype

trunk curl 16 | 16
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 10 | 11,493
glioblastoma 9 | 5,792
medulloblastoma, large-cell 9 | 6,241
adult high grade glioma 8 | 3,801
ependymoma 8 | 4,679
osteosarcoma 8 | 7,950
atypical teratoid / rhabdoid tumor 7 | 5,112
ovarian cancer 7 | 8,520
psoriasis 7 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
primitive neuroectodermal tumor 6 | 3,035
subependymal giant cell astrocytoma 6 | 2,287
Astrocytoma, Pilocytic 5 | 3,081
group 3 medulloblastoma 5 | 4,104
lung cancer 5 | 4,740
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
Breast cancer 4 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
pancreatic cancer 4 | 2,398
Autosomal recessive predisposition 3 | 1,442
Cancer 3 | 2,499
Kidney cancer 3 | 2,613
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
juvenile dermatomyositis 3 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
spina bifida 3 | 1,074
Abnormal vision 2 | 52
Abnormality of cochlea 2 | 6
Absent vestibular function 2 | 2
Atopic dermatitis 2 | 952
Blindness 2 | 88
Cataract 2 | 297
Cerebellar Ataxia 2 | 304
Cerebellar hypoplasia and atrophy 2 | 41
Cognitive delay 2 | 608
Diabetes Mellitus, Experimental 2 | 108
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Difficulties with night vision 2 | 87
Dull intelligence 2 | 645
Electroretinogram abnormal 2 | 95
Extinguished electroretinogram 2 | 15
Global developmental delay 2 | 608
Hemianopsia 2 | 15
Hepatomegaly 2 | 285
High-grade hypermetropia 2 | 24
Hypertension 2 | 396
Hypertensive disease 2 | 292
Intellectual disability 2 | 1,016
Lens Opacities 2 | 231
Low intelligence 2 | 645
Melanoma 2 | 711
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Motor delay 2 | 147
Multiple myeloma 2 | 1,332
Night Blindness 2 | 101
No development of motor milestones 2 | 147
Nonsyndromic deafness 2 | 142
Pick disease 2 | 1,894
Pigmentary iris degeneration 2 | 20
Poor school performance 2 | 645
Retinal blind spot 2 | 11
Retinitis Pigmentosa 2 | 226
Schizophrenia 2 | 1,160
Scotoma 2 | 22
Sensorineural Hearing Loss (disorder) 2 | 284
Sensorineural hearing loss 2 | 106
Usher Syndrome, Type 1 2 | 7
Usher Syndrome, Type I 2 | 6
Usher syndrome 2 | 32
Usher syndrome, type 1B 2 | 2
Vestibular hypofunction 2 | 7
acute quadriplegic myopathy 2 | 1,158
astrocytic glioma 2 | 2,597
atypical teratoid/rhabdoid tumor 2 | 357
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
esophageal adenocarcinoma 2 | 737
group 4 medulloblastoma 2 | 1,855
interstitial cystitis 2 | 2,312
oligodendroglioma 2 | 2,850
pediatric high grade glioma 2 | 1,064
periodontitis 2 | 293
tuberculosis and treatment for 6 months 2 | 409
Gestational diabetes 1 | 26
Hyperpigmented macules 1 | 42
Tracheoesophageal Fistula 1 | 36

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Non-IDG 11 | 12,091
Enzyme 3 | 4,145
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase NSD3 NSD3 Tbio Epigenetic -1.36629 23.0 234
Discoidin, CUB and LCCL domain-containing protein 2 DCBLD2 Tbio Non-IDG -1.08601 14.5 196
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Harmonin USH1C Tbio Non-IDG -2.10689 124.7 188
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129
Syntaxin-8 STX8 Tbio Non-IDG -2.59234 391.5 134
Protein spinster homolog 2 SPNS2 Tbio Non-IDG -1.42853 26.4 88
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
DOMON domain-containing protein FRRS1L FRRS1L Tbio Non-IDG -1.59651 36.0 58
Mesoderm induction early response protein 1 MIER1 Tbio Non-IDG -2.21641 165.6 93