Development Level

Tbio 9 | 11,445
Tdark 5 | 6,588
Tchem 1 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

small thymus 16 | 16
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 13 | 11,493
ovarian cancer 9 | 8,520
psoriasis 8 | 6,694
glioblastoma 7 | 5,792
medulloblastoma, large-cell 6 | 6,241
osteosarcoma 6 | 7,950
atypical teratoid / rhabdoid tumor 5 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung carcinoma 5 | 2,843
Kidney cancer 4 | 2,613
Obesity 4 | 678
Rheumatoid arthritis 4 | 1,191
subependymal giant cell astrocytoma 4 | 2,287
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Endometrial cancer 3 | 311
Multiple myeloma 3 | 1,332
Pick disease 3 | 1,894
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
ependymoma 3 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Asperger syndrome 2 | 37
Astrocytoma, Pilocytic 2 | 3,081
Autism spectrum disorder 2 | 101
Autistic Disorder 2 | 364
Bipolar Disorder 2 | 666
Corneal disease 2 | 31
Curvature of spine 2 | 282
Epilepsy 2 | 792
Gilles de la Tourette syndrome 2 | 47
Intellectual disability 2 | 1,016
Large intestine cancer 2 | 126
Liver cancer 2 | 604
Motor neuron disease 2 | 49
Neurodegenerative disease 2 | 414
Nicotine dependence 2 | 54
Pitt-Hopkins syndrome 2 | 20
Pitt-Hopkins-Like Syndrome 2 2 | 2
Schizophrenia 2 | 1,160
Systemic lupus erythematosus 2 | 194
Vascular disease 2 | 319
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
breast carcinoma 2 | 1,638
cystic fibrosis 2 | 1,696
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
juvenile dermatomyositis 2 | 1,187
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 468
primitive neuroectodermal tumor 2 | 3,035
Abnormalities, Multiple 1 | 13
Advanced bone age 1 | 35
Amenorrhea 1 | 58
Anovulation 1 | 21
Ascariasis 1 | 7
Autism Spectrum Disorders 1 | 75
Autosomal dominant cerebellar ataxia 1 | 33
CHROMOSOME 2p16.3 DELETION SYNDROME 1 | 1
Charcot-Marie-Tooth disease 1 | 62
Childhood onset 1 | 38
Congenital adrenal hyperplasia 1 | 73
Cortical Dysplasia-Focal Epilepsy Syndrome 1 | 2
DOID:9917 1 | 31
Drooling 1 | 27
Elevated gonadotropins 1 | 15
Epileptic encephalopathy 1 | 26
Hair shaft abnormalities 1 | 30
Hereditary renal cell carcinoma 1 | 3
Hypomyelinating leukodystrophy 6 1 | 26
Hypospadias 1 | 53
Kyphoscoliosis deformity of spine 1 | 60
Lactocele 1 | 3
Language Development Disorders 1 | 11
Legg-Calve-Perthes disease 1 | 14
Leydig Cell Hypoplasia, Type 1 1 | 2
Muscle weakness of limb 1 | 21
Osteopetrosis 1 | 43
Ovarian hyperstimulation syndrome 1 | 19
Peripheral Neuropathy 1 | 134
Precocious Puberty 1 | 28
Precocious Puberty, Male-Limited 1 | 2
Premature ovarian failure 1 | 65
Primary hypogonadism 1 | 37
Protrusion of tongue 1 | 11
Pulmonary Stenosis 1 | 45
Rhinitis 1 | 54
Sialorrhea 1 | 28
Small testicle 1 | 75
Tall stature 1 | 34
hair abnormalities (non-specific) 1 | 30

Tissue

Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Skin and soft tissues 15 | 17,230
Cardiovascular System 14 | 15,192
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Urinary Tract 14 | 16,678
Blood and immune system 13 | 16,909
Nervous System 13 | 16,725
Respiratory system 13 | 16,393

Target Family

Non-IDG 11 | 12,091
Enzyme 2 | 4,145
GPCR 1 | 408
Kinase 1 | 634
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
Sn1-specific diacylglycerol lipase alpha DAGLA Tchem Enzyme -1.11500 11.4 129
Transmembrane protein 248 TMEM248 Tdark Non-IDG 0.00000 47
COP9 signalosome complex subunit 7a COPS7A Tbio Non-IDG -1.50943 32.2 154
Leucine-rich repeat-containing protein 30 LRRC30 Tdark Non-IDG 0.00000 5
Leucine-rich repeat serine/threonine-protein kinase 1 LRRK1 Tbio Kinase -1.33128 18.1 134
Neurexin-1-beta NRXN1 Tbio Non-IDG -1.88807 125.1 174
Ganglioside-induced differentiation-associated protein 1 GDAP1 Tbio Non-IDG -1.99050 105.9 77
Lutropin-choriogonadotropic hormone receptor LHCGR Tclin GPCR -2.58909 376.4 243
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial RSAD1 Tdark Non-IDG -0.05115 1.13 101