Development Level

Tbio 10 | 11,445
Tchem 3 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

small adrenal glands 16 | 16
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 11 | 11,493
atypical teratoid / rhabdoid tumor 11 | 5,112
medulloblastoma, large-cell 10 | 6,241
ovarian cancer 10 | 8,520
lung cancer 9 | 4,740
glioblastoma 8 | 5,792
osteosarcoma 8 | 7,950
ependymoma 7 | 4,679
psoriasis 7 | 6,694
Astrocytoma, Pilocytic 6 | 3,081
group 3 medulloblastoma 6 | 4,104
adult high grade glioma 5 | 3,801
astrocytic glioma 5 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
Autosomal recessive predisposition 4 | 1,442
Breast cancer 4 | 3,578
astrocytoma 4 | 1,146
lung carcinoma 4 | 2,843
non-small cell lung cancer 4 | 2,890
primitive neuroectodermal tumor 4 | 3,035
Cognitive delay 3 | 608
Global developmental delay 3 | 608
Infantile onset 3 | 238
Kidney cancer 3 | 2,613
Mental and motor retardation 3 | 608
Multiple myeloma 3 | 1,332
Pick disease 3 | 1,894
colon cancer 3 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
non primary Sjogren syndrome sicca 3 | 891
ulcerative colitis 3 | 1,819
Colorectal Neoplasms 2 | 243
Dull intelligence 2 | 645
Epilepsy 2 | 792
Intellectual disability 2 | 1,016
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Muscle hypotonia 2 | 571
Neurodegenerative disease 2 | 414
Poor school performance 2 | 645
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Sensorineural hearing loss 2 | 106
Waldenstrons macroglobulinemia 2 | 765
acute quadriplegic myopathy 2 | 1,158
breast carcinoma 2 | 1,638
chronic rhinosinusitis 2 | 512
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
group 4 medulloblastoma 2 | 1,855
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
invasive ductal carcinoma 2 | 2,951
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
ANONYCHIA 1 | 20
Acute Promyelocytic Leukemia 1 | 40
Autosomal recessive polycystic kidney disease 1 | 41
Bushy eyebrows 1 | 49
CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASE DEFICIENCY 3 1 | 1
CNS hypomyelination 1 | 17
Carcinoma of pancreas 1 | 5
Cardioencephalomyopathy, Fatal Infantile, due to Cytochrome C Oxidase Deficiency 1 | 4
Charcot-Marie-Tooth disease 1 | 62
Charcot-Marie-Tooth disease axonal type 2K 1 | 2
Charcot-Marie-Tooth disease, Type 2K 1 | 2
Childhood onset 1 | 38
DOID:9917 1 | 31
Decreased motor NCV 1 | 22
Deglutition Disorders 1 | 132
Fatal infantile cytochrome C oxidase deficiency 1 | 5
Hypomyelination 1 | 17
Juvenile myoclonic epilepsy 1 | 21
Kyphoscoliosis deformity of spine 1 | 60
Micronychia (disorder) 1 | 24
Muscle weakness of limb 1 | 21
Neonatal onset 1 | 21
Neurofibrillary degeneration (morphologic abnormality) 1 | 9
Peripheral Neuropathy 1 | 134
Pigmented villonodular synovitis 1 | 9
Polyneuropathy 1 | 64
Rapidly progressive 1 | 27
Rapidly progressive disorder 1 | 27
Robinow syndrome 1 | 11
Serine deficiency 1 | 9
Synophrys 1 | 40
Thick vermilion border 1 | 25
Vulvitis 1 | 4
cytochrome-c oxidase deficiency disease 1 | 19

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Cardiovascular System 15 | 15,192

Target Family

Non-IDG 8 | 12,091
Enzyme 5 | 4,145
Transporter 2 | 473
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome c oxidase assembly factor 5 COA5 Tdark Enzyme -0.77512 6.90 3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit DDOST Tchem Enzyme -1.60313 44.1 140
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
V-type proton ATPase subunit B, brain isoform ATP6V1B2 Tchem Enzyme -1.39933 24.1 157
Activin receptor type-1B ACVR1B Tchem Kinase -2.00550 91.2 418
Ganglioside-induced differentiation-associated protein 1 GDAP1 Tbio Non-IDG -1.99050 105.9 77
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial RSAD1 Tdark Non-IDG -0.05115 1.13 101
Glypican-2 GPC2 Tbio Non-IDG -1.10212 12.9 106
Phosphoserine phosphatase PSPH Tbio Enzyme -1.56433 55.8 252
Solute carrier family 52, riboflavin transporter, member 2 SLC52A2 Tbio Transporter -1.42102 23.2 37