Development Level

Tbio 69 | 11,651
Tdark 17 | 6,593
Tchem 10 | 1,388
Tclin 1 | 612

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

short tibia 97 | 97
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 70 | 11,493
ovarian cancer 59 | 8,520
atypical teratoid / rhabdoid tumor 41 | 5,112
glioblastoma 40 | 5,792
medulloblastoma, large-cell 39 | 6,241
osteosarcoma 37 | 7,950
psoriasis 36 | 6,694
ependymoma 32 | 4,679
Breast cancer 30 | 3,578
lung cancer 27 | 4,740
adult high grade glioma 24 | 3,801
group 3 medulloblastoma 24 | 4,104
primitive neuroectodermal tumor 21 | 3,035
Astrocytoma, Pilocytic 20 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
pancreatic cancer 18 | 2,398
Kidney cancer 17 | 2,613
astrocytic glioma 17 | 2,597
invasive ductal carcinoma 17 | 2,951
malignant mesothelioma 17 | 3,232
oligodendroglioma 17 | 2,850
Cancer 16 | 2,499
Autosomal recessive predisposition 15 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
pituitary cancer 15 | 1,972
ulcerative colitis 15 | 1,819
Schizophrenia 14 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
lung adenocarcinoma 14 | 2,716
lung carcinoma 14 | 2,843
group 4 medulloblastoma 13 | 1,855
non-small cell lung cancer 13 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
subependymal giant cell astrocytoma 13 | 2,287
Intellectual disability 12 | 1,016
breast carcinoma 12 | 1,638
interstitial cystitis 12 | 2,312
Rheumatoid arthritis 11 | 1,191
primary pancreatic ductal adenocarcinoma 11 | 1,109
Obesity 10 | 678
tuberculosis 10 | 2,010
Liver Cirrhosis, Experimental 9 | 769
Pick disease 9 | 1,894
acute quadriplegic myopathy 9 | 1,158
diabetes mellitus 9 | 1,728
Bipolar Disorder 8 | 666
Epilepsy 8 | 792
adrenocortical carcinoma 8 | 1,428
astrocytoma 8 | 1,146
cutaneous lupus erythematosus 8 | 1,057
ductal carcinoma in situ 8 | 1,745
juvenile dermatomyositis 8 | 1,187
pediatric high grade glioma 8 | 1,064
colon cancer 7 | 1,478
cystic fibrosis 7 | 1,696
dermatomyositis 7 | 966
primary Sjogren syndrome 7 | 735
spina bifida 7 | 1,074
Duchenne muscular dystrophy 6 | 601
Dull intelligence 6 | 645
Liver cancer 6 | 604
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Multiple myeloma 6 | 1,332
Muscle hypotonia 6 | 571
Poor school performance 6 | 645
non primary Sjogren syndrome sicca 6 | 891
Alzheimer's disease 5 | 658
Atopic dermatitis 5 | 952
Hepatomegaly 5 | 285
Melanoma 5 | 711
Mental Depression 5 | 333
Multiple Sclerosis 5 | 540
Osteoporosis 5 | 363
Parkinson's disease 5 | 392
Prostatic Neoplasms 5 | 495
Short stature 5 | 531
acute myeloid leukemia 5 | 783
esophageal adenocarcinoma 5 | 737
gastric carcinoma 5 | 807
interstitial lung disease 5 | 298
Autistic Disorder 4 | 364
Cognitive delay 4 | 608
Colorectal Neoplasms 4 | 243
Dysarthria 4 | 192
Endometrial cancer 4 | 311
Frontal bossing 4 | 157
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Polycystic ovary syndrome 4 | 360
Skin cancer 4 | 469
Type 2 diabetes mellitus 4 | 272
active Crohn's disease 4 | 922
tuberculosis and treatment for 6 months 4 | 409
Arthritis 3 | 290
Depressive disorder 3 | 409
Endometriosis 3 | 540
Vascular disease 3 | 319
nephrosclerosis 3 | 333

Tissue

Digestive Tract 96 | 17,369
Endocrine System 96 | 18,159
Female tissues 96 | 17,400
Skin and soft tissues 96 | 17,230
Liver and Pancreas 95 | 16,750
Urinary Tract 95 | 16,678
Blood and immune system 94 | 16,909
Male tissues 94 | 17,142
Nervous System 94 | 16,725
Respiratory system 92 | 16,393
Cardiovascular System 89 | 15,192

Target Family

Non-IDG 63 | 12,091
Enzyme 19 | 4,145
Epigenetic 4 | 242
Transcription Factor 3 | 1,400
GPCR 2 | 408
Kinase 2 | 634
Transporter 2 | 473
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription initiation factor IIB GTF2B Tbio Non-IDG -2.63302 410.1 286
Synaptotagmin-17 SYT17 Tbio Non-IDG -0.77330 6.07 106
Spermatogenesis-associated protein 6 SPATA6 Tbio Non-IDG -1.67486 40.9 62
Protein Hook homolog 3 HOOK3 Tbio Non-IDG -1.22079 6.06 60
Reticulophagy regulator 3 RETREG3 Tdark Non-IDG 0.19 0.44 53
Proline dehydrogenase 1, mitochondrial PRODH Tbio Enzyme -2.88785 779.3 222
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 TNFAIP1 Tbio Non-IDG -1.31215 21.6 197
Inducible T-cell costimulator ICOS Tbio Non-IDG -1.63332 39.2 649
Ras-specific guanine nucleotide-releasing factor 1 RASGRF1 Tbio Non-IDG -1.96671 95.3 233
Alpha-2-HS-glycoprotein AHSG Tbio Non-IDG -3.09085 1300.3 437