Development Level

Tbio 343 | 11,651
Tdark 82 | 6,593
Tchem 54 | 1,388
Tclin 20 | 612

Collection

RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Target... 7 | 125
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, incomple... 499 | 499
preweaning lethality, complete... 979 | 979
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 344 | 11,493
ovarian cancer 283 | 8,520
osteosarcoma 254 | 7,950
medulloblastoma, large-cell 228 | 6,241
glioblastoma 211 | 5,792
atypical teratoid / rhabdoid tumor 191 | 5,112
psoriasis 187 | 6,694
lung cancer 166 | 4,740
ependymoma 161 | 4,679
group 3 medulloblastoma 149 | 4,104
Breast cancer 134 | 3,578
adult high grade glioma 130 | 3,801
primitive neuroectodermal tumor 120 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 115 | 3,291
oligodendroglioma 113 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 111 | 2,955
Astrocytoma, Pilocytic 109 | 3,081
malignant mesothelioma 108 | 3,232
invasive ductal carcinoma 102 | 2,951
lung adenocarcinoma 101 | 2,716
astrocytic glioma 99 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 98 | 2,989
non-small cell lung cancer 98 | 2,890
lung carcinoma 94 | 2,843
Kidney cancer 91 | 2,613
Pick disease 89 | 1,894
Cancer 85 | 2,499
interstitial cystitis 80 | 2,312
pancreatic cancer 75 | 2,398
subependymal giant cell astrocytoma 73 | 2,287
group 4 medulloblastoma 68 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 66 | 1,962
pituitary cancer 66 | 1,972
ulcerative colitis 66 | 1,819
breast carcinoma 65 | 1,638
ductal carcinoma in situ 62 | 1,745
tuberculosis 55 | 2,010
colon cancer 53 | 1,478
cystic fibrosis 52 | 1,696
adrenocortical carcinoma 50 | 1,428
spina bifida 49 | 1,074
pediatric high grade glioma 48 | 1,064
Rheumatoid arthritis 47 | 1,191
Autosomal recessive predisposition 45 | 1,442
Schizophrenia 44 | 1,160
juvenile dermatomyositis 43 | 1,187
diabetes mellitus 42 | 1,728
acute myeloid leukemia 39 | 783
Multiple myeloma 37 | 1,332
acute quadriplegic myopathy 37 | 1,158
astrocytoma 37 | 1,146
nasopharyngeal carcinoma 37 | 1,058
dermatomyositis 32 | 966
primary pancreatic ductal adenocarcinoma 32 | 1,109
Alzheimer's disease 31 | 658
active Crohn's disease 31 | 922
Down syndrome 30 | 499
Intellectual disability 30 | 1,016
Atopic dermatitis 29 | 952
Liver Cirrhosis, Experimental 29 | 769
esophageal adenocarcinoma 29 | 737
medulloblastoma 28 | 720
cutaneous lupus erythematosus 27 | 1,057
Bipolar Disorder 26 | 666
Waldenstrons macroglobulinemia 26 | 765
active ulcerative colitis 24 | 764
gastric carcinoma 24 | 807
Epilepsy 23 | 792
Seizures 23 | 596
Duchenne muscular dystrophy 22 | 601
Obesity 22 | 678
non primary Sjogren syndrome sicca 22 | 891
Parkinson's disease 21 | 392
Prostatic Neoplasms 21 | 495
progressive supranuclear palsy 21 | 676
Amyotrophic lateral sclerosis 20 | 451
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
Dull intelligence 19 | 645
Low intelligence 19 | 645
Mental Retardation 19 | 645
Mental deficiency 19 | 645
Poor school performance 19 | 645
chronic rhinosinusitis 19 | 512
Depressive disorder 18 | 409
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 510
gastric cancer 18 | 459
sonic hedgehog group medulloblastoma 18 | 467
Endometriosis 17 | 540
Liver cancer 17 | 604
Mental Depression 17 | 333
aldosterone-producing adenoma 17 | 665
hereditary spastic paraplegia 17 | 318
posterior fossa group A ependymoma 17 | 468
Melanoma 16 | 711
Neurodegenerative disease 16 | 414
Short stature 16 | 531
pancreatic carcinoma 16 | 562
primary Sjogren syndrome 16 | 735

Tissue

Endocrine System 496 | 18,159
Digestive Tract 488 | 17,369
Skin and soft tissues 486 | 17,230
Female tissues 484 | 17,400
Male tissues 482 | 17,142
Nervous System 482 | 16,725
Liver and Pancreas 479 | 16,750
Blood and immune system 476 | 16,909
Urinary Tract 476 | 16,678
Respiratory system 474 | 16,393
Cardiovascular System 443 | 15,192

Target Family

Non-IDG 267 | 12,091
Enzyme 123 | 4,145
Transcription Factor 34 | 1,400
Kinase 30 | 634
Epigenetic 15 | 242
Transporter 14 | 473
GPCR 8 | 408
Ion Channel 4 | 344
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242
Parathymosin PTMS Tbio Non-IDG -1.95003 86.3 141
tRNA (guanine(26)-N(2))-dimethyltransferase TRMT1 Tbio Enzyme -1.61554 40.5 122
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
Basic leucine zipper and W2 domain-containing protein 2 BZW2 Tbio Non-IDG -0.20261 1.21 83
Ubiquitin carboxyl-terminal hydrolase 3 USP3 Tbio Enzyme -1.16770 14.5 246
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
GTP-binding protein 10 GTPBP10 Tdark Non-IDG -0.23899 1.73 121