Development Level

Tbio 729 | 11,651
Tchem 108 | 1,388
Tdark 105 | 6,593
Tclin 37 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 655 | 11,493
ovarian cancer 611 | 8,520
osteosarcoma 496 | 7,950
psoriasis 342 | 6,694
medulloblastoma, large-cell 341 | 6,241
lung cancer 302 | 4,740
glioblastoma 299 | 5,792
atypical teratoid / rhabdoid tumor 266 | 5,112
group 3 medulloblastoma 260 | 4,104
ependymoma 232 | 4,679
Breast cancer 211 | 3,578
malignant mesothelioma 205 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 187 | 3,291
Cancer 180 | 2,499
Kidney cancer 174 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 170 | 2,989
oligodendroglioma 159 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 157 | 2,955
Autosomal recessive predisposition 156 | 1,442
primitive neuroectodermal tumor 155 | 3,035
adult high grade glioma 153 | 3,801
non-small cell lung cancer 152 | 2,890
invasive ductal carcinoma 145 | 2,951
astrocytic glioma 144 | 2,597
lung adenocarcinoma 144 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 142 | 1,962
Multiple myeloma 126 | 1,332
pancreatic cancer 124 | 2,398
Pick disease 119 | 1,894
Intellectual disability 108 | 1,016
Astrocytoma, Pilocytic 104 | 3,081
lung carcinoma 104 | 2,843
diabetes mellitus 100 | 1,728
subependymal giant cell astrocytoma 99 | 2,287
group 4 medulloblastoma 98 | 1,855
pituitary cancer 97 | 1,972
breast carcinoma 96 | 1,638
tuberculosis 91 | 2,010
adrenocortical carcinoma 90 | 1,428
Cognitive delay 86 | 608
Global developmental delay 86 | 608
Mental and motor retardation 86 | 608
dermatomyositis 86 | 966
Epilepsy 84 | 792
ductal carcinoma in situ 83 | 1,745
acute quadriplegic myopathy 80 | 1,158
astrocytoma 78 | 1,146
juvenile dermatomyositis 76 | 1,187
ulcerative colitis 76 | 1,819
colon cancer 75 | 1,478
Dull intelligence 74 | 645
Low intelligence 74 | 645
Mental Retardation 74 | 645
Mental deficiency 74 | 645
Poor school performance 74 | 645
Muscle hypotonia 72 | 571
Schizophrenia 72 | 1,160
interstitial cystitis 72 | 2,312
Rheumatoid arthritis 71 | 1,191
acute myeloid leukemia 70 | 783
Waldenstrons macroglobulinemia 69 | 765
Seizures 68 | 596
primary pancreatic ductal adenocarcinoma 65 | 1,109
Short stature 63 | 531
spina bifida 63 | 1,074
pediatric high grade glioma 62 | 1,064
non primary Sjogren syndrome sicca 55 | 891
Failure to gain weight 50 | 365
Pediatric failure to thrive 50 | 365
cystic fibrosis 50 | 1,696
Small head 48 | 374
Hypoplastic mandible condyle 46 | 275
Mandibular hypoplasia 46 | 275
Micrognathism 46 | 275
medulloblastoma 45 | 720
Alzheimer's disease 44 | 658
Cerebellar Ataxia 44 | 304
Obesity 44 | 678
Liver cancer 43 | 604
progressive supranuclear palsy 43 | 676
Optic Atrophy 42 | 242
nasopharyngeal carcinoma 42 | 1,058
Orbital separation excessive 41 | 244
Strabismus 39 | 270
hepatocellular carcinoma 39 | 547
tuberculosis and treatment for 6 months 39 | 409
Bipolar Disorder 38 | 666
Cleft Palate 38 | 271
Melanoma 38 | 711
Neurodegenerative disease 38 | 414
Amyotrophic lateral sclerosis 37 | 451
Breast Neoplasms 37 | 445
cutaneous lupus erythematosus 37 | 1,057
Atopic dermatitis 36 | 952
aldosterone-producing adenoma 35 | 665
Acquired scoliosis 34 | 281
Blepharoptosis 34 | 231
Curvature of spine 34 | 282
active Crohn's disease 34 | 922
esophageal adenocarcinoma 34 | 737

Tissue

Endocrine System 971 | 18,159
Digestive Tract 964 | 17,369
Female tissues 963 | 17,400
Skin and soft tissues 963 | 17,230
Male tissues 961 | 17,142
Urinary Tract 960 | 16,678
Blood and immune system 959 | 16,909
Nervous System 958 | 16,725
Liver and Pancreas 954 | 16,750
Respiratory system 952 | 16,393
Cardiovascular System 936 | 15,192

Target Family

Non-IDG 507 | 12,091
Enzyme 294 | 4,145
Transcription Factor 46 | 1,400
Kinase 40 | 634
Epigenetic 34 | 242
Transporter 23 | 473
Ion Channel 16 | 344
GPCR 10 | 408
TF/Epigenetic 6 | 38
Nuclear Receptor 3 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Fat storage-inducing transmembrane protein 2 FITM2 Tdark Non-IDG -1.27967 17.3 2
Solute carrier family 52, riboflavin transporter, member 3 SLC52A3 Tbio Transporter -1.82473 71.3 31
snRNA-activating protein complex subunit 4 SNAPC4 Tbio Transcription Factor -0.99715 10.0 160