Development Level

Tbio 427 | 10,625
Tchem 94 | 1,890
Tdark 87 | 7,003
Tclin 25 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 394 | 8,484
osteosarcoma 307 | 7,933
medulloblastoma, large-cell 222 | 6,234
psoriasis 221 | 6,685
lung cancer 191 | 4,466
glioblastoma 188 | 5,572
atypical teratoid / rhabdoid tumor 156 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 132 | 3,289
Breast cancer 131 | 3,094
malignant mesothelioma 122 | 3,162
Cancer 108 | 2,346
non-small cell lung cancer 106 | 2,798
group 3 medulloblastoma 105 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 105 | 2,988
invasive ductal carcinoma 98 | 2,950
primitive neuroectodermal tumor 98 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 94 | 2,956
oligodendroglioma 93 | 2,849
lung adenocarcinoma 92 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 87 | 1,795
Carcinoma 86 | 2,147
pancreatic cancer 85 | 2,300
pediatric high grade glioma 85 | 2,712
ependymoma 83 | 2,514
Multiple myeloma 80 | 1,327
astrocytic glioma 73 | 2,241
breast carcinoma 70 | 1,614
group 4 medulloblastoma 69 | 1,875
Pick disease 68 | 1,893
adrenocortical carcinoma 68 | 1,427
lung carcinoma 68 | 2,844
pilocytic astrocytoma 68 | 3,086
astrocytoma 67 | 1,493
ductal carcinoma in situ 67 | 1,745
diabetes mellitus 66 | 1,663
pituitary cancer 65 | 1,972
ulcerative colitis 61 | 2,087
subependymal giant cell astrocytoma 60 | 2,287
colon cancer 58 | 1,475
adult high grade glioma 56 | 2,148
dermatomyositis 56 | 933
interstitial cystitis 56 | 2,299
sonic hedgehog group medulloblastoma 56 | 1,482
tuberculosis 54 | 1,557
acute quadriplegic myopathy 51 | 1,157
medulloblastoma 50 | 1,524
Waldenstrons macroglobulinemia 48 | 765
acute myeloid leukemia 48 | 780
posterior fossa group B ependymoma 47 | 1,530
primary pancreatic ductal adenocarcinoma 47 | 1,271
posterior fossa group A ependymoma 43 | 1,511
Rheumatoid Arthritis 42 | 1,160
juvenile dermatomyositis 42 | 1,189
spina bifida 38 | 1,064
non primary Sjogren syndrome sicca 34 | 840
Atopic dermatitis 32 | 944
nasopharyngeal carcinoma 31 | 1,056
tuberculosis and treatment for 6 months 31 | 686
Alzheimer's disease 30 | 644
cystic fibrosis 29 | 1,665
Intellectual disability 28 | 573
progressive supranuclear palsy 28 | 674
atypical teratoid/rhabdoid tumor 27 | 1,095
aldosterone-producing adenoma 26 | 664
cutaneous lupus erythematosus 26 | 1,056
esophageal adenocarcinoma 26 | 737
hepatocellular carcinoma 25 | 532
IGA Glomerulonephritis 24 | 454
Obesity 24 | 616
Endometriosis 23 | 535
Neurodegenerative disease 23 | 383
active Crohn's disease 22 | 918
gastric carcinoma 22 | 832
Amyotrophic Lateral Sclerosis 21 | 431
Mammary Neoplasms 21 | 410
hereditary spastic paraplegia 21 | 313
pancreatic carcinoma 21 | 567
Parkinson's disease 20 | 364
Epilepsy 19 | 346
Schizophrenia 19 | 501
fibroadenoma 19 | 557
primary Sjogren syndrome 19 | 789
Prostatic Neoplasms 18 | 471
chronic rhinosinusitis 18 | 512
gastric cancer 18 | 430
Cerebrovascular disease 17 | 231
Colorectal Neoplasms 17 | 217
Down syndrome 17 | 548
Neuropathy 17 | 210
Polycystic Ovary Syndrome 17 | 332
glioblastoma multiforme 17 | 347
Heart disease 15 | 279
Microcephaly 15 | 149
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
inflammatory breast cancer 15 | 404
Cleft palate 14 | 125
Duchenne muscular dystrophy 14 | 602
mucosa-associated lymphoid tissue lymphoma 14 | 480
Coronary artery disease 13 | 240
Kidney disease 13 | 396

Tissue

Female tissues 632 | 18,647
Liver and Pancreas 632 | 18,136
Nervous System 632 | 18,561
Blood and immune system 631 | 17,995
Digestive Tract 631 | 18,473
Endocrine System 631 | 18,512
Male tissues 631 | 17,969
Cardiovascular System 630 | 17,958
Urinary Tract 630 | 18,444
Respiratory system 626 | 17,484
Skin and soft tissues 625 | 18,115

Target Family

Non-IDG 324 | 11,971
Enzyme 202 | 4,146
Transcription Factor 29 | 1,400
Kinase 28 | 634
Transporter 16 | 473
Epigenetic 14 | 242
Ion Channel 9 | 341
GPCR 7 | 406
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
CUGBP Elav-like family member 4 CELF4 Tbio Non-IDG -1.46075 29.8 40
NHL repeat-containing protein 2 NHLRC2 Tdark Non-IDG 0.78 1.17 50
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100