Development Level

Tbio 16 | 11,651
Tdark 9 | 6,593
Tchem 2 | 1,388
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

prenatal lethality 28 | 28
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 19 | 11,493
osteosarcoma 14 | 7,950
ovarian cancer 11 | 8,520
glioblastoma 9 | 5,792
group 3 medulloblastoma 9 | 4,104
Kidney cancer 8 | 2,613
atypical teratoid / rhabdoid tumor 8 | 5,112
medulloblastoma, large-cell 7 | 6,241
Autosomal recessive predisposition 6 | 1,442
lung cancer 6 | 4,740
psoriasis 6 | 6,694
Breast cancer 5 | 3,578
Pick disease 5 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
Astrocytoma, Pilocytic 4 | 3,081
Cancer 4 | 2,499
acute myeloid leukemia 4 | 783
ependymoma 4 | 4,679
interstitial cystitis 4 | 2,312
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
Decreased projection of midface 3 | 105
Epilepsy 3 | 792
Hypotrophic midface 3 | 105
Intellectual disability 3 | 1,016
Midface retrusion 3 | 105
Obesity 3 | 678
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Short stature 3 | 531
Small midface 3 | 105
acute quadriplegic myopathy 3 | 1,158
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
lung carcinoma 3 | 2,843
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
ulcerative colitis 3 | 1,819
Acquired scoliosis 2 | 281
Alopecia 2 | 115
Atrial Fibrillation 2 | 124
Bipolar Disorder 2 | 666
Broad flat nasal bridge 2 | 236
Byzanthine arch palate 2 | 194
Cardiac Arrhythmia 2 | 103
Cerebral atrophy 2 | 178
Cognitive delay 2 | 608
Corneal diameter decreased 2 | 47
Curvature of spine 2 | 282
Decreased projection of maxilla 2 | 66
Deficiency of upper jaw bones 2 | 66
Dilated ventricles (finding) 2 | 121
Downward slant of palpebral fissure 2 | 158
Dull intelligence 2 | 645
Gastrointestinal Stromal Tumors 2 | 48
Global developmental delay 2 | 608
Highly variable severity 2 | 157
Hyperhidrosis disorder 2 | 81
Hyperreflexia 2 | 209
Hypoplasia of the maxilla 2 | 66
Hypoplastic mandible condyle 2 | 275
Hypotrophic maxilla 2 | 66
Increased sweating 2 | 81
Infantile onset 2 | 238
Low intelligence 2 | 645
Maxillary retrognathia 2 | 66
Melanoma 2 | 711
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Nasal bridge wide 2 | 236
Poor school performance 2 | 645
Prenatal onset 2 | 139
Quadriplegia 2 | 20
Retrusion of upper jaw bones 2 | 66
Short philtrum 2 | 53
Skin cancer 2 | 469
Small head 2 | 374
Strabismus 2 | 270
Sweating 2 | 81
Telecanthus 2 | 62
Tooth Abnormalities 2 | 69
Type 2 diabetes mellitus 2 | 272
Variable expressivity 2 | 157
Visceral heterotaxy 2 | 14
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
gastric cancer 2 | 459
invasive ductal carcinoma 2 | 2,951
medulloblastoma 2 | 720
tuberculosis and treatment for 6 months 2 | 409

Tissue

Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Male tissues 28 | 17,142
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678
Blood and immune system 27 | 16,909
Liver and Pancreas 27 | 16,750
Nervous System 27 | 16,725
Respiratory system 27 | 16,393
Cardiovascular System 24 | 15,192

Target Family

Non-IDG 14 | 12,091
Enzyme 8 | 4,145
Transcription Factor 3 | 1,400
GPCR 1 | 408
Ion Channel 1 | 344
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-23 RAB23 Tbio Enzyme -1.63391 45.2 211
Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S Tclin Ion Channel -2.21321 163.9 114
Chromosome transmission fidelity protein 18 homolog CHTF18 Tbio Non-IDG -1.51235 35.5 138
Katanin p80 WD40 repeat-containing subunit B1 KATNB1 Tbio Non-IDG -1.06612 10.7 174
AP-4 complex subunit epsilon-1 AP4E1 Tdark Non-IDG -0.66901 5.48 24
Protein MEMO1 MEMO1 Tbio Non-IDG -2.04134 109.4 87
Pituitary homeobox 2 PITX2 Tbio Transcription Factor -2.67290 480.0 220
Protein SMG9 SMG9 Tdark Non-IDG -1.83838 66.8 40
Essential MCU regulator, mitochondrial SMDT1 Tbio Non-IDG -1.60735 39.4 11
Junction plakoglobin JUP Tbio Non-IDG -2.01808 101.8 719