Development Level

Tbio 27 | 11,445
Tchem 3 | 1,598
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

persistence of hyaloid vascula... 33 | 33
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 23 | 11,493
ovarian cancer 20 | 8,520
osteosarcoma 15 | 7,950
ependymoma 14 | 4,679
psoriasis 12 | 6,694
glioblastoma 11 | 5,792
medulloblastoma, large-cell 11 | 6,241
Kidney cancer 9 | 2,613
Autosomal recessive predisposition 8 | 1,442
atypical teratoid / rhabdoid tumor 8 | 5,112
lung cancer 8 | 4,740
non-small cell lung cancer 8 | 2,890
primitive neuroectodermal tumor 8 | 3,035
Breast cancer 7 | 3,578
adult high grade glioma 7 | 3,801
group 3 medulloblastoma 7 | 4,104
oligodendroglioma 7 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Pick disease 6 | 1,894
astrocytic glioma 6 | 2,597
invasive ductal carcinoma 6 | 2,951
Intellectual disability 5 | 1,016
interstitial cystitis 5 | 2,312
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
subependymal giant cell astrocytoma 5 | 2,287
Alzheimer's disease 4 | 658
Astrocytoma, Pilocytic 4 | 3,081
Down syndrome 4 | 499
Melanoma 4 | 711
Schizophrenia 4 | 1,160
acute quadriplegic myopathy 4 | 1,158
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung carcinoma 4 | 2,843
pituitary cancer 4 | 1,972
spina bifida 4 | 1,074
Atopic dermatitis 3 | 952
Cancer 3 | 2,499
Dull intelligence 3 | 645
Liver Cirrhosis, Experimental 3 | 769
Liver cancer 3 | 604
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple myeloma 3 | 1,332
Myopia 3 | 176
Poor school performance 3 | 645
Prenatal onset 3 | 139
Prostatic Neoplasms 3 | 495
Sensorineural Hearing Loss (disorder) 3 | 284
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
lung adenocarcinoma 3 | 2,716
medulloblastoma 3 | 720
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676
sonic hedgehog group medulloblastoma 3 | 467
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819
Acidosis, Lactic 2 | 97
Autistic Disorder 2 | 364
Bipolar Disorder 2 | 666
Cognitive delay 2 | 608
Duchenne muscular dystrophy 2 | 601
Dystonia 2 | 164
Dystonic disease 2 | 106
Endometrial cancer 2 | 311
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Global developmental delay 2 | 608
Hepatomegaly 2 | 285
Kidney disease 2 | 430
Lactic acidemia 2 | 95
Lactic acidosis 2 | 51
Liver Cirrhosis 2 | 181
Malabsorption 2 | 82
Mental and motor retardation 2 | 608
Neurodegenerative disease 2 | 414
Optic Atrophy 2 | 242
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Progressive disorder 2 | 142
Proteinuria 2 | 144
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Skin cancer 2 | 469
Small head 2 | 374
Splenomegaly 2 | 190
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
hereditary spastic paraplegia 2 | 318
juvenile dermatomyositis 2 | 1,187
pediatric high grade glioma 2 | 1,064
periodontitis 2 | 293
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Cardiovascular System 30 | 15,192

Target Family

Non-IDG 16 | 12,091
Enzyme 10 | 4,145
Epigenetic 3 | 242
Kinase 2 | 634
Transcription Factor 1 | 1,400
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 AGAP1 Tbio Enzyme -0.83079 8.71 94
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial COQ6 Tbio Enzyme -1.26796 18.5 102
Unconventional myosin-X MYO10 Tbio Non-IDG -1.49855 36.4 47
Chromobox protein homolog 2 CBX2 Tchem Epigenetic -1.37369 24.3 223
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129
Calsyntenin-1 CLSTN1 Tbio Non-IDG -1.09760 15.0 131
Synaptojanin-1 SYNJ1 Tbio Non-IDG -1.76329 62.0 93
YLP motif-containing protein 1 YLPM1 Tdark Non-IDG -0.15611 1.37 11
Dynamin-1-like protein DNM1L Tbio Non-IDG -2.65717 476.9 426
Coiled-coil domain-containing protein R3HCC1L R3HCC1L Tbio Non-IDG -1.17689 12.7 71