Development Level

Tbio 73 | 11,445
Tdark 31 | 6,588
Tchem 15 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

male infertility 123 | 123
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 93 | 11,493
ovarian cancer 61 | 8,520
osteosarcoma 55 | 7,950
psoriasis 47 | 6,694
medulloblastoma, large-cell 46 | 6,241
atypical teratoid / rhabdoid tumor 40 | 5,112
glioblastoma 40 | 5,792
ependymoma 38 | 4,679
group 3 medulloblastoma 34 | 4,104
lung cancer 31 | 4,740
primitive neuroectodermal tumor 29 | 3,035
Breast cancer 24 | 3,578
adult high grade glioma 23 | 3,801
malignant mesothelioma 23 | 3,232
Kidney cancer 22 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
invasive ductal carcinoma 22 | 2,951
lung adenocarcinoma 20 | 2,716
Astrocytoma, Pilocytic 19 | 3,081
non-small cell lung cancer 18 | 2,890
astrocytic glioma 16 | 2,597
oligodendroglioma 16 | 2,850
pituitary cancer 16 | 1,972
Autosomal recessive predisposition 15 | 1,442
Cancer 15 | 2,499
breast carcinoma 15 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
lung carcinoma 14 | 2,843
Pick disease 13 | 1,894
colon cancer 12 | 1,478
cutaneous lupus erythematosus 12 | 1,057
subependymal giant cell astrocytoma 12 | 2,287
group 4 medulloblastoma 11 | 1,855
ulcerative colitis 11 | 1,819
Multiple myeloma 10 | 1,332
interstitial cystitis 10 | 2,312
pancreatic cancer 10 | 2,398
Intellectual disability 9 | 1,016
Rheumatoid arthritis 9 | 1,191
ductal carcinoma in situ 9 | 1,745
nasopharyngeal carcinoma 9 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Male infertility 8 | 206
Muscle hypotonia 8 | 571
astrocytoma 8 | 1,146
juvenile dermatomyositis 8 | 1,187
medulloblastoma 8 | 720
tuberculosis 8 | 2,010
Schizophrenia 7 | 1,160
non primary Sjogren syndrome sicca 7 | 891
pediatric high grade glioma 7 | 1,064
spina bifida 7 | 1,074
Cerebellar Ataxia 6 | 304
Dysarthria 6 | 192
Endometriosis 6 | 540
Epilepsy 6 | 792
Infertility 6 | 188
Melanoma 6 | 711
Neurodegenerative disease 6 | 414
Seizures 6 | 596
acute myeloid leukemia 6 | 783
adrenocortical carcinoma 6 | 1,428
chronic rhinosinusitis 6 | 512
primary Sjogren syndrome 6 | 735
progressive supranuclear palsy 6 | 676
Atopic dermatitis 5 | 952
Attention deficit hyperactivity disorder 5 | 278
Bipolar Disorder 5 | 666
Depressive disorder 5 | 409
Down syndrome 5 | 499
Hyperreflexia 5 | 209
Liver cancer 5 | 604
Parkinson's disease 5 | 392
Short stature 5 | 531
active Crohn's disease 5 | 922
dermatomyositis 5 | 966
mucosa-associated lymphoid tissue lymphoma 5 | 484
Anemia 4 | 365
Cognitive delay 4 | 608
Dull intelligence 4 | 645
Global developmental delay 4 | 608
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental and motor retardation 4 | 608
Mental deficiency 4 | 645
Nystagmus 4 | 317
Orbital separation excessive 4 | 244
Poor school performance 4 | 645
Retinitis Pigmentosa 4 | 226
Small head 4 | 374
Strabismus 4 | 270
Waldenstrons macroglobulinemia 4 | 765
aldosterone-producing adenoma 4 | 665
cystic fibrosis 4 | 1,696
esophageal adenocarcinoma 4 | 737
gastric cancer 4 | 459
hepatocellular carcinoma 4 | 547
nephrosclerosis 4 | 333
pancreatic carcinoma 4 | 562

Tissue

Endocrine System 120 | 18,159
Male tissues 114 | 17,142
Female tissues 113 | 17,400
Skin and soft tissues 113 | 17,230
Digestive Tract 112 | 17,369
Blood and immune system 111 | 16,909
Nervous System 110 | 16,725
Respiratory system 108 | 16,393
Urinary Tract 108 | 16,678
Liver and Pancreas 106 | 16,750
Cardiovascular System 98 | 15,192

Target Family

Non-IDG 66 | 12,091
Enzyme 37 | 4,145
Transcription Factor 7 | 1,400
Epigenetic 6 | 242
Kinase 3 | 634
GPCR 2 | 408
Ion Channel 1 | 344
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-citrylglutamate synthase B RIMKLB Tdark Enzyme -0.33579 2.63 48
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Actin-like protein 7B ACTL7B Tbio Non-IDG -1.01072 10.7 211
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Cohesin subunit SA-3 STAG3 Tbio Non-IDG -1.30055 20.0 104
Ubiquitin carboxyl-terminal hydrolase 15 USP15 Tbio Enzyme -1.64742 41.6 242
Spermine synthase SMS Tchem Enzyme -1.50353 28.6 215
F-box only protein 47 FBXO47 Tdark Non-IDG -0.03476 0.95 58
Spermatogenesis-associated protein 16 SPATA16 Tbio Non-IDG -0.85496 7.02 48
Centrosomal protein of 41 kDa CEP41 Tdark Non-IDG -0.41185 3.40 46