Development Level

Tbio 93 | 11,651
Tdark 20 | 6,593
Tchem 13 | 1,388
Tclin 8 | 612

IMPC Phenotype

increased total body fat amoun... 134 | 134
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 90 | 11,493
ovarian cancer 73 | 8,520
osteosarcoma 63 | 7,950
medulloblastoma, large-cell 55 | 6,241
glioblastoma 53 | 5,792
psoriasis 53 | 6,694
ependymoma 47 | 4,679
atypical teratoid / rhabdoid tumor 46 | 5,112
lung cancer 40 | 4,740
Breast cancer 38 | 3,578
group 3 medulloblastoma 38 | 4,104
Pick disease 32 | 1,894
adult high grade glioma 30 | 3,801
invasive ductal carcinoma 29 | 2,951
Kidney cancer 28 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
subependymal giant cell astrocytoma 26 | 2,287
Cancer 25 | 2,499
Astrocytoma, Pilocytic 24 | 3,081
astrocytic glioma 24 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
pituitary cancer 24 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
malignant mesothelioma 22 | 3,232
non-small cell lung cancer 22 | 2,890
oligodendroglioma 22 | 2,850
primitive neuroectodermal tumor 21 | 3,035
Obesity 19 | 678
colon cancer 18 | 1,478
diabetes mellitus 18 | 1,728
group 4 medulloblastoma 18 | 1,855
lung carcinoma 18 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
tuberculosis 18 | 2,010
Autosomal recessive predisposition 17 | 1,442
adrenocortical carcinoma 17 | 1,428
lung adenocarcinoma 17 | 2,716
Intellectual disability 16 | 1,016
breast carcinoma 16 | 1,638
pancreatic cancer 16 | 2,398
ductal carcinoma in situ 15 | 1,745
Rheumatoid arthritis 14 | 1,191
interstitial cystitis 14 | 2,312
Epilepsy 13 | 792
Schizophrenia 13 | 1,160
active Crohn's disease 13 | 922
Alzheimer's disease 12 | 658
Atopic dermatitis 11 | 952
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
nasopharyngeal carcinoma 11 | 1,058
Bipolar Disorder 10 | 666
Breast Neoplasms 10 | 445
Down syndrome 10 | 499
Mammary Neoplasms 10 | 425
Seizures 10 | 596
acute myeloid leukemia 10 | 783
astrocytoma 10 | 1,146
pediatric high grade glioma 10 | 1,064
ulcerative colitis 10 | 1,819
Hypertension 9 | 396
Melanoma 9 | 711
Neurodegenerative disease 9 | 414
Osteoporosis 9 | 363
Short stature 9 | 531
cystic fibrosis 9 | 1,696
spina bifida 9 | 1,074
tuberculosis and treatment for 6 months 9 | 409
Endometriosis 8 | 540
Multiple myeloma 8 | 1,332
Parkinson's disease 8 | 392
primary Sjogren syndrome 8 | 735
progressive supranuclear palsy 8 | 676
Endometrial cancer 7 | 311
Hypogonadism 7 | 173
Liver cancer 7 | 604
Vascular disease 7 | 319
juvenile dermatomyositis 7 | 1,187
non primary Sjogren syndrome sicca 7 | 891
Adenoma 6 | 167
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Hypertensive disease 6 | 292
Mental and motor retardation 6 | 608
Prostatic Neoplasms 6 | 495
dermatomyositis 6 | 966
fibroadenoma 6 | 559
primary pancreatic ductal adenocarcinoma 6 | 1,109
Cataract 5 | 297
Infertility 5 | 188
Kidney disease 5 | 430
Muscle hypotonia 5 | 571
Skin cancer 5 | 469
Strabismus 5 | 270
acute quadriplegic myopathy 5 | 1,158
cutaneous lupus erythematosus 5 | 1,057
esophageal adenocarcinoma 5 | 737

Tissue

Digestive Tract 129 | 17,369
Endocrine System 129 | 18,159
Female tissues 128 | 17,400
Liver and Pancreas 127 | 16,750
Skin and soft tissues 127 | 17,230
Male tissues 126 | 17,142
Urinary Tract 126 | 16,678
Nervous System 125 | 16,725
Respiratory system 125 | 16,393
Blood and immune system 124 | 16,909
Cardiovascular System 119 | 15,192

Target Family

Non-IDG 72 | 12,091
Enzyme 33 | 4,145
Transcription Factor 8 | 1,400
GPCR 5 | 408
Kinase 5 | 634
Ion Channel 3 | 344
TF/Epigenetic 3 | 38
Epigenetic 2 | 242
Transporter 2 | 473
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
Glycogen [starch] synthase, liver GYS2 Tbio Enzyme -1.61077 38.6 69
KICSTOR complex protein kaptin KPTN Tbio Non-IDG -1.45875 26.8 153
U4/U6 small nuclear ribonucleoprotein Prp31 PRPF31 Tbio Non-IDG -1.84397 72.4 216
Short transient receptor potential channel 3 TRPC3 Tchem Ion Channel -2.46704 294.6 217
Transcriptional enhancer factor TEF-1 TEAD1 Tbio Transcription Factor -1.71108 45.2 164
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 TNFAIP1 Tbio Non-IDG -1.31215 21.6 197
Signal peptidase complex catalytic subunit SEC11C SEC11C Tdark Enzyme -0.46982 3.63 31
Protein regulator of cytokinesis 1 PRC1 Tbio Non-IDG -0.99763 6.30 172