Development Level

Tchem 5 | 1,598
Tbio 2 | 11,445
Tclin 2 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

increased spleen weight 10 | 10
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

ovarian cancer 9 | 8,520
medulloblastoma, large-cell 8 | 6,241
osteosarcoma 8 | 7,950
Carcinoma 6 | 11,493
glioblastoma 6 | 5,792
lung cancer 6 | 4,740
atypical teratoid / rhabdoid tumor 5 | 5,112
lung carcinoma 5 | 2,843
psoriasis 5 | 6,694
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Astrocytoma, Pilocytic 4 | 3,081
Cancer 4 | 2,499
group 3 medulloblastoma 4 | 4,104
interstitial cystitis 4 | 2,312
Breast cancer 3 | 3,578
Kidney cancer 3 | 2,613
adult high grade glioma 3 | 3,801
cutaneous lupus erythematosus 3 | 1,057
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
pediatric high grade glioma 3 | 1,064
primitive neuroectodermal tumor 3 | 3,035
Chronic Lymphocytic Leukemia 2 | 262
Endometrial cancer 2 | 311
Fever 2 | 138
HIV Infections 2 | 102
Multiple myeloma 2 | 1,332
Neurodegenerative disease 2 | 414
Parkinson's disease 2 | 392
Pick disease 2 | 1,894
Recurrent respiratory infections 2 | 141
Waldenstrons macroglobulinemia 2 | 765
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
ependymoma 2 | 4,679
esophageal adenocarcinoma 2 | 737
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
periodontitis 2 | 293
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
ulcerative colitis 2 | 1,819
Aarskog syndrome 1 | 12
Acquired flat foot 1 | 72
Adams-Oliver syndrome 1 | 15
Adrenal Gland Neoplasms 1 | 11
Autosomal dominant late onset Parkinson disease 1 | 7
Blastic phase chronic myeloid leukemia 1 | 58
Centronuclear myopathy 1 | 27
Chromoblastomycosis 1 | 10
Chronic Myelocytic Leukemia Accelerated Phase 1 | 59
Chronic Obstructive Airway Disease 1 | 37
Clostridium difficile colitis 1 | 12
Congenital Structural Myopathy 1 | 4
Congenital myopathy with fiber type disproportion 1 | 9
Difficulty running 1 | 7
Eczema 1 | 45
Elevated heart rate 1 | 25
External Ophthalmoplegia 1 | 6
Flatfoot 1 | 73
Glomerulonephritis 1 | 46
Granulomatosis 1 | 7
Human immunodeficiency virus infectious disease 1 | 138
Hydrops Fetalis 1 | 21
Hyperkalemia 1 | 17
Hyperphosphatemia (disorder) 1 | 17
Hypotension 1 | 82
Increased connective tissue 1 | 7
Joint laxity 1 | 54
Kidney Failure, Chronic 1 | 46
Malignant hyperpyrexia due to anesthesia 1 | 10
Metaphyseal dysplasia 1 | 11
Myocardial Reperfusion Injury 1 | 37
Myopathies, Structural, Congenital 1 | 15
Narrow face 1 | 54
Neonatal onset 1 | 21
Neuroleptic malignant syndrome 1 | 9
Nonprogressive 1 | 12
Paranasal Sinus Diseases 1 | 34
Photosensitivity of skin 1 | 51
Primary immunodeficiency disease 1 | 54
Progressive multifocal leukoencephalopathy 1 | 25
Rectum cancer 1 | 12
Recurrent Staphylococcus aureus infections 1 | 4
Recurrent bacterial skin infections 1 | 8
Respiratory insufficiency due to muscle weakness 1 | 37
SERUM PHOSPHATE ELEVATED 1 | 14
Sinusitis 1 | 65
Thin face 1 | 54
Variation in muscle fiber size 1 | 16
Weak cry 1 | 17
Wiskott-Aldrich syndrome 1 | 30

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 4 | 12,091
Kinase 3 | 634
Ion Channel 2 | 344
Enzyme 1 | 4,145

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.09698 1276.8 315
GRB10-interacting GYF protein 2 GIGYF2 Tchem Non-IDG -1.52965 37.1 43
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Leucine-rich repeat serine/threonine-protein kinase 1 LRRK1 Tbio Kinase -1.33128 18.1 134
B-cell lymphoma 3 protein BCL3 Tbio Non-IDG -2.44266 291.3 279
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
Leptin receptor overlapping transcript-like 1 LEPROTL1 Tdark Non-IDG -1.50345 26.7 21
L-selectin SELL Tchem Non-IDG -3.46505 2829.9 1166
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 Tchem Kinase -1.52519 32.5 532
Tyrosine-protein kinase Lyn LYN Tclin Kinase -2.83644 683.2 589