Development Level

Tbio 29 | 11,445
Tdark 4 | 6,588
Tchem 1 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

increased red blood cell distr... 34 | 34
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 22 | 11,493
osteosarcoma 20 | 7,950
ovarian cancer 20 | 8,520
psoriasis 17 | 6,694
atypical teratoid / rhabdoid tumor 15 | 5,112
medulloblastoma, large-cell 15 | 6,241
glioblastoma 14 | 5,792
ependymoma 13 | 4,679
Breast cancer 11 | 3,578
Kidney cancer 11 | 2,613
primitive neuroectodermal tumor 11 | 3,035
Astrocytoma, Pilocytic 10 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
oligodendroglioma 10 | 2,850
group 3 medulloblastoma 9 | 4,104
lung cancer 9 | 4,740
Pick disease 8 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
astrocytic glioma 7 | 2,597
group 4 medulloblastoma 7 | 1,855
adult high grade glioma 6 | 3,801
malignant mesothelioma 6 | 3,232
non-small cell lung cancer 6 | 2,890
subependymal giant cell astrocytoma 6 | 2,287
Liver cancer 5 | 604
Obesity 5 | 678
Rheumatoid arthritis 5 | 1,191
esophageal adenocarcinoma 5 | 737
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
Neurodegenerative disease 4 | 414
Schizophrenia 4 | 1,160
astrocytoma 4 | 1,146
diabetes mellitus 4 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
Alzheimer's disease 3 | 658
Autosomal recessive predisposition 3 | 1,442
Bipolar Disorder 3 | 666
Cancer 3 | 2,499
Down syndrome 3 | 499
Endometrial cancer 3 | 311
Epilepsy 3 | 792
Large intestine cancer 3 | 126
Multiple myeloma 3 | 1,332
Parkinson's disease 3 | 392
Type 2 diabetes mellitus 3 | 272
Vascular disease 3 | 319
active Crohn's disease 3 | 922
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
juvenile dermatomyositis 3 | 1,187
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
Asperger syndrome 2 | 37
Autism spectrum disorder 2 | 101
Autistic Disorder 2 | 364
Decreased platelet count 2 | 111
Duchenne muscular dystrophy 2 | 601
Gaucher disease type 1 2 | 180
Gilles de la Tourette syndrome 2 | 47
Intellectual disability 2 | 1,016
Liver Cirrhosis, Experimental 2 | 769
Melanoma 2 | 711
Motor neuron disease 2 | 49
Nephrotic Syndrome 2 | 78
Nicotine dependence 2 | 54
Pitt-Hopkins syndrome 2 | 20
Pitt-Hopkins-Like Syndrome 2 2 | 2
Polycystic ovary syndrome 2 | 360
Skin cancer 2 | 469
Systemic lupus erythematosus 2 | 194
Thrombocytopenia 2 | 197
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
fibroadenoma 2 | 559
gastric carcinoma 2 | 807
limb girdle muscular dystrophy 2B 2 | 40
lung adenocarcinoma 2 | 2,716
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
non diabetic and post-ischemic heart failure 2 | 200
non primary Sjogren syndrome sicca 2 | 891
pancreatic cancer 2 | 2,398
periodontitis 2 | 293
sarcoidosis 2 | 370
ulcerative colitis 2 | 1,819
Esophageal Stenosis 1 | 15
Gingival Diseases 1 | 19
Leukoplakia, Oral 1 | 20
Periodontal Diseases 1 | 21
Tracheoesophageal Fistula 1 | 36

Tissue

Blood and immune system 32 | 16,909
Cardiovascular System 32 | 15,192
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678

Target Family

Non-IDG 25 | 12,091
Enzyme 6 | 4,145
Kinase 2 | 634
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ewing's tumor-associated antigen 1 ETAA1 Tbio Non-IDG -0.76616 7.50 40
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.74520 518.6 163
Polypeptide N-acetylgalactosaminyltransferase 18 GALNT18 Tbio Enzyme -0.54647 3.29 37
Cullin-associated NEDD8-dissociated protein 2 CAND2 Tbio Non-IDG -2.62148 386.7 53
Phospholipase D3 PLD3 Tbio Enzyme -1.77419 62.1 99
Phosphatidate phosphatase LPIN2 LPIN2 Tbio Enzyme -1.50639 30.9 152
Leucine-rich repeat serine/threonine-protein kinase 1 LRRK1 Tbio Kinase -1.33128 18.1 134
Kidney mitochondrial carrier protein 1 SLC25A30 Tdark Transporter 0.10 0.91 13
Vacuolar protein sorting-associated protein 13C VPS13C Tbio Non-IDG -0.93054 8.73 9