Development Level

Tbio 77 | 11,178
Tdark 15 | 6,569
Tchem 9 | 1,885

Collection

GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

increased or absent threshold ... 101 | 101
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 73 | 11,192
ovarian cancer 51 | 8,297
osteosarcoma 46 | 7,766
psoriasis 40 | 6,514
atypical teratoid / rhabdoid tumor 38 | 4,971
medulloblastoma, large-cell 36 | 6,086
glioblastoma 34 | 5,635
ependymoma 31 | 4,559
lung cancer 31 | 4,607
adult high grade glioma 26 | 3,701
invasive ductal carcinoma 26 | 2,867
group 3 medulloblastoma 25 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,204
interstitial cystitis 21 | 2,237
lung carcinoma 21 | 2,755
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,902
Breast cancer 18 | 3,469
group 4 medulloblastoma 18 | 1,806
oligodendroglioma 18 | 2,768
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,911
primitive neuroectodermal tumor 18 | 2,957
Kidney cancer 17 | 2,548
astrocytic glioma 17 | 2,530
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,872
pituitary cancer 15 | 1,915
Astrocytoma, Pilocytic 14 | 3,006
Intellectual disability 14 | 998
Pick disease 14 | 1,856
lung adenocarcinoma 14 | 2,627
malignant mesothelioma 14 | 3,135
non-small cell lung cancer 14 | 2,799
spina bifida 14 | 1,053
breast carcinoma 13 | 1,589
Autosomal recessive predisposition 12 | 1,407
cystic fibrosis 12 | 1,629
ulcerative colitis 12 | 1,765
ductal carcinoma in situ 11 | 1,686
subependymal giant cell astrocytoma 11 | 2,230
Nonsyndromic deafness 10 | 137
adrenocortical carcinoma 10 | 1,385
colon cancer 10 | 1,428
acute quadriplegic myopathy 9 | 1,133
pancreatic cancer 9 | 2,322
Atopic dermatitis 8 | 915
Multiple myeloma 8 | 1,296
Schizophrenia 8 | 1,136
juvenile dermatomyositis 8 | 1,147
tuberculosis 8 | 1,963
Cancer 7 | 2,388
Dull intelligence 7 | 634
Epilepsy 7 | 775
Low intelligence 7 | 634
Melanoma 7 | 689
Mental Retardation 7 | 634
Mental deficiency 7 | 634
Poor school performance 7 | 634
Sensorineural Hearing Loss (disorder) 7 | 281
cutaneous lupus erythematosus 7 | 1,016
progressive supranuclear palsy 7 | 656
Cataract 6 | 290
Rheumatoid arthritis 6 | 1,156
Sensorineural hearing loss 6 | 102
aldosterone-producing adenoma 6 | 646
dermatomyositis 6 | 941
diabetes mellitus 6 | 1,683
non primary Sjogren syndrome sicca 6 | 861
Cognitive delay 5 | 596
Global developmental delay 5 | 596
Lens Opacities 5 | 227
Mental and motor retardation 5 | 596
Neurodegenerative disease 5 | 402
Obesity 5 | 655
Waldenstrons macroglobulinemia 5 | 742
active Crohn's disease 5 | 882
medulloblastoma 5 | 702
primary Sjogren syndrome 5 | 710
Alzheimer's disease 4 | 640
Amyotrophic lateral sclerosis 4 | 437
Blindness 4 | 86
Cerebellar Ataxia 4 | 302
Cleft Palate 4 | 265
Endometrial cancer 4 | 301
Hodgkin's lymphoma, nodular sclerosis 4 | 22
Liver cancer 4 | 589
Prenatal onset 4 | 137
Retinitis Pigmentosa 4 | 223
Seizures 4 | 584
Short stature 4 | 514
Small head 4 | 366
Usher syndrome 4 | 32
astrocytoma 4 | 1,113
esophageal adenocarcinoma 4 | 696
fibroadenoma 4 | 538
gastric carcinoma 4 | 781
interstitial lung disease 4 | 287
nasopharyngeal carcinoma 4 | 1,024
nephrosclerosis 4 | 314
pediatric high grade glioma 4 | 1,035
posterior fossa group A ependymoma 4 | 456
tuberculosis and treatment for 6 months 4 | 399

Tissue

Endocrine System 99 | 18,159
Male tissues 98 | 17,142
Blood and immune system 97 | 16,909
Digestive Tract 97 | 17,369
Female tissues 97 | 17,400
Liver and Pancreas 97 | 16,750
Skin and soft tissues 97 | 17,230
Nervous System 94 | 16,725
Respiratory system 93 | 16,393
Urinary Tract 93 | 16,678
Cardiovascular System 87 | 15,192

Target Family

Non-IDG 64 | 12,091
Enzyme 16 | 4,145
Transcription Factor 6 | 1,400
Kinase 5 | 634
GPCR 3 | 408
Epigenetic 2 | 242
Transporter 2 | 473
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
AP2-associated protein kinase 1 AAK1 Tchem Kinase -1.28486 18.8 271
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 PLCB4 Tbio Enzyme -1.77110 57.7 19
Deoxycytidylate deaminase DCTD Tchem Enzyme -1.82599 65.4 147
Probable G-protein coupled receptor 152 GPR152 Tbio GPCR -1.60692 41.8 107
PDZ domain-containing protein GIPC3 GIPC3 Tbio Non-IDG -0.70115 6.45 127
Colorectal cancer-associated protein 2 COLCA2 Tdark Non-IDG -0.53285 3.32 0
Flavin reductase (NADPH) BLVRB Tbio Enzyme -2.31527 194.9 246
Solute carrier family 52, riboflavin transporter, member 2 SLC52A2 Tbio Transporter -1.42102 23.2 37
Sodium-driven chloride bicarbonate exchanger SLC4A10 Tbio Transporter -1.39974 27.9 12
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial RSAD1 Tdark Non-IDG -0.05115 1.13 101