Development Level

Tbio 78 | 11,651
Tdark 15 | 6,593
Tchem 8 | 1,388

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

increased or absent threshold ... 101 | 101
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 74 | 11,493
ovarian cancer 51 | 8,520
osteosarcoma 46 | 7,950
psoriasis 41 | 6,694
atypical teratoid / rhabdoid tumor 38 | 5,112
medulloblastoma, large-cell 36 | 6,241
glioblastoma 34 | 5,792
ependymoma 31 | 4,679
lung cancer 31 | 4,740
adult high grade glioma 26 | 3,801
invasive ductal carcinoma 26 | 2,951
group 3 medulloblastoma 25 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
interstitial cystitis 21 | 2,312
lung carcinoma 21 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Breast cancer 18 | 3,578
group 4 medulloblastoma 18 | 1,855
oligodendroglioma 18 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
primitive neuroectodermal tumor 18 | 3,035
Kidney cancer 17 | 2,613
astrocytic glioma 17 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
pituitary cancer 15 | 1,972
Astrocytoma, Pilocytic 14 | 3,081
Intellectual disability 14 | 1,016
Pick disease 14 | 1,894
lung adenocarcinoma 14 | 2,716
malignant mesothelioma 14 | 3,232
non-small cell lung cancer 14 | 2,890
spina bifida 14 | 1,074
breast carcinoma 13 | 1,638
Autosomal recessive predisposition 12 | 1,442
cystic fibrosis 12 | 1,696
ulcerative colitis 12 | 1,819
ductal carcinoma in situ 11 | 1,745
subependymal giant cell astrocytoma 11 | 2,287
Nonsyndromic deafness 10 | 142
adrenocortical carcinoma 10 | 1,428
colon cancer 10 | 1,478
acute quadriplegic myopathy 9 | 1,158
pancreatic cancer 9 | 2,398
Atopic dermatitis 8 | 952
Cancer 8 | 2,499
Multiple myeloma 8 | 1,332
Schizophrenia 8 | 1,160
juvenile dermatomyositis 8 | 1,187
tuberculosis 8 | 2,010
Dull intelligence 7 | 645
Epilepsy 7 | 792
Low intelligence 7 | 645
Melanoma 7 | 711
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Sensorineural Hearing Loss (disorder) 7 | 284
cutaneous lupus erythematosus 7 | 1,057
diabetes mellitus 7 | 1,728
progressive supranuclear palsy 7 | 676
Cataract 6 | 297
Obesity 6 | 678
Rheumatoid arthritis 6 | 1,191
Sensorineural hearing loss 6 | 106
aldosterone-producing adenoma 6 | 665
dermatomyositis 6 | 966
non primary Sjogren syndrome sicca 6 | 891
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Lens Opacities 5 | 231
Mental and motor retardation 5 | 608
Neurodegenerative disease 5 | 414
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 922
medulloblastoma 5 | 720
primary Sjogren syndrome 5 | 735
Alzheimer's disease 4 | 658
Amyotrophic lateral sclerosis 4 | 451
Blindness 4 | 88
Cerebellar Ataxia 4 | 304
Cleft Palate 4 | 271
Endometrial cancer 4 | 311
Hodgkin's lymphoma, nodular sclerosis 4 | 22
Liver cancer 4 | 604
Prenatal onset 4 | 139
Retinitis Pigmentosa 4 | 226
Seizures 4 | 596
Short stature 4 | 531
Small head 4 | 374
Usher syndrome 4 | 32
astrocytoma 4 | 1,146
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
gastric carcinoma 4 | 807
interstitial lung disease 4 | 298
nasopharyngeal carcinoma 4 | 1,058
nephrosclerosis 4 | 333
pediatric high grade glioma 4 | 1,064
posterior fossa group A ependymoma 4 | 468
tuberculosis and treatment for 6 months 4 | 409

Tissue

Endocrine System 99 | 18,159
Male tissues 98 | 17,142
Blood and immune system 97 | 16,909
Digestive Tract 97 | 17,369
Female tissues 97 | 17,400
Liver and Pancreas 97 | 16,750
Skin and soft tissues 97 | 17,230
Nervous System 94 | 16,725
Respiratory system 93 | 16,393
Urinary Tract 93 | 16,678
Cardiovascular System 87 | 15,192

Target Family

Non-IDG 64 | 12,091
Enzyme 16 | 4,145
Transcription Factor 6 | 1,400
Kinase 5 | 634
GPCR 3 | 408
Epigenetic 2 | 242
Transporter 2 | 473
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase VRK1 VRK1 Tbio Kinase -2.05267 119.8 168
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.52486 353.9 144
ADP-ribosylation factor-binding protein GGA1 GGA1 Tbio Non-IDG -1.92140 81.7 174
Interleukin-10 receptor subunit alpha IL10RA Tbio Non-IDG -2.08222 94.9 599
Protein-arginine deiminase type-3 PADI3 Tchem Enzyme -1.64865 41.7 53
Alpha-2-HS-glycoprotein AHSG Tbio Non-IDG -3.09085 1300.3 437
Taperin TPRN Tbio Non-IDG -0.79018 6.82 33
Coiled-coil domain-containing protein 92 CCDC92 Tdark Non-IDG -0.33632 1.56 91
Kelch-like protein 18 KLHL18 Tdark Non-IDG 0.19 0.56 37
AP-4 complex subunit epsilon-1 AP4E1 Tdark Non-IDG -0.66901 5.48 24