Development Level

Tbio 92 | 10,625
Tdark 21 | 7,003
Tchem 12 | 1,890
Tclin 3 | 602

IMPC Term

increased or absent threshold ... 128 | 128
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 65 | 8,492
osteosarcoma 57 | 7,933
medulloblastoma, large-cell 54 | 6,234
glioblastoma 52 | 5,572
psoriasis 51 | 6,685
atypical teratoid / rhabdoid tumor 41 | 4,369
lung cancer 40 | 4,473
invasive ductal carcinoma 28 | 2,950
primitive neuroectodermal tumor 27 | 3,031
group 3 medulloblastoma 25 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
oligodendroglioma 25 | 2,849
pediatric high grade glioma 25 | 2,712
pilocytic astrocytoma 24 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
adult high grade glioma 21 | 2,148
interstitial cystitis 21 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
posterior fossa group A ependymoma 21 | 1,511
pituitary cancer 20 | 1,972
Pick disease 19 | 1,893
astrocytic glioma 19 | 2,241
astrocytoma 19 | 1,493
ependymoma 19 | 2,514
lung adenocarcinoma 19 | 2,714
lung carcinoma 19 | 2,844
malignant mesothelioma 19 | 3,163
subependymal giant cell astrocytoma 19 | 2,287
Breast cancer 18 | 3,099
breast carcinoma 18 | 1,614
ductal carcinoma in situ 18 | 1,745
Carcinoma 17 | 2,147
spina bifida 17 | 1,064
group 4 medulloblastoma 16 | 1,875
adrenocortical carcinoma 15 | 1,427
atypical teratoid/rhabdoid tumor 15 | 1,095
colon cancer 15 | 1,475
non-small cell lung cancer 15 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
ulcerative colitis 15 | 2,087
diabetes mellitus 13 | 1,663
cystic fibrosis 12 | 1,670
progressive supranuclear palsy 12 | 674
Cancer 11 | 2,346
Intellectual disability 10 | 573
Obesity 10 | 616
pancreatic cancer 10 | 2,300
sonic hedgehog group medulloblastoma 10 | 1,482
tuberculosis 10 | 1,563
Alzheimer's disease 9 | 644
Multiple myeloma 9 | 1,328
Nonsyndromic deafness 9 | 121
active Crohn's disease 9 | 918
posterior fossa group B ependymoma 9 | 1,530
Atopic dermatitis 8 | 944
Rheumatoid Arthritis 8 | 1,171
acute quadriplegic myopathy 8 | 1,157
medulloblastoma 8 | 1,524
Neurodegenerative disease 7 | 383
Sensorineural hearing loss 7 | 107
Prostatic Neoplasms 6 | 471
esophageal adenocarcinoma 6 | 737
hereditary spastic paraplegia 6 | 313
interstitial lung disease 6 | 292
juvenile dermatomyositis 6 | 1,189
Multiple Sclerosis 5 | 498
active ulcerative colitis 5 | 477
aldosterone-producing adenoma 5 | 664
dermatomyositis 5 | 967
fibroadenoma 5 | 557
nasopharyngeal carcinoma 5 | 1,056
nephrosclerosis 5 | 329
non primary Sjogren syndrome sicca 5 | 840
primary Sjogren syndrome 5 | 789
Atherosclerosis 4 | 275
Blindness 4 | 84
Down syndrome 4 | 548
Fatty liver disease 4 | 86
Kidney disease 4 | 397
Mammary Neoplasms 4 | 410
Melanoma 4 | 261
Neuropathy 4 | 210
Retinitis pigmentosa 4 | 156
Schizophrenia 4 | 503
Usher syndrome 4 | 34
acute myeloid leukemia 4 | 785
gastric carcinoma 4 | 832
Amyotrophic Lateral Sclerosis 3 | 432
Epilepsy 3 | 346
Heart disease 3 | 279
Hypertensive disease 3 | 193
Metabolic syndrome X 3 | 155
Paraplegia 3 | 71
Parkinson's disease 3 | 364
Vascular disease 3 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
chronic rhinosinusitis 3 | 512
cutaneous lupus erythematosus 3 | 1,056
glioblastoma multiforme 3 | 347
tuberculosis and treatment for 6 months 3 | 686

Tissue

Nervous System 128 | 18,561
Digestive Tract 127 | 18,473
Female tissues 127 | 18,647
Liver and Pancreas 127 | 18,136
Urinary Tract 127 | 18,444
Blood and immune system 126 | 17,995
Cardiovascular System 126 | 17,958
Endocrine System 126 | 18,512
Skin and soft tissues 126 | 18,115
Male tissues 125 | 17,969
Respiratory system 124 | 17,484

Target Family

Non-IDG 81 | 11,969
Enzyme 23 | 4,146
Transcription Factor 11 | 1,400
GPCR 5 | 408
Kinase 4 | 634
Epigenetic 2 | 242
Ion Channel 1 | 341
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ankyrin repeat domain-containing protein 53 ANKRD53 Tbio Non-IDG 0.30 0.62 79
Activin receptor type-2A ACVR2A Tchem Kinase -2.04309 96.6 269
Transcriptional enhancer factor TEF-1 TEAD1 Tbio Transcription Factor -1.64251 37.7 135
Smoothened homolog SMO Tclin GPCR -1.11229 12.5 388
TBCC domain-containing protein 1 TBCCD1 Tbio Non-IDG -0.36798 3.22 55
Regulating synaptic membrane exocytosis protein 3 RIMS3 Tbio Non-IDG -1.18089 14.9 67
Patched domain-containing protein 1 PTCHD1 Tbio Non-IDG -0.80683 6.52 70
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.10835 131.7 114
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.64445 3.33 246
Complement C1q tumor necrosis factor-related protein 5 C1QTNF5 Tbio Non-IDG -0.17609 1.14 162