Development Level

Tbio 37 | 11,445
Tdark 12 | 6,588
Tchem 10 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

increased monocyte cell number 63 | 63
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 44 | 11,493
osteosarcoma 34 | 7,950
ovarian cancer 31 | 8,520
medulloblastoma, large-cell 29 | 6,241
psoriasis 28 | 6,694
glioblastoma 26 | 5,792
atypical teratoid / rhabdoid tumor 20 | 5,112
ependymoma 20 | 4,679
lung cancer 20 | 4,740
group 3 medulloblastoma 18 | 4,104
adult high grade glioma 17 | 3,801
interstitial cystitis 17 | 2,312
malignant mesothelioma 17 | 3,232
Astrocytoma, Pilocytic 16 | 3,081
oligodendroglioma 16 | 2,850
non-small cell lung cancer 15 | 2,890
primitive neuroectodermal tumor 15 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Cancer 13 | 2,499
Kidney cancer 13 | 2,613
astrocytic glioma 13 | 2,597
invasive ductal carcinoma 13 | 2,951
lung carcinoma 13 | 2,843
Pick disease 12 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
lung adenocarcinoma 12 | 2,716
ulcerative colitis 12 | 1,819
group 4 medulloblastoma 11 | 1,855
Breast cancer 10 | 3,578
pancreatic cancer 10 | 2,398
pituitary cancer 10 | 1,972
tuberculosis 10 | 2,010
subependymal giant cell astrocytoma 9 | 2,287
Schizophrenia 8 | 1,160
cutaneous lupus erythematosus 8 | 1,057
primary Sjogren syndrome 8 | 735
Asthma 7 | 385
Autosomal recessive predisposition 7 | 1,442
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
acute quadriplegic myopathy 6 | 1,158
colon cancer 6 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Melanoma 5 | 711
active Crohn's disease 5 | 922
astrocytoma 5 | 1,146
ductal carcinoma in situ 5 | 1,745
gastric carcinoma 5 | 807
hepatocellular carcinoma 5 | 547
juvenile dermatomyositis 5 | 1,187
sarcoidosis 5 | 370
Atopic dermatitis 4 | 952
Bipolar Disorder 4 | 666
Breast Neoplasms 4 | 445
Muscle hypotonia 4 | 571
Neurodegenerative disease 4 | 414
acute myeloid leukemia 4 | 783
esophageal adenocarcinoma 4 | 737
medulloblastoma 4 | 720
nasopharyngeal carcinoma 4 | 1,058
pancreatic carcinoma 4 | 562
periodontitis 4 | 293
Acquired metabolic disease 3 | 336
Anemia 3 | 365
Cardiovascular system disease 3 | 246
Chronic Lymphocytic Leukemia 3 | 262
Common variable immunodeficiency 3 | 101
Coronary artery disease 3 | 268
Endometriosis 3 | 540
Gaucher disease type 1 3 | 180
HIV Infections 3 | 102
Hypertension 3 | 396
Hypogonadism 3 | 173
Intellectual disability 3 | 1,016
Liver Cirrhosis, Experimental 3 | 769
Liver cancer 3 | 604
Major Depressive Disorder 3 | 301
Mammary Neoplasms 3 | 425
Nystagmus 3 | 317
Optic Atrophy 3 | 242
Rheumatoid arthritis 3 | 1,191
Systemic lupus erythematosus 3 | 194
Unipolar Depression 3 | 250
active ulcerative colitis 3 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
mucosa-associated lymphoid tissue lymphoma 3 | 484
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
Allergic hypersensitivity disease 2 | 126
Anorexia nervosa 2 | 80
Atherosclerosis 2 | 291
Heart disease 2 | 306
Kidney disease 2 | 430
Malaria 2 | 160
Type 2 diabetes mellitus 2 | 272
Vascular disease 2 | 319
chronic rhinosinusitis 2 | 512
pediatric high grade glioma 2 | 1,064

Tissue

Digestive Tract 63 | 17,369
Endocrine System 63 | 18,159
Female tissues 63 | 17,400
Skin and soft tissues 63 | 17,230
Male tissues 62 | 17,142
Blood and immune system 61 | 16,909
Liver and Pancreas 61 | 16,750
Respiratory system 60 | 16,393
Urinary Tract 60 | 16,678
Nervous System 58 | 16,725
Cardiovascular System 57 | 15,192

Target Family

Non-IDG 29 | 12,091
Enzyme 16 | 4,145
Kinase 5 | 634
Transcription Factor 5 | 1,400
Ion Channel 3 | 344
Transporter 3 | 473
Epigenetic 1 | 242
GPCR 1 | 408

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caskin-1 CASKIN1 Tdark Non-IDG -0.63111 5.31 22
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Tyrosine-protein kinase TXK TXK Tchem Kinase -2.28365 191.1 194
Cellular retinoic acid-binding protein 1 CRABP1 Tbio Non-IDG -2.48395 306.2 152
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha PDE6A Tclin Enzyme -1.29228 20.3 111
ETS domain-containing transcription factor ERF ERF Tbio Transcription Factor -2.42588 268.8 257
Multiple C2 and transmembrane domain-containing protein 1 MCTP1 Tdark Non-IDG -0.49248 3.44 49
Rho guanine nucleotide exchange factor 12 ARHGEF12 Tbio Non-IDG -2.63794 448.3 88
E3 ubiquitin-protein ligase RNF216 RNF216 Tbio Enzyme -1.27012 17.8 170
Poly(A) RNA polymerase, mitochondrial MTPAP Tbio Enzyme -1.36829 24.0 68