Development Level

Tbio 69 | 10,625
Tdark 13 | 7,003
Tchem 8 | 1,890
Tclin 3 | 602

Collection

Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

increased mean corpuscular hem... 93 | 93
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 54 | 8,484
osteosarcoma 50 | 7,933
psoriasis 40 | 6,685
medulloblastoma, large-cell 34 | 6,234
lung cancer 33 | 4,466
glioblastoma 30 | 5,572
atypical teratoid / rhabdoid tumor 25 | 4,369
lung adenocarcinoma 22 | 2,713
pilocytic astrocytoma 21 | 3,086
non-small cell lung cancer 20 | 2,798
primitive neuroectodermal tumor 20 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
Breast cancer 18 | 3,094
group 3 medulloblastoma 18 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
invasive ductal carcinoma 18 | 2,950
lung carcinoma 17 | 2,844
malignant mesothelioma 17 | 3,162
pancreatic cancer 17 | 2,300
ulcerative colitis 17 | 2,087
Pick disease 16 | 1,893
ependymoma 16 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
Cancer 14 | 2,346
Carcinoma 14 | 2,147
breast carcinoma 14 | 1,614
pediatric high grade glioma 14 | 2,712
adrenocortical carcinoma 13 | 1,427
subependymal giant cell astrocytoma 13 | 2,287
ductal carcinoma in situ 12 | 1,745
adult high grade glioma 11 | 2,148
interstitial cystitis 11 | 2,299
oligodendroglioma 11 | 2,849
pituitary cancer 11 | 1,972
dermatomyositis 10 | 933
acute quadriplegic myopathy 9 | 1,157
astrocytic glioma 9 | 2,241
astrocytoma 9 | 1,493
cutaneous lupus erythematosus 9 | 1,056
group 4 medulloblastoma 9 | 1,875
posterior fossa group A ependymoma 9 | 1,511
primary pancreatic ductal adenocarcinoma 9 | 1,271
Obesity 8 | 616
colon cancer 8 | 1,475
diabetes mellitus 8 | 1,663
pancreatic carcinoma 8 | 567
sonic hedgehog group medulloblastoma 8 | 1,482
Atopic dermatitis 7 | 944
IGA Glomerulonephritis 7 | 454
primary Sjogren syndrome 7 | 789
tuberculosis 7 | 1,557
tuberculosis and treatment for 6 months 7 | 686
Rheumatoid Arthritis 6 | 1,160
aldosterone-producing adenoma 6 | 664
juvenile dermatomyositis 6 | 1,189
medulloblastoma 6 | 1,524
Acquired metabolic disease 5 | 267
Alzheimer's disease 5 | 644
Multiple myeloma 5 | 1,327
Schizophrenia 5 | 501
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
cystic fibrosis 5 | 1,665
inflammatory breast cancer 5 | 404
nasopharyngeal carcinoma 5 | 1,056
spina bifida 5 | 1,064
Anemia 4 | 252
Crohn's disease 4 | 304
Gaucher disease type 3 4 | 76
Inflammatory Bowel Diseases 4 | 87
Kidney disease 4 | 396
Mammary Neoplasms 4 | 410
Neurodegenerative disease 4 | 383
atypical teratoid/rhabdoid tumor 4 | 1,095
chronic rhinosinusitis 4 | 512
cystic fibrosis and chronic rhinosinusitis 4 | 213
esophageal adenocarcinoma 4 | 737
gastric cancer 4 | 430
gastric carcinoma 4 | 832
hepatocellular carcinoma 4 | 532
hereditary spastic paraplegia 4 | 313
posterior fossa group B ependymoma 4 | 1,530
Amyotrophic Lateral Sclerosis 3 | 431
Crohn Disease 3 | 97
Diabetes Mellitus, Non-Insulin-Dependent 3 | 157
Down syndrome 3 | 548
Duchenne muscular dystrophy 3 | 602
Endometriosis 3 | 535
Hypertensive disease 3 | 193
Intellectual disability 3 | 573
Liver carcinoma 3 | 217
Neuropathy 3 | 210
Peripheral Neuropathy 3 | 303
Polycystic Ovary Syndrome 3 | 332
active ulcerative colitis 3 | 477
non-small cell lung carcinoma 3 | 413
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 3 months 3 | 327

Tissue

Cardiovascular System 92 | 17,958
Liver and Pancreas 92 | 18,136
Nervous System 92 | 18,561
Blood and immune system 91 | 17,995
Digestive Tract 91 | 18,473
Endocrine System 91 | 18,512
Female tissues 91 | 18,647
Male tissues 91 | 17,969
Respiratory system 91 | 17,484
Skin and soft tissues 91 | 18,115
Urinary Tract 91 | 18,444

Target Family

Non-IDG 54 | 11,971
Enzyme 22 | 4,146
Transporter 6 | 473
Transcription Factor 5 | 1,400
Kinase 3 | 634
Epigenetic 2 | 242
GPCR 1 | 406

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Krueppel-like factor 9 KLF9 Tbio Transcription Factor -1.87911 88.8 139
Ubiquitin carboxyl-terminal hydrolase 11 USP11 Tbio Enzyme -1.06624 14.9 210
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Ras-related protein Rab-43 RAB43 Tbio Enzyme -1.56506 35.9 63
Tetraspanin-18 TSPAN18 Tbio Non-IDG -0.83372 7.78 40
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.40675 26.5 184
Cytochrome b5 domain-containing protein 1 CYB5D1 Tdark Non-IDG -0.09691 1.25 65
Leptin receptor LEPR Tclin Non-IDG -2.98449 751.7 530
Hepatocyte growth factor-like protein MST1 Tbio Enzyme -2.02220 90.5 0
Hemojuvelin HFE2 Tbio Non-IDG -2.13078 140.4 244