Development Level

Tbio 71 | 11,178
Tdark 14 | 6,569
Tchem 9 | 1,885
Tclin 2 | 612

IMPC Phenotype

increased mean corpuscular hem... 96 | 96
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 61 | 11,192
osteosarcoma 44 | 7,766
ovarian cancer 42 | 8,297
psoriasis 31 | 6,514
medulloblastoma, large-cell 30 | 6,086
atypical teratoid / rhabdoid tumor 28 | 4,971
glioblastoma 28 | 5,635
group 3 medulloblastoma 24 | 4,002
lung cancer 24 | 4,607
Astrocytoma, Pilocytic 22 | 3,006
ependymoma 22 | 4,559
adult high grade glioma 20 | 3,701
lung adenocarcinoma 20 | 2,627
Breast cancer 19 | 3,469
Cancer 19 | 2,388
non-small cell lung cancer 19 | 2,799
primitive neuroectodermal tumor 18 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,902
Kidney cancer 16 | 2,548
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,204
malignant mesothelioma 16 | 3,135
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,872
ulcerative colitis 15 | 1,765
Pick disease 14 | 1,856
adrenocortical carcinoma 14 | 1,385
invasive ductal carcinoma 14 | 2,867
Autosomal recessive predisposition 13 | 1,407
astrocytic glioma 13 | 2,530
lung carcinoma 13 | 2,755
subependymal giant cell astrocytoma 13 | 2,230
interstitial cystitis 12 | 2,237
oligodendroglioma 12 | 2,768
pancreatic cancer 11 | 2,322
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,911
Intellectual disability 10 | 998
breast carcinoma 10 | 1,589
ductal carcinoma in situ 9 | 1,686
tuberculosis 9 | 1,963
Epilepsy 8 | 775
group 4 medulloblastoma 8 | 1,806
pituitary cancer 8 | 1,915
Muscle hypotonia 7 | 562
Schizophrenia 7 | 1,136
cutaneous lupus erythematosus 7 | 1,016
diabetes mellitus 7 | 1,683
pediatric high grade glioma 7 | 1,035
Failure to gain weight 6 | 359
Kidney disease 6 | 411
Pediatric failure to thrive 6 | 359
Rheumatoid arthritis 6 | 1,156
colon cancer 6 | 1,428
juvenile dermatomyositis 6 | 1,147
Anemia 5 | 353
Atopic dermatitis 5 | 915
Cognitive delay 5 | 596
Dull intelligence 5 | 634
Global developmental delay 5 | 596
Liver Cirrhosis, Experimental 5 | 733
Low intelligence 5 | 634
Mental Retardation 5 | 634
Mental and motor retardation 5 | 596
Mental deficiency 5 | 634
Obesity 5 | 655
Poor school performance 5 | 634
Seizures 5 | 584
Sensorineural Hearing Loss (disorder) 5 | 281
acute myeloid leukemia 5 | 760
astrocytoma 5 | 1,113
dermatomyositis 5 | 941
medulloblastoma 5 | 702
primary Sjogren syndrome 5 | 710
Anteverted nostril 4 | 186
Breast Neoplasms 4 | 423
Colorectal Neoplasms 4 | 235
Duchenne muscular dystrophy 4 | 587
Hyperreflexia 4 | 208
Infantile onset 4 | 236
Kidney Failure 4 | 108
Multiple myeloma 4 | 1,296
Muscle Spasticity 4 | 192
Nystagmus 4 | 309
Small head 4 | 366
Strabismus 4 | 265
Thrombocytopenia 4 | 193
Tremor 4 | 112
Waldenstrons macroglobulinemia 4 | 742
active ulcerative colitis 4 | 736
aldosterone-producing adenoma 4 | 646
gastric carcinoma 4 | 781
head and neck cancer and chronic obstructive pulmonary disease 4 | 226
nasopharyngeal carcinoma 4 | 1,024
pancreatic carcinoma 4 | 555
primary pancreatic ductal adenocarcinoma 4 | 1,071
sonic hedgehog group medulloblastoma 4 | 459
spina bifida 4 | 1,053
tuberculosis and treatment for 6 months 4 | 399
Endometriosis 3 | 521
acute quadriplegic myopathy 3 | 1,133
esophageal adenocarcinoma 3 | 696
fibroadenoma 3 | 538

Tissue

Digestive Tract 93 | 17,369
Endocrine System 93 | 18,159
Male tissues 92 | 17,142
Blood and immune system 91 | 16,909
Female tissues 91 | 17,400
Liver and Pancreas 91 | 16,750
Nervous System 90 | 16,725
Skin and soft tissues 90 | 17,230
Urinary Tract 89 | 16,678
Respiratory system 88 | 16,393
Cardiovascular System 85 | 15,192

Target Family

Non-IDG 54 | 12,091
Enzyme 23 | 4,145
Transcription Factor 6 | 1,400
Transporter 6 | 473
Epigenetic 3 | 242
Kinase 3 | 634
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP Tbio Enzyme -2.67803 471.0 188
Membrane-associated phosphatidylinositol transfer protein 1 PITPNM1 Tbio Non-IDG -1.99576 100.1 173
Solute carrier family 35 member F6 SLC35F6 Tbio Transporter 0.23 1.07 109
Protein FAM53B FAM53B Tbio Non-IDG -1.70473 50.6 24
Retinal-specific ATP-binding cassette transporter ABCA4 Tbio Transporter -2.71831 511.1 119
Espin ESPN Tbio Non-IDG -2.01425 100.4 63
Sodium-driven chloride bicarbonate exchanger SLC4A10 Tbio Transporter -1.39974 27.9 12
Interferon regulatory factor 8 IRF8 Tbio Transcription Factor -2.37977 273.3 336
Lamin-B1 LMNB1 Tbio Non-IDG -2.58749 373.5 496
Peroxisomal biogenesis factor 3 PEX3 Tbio Non-IDG -1.79362 72.7 79