Development Level

Tbio 38 | 11,445
Tchem 7 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

increased leukocyte cell numbe... 47 | 47
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 33 | 11,493
medulloblastoma, large-cell 24 | 6,241
ovarian cancer 24 | 8,520
psoriasis 22 | 6,694
glioblastoma 19 | 5,792
group 3 medulloblastoma 18 | 4,104
ependymoma 17 | 4,679
atypical teratoid / rhabdoid tumor 16 | 5,112
osteosarcoma 16 | 7,950
lung cancer 15 | 4,740
Breast cancer 14 | 3,578
astrocytic glioma 12 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
malignant mesothelioma 11 | 3,232
Astrocytoma, Pilocytic 10 | 3,081
lung adenocarcinoma 10 | 2,716
lung carcinoma 9 | 2,843
Autosomal recessive predisposition 8 | 1,442
Kidney cancer 8 | 2,613
Pick disease 8 | 1,894
cystic fibrosis 8 | 1,696
invasive ductal carcinoma 8 | 2,951
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
pituitary cancer 8 | 1,972
Cancer 7 | 2,499
breast carcinoma 7 | 1,638
juvenile dermatomyositis 7 | 1,187
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
Atopic dermatitis 6 | 952
acute quadriplegic myopathy 6 | 1,158
adult high grade glioma 6 | 3,801
diabetes mellitus 6 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
subependymal giant cell astrocytoma 6 | 2,287
ulcerative colitis 6 | 1,819
Multiple myeloma 5 | 1,332
Splenomegaly 5 | 190
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
interstitial cystitis 5 | 2,312
pancreatic carcinoma 5 | 562
primary pancreatic ductal adenocarcinoma 5 | 1,109
Epilepsy 4 | 792
Obesity 4 | 678
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
dermatomyositis 4 | 966
ductal carcinoma in situ 4 | 1,745
group 4 medulloblastoma 4 | 1,855
pediatric high grade glioma 4 | 1,064
Abdominal Pain 3 | 98
Acquired metabolic disease 3 | 336
Amyotrophic lateral sclerosis 3 | 451
Brain Ischemia 3 | 110
Coronary artery disease 3 | 268
Diarrhea 3 | 253
Ecchymosis 3 | 66
Heart failure 3 | 162
Increased tendency to bruise 3 | 66
Inflammatory bowel disease 3 | 151
Lymphadenopathy 3 | 62
Multiple Sclerosis 3 | 540
Premature ovarian failure 3 | 65
Sensorineural Hearing Loss (disorder) 3 | 284
Thrombocytopenia 3 | 197
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
non primary Sjogren syndrome sicca 3 | 891
progressive supranuclear palsy 3 | 676
tuberculosis 3 | 2,010
Anemia 2 | 365
Arthritis, Juvenile 2 | 126
Autoimmune Diseases 2 | 67
Choreatic disease 2 | 52
Delayed bone age 2 | 136
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Endometriosis 2 | 540
Gaucher disease type 1 2 | 180
Hepatomegaly 2 | 285
Highly variable severity 2 | 157
Hypersensitivity reaction type II disease 2 | 253
Juvenile arthritis 2 | 126
Kidney disease 2 | 430
Male infertility 2 | 206
Nonsyndromic deafness 2 | 142
Pneumonia 2 | 174
Polycystic ovary syndrome 2 | 360
Sensorineural hearing loss 2 | 106
Type 2 diabetes mellitus 2 | 272
Variable expressivity 2 | 157
active Crohn's disease 2 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
chronic rhinosinusitis 2 | 512
medulloblastoma 2 | 720
posterior fossa group B ependymoma 2 | 416

Tissue

Endocrine System 47 | 18,159
Blood and immune system 46 | 16,909
Digestive Tract 46 | 17,369
Female tissues 46 | 17,400
Liver and Pancreas 46 | 16,750
Nervous System 45 | 16,725
Skin and soft tissues 45 | 17,230
Male tissues 43 | 17,142
Urinary Tract 43 | 16,678
Respiratory system 42 | 16,393
Cardiovascular System 40 | 15,192

Target Family

Non-IDG 28 | 12,091
Enzyme 13 | 4,145
Transcription Factor 2 | 1,400
Transporter 2 | 473
GPCR 1 | 408
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tumor necrosis factor receptor superfamily member 1A TNFRSF1A Tchem Non-IDG -3.31515 1897.3 1051
Probable phospholipid-transporting ATPase IH ATP11A Tbio Transporter -3.26278 1708.8 47
Delta-like protein 1 DLL1 Tbio Non-IDG -3.09375 1190.2 344
Lymphotoxin-alpha LTA Tbio Non-IDG -2.87108 629.6 561
Follicle-stimulating hormone receptor FSHR Tclin GPCR -2.79144 610.7 386
Enteropeptidase TMPRSS15 Tchem Enzyme -2.78466 584.5 140
Nuclear factor NF-kappa-B p105 subunit NFKB1 Tchem Transcription Factor -2.74349 505.0 1762
Platelet glycoprotein VI GP6 Tbio Non-IDG -2.73714 584.5 201
Cholesterol 7-alpha-monooxygenase CYP7A1 Tbio Enzyme -2.70498 494.6 94
ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP Tbio Enzyme -2.67803 471.0 188