Development Level

Tbio 38 | 11,445
Tchem 7 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

increased leukocyte cell numbe... 47 | 47
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 33 | 11,493
medulloblastoma, large-cell 24 | 6,241
ovarian cancer 24 | 8,520
psoriasis 22 | 6,694
glioblastoma 19 | 5,792
group 3 medulloblastoma 18 | 4,104
ependymoma 17 | 4,679
atypical teratoid / rhabdoid tumor 16 | 5,112
osteosarcoma 16 | 7,950
lung cancer 15 | 4,740
Breast cancer 14 | 3,578
astrocytic glioma 12 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
malignant mesothelioma 11 | 3,232
Astrocytoma, Pilocytic 10 | 3,081
lung adenocarcinoma 10 | 2,716
lung carcinoma 9 | 2,843
Autosomal recessive predisposition 8 | 1,442
Kidney cancer 8 | 2,613
Pick disease 8 | 1,894
cystic fibrosis 8 | 1,696
invasive ductal carcinoma 8 | 2,951
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
pituitary cancer 8 | 1,972
Cancer 7 | 2,499
breast carcinoma 7 | 1,638
juvenile dermatomyositis 7 | 1,187
non-small cell lung cancer 7 | 2,890
primitive neuroectodermal tumor 7 | 3,035
Atopic dermatitis 6 | 952
acute quadriplegic myopathy 6 | 1,158
adult high grade glioma 6 | 3,801
diabetes mellitus 6 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
subependymal giant cell astrocytoma 6 | 2,287
ulcerative colitis 6 | 1,819
Multiple myeloma 5 | 1,332
Splenomegaly 5 | 190
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
interstitial cystitis 5 | 2,312
pancreatic carcinoma 5 | 562
primary pancreatic ductal adenocarcinoma 5 | 1,109
Epilepsy 4 | 792
Obesity 4 | 678
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
dermatomyositis 4 | 966
ductal carcinoma in situ 4 | 1,745
group 4 medulloblastoma 4 | 1,855
pediatric high grade glioma 4 | 1,064
Abdominal Pain 3 | 98
Acquired metabolic disease 3 | 336
Amyotrophic lateral sclerosis 3 | 451
Brain Ischemia 3 | 110
Coronary artery disease 3 | 268
Diarrhea 3 | 253
Ecchymosis 3 | 66
Heart failure 3 | 162
Increased tendency to bruise 3 | 66
Inflammatory bowel disease 3 | 151
Lymphadenopathy 3 | 62
Multiple Sclerosis 3 | 540
Premature ovarian failure 3 | 65
Sensorineural Hearing Loss (disorder) 3 | 284
Thrombocytopenia 3 | 197
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
non primary Sjogren syndrome sicca 3 | 891
progressive supranuclear palsy 3 | 676
tuberculosis 3 | 2,010
Anemia 2 | 365
Arthritis, Juvenile 2 | 126
Autoimmune Diseases 2 | 67
Choreatic disease 2 | 52
Delayed bone age 2 | 136
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Endometriosis 2 | 540
Gaucher disease type 1 2 | 180
Hepatomegaly 2 | 285
Highly variable severity 2 | 157
Hypersensitivity reaction type II disease 2 | 253
Juvenile arthritis 2 | 126
Kidney disease 2 | 430
Male infertility 2 | 206
Nonsyndromic deafness 2 | 142
Pneumonia 2 | 174
Polycystic ovary syndrome 2 | 360
Sensorineural hearing loss 2 | 106
Type 2 diabetes mellitus 2 | 272
Variable expressivity 2 | 157
active Crohn's disease 2 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
chronic rhinosinusitis 2 | 512
medulloblastoma 2 | 720
posterior fossa group B ependymoma 2 | 416

Tissue

Endocrine System 47 | 18,159
Blood and immune system 46 | 16,909
Digestive Tract 46 | 17,369
Female tissues 46 | 17,400
Liver and Pancreas 46 | 16,750
Nervous System 45 | 16,725
Skin and soft tissues 45 | 17,230
Male tissues 43 | 17,142
Urinary Tract 43 | 16,678
Respiratory system 42 | 16,393
Cardiovascular System 40 | 15,192

Target Family

Non-IDG 28 | 12,091
Enzyme 13 | 4,145
Transcription Factor 2 | 1,400
Transporter 2 | 473
GPCR 1 | 408
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear factor NF-kappa-B p105 subunit NFKB1 Tchem Transcription Factor -2.74349 505.0 1762
T-cell-specific surface glycoprotein CD28 CD28 Tbio Non-IDG -1.96865 108.8 1508
Tumor necrosis factor receptor superfamily member 1A TNFRSF1A Tchem Non-IDG -3.31515 1897.3 1051
Lymphotoxin-alpha LTA Tbio Non-IDG -2.87108 629.6 561
Integrin beta-5 ITGB5 Tbio Non-IDG -1.48377 29.3 416
Follicle-stimulating hormone receptor FSHR Tclin GPCR -2.79144 610.7 386
Delta-like protein 1 DLL1 Tbio Non-IDG -3.09375 1190.2 344
Serine/threonine-protein kinase Nek9 NEK9 Tchem Kinase -1.37388 27.9 320
Lysosome membrane protein 2 SCARB2 Tbio Non-IDG -2.40121 240.5 282
Ras-related protein Ral-B RALB Tbio Enzyme -1.71078 50.9 228