Development Level

Tbio 114 | 11,651
Tdark 34 | 6,593
Tchem 21 | 1,388
Tclin 3 | 612

Collection

GPCR: IDG Consortium (Targets) 2 | 126
RFA-RM-18-021 2 | 328

IMPC Phenotype

increased lean body mass 172 | 172
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 123 | 11,493
ovarian cancer 106 | 8,520
osteosarcoma 95 | 7,950
medulloblastoma, large-cell 81 | 6,241
glioblastoma 78 | 5,792
psoriasis 73 | 6,694
atypical teratoid / rhabdoid tumor 71 | 5,112
ependymoma 61 | 4,679
lung cancer 58 | 4,740
group 3 medulloblastoma 54 | 4,104
Breast cancer 44 | 3,578
adult high grade glioma 43 | 3,801
primitive neuroectodermal tumor 40 | 3,035
malignant mesothelioma 39 | 3,232
oligodendroglioma 38 | 2,850
subependymal giant cell astrocytoma 38 | 2,287
invasive ductal carcinoma 37 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
Astrocytoma, Pilocytic 34 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,955
astrocytic glioma 32 | 2,597
Kidney cancer 30 | 2,613
Pick disease 30 | 1,894
pituitary cancer 30 | 1,972
lung carcinoma 29 | 2,843
lung adenocarcinoma 28 | 2,716
pancreatic cancer 28 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
non-small cell lung cancer 25 | 2,890
Cancer 24 | 2,499
astrocytoma 24 | 1,146
group 4 medulloblastoma 24 | 1,855
interstitial cystitis 23 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
spina bifida 22 | 1,074
breast carcinoma 21 | 1,638
ductal carcinoma in situ 21 | 1,745
tuberculosis 19 | 2,010
Autosomal recessive predisposition 18 | 1,442
cystic fibrosis 18 | 1,696
pediatric high grade glioma 18 | 1,064
Schizophrenia 17 | 1,160
colon cancer 17 | 1,478
ulcerative colitis 17 | 1,819
adrenocortical carcinoma 16 | 1,428
Bipolar Disorder 15 | 666
Intellectual disability 15 | 1,016
Multiple myeloma 15 | 1,332
Rheumatoid arthritis 14 | 1,191
esophageal adenocarcinoma 14 | 737
juvenile dermatomyositis 14 | 1,187
primary pancreatic ductal adenocarcinoma 14 | 1,109
Epilepsy 13 | 792
active Crohn's disease 13 | 922
acute quadriplegic myopathy 13 | 1,158
diabetes mellitus 13 | 1,728
Alzheimer's disease 12 | 658
Atopic dermatitis 12 | 952
acute myeloid leukemia 12 | 783
Obesity 11 | 678
active ulcerative colitis 11 | 764
nasopharyngeal carcinoma 11 | 1,058
Neurodegenerative disease 10 | 414
aldosterone-producing adenoma 10 | 665
cutaneous lupus erythematosus 10 | 1,057
dermatomyositis 10 | 966
non primary Sjogren syndrome sicca 10 | 891
Melanoma 9 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
Autistic Disorder 8 | 364
Cognitive delay 8 | 608
Dull intelligence 8 | 645
Global developmental delay 8 | 608
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Poor school performance 8 | 645
Seizures 8 | 596
gastric carcinoma 8 | 807
pancreatic carcinoma 8 | 562
progressive supranuclear palsy 8 | 676
Down syndrome 7 | 499
Liver cancer 7 | 604
Short stature 7 | 531
Waldenstrons macroglobulinemia 7 | 765
chronic rhinosinusitis 7 | 512
hereditary spastic paraplegia 7 | 318
primary Sjogren syndrome 7 | 735
Autism spectrum disorder 6 | 101
Cerebellar Ataxia 6 | 304
Depressive disorder 6 | 409
Duchenne muscular dystrophy 6 | 601
Mental Depression 6 | 333
Muscle hypotonia 6 | 571
Polycystic ovary syndrome 6 | 360
fibroadenoma 6 | 559
gastric cancer 6 | 459
sonic hedgehog group medulloblastoma 6 | 467
urothelial carcinoma 6 | 318

Tissue

Endocrine System 168 | 18,159
Female tissues 168 | 17,400
Urinary Tract 166 | 16,678
Digestive Tract 165 | 17,369
Male tissues 165 | 17,142
Skin and soft tissues 165 | 17,230
Liver and Pancreas 164 | 16,750
Nervous System 162 | 16,725
Blood and immune system 161 | 16,909
Respiratory system 159 | 16,393
Cardiovascular System 157 | 15,192

Target Family

Non-IDG 94 | 12,091
Enzyme 41 | 4,145
Transcription Factor 11 | 1,400
Epigenetic 7 | 242
GPCR 5 | 408
Kinase 4 | 634
Transporter 4 | 473
Ion Channel 3 | 344
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CMRF35-like molecule 9 CD300LG Tdark Non-IDG -0.92828 10.3 49
Protein NATD1 NATD1 Tdark Non-IDG 0.00000 5
Basic leucine zipper and W2 domain-containing protein 2 BZW2 Tbio Non-IDG -0.20261 1.21 83
Glycogen [starch] synthase, liver GYS2 Tbio Enzyme -1.61077 38.6 69
Transcription factor AP-4 TFAP4 Tbio Transcription Factor -1.33384 19.4 276
Short transient receptor potential channel 3 TRPC3 Tchem Ion Channel -2.46704 294.6 217
Band 4.1-like protein 5 EPB41L5 Tbio Non-IDG -1.31136 21.8 109
Endoplasmic reticulum resident protein 44 ERP44 Tbio Non-IDG -1.46425 28.0 204
Transcriptional enhancer factor TEF-1 TEAD1 Tbio Transcription Factor -1.71108 45.2 164
ADP-dependent glucokinase ADPGK Tbio Kinase -0.86342 7.82 154