Development Level

Tbio 111 | 11,178
Tdark 34 | 6,569
Tchem 24 | 1,885
Tclin 3 | 612

Collection

GPCR: IDG Consortium (Targets) 2 | 126

IMPC Phenotype

increased lean body mass 172 | 172
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 121 | 11,192
ovarian cancer 104 | 8,297
osteosarcoma 93 | 7,766
medulloblastoma, large-cell 79 | 6,086
glioblastoma 76 | 5,635
psoriasis 72 | 6,514
atypical teratoid / rhabdoid tumor 70 | 4,971
ependymoma 60 | 4,559
lung cancer 57 | 4,607
group 3 medulloblastoma 53 | 4,002
Breast cancer 44 | 3,469
adult high grade glioma 42 | 3,701
malignant mesothelioma 39 | 3,135
primitive neuroectodermal tumor 39 | 2,957
oligodendroglioma 38 | 2,768
subependymal giant cell astrocytoma 37 | 2,230
invasive ductal carcinoma 36 | 2,867
Astrocytoma, Pilocytic 34 | 3,006
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,204
astrocytic glioma 32 | 2,530
Kidney cancer 30 | 2,548
Pick disease 30 | 1,856
pituitary cancer 29 | 1,915
lung adenocarcinoma 28 | 2,627
lung carcinoma 28 | 2,755
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,902
pancreatic cancer 27 | 2,322
non-small cell lung cancer 25 | 2,799
group 4 medulloblastoma 24 | 1,806
Cancer 23 | 2,388
astrocytoma 23 | 1,113
interstitial cystitis 23 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,911
breast carcinoma 21 | 1,589
ductal carcinoma in situ 21 | 1,686
spina bifida 21 | 1,053
Autosomal recessive predisposition 18 | 1,407
cystic fibrosis 18 | 1,629
pediatric high grade glioma 18 | 1,035
tuberculosis 18 | 1,963
colon cancer 17 | 1,428
ulcerative colitis 17 | 1,765
Schizophrenia 16 | 1,136
Intellectual disability 15 | 998
Multiple myeloma 15 | 1,296
adrenocortical carcinoma 15 | 1,385
Bipolar Disorder 14 | 646
Rheumatoid arthritis 14 | 1,156
esophageal adenocarcinoma 14 | 696
juvenile dermatomyositis 14 | 1,147
Epilepsy 13 | 775
active Crohn's disease 13 | 882
primary pancreatic ductal adenocarcinoma 13 | 1,071
Alzheimer's disease 12 | 640
Atopic dermatitis 12 | 915
acute quadriplegic myopathy 12 | 1,133
diabetes mellitus 12 | 1,683
Obesity 11 | 655
nasopharyngeal carcinoma 11 | 1,024
Neurodegenerative disease 10 | 402
active ulcerative colitis 10 | 736
acute myeloid leukemia 10 | 760
cutaneous lupus erythematosus 10 | 1,016
dermatomyositis 10 | 941
non primary Sjogren syndrome sicca 10 | 861
Melanoma 9 | 689
aldosterone-producing adenoma 9 | 646
Autistic Disorder 8 | 358
Cognitive delay 8 | 596
Dull intelligence 8 | 634
Global developmental delay 8 | 596
Low intelligence 8 | 634
Mental Retardation 8 | 634
Mental and motor retardation 8 | 596
Mental deficiency 8 | 634
Poor school performance 8 | 634
Seizures 8 | 584
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 492
pancreatic carcinoma 8 | 555
progressive supranuclear palsy 8 | 656
Down syndrome 7 | 480
Liver cancer 7 | 589
Short stature 7 | 514
Waldenstrons macroglobulinemia 7 | 742
chronic rhinosinusitis 7 | 505
gastric carcinoma 7 | 781
hereditary spastic paraplegia 7 | 313
primary Sjogren syndrome 7 | 710
Autism spectrum disorder 6 | 99
Cerebellar Ataxia 6 | 302
Depressive disorder 6 | 401
Duchenne muscular dystrophy 6 | 587
Liver Cirrhosis, Experimental 6 | 733
Mental Depression 6 | 325
Muscle hypotonia 6 | 562
Polycystic ovary syndrome 6 | 348
fibroadenoma 6 | 538
gastric cancer 6 | 445
sonic hedgehog group medulloblastoma 6 | 459

Tissue

Endocrine System 168 | 18,159
Female tissues 168 | 17,400
Urinary Tract 166 | 16,678
Digestive Tract 165 | 17,369
Male tissues 165 | 17,142
Skin and soft tissues 165 | 17,230
Liver and Pancreas 164 | 16,750
Nervous System 162 | 16,725
Blood and immune system 161 | 16,909
Respiratory system 159 | 16,393
Cardiovascular System 157 | 15,192

Target Family

Non-IDG 94 | 12,091
Enzyme 41 | 4,145
Transcription Factor 11 | 1,400
Epigenetic 7 | 242
GPCR 5 | 408
Kinase 4 | 634
Transporter 4 | 473
Ion Channel 3 | 344
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol-glycan-specific phospholipase D GPLD1 Tbio Enzyme -2.08209 126.8 222
Histone-lysine N-methyltransferase 2A KMT2A Tchem Epigenetic -2.88228 736.0 334
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 PLCB4 Tbio Enzyme -1.77110 57.7 19
G-protein coupled bile acid receptor 1 GPBAR1 Tchem GPCR -2.54070 373.2 189
28S ribosomal protein S35, mitochondrial MRPS35 Tdark Non-IDG 0.00000 84
Zinc finger SWIM domain-containing protein 5 ZSWIM5 Tdark Non-IDG 0.29 0.58 65
Dynein light chain roadblock-type 2 DYNLRB2 Tbio Non-IDG -0.65444 2.59 77
Homeobox protein EMX1 EMX1 Tbio Transcription Factor -1.76097 51.7 154
Tripartite motif-containing protein 29 TRIM29 Tbio Non-IDG -1.42599 31.3 334
Maturin MTURN Tdark Non-IDG -0.95020 9.61 6