Development Level

Tbio 69 | 10,625
Tdark 25 | 7,003
Tchem 11 | 1,890
Tclin 2 | 602

Collection

Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

increased lean body mass 107 | 107
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 70 | 8,492
osteosarcoma 58 | 7,933
medulloblastoma, large-cell 53 | 6,234
psoriasis 49 | 6,685
glioblastoma 46 | 5,572
atypical teratoid / rhabdoid tumor 42 | 4,369
lung cancer 35 | 4,473
pilocytic astrocytoma 29 | 3,086
primitive neuroectodermal tumor 29 | 3,031
Breast cancer 28 | 3,099
oligodendroglioma 28 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
pediatric high grade glioma 27 | 2,712
Pick disease 26 | 1,893
malignant mesothelioma 24 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
ependymoma 21 | 2,514
invasive ductal carcinoma 21 | 2,950
lung adenocarcinoma 21 | 2,714
subependymal giant cell astrocytoma 21 | 2,287
astrocytic glioma 20 | 2,241
pancreatic cancer 20 | 2,300
group 3 medulloblastoma 19 | 2,254
lung carcinoma 19 | 2,844
non-small cell lung cancer 19 | 2,798
astrocytoma 17 | 1,493
medulloblastoma 17 | 1,524
pituitary cancer 17 | 1,972
group 4 medulloblastoma 16 | 1,875
Carcinoma 15 | 2,147
breast carcinoma 15 | 1,614
posterior fossa group A ependymoma 15 | 1,511
ductal carcinoma in situ 14 | 1,745
interstitial cystitis 14 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Cancer 13 | 2,346
Alzheimer's disease 12 | 644
adult high grade glioma 12 | 2,148
cystic fibrosis 12 | 1,670
spina bifida 12 | 1,064
ulcerative colitis 12 | 2,087
juvenile dermatomyositis 11 | 1,189
tuberculosis 11 | 1,563
Rheumatoid Arthritis 10 | 1,171
adrenocortical carcinoma 10 | 1,427
colon cancer 10 | 1,475
Atopic dermatitis 9 | 944
acute quadriplegic myopathy 9 | 1,157
esophageal adenocarcinoma 9 | 737
posterior fossa group B ependymoma 9 | 1,530
primary pancreatic ductal adenocarcinoma 9 | 1,271
sonic hedgehog group medulloblastoma 9 | 1,482
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
cutaneous lupus erythematosus 8 | 1,056
nasopharyngeal carcinoma 8 | 1,056
pancreatic carcinoma 8 | 567
progressive supranuclear palsy 8 | 674
Autistic Disorder 7 | 320
Down syndrome 7 | 548
Intellectual disability 7 | 573
Multiple myeloma 7 | 1,328
diabetes mellitus 7 | 1,663
Bipolar Disorder 6 | 266
Epilepsy 6 | 346
Schizophrenia 6 | 503
aldosterone-producing adenoma 6 | 664
atypical teratoid/rhabdoid tumor 6 | 1,095
gastric carcinoma 6 | 832
non-inflammatory breast cancer 6 | 208
Duchenne muscular dystrophy 5 | 602
Obesity 5 | 616
Parkinson's disease 5 | 364
Toxic encephalopathy 5 | 131
active Crohn's disease 5 | 918
active ulcerative colitis 5 | 477
acute myeloid leukemia 5 | 785
dermatomyositis 5 | 967
hereditary spastic paraplegia 5 | 313
non primary Sjogren syndrome sicca 5 | 840
primary Sjogren syndrome 5 | 789
Amyotrophic Lateral Sclerosis 4 | 432
Neurodegenerative disease 4 | 383
Vascular disease 4 | 281
chronic rhinosinusitis 4 | 512
interstitial lung disease 4 | 292
mucosa-associated lymphoid tissue lymphoma 4 | 480
Attention deficit hyperactivity disorder 3 | 156
Juvenile arthritis 3 | 124
Multiple Sclerosis 3 | 498
Polycystic Ovary Syndrome 3 | 335
Prostatic Neoplasms 3 | 471
Type 2 diabetes mellitus 3 | 192
Waldenstrons macroglobulinemia 3 | 765
chronic lymphocytic leukemia 3 | 244
gastric cancer 3 | 436
hepatocellular carcinoma 3 | 550
nephrosclerosis 3 | 329
tuberculosis and treatment for 6 months 3 | 686
urothelial carcinoma 3 | 318

Tissue

Liver and Pancreas 106 | 18,136
Nervous System 106 | 18,561
Blood and immune system 105 | 17,995
Cardiovascular System 105 | 17,958
Digestive Tract 105 | 18,473
Endocrine System 105 | 18,512
Female tissues 105 | 18,647
Urinary Tract 105 | 18,444
Male tissues 104 | 17,969
Skin and soft tissues 104 | 18,115
Respiratory system 102 | 17,484

Target Family

Non-IDG 63 | 11,969
Enzyme 23 | 4,146
Transcription Factor 7 | 1,400
Kinase 4 | 634
Epigenetic 3 | 242
Transporter 3 | 473
GPCR 2 | 408
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmic reticulum resident protein 44 ERP44 Tbio Non-IDG -1.45074 26.7 194
Protein Hook homolog 3 HOOK3 Tbio Non-IDG -1.18684 0.00000 55
Protein FAM134C FAM134C Tdark Non-IDG 0.30 0.44 50
HBS1-like protein HBS1L Tbio Non-IDG -2.52098 316.2 144
Band 4.1-like protein 5 EPB41L5 Tbio Non-IDG -1.29631 20.6 94
Protocadherin-18 PCDH18 Tdark Non-IDG -0.52190 3.43 78
Transcriptional enhancer factor TEF-1 TEAD1 Tbio Transcription Factor -1.64251 37.7 135
ADP-dependent glucokinase ADPGK Tbio Kinase -0.76066 6.95 123
Interleukin-12 receptor subunit beta-1 IL12RB1 Tbio Non-IDG -2.31330 207.1 227
Patched domain-containing protein 1 PTCHD1 Tbio Non-IDG -0.80683 6.52 70