Development Level

Tbio 32 | 11,445
Tchem 7 | 1,598
Tclin 3 | 613
Tdark 3 | 6,588

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

increased hemoglobin content 45 | 45
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 36 | 11,493
ovarian cancer 22 | 8,520
osteosarcoma 19 | 7,950
psoriasis 17 | 6,694
atypical teratoid / rhabdoid tumor 16 | 5,112
glioblastoma 16 | 5,792
group 3 medulloblastoma 16 | 4,104
Breast cancer 14 | 3,578
medulloblastoma, large-cell 13 | 6,241
ependymoma 12 | 4,679
pancreatic cancer 12 | 2,398
adult high grade glioma 11 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
lung cancer 10 | 4,740
primitive neuroectodermal tumor 10 | 3,035
Cancer 9 | 2,499
Pick disease 9 | 1,894
oligodendroglioma 9 | 2,850
Astrocytoma, Pilocytic 8 | 3,081
astrocytic glioma 8 | 2,597
diabetes mellitus 8 | 1,728
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
invasive ductal carcinoma 8 | 2,951
malignant mesothelioma 7 | 3,232
pancreatic carcinoma 7 | 562
Kidney cancer 6 | 2,613
Schizophrenia 6 | 1,160
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Waldenstrons macroglobulinemia 5 | 765
group 4 medulloblastoma 5 | 1,855
pituitary cancer 5 | 1,972
Acquired metabolic disease 4 | 336
Autosomal recessive predisposition 4 | 1,442
Endometriosis 4 | 540
Multiple myeloma 4 | 1,332
Rheumatoid arthritis 4 | 1,191
breast carcinoma 4 | 1,638
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
interstitial cystitis 4 | 2,312
lung carcinoma 4 | 2,843
primary Sjogren syndrome 4 | 735
primary pancreatic ductal adenocarcinoma 4 | 1,109
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Alzheimer's disease 3 | 658
Atopic dermatitis 3 | 952
Breast Neoplasms 3 | 445
Crohn's disease 3 | 321
Hypertensive disease 3 | 292
Infertility 3 | 188
Mammary Neoplasms 3 | 425
Obesity 3 | 678
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
progressive supranuclear palsy 3 | 676
subependymal giant cell astrocytoma 3 | 2,287
Alopecia areata 2 | 41
Anemia 2 | 365
Arrhythmogenic right ventricular cardiomyopathy 2 | 30
Arthritis, Rheumatoid 2 | 174
Cardiac Arrhythmia 2 | 103
Celiac disease 2 | 116
Colorectal Neoplasms 2 | 243
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Diffuse large B-cell lymphoma 2 | 39
Female infertility 2 | 30
Hepatomegaly 2 | 285
Hyperglycemia 2 | 137
Hypertension 2 | 396
Hypertriglyceridemia result 2 | 37
Hypogonadism 2 | 173
Infertility, Female 2 | 28
Kidney Failure 2 | 111
Kidney disease 2 | 430
Liver Cirrhosis, Experimental 2 | 769
Lymphopenia 2 | 67
Motor delay 2 | 147
No development of motor milestones 2 | 147
Primary hypogonadism 2 | 37
Primary physiologic amenorrhea 2 | 55
Prostatic Neoplasms 2 | 495
Sensorineural Hearing Loss (disorder) 2 | 284
Type 1 diabetes mellitus 2 | 109
Type 2 diabetes mellitus 2 | 272
active Crohn's disease 2 | 922
fibroadenoma 2 | 559
non diabetic and post-ischemic heart failure 2 | 200
pediatric high grade glioma 2 | 1,064
spina bifida 2 | 1,074

Tissue

Endocrine System 44 | 18,159
Skin and soft tissues 43 | 17,230
Digestive Tract 42 | 17,369
Male tissues 42 | 17,142
Blood and immune system 40 | 16,909
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Respiratory system 40 | 16,393
Urinary Tract 40 | 16,678
Cardiovascular System 39 | 15,192
Nervous System 39 | 16,725

Target Family

Non-IDG 28 | 12,091
Enzyme 5 | 4,145
GPCR 3 | 408
Transcription Factor 3 | 1,400
Kinase 2 | 634
Nuclear Receptor 2 | 48
Epigenetic 1 | 242
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
BAG family molecular chaperone regulator 1 BAG1 Tbio Non-IDG -2.50252 335.1 394
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
COP9 signalosome complex subunit 4 COPS4 Tbio Non-IDG -0.91181 7.39 88
Aryl hydrocarbon receptor repressor AHRR Tbio Transcription Factor -1.68768 52.8 77
Ras-related protein Rab-36 RAB36 Tdark Enzyme -0.51688 3.97 90
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 SMARCAL1 Tbio Non-IDG -1.74852 65.1 133
Protein angel homolog 1 ANGEL1 Tbio Non-IDG -0.17609 1.15 94