Development Level

Tbio 33 | 10,625
Tdark 6 | 7,003
Tchem 5 | 1,890
Tclin 1 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

increased hemoglobin content 45 | 45
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

osteosarcoma 22 | 7,933
ovarian cancer 21 | 8,484
psoriasis 21 | 6,685
glioblastoma 17 | 5,572
atypical teratoid / rhabdoid tumor 13 | 4,369
medulloblastoma, large-cell 13 | 6,234
pancreatic cancer 12 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,956
invasive ductal carcinoma 11 | 2,950
Breast cancer 10 | 3,094
Pick disease 10 | 1,893
lung cancer 10 | 4,466
oligodendroglioma 10 | 2,849
pilocytic astrocytoma 10 | 3,086
primitive neuroectodermal tumor 10 | 3,031
ductal carcinoma in situ 9 | 1,745
group 3 medulloblastoma 9 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
malignant mesothelioma 9 | 3,162
non-small cell lung cancer 9 | 2,798
astrocytic glioma 8 | 2,241
diabetes mellitus 8 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
ulcerative colitis 8 | 2,087
ependymoma 7 | 2,514
pancreatic carcinoma 7 | 567
Cancer 6 | 2,346
group 4 medulloblastoma 6 | 1,875
interstitial cystitis 6 | 2,299
lung adenocarcinoma 6 | 2,713
pediatric high grade glioma 6 | 2,712
pituitary cancer 6 | 1,972
adrenocortical carcinoma 5 | 1,427
adult high grade glioma 5 | 2,148
cutaneous lupus erythematosus 5 | 1,056
cystic fibrosis 5 | 1,665
medulloblastoma 5 | 1,524
primary Sjogren syndrome 5 | 789
tuberculosis 5 | 1,557
Atopic dermatitis 4 | 944
Carcinoma 4 | 2,147
Rheumatoid Arthritis 4 | 1,160
Waldenstrons macroglobulinemia 4 | 765
breast carcinoma 4 | 1,614
lung carcinoma 4 | 2,844
nasopharyngeal carcinoma 4 | 1,056
posterior fossa group B ependymoma 4 | 1,530
primary pancreatic ductal adenocarcinoma 4 | 1,271
progressive supranuclear palsy 4 | 674
Acquired metabolic disease 3 | 267
Alzheimer's disease 3 | 644
Crohn's disease 3 | 304
Down syndrome 3 | 548
Hyperglycemia 3 | 120
Hypertensive disease 3 | 193
IGA Glomerulonephritis 3 | 454
Kidney disease 3 | 396
Obesity 3 | 616
acute myeloid leukemia 3 | 780
aldosterone-producing adenoma 3 | 664
colon cancer 3 | 1,475
dermatomyositis 3 | 933
esophageal adenocarcinoma 3 | 737
juvenile dermatomyositis 3 | 1,189
posterior fossa group A ependymoma 3 | 1,511
subependymal giant cell astrocytoma 3 | 2,287
Age related macular degeneration 2 | 84
Arrhythmogenic right ventricular cardiomyopathy 2 | 27
Cardiovascular system disease 2 | 194
Celiac disease 2 | 112
Coronary heart disease 2 | 59
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Endometriosis 2 | 535
Hyperlipidemia 2 | 25
Hypertension 2 | 287
Infertility 2 | 163
Inflammatory Bowel Diseases 2 | 87
Intellectual disability 2 | 573
Leishmaniasis 2 | 49
Mammary Neoplasms 2 | 410
Metabolic syndrome X 2 | 155
Multiple Sclerosis 2 | 498
Neurodegenerative disease 2 | 383
Parkinson's disease 2 | 364
Schizophrenia 2 | 501
Type 1 diabetes mellitus 2 | 101
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
astrocytoma 2 | 1,493
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
gastric carcinoma 2 | 832
head and neck cancer and chronic obstructive pulmonary disease 2 | 237
hereditary spastic paraplegia 2 | 313
nephrosclerosis 2 | 329
non diabetic and post-ischemic heart failure 2 | 200
non primary Sjogren syndrome sicca 2 | 840
sonic hedgehog group medulloblastoma 2 | 1,482
spina bifida 2 | 1,064
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 45 | 17,995
Digestive Tract 45 | 18,473
Female tissues 45 | 18,647
Liver and Pancreas 45 | 18,136
Male tissues 45 | 17,969
Nervous System 45 | 18,561
Urinary Tract 45 | 18,444
Cardiovascular System 44 | 17,958
Endocrine System 44 | 18,512
Respiratory system 44 | 17,484
Skin and soft tissues 44 | 18,115

Target Family

Non-IDG 28 | 11,971
Enzyme 7 | 4,146
Kinase 3 | 634
Transcription Factor 3 | 1,400
GPCR 2 | 406
Nuclear Receptor 1 | 48
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Cytochrome b561 CYB561 Tbio Non-IDG -1.41910 20.4 45
Leptin receptor LEPR Tclin Non-IDG -2.98449 751.7 530
Hemojuvelin HFE2 Tbio Non-IDG -2.13078 140.4 244
Atlastin-2 ATL2 Tbio Non-IDG -1.16934 14.0 77
Ankyrin repeat domain-containing protein 13A ANKRD13A Tdark Non-IDG -0.36798 2.26 39
All-trans-retinol 13,14-reductase RETSAT Tdark Enzyme -0.66366 5.73 8
Zinc transporter 8 SLC30A8 Tbio Transporter -2.13184 153.6 103
Aryl hydrocarbon receptor repressor AHRR Tbio Transcription Factor -1.57413 47.1 66
Cytokine receptor-like factor 3 CRLF3 Tbio Non-IDG -0.42402 3.37 66