Development Level

Tbio 60 | 11,445
Tdark 9 | 6,588
Tchem 4 | 1,598
Tclin 3 | 613

Collection

RFA-RM-18-021 3 | 328
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

increased fasted circulating g... 76 | 76
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 45 | 11,493
glioblastoma 35 | 5,792
ovarian cancer 35 | 8,520
osteosarcoma 33 | 7,950
medulloblastoma, large-cell 32 | 6,241
atypical teratoid / rhabdoid tumor 28 | 5,112
Breast cancer 23 | 3,578
primitive neuroectodermal tumor 23 | 3,035
lung cancer 22 | 4,740
psoriasis 22 | 6,694
group 3 medulloblastoma 19 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
non-small cell lung cancer 18 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
pancreatic cancer 17 | 2,398
adult high grade glioma 15 | 3,801
ependymoma 15 | 4,679
lung carcinoma 15 | 2,843
astrocytic glioma 14 | 2,597
invasive ductal carcinoma 14 | 2,951
Astrocytoma, Pilocytic 13 | 3,081
interstitial cystitis 13 | 2,312
oligodendroglioma 13 | 2,850
lung adenocarcinoma 12 | 2,716
malignant mesothelioma 12 | 3,232
Cancer 11 | 2,499
Kidney cancer 10 | 2,613
Pick disease 10 | 1,894
adrenocortical carcinoma 10 | 1,428
astrocytoma 9 | 1,146
colon cancer 9 | 1,478
diabetes mellitus 9 | 1,728
Atopic dermatitis 8 | 952
Intellectual disability 8 | 1,016
breast carcinoma 8 | 1,638
dermatomyositis 8 | 966
gastric carcinoma 8 | 807
juvenile dermatomyositis 8 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
pediatric high grade glioma 8 | 1,064
pituitary cancer 8 | 1,972
tuberculosis 8 | 2,010
ulcerative colitis 8 | 1,819
Autosomal recessive predisposition 7 | 1,442
Multiple myeloma 7 | 1,332
ductal carcinoma in situ 7 | 1,745
primary pancreatic ductal adenocarcinoma 7 | 1,109
spina bifida 7 | 1,074
Neurodegenerative disease 6 | 414
Obesity 6 | 678
Schizophrenia 6 | 1,160
group 4 medulloblastoma 6 | 1,855
Alzheimer's disease 5 | 658
Cognitive delay 5 | 608
Duchenne muscular dystrophy 5 | 601
Epilepsy 5 | 792
Glaucoma 5 | 239
Global developmental delay 5 | 608
Liver Cirrhosis, Experimental 5 | 769
Mental and motor retardation 5 | 608
aldosterone-producing adenoma 5 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
fibroadenoma 5 | 559
nasopharyngeal carcinoma 5 | 1,058
posterior fossa group A ependymoma 5 | 468
Autistic Disorder 4 | 364
Cardiovascular system disease 4 | 246
Cataract 4 | 297
Dementia 4 | 175
Dull intelligence 4 | 645
Hydrocephalus 4 | 152
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Prostatic Neoplasms 4 | 495
Seizures 4 | 596
active ulcerative colitis 4 | 764
acute myeloid leukemia 4 | 783
progressive supranuclear palsy 4 | 676
subependymal giant cell astrocytoma 4 | 2,287
urothelial carcinoma 4 | 318
Bipolar Disorder 3 | 666
Depressive disorder 3 | 409
Endometriosis 3 | 540
Lens Opacities 3 | 231
Optic Atrophy 3 | 242
Rheumatoid arthritis 3 | 1,191
Short stature 3 | 531
Type 2 diabetes mellitus 3 | 272
Vascular disease 3 | 319
acute quadriplegic myopathy 3 | 1,158
medulloblastoma 3 | 720
mucosa-associated lymphoid tissue lymphoma 3 | 484
primary Sjogren syndrome 3 | 735
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 74 | 18,159
Male tissues 74 | 17,142
Female tissues 73 | 17,400
Nervous System 73 | 16,725
Skin and soft tissues 73 | 17,230
Blood and immune system 72 | 16,909
Digestive Tract 72 | 17,369
Liver and Pancreas 71 | 16,750
Urinary Tract 71 | 16,678
Respiratory system 69 | 16,393
Cardiovascular System 65 | 15,192

Target Family

Non-IDG 46 | 12,091
Enzyme 16 | 4,145
Transcription Factor 4 | 1,400
GPCR 3 | 408
Epigenetic 2 | 242
Ion Channel 2 | 344
Kinase 2 | 634
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
Cleavage and polyadenylation specificity factor subunit 3 CPSF3 Tbio Non-IDG -1.47182 27.3 190
von Willebrand factor A domain-containing protein 8 VWA8 Tbio Non-IDG -0.36798 2.42 8
Protein patched homolog 2 PTCH2 Tbio Non-IDG -1.80541 50.4 92
Methylmalonic aciduria and homocystinuria type C protein MMACHC Tbio Non-IDG -1.83573 76.5 233
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Disheveled-associated activator of morphogenesis 1 DAAM1 Tbio Non-IDG -1.45166 30.8 269
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.47780 298.9 332
Collagen alpha-1(XVIII) chain COL18A1 Tbio Non-IDG -3.18339 1561.4 433
Complement C1q tumor necrosis factor-related protein 5 C1QTNF5 Tbio Non-IDG -0.39794 1.27 209