Development Level

Tbio 27 | 11,445
Tchem 9 | 1,598
Tdark 4 | 6,588
Tclin 2 | 613

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

increased circulating triglyce... 42 | 42
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 32 | 11,493
ovarian cancer 28 | 8,520
osteosarcoma 24 | 7,950
psoriasis 23 | 6,694
atypical teratoid / rhabdoid tumor 22 | 5,112
medulloblastoma, large-cell 22 | 6,241
ependymoma 20 | 4,679
glioblastoma 20 | 5,792
lung cancer 18 | 4,740
Breast cancer 16 | 3,578
adult high grade glioma 16 | 3,801
oligodendroglioma 16 | 2,850
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Kidney cancer 13 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
primitive neuroectodermal tumor 13 | 3,035
astrocytic glioma 12 | 2,597
lung carcinoma 12 | 2,843
Schizophrenia 11 | 1,160
interstitial cystitis 11 | 2,312
cystic fibrosis 10 | 1,696
Astrocytoma, Pilocytic 9 | 3,081
Cancer 9 | 2,499
Pick disease 9 | 1,894
invasive ductal carcinoma 9 | 2,951
malignant mesothelioma 9 | 3,232
non-small cell lung cancer 9 | 2,890
subependymal giant cell astrocytoma 9 | 2,287
adrenocortical carcinoma 8 | 1,428
pancreatic cancer 8 | 2,398
Bipolar Disorder 7 | 666
Obesity 7 | 678
breast carcinoma 7 | 1,638
ductal carcinoma in situ 7 | 1,745
group 4 medulloblastoma 7 | 1,855
lung adenocarcinoma 7 | 2,716
ulcerative colitis 7 | 1,819
Atopic dermatitis 6 | 952
Liver cancer 6 | 604
nasopharyngeal carcinoma 6 | 1,058
spina bifida 6 | 1,074
astrocytoma 5 | 1,146
diabetes mellitus 5 | 1,728
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
Down syndrome 4 | 499
Endometriosis 4 | 540
Fatty liver disease 4 | 103
Melanoma 4 | 711
Proteinuria 4 | 144
Rheumatoid arthritis 4 | 1,191
Skin cancer 4 | 469
active Crohn's disease 4 | 922
aldosterone-producing adenoma 4 | 665
colon cancer 4 | 1,478
juvenile dermatomyositis 4 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary pancreatic ductal adenocarcinoma 4 | 1,109
progressive supranuclear palsy 4 | 676
Alzheimer's disease 3 | 658
Autosomal recessive predisposition 3 | 1,442
Cerebrovascular disease 3 | 238
Cognitive delay 3 | 608
Coronary artery disease 3 | 268
Decreased platelet count 3 | 111
Duchenne muscular dystrophy 3 | 601
Global developmental delay 3 | 608
Hypertensive disease 3 | 292
Kidney disease 3 | 430
Liver disease 3 | 237
Lymphoid leukemia 3 | 160
Mental and motor retardation 3 | 608
Orbital separation excessive 3 | 244
Orofacial cleft 3 | 54
Parkinson's disease 3 | 392
Thrombocytopenia 3 | 197
cutaneous lupus erythematosus 3 | 1,057
gastric carcinoma 3 | 807
nephrosclerosis 3 | 333
non diabetic and post-ischemic heart failure 3 | 200
posterior fossa group B ependymoma 3 | 416
Attention deficit hyperactivity disorder 2 | 278
Congenital Epicanthus 2 | 177
Curvature of spine 2 | 282
Epilepsy 2 | 792
Mental Depression 2 | 333
Seizures 2 | 596
Strabismus 2 | 270
Vascular disease 2 | 319
acute quadriplegic myopathy 2 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
chronic rhinosinusitis 2 | 512
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
hepatocellular carcinoma 2 | 547
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
urothelial carcinoma 2 | 318

Tissue

Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Skin and soft tissues 42 | 17,230
Female tissues 41 | 17,400
Liver and Pancreas 41 | 16,750
Male tissues 41 | 17,142
Blood and immune system 40 | 16,909
Nervous System 40 | 16,725
Urinary Tract 40 | 16,678
Respiratory system 38 | 16,393
Cardiovascular System 37 | 15,192

Target Family

Non-IDG 24 | 12,091
Ion Channel 4 | 344
Epigenetic 3 | 242
Transcription Factor 3 | 1,400
Enzyme 2 | 4,145
GPCR 2 | 408
Nuclear Receptor 2 | 48
Kinase 1 | 634
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 MAGI2 Tbio Enzyme -1.54170 33.0 178
SET domain-containing protein 4 SETD4 Tdark Epigenetic -0.13929 2.27 99
Cytochrome b561 CYB561 Tbio Non-IDG -1.41422 21.1 62
Neurofascin NFASC Tbio Non-IDG -2.09540 119.2 154
Unconventional myosin-XVIIIb MYO18B Tbio Non-IDG -1.22641 17.7 0
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.24422 170.7 75
Integrin alpha-8 ITGA8 Tbio Non-IDG -1.36974 22.0 145
Elongation of very long chain fatty acids protein 6 ELOVL6 Tchem Non-IDG -1.88496 74.1 147