Development Level

Tbio 44 | 11,445
Tdark 13 | 6,588
Tchem 11 | 1,598
Tclin 3 | 613

Collection

RFA-RM-18-021 3 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

increased circulating sodium l... 71 | 71
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 43 | 11,493
osteosarcoma 33 | 7,950
psoriasis 28 | 6,694
ovarian cancer 26 | 8,520
glioblastoma 24 | 5,792
medulloblastoma, large-cell 24 | 6,241
lung cancer 22 | 4,740
ependymoma 17 | 4,679
Kidney cancer 16 | 2,613
atypical teratoid / rhabdoid tumor 16 | 5,112
group 3 medulloblastoma 16 | 4,104
malignant mesothelioma 15 | 3,232
adult high grade glioma 14 | 3,801
lung adenocarcinoma 14 | 2,716
Astrocytoma, Pilocytic 13 | 3,081
Autosomal recessive predisposition 13 | 1,442
astrocytic glioma 13 | 2,597
primitive neuroectodermal tumor 13 | 3,035
lung carcinoma 12 | 2,843
oligodendroglioma 12 | 2,850
pediatric high grade glioma 12 | 1,064
subependymal giant cell astrocytoma 12 | 2,287
pituitary cancer 11 | 1,972
tuberculosis 11 | 2,010
Schizophrenia 10 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Cancer 9 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
non-small cell lung cancer 9 | 2,890
Breast cancer 8 | 3,578
group 4 medulloblastoma 8 | 1,855
invasive ductal carcinoma 8 | 2,951
Alzheimer's disease 7 | 658
diabetes mellitus 7 | 1,728
ulcerative colitis 7 | 1,819
cystic fibrosis 6 | 1,696
interstitial cystitis 6 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Bipolar Disorder 5 | 666
Cognitive delay 5 | 608
Epilepsy 5 | 792
Global developmental delay 5 | 608
Infantile onset 5 | 238
Intellectual disability 5 | 1,016
Liver cancer 5 | 604
Mental and motor retardation 5 | 608
Pick disease 5 | 1,894
Seizures 5 | 596
Sensorineural Hearing Loss (disorder) 5 | 284
adrenocortical carcinoma 5 | 1,428
esophageal adenocarcinoma 5 | 737
juvenile dermatomyositis 5 | 1,187
pancreatic cancer 5 | 2,398
primary Sjogren syndrome 5 | 735
Amyotrophic lateral sclerosis 4 | 451
Constipation 4 | 181
Dementia 4 | 175
Depressive disorder 4 | 409
Failure to gain weight 4 | 365
Major Depressive Disorder 4 | 301
Melanoma 4 | 711
Mental Depression 4 | 333
Mood Disorders 4 | 184
Parkinson's disease 4 | 392
Pediatric failure to thrive 4 | 365
Rheumatoid arthritis 4 | 1,191
Skin cancer 4 | 469
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
acute quadriplegic myopathy 4 | 1,158
aldosterone-producing adenoma 4 | 665
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
non primary Sjogren syndrome sicca 4 | 891
posterior fossa group A ependymoma 4 | 468
primary pancreatic ductal adenocarcinoma 4 | 1,109
Down syndrome 3 | 499
Dull intelligence 3 | 645
Dystonia 3 | 164
Low intelligence 3 | 645
Malaria 3 | 160
Mental deficiency 3 | 645
Multiple myeloma 3 | 1,332
Neuroblastoma 3 | 80
Poor school performance 3 | 645
Progressive disorder 3 | 142
Proteinuria 3 | 144
Retinitis Pigmentosa 3 | 226
Stomach Neoplasms 3 | 300
Strabismus 3 | 270
Toxic encephalopathy 3 | 141
astrocytoma 3 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
gastric carcinoma 3 | 807
nephrosclerosis 3 | 333
posterior fossa group B ependymoma 3 | 416

Tissue

Endocrine System 70 | 18,159
Skin and soft tissues 70 | 17,230
Blood and immune system 68 | 16,909
Female tissues 68 | 17,400
Liver and Pancreas 68 | 16,750
Digestive Tract 67 | 17,369
Male tissues 66 | 17,142
Nervous System 64 | 16,725
Respiratory system 63 | 16,393
Urinary Tract 62 | 16,678
Cardiovascular System 59 | 15,192

Target Family

Non-IDG 37 | 12,091
Enzyme 15 | 4,145
GPCR 4 | 408
Transcription Factor 4 | 1,400
Kinase 3 | 634
Transporter 3 | 473
Epigenetic 2 | 242
Ion Channel 2 | 344
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Synaptonemal complex central element protein 1-like SYCE1L Tdark Non-IDG 0.60 0.08 50
Enteropeptidase TMPRSS15 Tchem Enzyme -2.78466 584.5 140
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit DDOST Tchem Enzyme -1.60313 44.1 140
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial COQ6 Tbio Enzyme -1.26796 18.5 102
Adherens junction-associated protein 1 AJAP1 Tbio Non-IDG -1.20907 21.2 25
Cytosolic Fe-S cluster assembly factor NUBP2 NUBP2 Tbio Non-IDG -1.46950 32.1 59
Harmonin USH1C Tbio Non-IDG -2.10689 124.7 188
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207
Ras-related protein Rab-40C RAB40C Tbio Non-IDG -0.89913 7.57 111
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129