Development Level

Tbio 43 | 10,625
Tdark 14 | 7,003
Tchem 12 | 1,890
Tclin 2 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

increased circulating sodium l... 71 | 71
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

osteosarcoma 36 | 7,933
ovarian cancer 27 | 8,484
psoriasis 26 | 6,685
medulloblastoma, large-cell 25 | 6,234
glioblastoma 23 | 5,572
lung cancer 23 | 4,466
pediatric high grade glioma 21 | 2,712
atypical teratoid / rhabdoid tumor 15 | 4,369
lung adenocarcinoma 14 | 2,713
malignant mesothelioma 14 | 3,162
pilocytic astrocytoma 13 | 3,086
primitive neuroectodermal tumor 13 | 3,031
pituitary cancer 12 | 1,972
Carcinoma 11 | 2,147
ependymoma 11 | 2,514
group 4 medulloblastoma 11 | 1,875
non-small cell lung cancer 11 | 2,798
oligodendroglioma 11 | 2,849
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 11 | 1,557
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
invasive ductal carcinoma 10 | 2,950
lung carcinoma 10 | 2,844
astrocytic glioma 9 | 2,241
interstitial cystitis 9 | 2,299
ulcerative colitis 9 | 2,087
Cancer 8 | 2,346
astrocytoma 8 | 1,493
group 3 medulloblastoma 8 | 2,254
Breast cancer 7 | 3,094
adrenocortical carcinoma 7 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
posterior fossa group A ependymoma 7 | 1,511
posterior fossa group B ependymoma 7 | 1,530
adult high grade glioma 6 | 2,148
cystic fibrosis 6 | 1,665
diabetes mellitus 6 | 1,663
esophageal adenocarcinoma 6 | 737
pancreatic cancer 6 | 2,300
primary pancreatic ductal adenocarcinoma 6 | 1,271
Alzheimer's disease 5 | 644
sonic hedgehog group medulloblastoma 5 | 1,482
Down syndrome 4 | 548
Pick disease 4 | 1,893
acute quadriplegic myopathy 4 | 1,157
aldosterone-producing adenoma 4 | 664
colon cancer 4 | 1,475
cutaneous lupus erythematosus 4 | 1,056
dermatomyositis 4 | 933
ductal carcinoma in situ 4 | 1,745
head and neck cancer and chronic obstructive pulmonary disease 4 | 237
primary Sjogren syndrome 4 | 789
Celiac disease 3 | 112
Multiple myeloma 3 | 1,327
Neurodegenerative disease 3 | 383
Nonsyndromic deafness 3 | 121
Rheumatoid Arthritis 3 | 1,160
Schizophrenia 3 | 501
Usher syndrome 3 | 34
Waldenstrons macroglobulinemia 3 | 765
active Crohn's disease 3 | 918
active ulcerative colitis 3 | 477
atypical teratoid/rhabdoid tumor 3 | 1,095
breast carcinoma 3 | 1,614
gastric carcinoma 3 | 832
hereditary spastic paraplegia 3 | 313
juvenile dermatomyositis 3 | 1,189
non primary Sjogren syndrome sicca 3 | 840
periodontitis 3 | 269
spina bifida 3 | 1,064
Amyotrophic Lateral Sclerosis 2 | 431
Blindness 2 | 84
Cardiomyopathy 2 | 110
Cocaine-Related Disorders 2 | 88
Dementia 2 | 129
Duchenne muscular dystrophy 2 | 602
Gaucher disease type 1 2 | 171
Globe disease 2 | 57
IGA Glomerulonephritis 2 | 454
Liver carcinoma 2 | 217
Multiple Sclerosis 2 | 498
Multiple acyl-CoA dehydrogenase deficiency 2 | 26
Neuroblastoma 2 | 78
Neuropathy 2 | 210
Parkinson's disease 2 | 364
Prostatic Neoplasms 2 | 471
Retinitis pigmentosa 2 | 153
Seizures 2 | 95
Stomach Neoplasms 2 | 282
Vascular disease 2 | 281
acute myeloid leukemia 2 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
limb girdle muscular dystrophy 2A 2 | 156
medulloblastoma 2 | 1,524
nasopharyngeal carcinoma 2 | 1,056
nephrosclerosis 2 | 329
non diabetic and post-ischemic heart failure 2 | 200
substance-related disorder 2 | 105

Tissue

Blood and immune system 71 | 17,995
Cardiovascular System 71 | 17,958
Digestive Tract 71 | 18,473
Endocrine System 71 | 18,512
Nervous System 71 | 18,561
Female tissues 70 | 18,647
Liver and Pancreas 70 | 18,136
Male tissues 70 | 17,969
Respiratory system 70 | 17,484
Skin and soft tissues 70 | 18,115
Urinary Tract 70 | 18,444

Target Family

Non-IDG 38 | 11,971
Enzyme 17 | 4,146
Transcription Factor 4 | 1,400
Transporter 4 | 473
GPCR 2 | 406
Ion Channel 2 | 341
Kinase 2 | 634
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
NAC-alpha domain-containing protein 1 NACAD Tbio Non-IDG -0.89395 7.61 52
Complement component C9 C9 Tbio Non-IDG -1.85517 71.0 229
Sestrin-3 SESN3 Tbio Non-IDG -1.01398 10.1 137
Ectonucleoside triphosphate diphosphohydrolase 1 ENTPD1 Tbio Enzyme -2.59508 482.4 411
Cytochrome b5 domain-containing protein 1 CYB5D1 Tdark Non-IDG -0.09691 1.25 65
Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 Tchem Ion Channel -1.00872 12.4 65
Neurocalcin-delta NCALD Tbio Non-IDG -1.29236 20.2 87
Carcinoembryonic antigen-related cell adhesion molecule 16 CEACAM16 Tbio Non-IDG -0.73655 11.1 64
Espin-like protein ESPNL Tdark Non-IDG 0.38 0.47 56