Development Level

Tbio 21 | 11,445
Tchem 3 | 1,598
Tdark 3 | 6,588
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

increased circulating potassiu... 29 | 29
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 22 | 11,493
ovarian cancer 15 | 8,520
osteosarcoma 14 | 7,950
ependymoma 13 | 4,679
glioblastoma 12 | 5,792
atypical teratoid / rhabdoid tumor 11 | 5,112
lung cancer 11 | 4,740
medulloblastoma, large-cell 11 | 6,241
psoriasis 11 | 6,694
Astrocytoma, Pilocytic 10 | 3,081
lung adenocarcinoma 9 | 2,716
group 3 medulloblastoma 8 | 4,104
malignant mesothelioma 8 | 3,232
primitive neuroectodermal tumor 8 | 3,035
tuberculosis 8 | 2,010
Autosomal recessive predisposition 7 | 1,442
Kidney cancer 7 | 2,613
adult high grade glioma 7 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
subependymal giant cell astrocytoma 7 | 2,287
Intellectual disability 6 | 1,016
astrocytic glioma 6 | 2,597
cystic fibrosis 6 | 1,696
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
cutaneous lupus erythematosus 5 | 1,057
oligodendroglioma 5 | 2,850
Breast cancer 4 | 3,578
Cancer 4 | 2,499
Dull intelligence 4 | 645
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Pick disease 4 | 1,894
Poor school performance 4 | 645
adrenocortical carcinoma 4 | 1,428
aldosterone-producing adenoma 4 | 665
astrocytoma 4 | 1,146
pancreatic cancer 4 | 2,398
pituitary cancer 4 | 1,972
Autistic Disorder 3 | 364
Breast Neoplasms 3 | 445
Cataract 3 | 297
Down syndrome 3 | 499
Failure to gain weight 3 | 365
Gaucher disease type 1 3 | 180
Hepatomegaly 3 | 285
Hypertension 3 | 396
Hypogonadism 3 | 173
Kidney Diseases 3 | 114
Mammary Neoplasms 3 | 425
Pediatric failure to thrive 3 | 365
Retinitis Pigmentosa 3 | 226
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Arthralgia 2 | 90
Atrophy of cerebellum 2 | 103
Bone pain 2 | 42
Cerebellar degeneration 2 | 103
Cognitive delay 2 | 608
Congenital deafness 2 | 185
Deafness 2 | 198
Epilepsy 2 | 792
Glaucoma 2 | 239
Global developmental delay 2 | 608
Hearing Loss, Partial 2 | 185
Hyperinsulinism 2 | 133
Hypertensive disease 2 | 292
Infantile onset 2 | 238
Infratentorial atrophy 2 | 103
Kidney disease 2 | 430
Lens Opacities 2 | 231
Mental and motor retardation 2 | 608
Mucopolysaccharidosis 2 | 26
Myocardial Ischemia 2 | 169
Obesity 2 | 678
Optic Atrophy 2 | 242
Sensorineural Hearing Loss (disorder) 2 | 284
Short stature 2 | 531
Splenomegaly 2 | 190
Strabismus 2 | 270
Waldenstrons macroglobulinemia 2 | 765
acute quadriplegic myopathy 2 | 1,158
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
gastric carcinoma 2 | 807
hearing impairment 2 | 199
hereditary spastic paraplegia 2 | 318
mucosa-associated lymphoid tissue lymphoma 2 | 484
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
primary Sjogren syndrome 2 | 735
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 28 | 16,909
Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678
Nervous System 27 | 16,725
Cardiovascular System 25 | 15,192

Target Family

Non-IDG 15 | 12,091
Enzyme 13 | 4,145
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
von Willebrand factor A domain-containing protein 8 VWA8 Tbio Non-IDG -0.36798 2.42 8
Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1 Tdark Non-IDG 0.19 0.86 20
Adherens junction-associated protein 1 AJAP1 Tbio Non-IDG -1.20907 21.2 25
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit DDOST Tchem Enzyme -1.60313 44.1 140
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 AGAP1 Tbio Enzyme -0.83079 8.71 94
SKI/DACH domain-containing protein 1 SKIDA1 Tdark Non-IDG -0.23045 1.67 0
Glycine amidinotransferase, mitochondrial GATM Tbio Enzyme -2.34742 219.1 219
Transcription initiation factor TFIID subunit 6 TAF6 Tbio Non-IDG -1.10650 12.8 159
Protein THEMIS2 THEMIS2 Tbio Non-IDG -1.22703 19.5 69
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615