Development Level

Tbio 21 | 11,445
Tchem 5 | 1,598
Tdark 3 | 6,588
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

increased circulating iron lev... 30 | 30
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 20 | 11,493
ovarian cancer 17 | 8,520
osteosarcoma 16 | 7,950
glioblastoma 15 | 5,792
medulloblastoma, large-cell 15 | 6,241
ependymoma 13 | 4,679
psoriasis 13 | 6,694
atypical teratoid / rhabdoid tumor 12 | 5,112
adult high grade glioma 9 | 3,801
Breast cancer 8 | 3,578
astrocytic glioma 7 | 2,597
lung cancer 7 | 4,740
non-small cell lung cancer 7 | 2,890
Astrocytoma, Pilocytic 6 | 3,081
invasive ductal carcinoma 6 | 2,951
oligodendroglioma 6 | 2,850
pancreatic cancer 6 | 2,398
primitive neuroectodermal tumor 6 | 3,035
Cancer 5 | 2,499
Pick disease 5 | 1,894
Schizophrenia 5 | 1,160
diabetes mellitus 5 | 1,728
ductal carcinoma in situ 5 | 1,745
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
juvenile dermatomyositis 5 | 1,187
malignant mesothelioma 5 | 3,232
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819
Gaucher disease type 1 4 | 180
Obesity 4 | 678
colon cancer 4 | 1,478
dermatomyositis 4 | 966
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
primary pancreatic ductal adenocarcinoma 4 | 1,109
subependymal giant cell astrocytoma 4 | 2,287
Alzheimer's disease 3 | 658
Anemia 3 | 365
Bipolar Disorder 3 | 666
Breast Neoplasms 3 | 445
Fatty liver disease 3 | 103
Hypertension 3 | 396
Hypertensive disease 3 | 292
Kidney cancer 3 | 2,613
Liver Cirrhosis 3 | 181
Mammary Neoplasms 3 | 425
acute myeloid leukemia 3 | 783
breast carcinoma 3 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
primary Sjogren syndrome 3 | 735
spina bifida 3 | 1,074
Autosomal dominant polycystic kidney disease 2 | 31
Autosomal recessive predisposition 2 | 1,442
Cardiovascular system disease 2 | 246
Coronary artery disease 2 | 268
Diarrhea 2 | 253
Dyslipidemias 2 | 27
Endometriosis 2 | 540
Epilepsy 2 | 792
Esophageal varix 2 | 12
Fatty Liver 2 | 70
Hemolytic anemia 2 | 77
Hyperglycemia 2 | 137
Hyperinsulinism 2 | 133
Hyperlipidemia 2 | 43
Hyperlipidemias 2 | 17
Hypothyroidism 2 | 122
Parkinson's disease 2 | 392
Peripheral vascular disease 2 | 87
Portal hypertension 2 | 20
Premature ovarian failure 2 | 65
Primary hypogonadism 2 | 37
Primary physiologic amenorrhea 2 | 55
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Thalassemia 2 | 53
Varicose veins 2 | 20
Vascular disease 2 | 319
adrenocortical carcinoma 2 | 1,428
astrocytoma 2 | 1,146
chronic rhinosinusitis 2 | 512
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
gastric cancer 2 | 459
interstitial cystitis 2 | 2,312
medulloblastoma 2 | 720
non diabetic and post-ischemic heart failure 2 | 200
posterior fossa group B ependymoma 2 | 416
Brain Neoplasms 1 | 33
Chromosome 1p36 deletion syndrome 1 | 23
Congenital hypothyroidism 1 | 26
Diabetic Neuropathies 1 | 14
Epilepsy, Temporal Lobe 1 | 23
Hyperprolactinemia 1 | 27

Tissue

Blood and immune system 30 | 16,909
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 29 | 17,142
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678
Cardiovascular System 28 | 15,192
Nervous System 28 | 16,725
Respiratory system 28 | 16,393

Target Family

Non-IDG 17 | 12,091
Enzyme 7 | 4,145
Kinase 3 | 634
Transporter 2 | 473
Epigenetic 1 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Lateral signaling target protein 2 homolog ZFYVE28 Tbio Non-IDG 0.04 0.75 77
Disheveled-associated activator of morphogenesis 1 DAAM1 Tbio Non-IDG -1.45166 30.8 269
Protein FAM122C FAM122C Tdark Non-IDG 1.20 0.08 13
Somatostatin SST Tbio Non-IDG -4.14886 13572.0 397
Putative sodium-coupled neutral amino acid transporter 10 SLC38A10 Tdark Transporter -0.27712 1.71 25
Cytochrome b561 CYB561 Tbio Non-IDG -1.41422 21.1 62
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP Tbio Enzyme -2.67803 471.0 188
Phosphatidate cytidylyltransferase, mitochondrial TAMM41 Tbio Enzyme -0.79472 6.33 123