Development Level

Tbio 17 | 11,651
Tdark 2 | 6,593
Tchem 1 | 1,388

IMPC Phenotype

increased circulating free fat... 20 | 20
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

ovarian cancer 14 | 8,520
Carcinoma 12 | 11,493
medulloblastoma, large-cell 8 | 6,241
glioblastoma 7 | 5,792
osteosarcoma 7 | 7,950
lung cancer 6 | 4,740
group 3 medulloblastoma 5 | 4,104
lung adenocarcinoma 5 | 2,716
Cancer 4 | 2,499
Multiple myeloma 4 | 1,332
diabetes mellitus 4 | 1,728
ependymoma 4 | 4,679
esophageal adenocarcinoma 4 | 737
invasive ductal carcinoma 4 | 2,951
malignant mesothelioma 4 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
psoriasis 4 | 6,694
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Astrocytoma, Pilocytic 3 | 3,081
Autosomal recessive predisposition 3 | 1,442
Breast cancer 3 | 3,578
Intellectual disability 3 | 1,016
adult high grade glioma 3 | 3,801
atypical teratoid / rhabdoid tumor 3 | 5,112
breast carcinoma 3 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
posterior fossa group B ependymoma 3 | 416
primitive neuroectodermal tumor 3 | 3,035
Adenocarcinoma 2 | 122
Alcoholic Intoxication, Chronic 2 | 289
Alzheimer's disease 2 | 658
Anus, Imperforate 2 | 46
Brachycephaly 2 | 88
Broad cranium shape 2 | 88
Crohn's disease 2 | 321
Disorder of eye 2 | 27
Duchenne muscular dystrophy 2 | 601
Dull intelligence 2 | 645
Elevated hepatic transaminases 2 | 81
Eye Abnormalities 2 | 35
Hepatic enzyme increased 2 | 81
Kidney cancer 2 | 2,613
Lipid metabolism disorder 2 | 114
Liver Dysfunction 2 | 99
Liver cancer 2 | 604
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Neurodegenerative disease 2 | 414
Penile hypospadias 2 | 106
Polycystic ovary syndrome 2 | 360
Poor school performance 2 | 645
Schizophrenia 2 | 1,160
Splenomegaly 2 | 190
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
Wide skull shape 2 | 88
acute myeloid leukemia 2 | 783
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
dermatomyositis 2 | 966
hereditary spastic paraplegia 2 | 318
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung carcinoma 2 | 2,843
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
spina bifida 2 | 1,074
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Alexander disease 1 | 11
Amyloidosis 1 | 67
Biliary cirrhosis 1 | 45
Bronchiectasis 1 | 64
Carotid Artery Diseases 1 | 11
Carotid stenosis 1 | 5
Chronic Obstructive Airway Disease 1 | 37
Decreased testosterone in males 1 | 28
Delirium 1 | 10
Dyslipidemias 1 | 27
Edema 1 | 81
Emphysema 1 | 12
Hepatolenticular Degeneration 1 | 24
Hypoplastic Left Heart Syndrome 1 | 14
Kidney Failure, Chronic 1 | 46
Liver Cirrhosis, Biliary 1 | 33
Macular Degeneration, Age-Related, 1 1 | 9
Neurofibrillary degeneration (morphologic abnormality) 1 | 9
Ovarian Cysts 1 | 41
Pathological accumulation of air in tissues 1 | 10
Recurrent bronchitis 1 | 23
Recurrent skin infections 1 | 21
Sparse axillary hair 1 | 28

Tissue

Blood and immune system 20 | 16,909
Cardiovascular System 20 | 15,192
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678

Target Family

Non-IDG 12 | 12,091
Enzyme 6 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
HBS1-like protein HBS1L Tbio Non-IDG -2.55785 357.2 263
Death-associated protein 1 DAP Tbio Non-IDG -2.28005 160.9 183
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 RPN2 Tbio Enzyme -1.51340 29.9 118
AP-2 complex subunit alpha-2 AP2A2 Tbio Non-IDG -0.65996 4.74 124
TBC1 domain family member 22A TBC1D22A Tbio Non-IDG -0.34282 1.72 112
Apolipoprotein E APOE Tbio Non-IDG -4.20176 15904.9 976
Peptidyl-prolyl cis-trans isomerase-like 3 PPIL3 Tbio Enzyme -0.91842 8.27 154
LON peptidase N-terminal domain and RING finger protein 3 LONRF3 Tdark Enzyme 0.00000 104
Elongation factor G, mitochondrial GFM1 Tbio Non-IDG -2.39993 250.5 121