Development Level

Tbio 24 | 11,445
Tchem 7 | 1,598
Tdark 4 | 6,588
Tclin 3 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

increased circulating creatini... 38 | 38
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38

Disease

Carcinoma 23 | 11,493
ovarian cancer 19 | 8,520
osteosarcoma 18 | 7,950
psoriasis 15 | 6,694
ependymoma 14 | 4,679
group 3 medulloblastoma 14 | 4,104
medulloblastoma, large-cell 14 | 6,241
atypical teratoid / rhabdoid tumor 13 | 5,112
adult high grade glioma 12 | 3,801
lung cancer 12 | 4,740
glioblastoma 11 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
oligodendroglioma 9 | 2,850
Cancer 8 | 2,499
astrocytic glioma 8 | 2,597
subependymal giant cell astrocytoma 8 | 2,287
Kidney cancer 7 | 2,613
malignant mesothelioma 7 | 3,232
pituitary cancer 7 | 1,972
Astrocytoma, Pilocytic 6 | 3,081
primitive neuroectodermal tumor 6 | 3,035
Breast cancer 5 | 3,578
Pick disease 5 | 1,894
Schizophrenia 5 | 1,160
active Crohn's disease 5 | 922
adrenocortical carcinoma 5 | 1,428
colon cancer 5 | 1,478
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
Alzheimer's disease 4 | 658
Kidney disease 4 | 430
breast carcinoma 4 | 1,638
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
progressive supranuclear palsy 4 | 676
tuberculosis 4 | 2,010
ulcerative colitis 4 | 1,819
Epilepsy 3 | 792
Female infertility 3 | 30
Hypertension 3 | 396
Infertility, Female 3 | 28
Liver Cirrhosis, Experimental 3 | 769
Obesity 3 | 678
Polycystic ovary syndrome 3 | 360
Rheumatoid arthritis 3 | 1,191
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
group 4 medulloblastoma 3 | 1,855
juvenile dermatomyositis 3 | 1,187
non primary Sjogren syndrome sicca 3 | 891
spina bifida 3 | 1,074
Acquired metabolic disease 2 | 336
Atopic dermatitis 2 | 952
Autosomal recessive predisposition 2 | 1,442
Bladder Neoplasm 2 | 112
Breast Neoplasms 2 | 445
Chemical and Drug Induced Liver Injury 2 | 195
Cholestasis 2 | 155
Cognitive delay 2 | 608
Constipation 2 | 181
Depressive disorder 2 | 409
Diarrhea 2 | 253
Down syndrome 2 | 499
Esophageal Neoplasms 2 | 69
Fatty Liver 2 | 70
Generalized muscle weakness 2 | 57
Global developmental delay 2 | 608
Goodpasture syndrome 2 | 6
Hyperaldosteronism 2 | 35
Hypertensive disease 2 | 292
Increase in blood pressure 2 | 119
Inflammatory bowel disease 2 | 151
Kidney Failure 2 | 111
Liver cancer 2 | 604
Major Depressive Disorder 2 | 301
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Mental and motor retardation 2 | 608
Multiple Sclerosis 2 | 540
Neurodegenerative disease 2 | 414
Parkinson's disease 2 | 392
Prostatic Neoplasms 2 | 495
Short stature 2 | 531
Unipolar Depression 2 | 250
Urinary Bladder Neoplasms 2 | 114
X-linked cerebral adrenoleukodystrophy 2 | 116
fibroadenoma 2 | 559
inflammatory breast cancer 2 | 286
medulloblastoma 2 | 720
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
permanent atrial fibrillation 2 | 45
urothelial carcinoma 2 | 318

Tissue

Digestive Tract 37 | 17,369
Endocrine System 37 | 18,159
Female tissues 37 | 17,400
Male tissues 37 | 17,142
Urinary Tract 37 | 16,678
Liver and Pancreas 36 | 16,750
Nervous System 36 | 16,725
Skin and soft tissues 36 | 17,230
Blood and immune system 35 | 16,909
Respiratory system 34 | 16,393
Cardiovascular System 32 | 15,192

Target Family

Non-IDG 19 | 12,091
Enzyme 7 | 4,145
Epigenetic 3 | 242
GPCR 3 | 408
Transporter 2 | 473
Ion Channel 1 | 344
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein arginine N-methyltransferase 1 PRMT1 Tchem Epigenetic -2.35804 229.5 394
Dynactin subunit 1 DCTN1 Tbio Non-IDG -2.05626 108.5 214
Protein Jumonji JARID2 Tbio TF/Epigenetic -1.80136 65.3 135
Polycystin-1 PKD1 Tbio Non-IDG -2.60276 379.9 123
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.24331 158.7 195
Aquaporin-3 AQP3 Tbio Non-IDG -2.61717 403.0 260
Drebrin DBN1 Tbio Non-IDG -2.10391 152.0 219
Lamin-B2 LMNB2 Tbio Non-IDG -2.00661 99.1 208
Steroid 17-alpha-hydroxylase/17,20 lyase CYP17A1 Tclin Enzyme -3.09734 1226.2 369
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204