Development Level

Tbio 17 | 10,625
Tchem 6 | 1,890
Tclin 3 | 602
Tdark 3 | 7,003

Collection

GPCR: IDG Consortium (Targets) 1 | 127

IMPC Phenotype

increased circulating creatini... 29 | 29
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat-hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

osteosarcoma 15 | 7,933
ovarian cancer 13 | 8,491
lung cancer 12 | 4,473
psoriasis 12 | 6,685
medulloblastoma, large-cell 10 | 6,234
atypical teratoid / rhabdoid tumor 9 | 4,369
glioblastoma 7 | 5,572
primitive neuroectodermal tumor 7 | 3,031
astrocytic glioma 6 | 2,241
oligodendroglioma 6 | 2,849
pituitary cancer 6 | 1,972
Cancer 5 | 2,346
Carcinoma 5 | 2,147
colon cancer 5 | 1,475
group 3 medulloblastoma 5 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
lung adenocarcinoma 5 | 2,714
lung carcinoma 5 | 2,844
malignant mesothelioma 5 | 3,163
medulloblastoma 5 | 1,524
pediatric high grade glioma 5 | 2,712
posterior fossa group B ependymoma 5 | 1,530
subependymal giant cell astrocytoma 5 | 2,287
Breast cancer 4 | 3,098
Pick disease 4 | 1,893
adult high grade glioma 4 | 2,148
diabetes mellitus 4 | 1,663
ependymoma 4 | 2,514
esophageal adenocarcinoma 4 | 737
pilocytic astrocytoma 4 | 3,086
Female infertility 3 | 28
Kidney disease 3 | 397
adrenocortical carcinoma 3 | 1,427
breast carcinoma 3 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
non-small cell lung cancer 3 | 2,798
pancreatic cancer 3 | 2,300
posterior fossa group A ependymoma 3 | 1,511
progressive supranuclear palsy 3 | 674
tuberculosis 3 | 1,563
Alzheimer's disease 2 | 644
Atopic dermatitis 2 | 944
Down syndrome 2 | 548
Epilepsy 2 | 346
Esophageal Neoplasms 2 | 67
Goodpasture syndrome 2 | 6
Hypertension 2 | 293
Hypokalemia 2 | 40
Inflammatory bowel disease 2 | 142
Metabolic syndrome X 2 | 155
Neurodegenerative disease 2 | 383
Obesity 2 | 616
Parkinson's disease 2 | 364
active Crohn's disease 2 | 918
astrocytoma 2 | 1,493
cutaneous lupus erythematosus 2 | 1,056
ductal carcinoma in situ 2 | 1,745
fibroadenoma 2 | 557
group 4 medulloblastoma 2 | 1,875
interstitial cystitis 2 | 2,299
invasive ductal carcinoma 2 | 2,950
non primary Sjogren syndrome sicca 2 | 840
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
spina bifida 2 | 1,064
ulcerative colitis 2 | 2,087
Acute pulmonary edema 1 | 1
Alport syndrome 1 | 21
Barrett Esophagus 1 | 20
Bartter Disease 1 | 12
Bartter disease type 1 1 | 3
Bartter syndrome 1, antenatal 1 | 1
Bartter syndrome, antenatal type 1 1 | 1
Bilirubin metabolic disorder 1 | 39
Calcinosis 1 | 63
Cerebrotendinous xanthomatosis 1 | 12
Cholera 1 | 33
Decompensated cardiac failure 1 | 9
Edema 1 | 38
Edema due to Hepatic Cirrhosis 1 | 3
Gastrointestinal system disease 1 | 50
Histoplasmosis 1 | 22
Hypertensive disorder 1 | 58
Leiomyoma 1 | 25
Malignant tumor of prostate 1 | 26
Meniere's disease 1 | 25
Mood Disorders 1 | 3
Neonatal jaundice 1 | 15
Ovarian Cysts 1 | 34
Papilloma 1 | 27
Peripheral Edema due to Chronic Heart Failure 1 | 10
Polyhydramnios 1 | 29
Premature ovarian failure 1 | 64
Pseudohermaphroditism 1 | 16
Pulmonary Edema due to Chronic Heart Failure 1 | 6
Renal Disease with Edema 1 | 2
Sclerosing cholangitis 1 | 17
Sepsis 1 | 21
Substance Withdrawal Syndrome 1 | 55
Tonsillitis 1 | 18

Tissue

Digestive Tract 29 | 18,472
Endocrine System 29 | 18,511
Female tissues 29 | 18,646
Liver and Pancreas 29 | 18,135
Nervous System 29 | 18,560
Respiratory system 29 | 17,483
Skin and soft tissues 29 | 18,114
Urinary Tract 29 | 18,443
Blood and immune system 28 | 17,994
Cardiovascular System 28 | 17,957
Male tissues 28 | 17,968

Target Family

Non-IDG 14 | 11,969
Enzyme 4 | 4,146
Epigenetic 3 | 242
GPCR 3 | 408
Transporter 2 | 473
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein arginine N-methyltransferase 1 PRMT1 Tchem Epigenetic -2.30739 200.5 309
Protein NDRG4 NDRG4 Tbio Non-IDG -1.41927 34.3 182
Cadherin EGF LAG seven-pass G-type receptor 1 CELSR1 Tbio GPCR -1.44011 31.7 110
Lysine-specific demethylase 4B KDM4B Tchem Epigenetic -1.51013 36.7 415
RING finger protein 10 RNF10 Tbio Non-IDG -0.78173 6.31 120
Nuclear receptor subfamily 1 group I member 2 NR1I2 Tchem Nuclear Receptor -3.12272 1473.5 263
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.22825 154.8 177
Adiponectin receptor protein 1 ADIPOR1 Tbio Non-IDG -2.34055 184.6 264
Aquaporin-3 AQP3 Tbio Non-IDG -2.57651 362.6 236
Urocortin-3 UCN3 Tbio Non-IDG -1.85116 70.6 116