Development Level

Tbio 48 | 11,651
Tchem 9 | 1,388
Tclin 5 | 612
Tdark 4 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

increased circulating choleste... 66 | 66
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 46 | 11,493
ovarian cancer 40 | 8,520
osteosarcoma 34 | 7,950
glioblastoma 32 | 5,792
psoriasis 30 | 6,694
medulloblastoma, large-cell 26 | 6,241
atypical teratoid / rhabdoid tumor 24 | 5,112
ependymoma 20 | 4,679
invasive ductal carcinoma 19 | 2,951
lung cancer 18 | 4,740
Astrocytoma, Pilocytic 16 | 3,081
Kidney cancer 16 | 2,613
group 4 medulloblastoma 16 | 1,855
adult high grade glioma 15 | 3,801
primitive neuroectodermal tumor 15 | 3,035
diabetes mellitus 14 | 1,728
Breast cancer 13 | 3,578
Cancer 13 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
pancreatic cancer 13 | 2,398
group 3 medulloblastoma 12 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
lung carcinoma 12 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
ductal carcinoma in situ 11 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
subependymal giant cell astrocytoma 11 | 2,287
Obesity 10 | 678
breast carcinoma 9 | 1,638
juvenile dermatomyositis 9 | 1,187
lung adenocarcinoma 9 | 2,716
Multiple myeloma 8 | 1,332
Schizophrenia 8 | 1,160
astrocytic glioma 8 | 2,597
cystic fibrosis 8 | 1,696
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
oligodendroglioma 8 | 2,850
pediatric high grade glioma 8 | 1,064
pituitary cancer 8 | 1,972
Autosomal recessive predisposition 7 | 1,442
Fatty liver disease 7 | 103
Hypertensive disease 7 | 292
Pick disease 7 | 1,894
dermatomyositis 7 | 966
interstitial cystitis 7 | 2,312
non primary Sjogren syndrome sicca 7 | 891
primary Sjogren syndrome 7 | 735
primary pancreatic ductal adenocarcinoma 7 | 1,109
Bipolar Disorder 6 | 666
Hypertension 6 | 396
Polycystic ovary syndrome 6 | 360
active Crohn's disease 6 | 922
adrenocortical carcinoma 6 | 1,428
cutaneous lupus erythematosus 6 | 1,057
spina bifida 6 | 1,074
tuberculosis 6 | 2,010
Atopic dermatitis 5 | 952
Breast Neoplasms 5 | 445
Down syndrome 5 | 499
Intellectual disability 5 | 1,016
Kidney disease 5 | 430
Mammary Neoplasms 5 | 425
Parkinson's disease 5 | 392
Vascular disease 5 | 319
acute myeloid leukemia 5 | 783
astrocytoma 5 | 1,146
nasopharyngeal carcinoma 5 | 1,058
ulcerative colitis 5 | 1,819
Alzheimer's disease 4 | 658
Atherosclerosis 4 | 291
Carcinoma, Hepatocellular 4 | 228
Gynecomastia 4 | 64
Hypertriglyceridemia result 4 | 37
Lipid metabolism disorder 4 | 114
Liver Cirrhosis, Experimental 4 | 769
Liver cancer 4 | 604
Liver carcinoma 4 | 240
Liver disease 4 | 237
Neurodegenerative disease 4 | 414
Primary hypogonadism 4 | 37
Primary physiologic amenorrhea 4 | 55
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
colon cancer 4 | 1,478
inflammatory breast cancer 4 | 286
medulloblastoma 4 | 720
pancreatic carcinoma 4 | 562
posterior fossa group B ependymoma 4 | 416
progressive supranuclear palsy 4 | 676
urothelial carcinoma 4 | 318
Coronary artery disease 3 | 268
Duchenne muscular dystrophy 3 | 601
Epilepsy 3 | 792
Hepatomegaly 3 | 285
Prostate cancer 3 | 175
fibroadenoma 3 | 559
gastric carcinoma 3 | 807
hepatocellular carcinoma 3 | 547
nephrosclerosis 3 | 333

Tissue

Endocrine System 66 | 18,159
Blood and immune system 64 | 16,909
Digestive Tract 64 | 17,369
Male tissues 64 | 17,142
Skin and soft tissues 63 | 17,230
Female tissues 62 | 17,400
Liver and Pancreas 61 | 16,750
Urinary Tract 61 | 16,678
Nervous System 60 | 16,725
Respiratory system 59 | 16,393
Cardiovascular System 55 | 15,192

Target Family

Non-IDG 36 | 12,091
Enzyme 15 | 4,145
Kinase 5 | 634
Epigenetic 2 | 242
GPCR 2 | 408
Nuclear Receptor 2 | 48
Ion Channel 1 | 344
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Yae1 domain-containing protein 1 YAE1D1 Tdark Non-IDG 0.26 0.54 89
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
F-box only protein 9 FBXO9 Tbio Non-IDG -0.42429 2.33 122
HBS1-like protein HBS1L Tbio Non-IDG -2.55785 357.2 263
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.06808 938.9 585
Geranylgeranyl pyrophosphate synthase GGPS1 Tchem Enzyme -2.30083 190.0 301
Fibroblast growth factor 22 FGF22 Tbio Non-IDG -1.15836 16.5 186
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Apolipoprotein E APOE Tbio Non-IDG -4.20176 15904.9 976