Development Level

Tbio 36 | 10,625
Tchem 10 | 1,890
Tclin 4 | 602
Tdark 3 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

increased circulating choleste... 53 | 53
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 30 | 8,492
medulloblastoma, large-cell 26 | 6,234
osteosarcoma 25 | 7,933
psoriasis 23 | 6,685
glioblastoma 22 | 5,572
atypical teratoid / rhabdoid tumor 16 | 4,369
Breast cancer 14 | 3,099
invasive ductal carcinoma 13 | 2,950
pilocytic astrocytoma 13 | 3,086
Cancer 12 | 2,346
pediatric high grade glioma 12 | 2,712
primitive neuroectodermal tumor 12 | 3,031
lung cancer 11 | 4,473
Obesity 10 | 616
adrenocortical carcinoma 10 | 1,427
diabetes mellitus 10 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
subependymal giant cell astrocytoma 10 | 2,287
group 4 medulloblastoma 9 | 1,875
ependymoma 8 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
juvenile dermatomyositis 8 | 1,189
malignant mesothelioma 8 | 3,163
medulloblastoma 8 | 1,524
non-small cell lung cancer 8 | 2,798
oligodendroglioma 8 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
ulcerative colitis 8 | 2,087
Multiple myeloma 7 | 1,328
adult high grade glioma 7 | 2,148
breast carcinoma 7 | 1,614
dermatomyositis 7 | 967
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
lung adenocarcinoma 7 | 2,714
lung carcinoma 7 | 2,844
non primary Sjogren syndrome sicca 7 | 840
pancreatic cancer 7 | 2,300
pituitary cancer 7 | 1,972
Alzheimer's disease 6 | 644
Carcinoma 6 | 2,147
Pick disease 6 | 1,893
astrocytic glioma 6 | 2,241
posterior fossa group A ependymoma 6 | 1,511
tuberculosis 6 | 1,563
Mammary Neoplasms 5 | 410
Rheumatoid Arthritis 5 | 1,171
cutaneous lupus erythematosus 5 | 1,056
cystic fibrosis 5 | 1,670
group 3 medulloblastoma 5 | 2,254
interstitial cystitis 5 | 2,299
spina bifida 5 | 1,064
Atopic dermatitis 4 | 944
Crohn's disease 4 | 304
Fatty liver disease 4 | 86
Kidney disease 4 | 397
Liver carcinoma 4 | 217
Metabolic syndrome X 4 | 155
Neurodegenerative disease 4 | 383
Parkinson's disease 4 | 364
active Crohn's disease 4 | 918
acute myeloid leukemia 4 | 785
acute quadriplegic myopathy 4 | 1,157
astrocytoma 4 | 1,493
colon cancer 4 | 1,475
nasopharyngeal carcinoma 4 | 1,056
posterior fossa group B ependymoma 4 | 1,530
primary Sjogren syndrome 4 | 789
primary pancreatic ductal adenocarcinoma 4 | 1,271
progressive supranuclear palsy 4 | 674
sonic hedgehog group medulloblastoma 4 | 1,482
Female infertility 3 | 28
Hypertension 3 | 293
Intellectual disability 3 | 573
Peripheral Neuropathy 3 | 303
Polycystic Ovary Syndrome 3 | 335
Toxic encephalopathy 3 | 131
atypical teratoid/rhabdoid tumor 3 | 1,095
pancreatic carcinoma 3 | 567
sarcoidosis 3 | 368
urothelial carcinoma 3 | 318
Atherosclerosis 2 | 275
Coronary artery disease 2 | 240
Crohn Disease 2 | 97
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Down syndrome 2 | 548
Duchenne muscular dystrophy 2 | 602
Endometriosis 2 | 535
IGA Glomerulonephritis 2 | 454
Inflammatory Bowel Diseases 2 | 87
Prostate cancer 2 | 172
Schizophrenia 2 | 503
Vascular disease 2 | 281
Waldenstrons macroglobulinemia 2 | 765
fibroadenoma 2 | 557
gastric carcinoma 2 | 832
hepatocellular carcinoma 2 | 550
inflammatory breast cancer 2 | 404
nephrosclerosis 2 | 329
tuberculosis and treatment for 6 months 2 | 686

Tissue

Digestive Tract 53 | 18,473
Endocrine System 53 | 18,512
Female tissues 53 | 18,647
Male tissues 53 | 17,969
Nervous System 53 | 18,561
Blood and immune system 52 | 17,995
Liver and Pancreas 52 | 18,136
Respiratory system 52 | 17,484
Skin and soft tissues 52 | 18,115
Urinary Tract 52 | 18,444
Cardiovascular System 51 | 17,958

Target Family

Non-IDG 28 | 11,969
Enzyme 10 | 4,146
Kinase 4 | 634
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
Transporter 2 | 473
GPCR 1 | 408
Ion Channel 1 | 341
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.29074 177.0 254
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.18574 145.2 256
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.13158 14.2 196
Oligoribonuclease, mitochondrial REXO2 Tbio Enzyme -2.13508 139.2 93
ATP-binding cassette sub-family G member 2 ABCG2 Tchem Transporter -3.38300 2531.5 239
BTB/POZ domain-containing protein 9 BTBD9 Tbio Non-IDG -1.30579 21.1 87
Trichoplein keratin filament-binding protein TCHP Tbio Non-IDG -2.30520 126.7 92
Probable tRNA pseudouridine synthase 2 TRUB2 Tdark Enzyme 0.08 0.76 104
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.52741 306.4 272
F-box only protein 9 FBXO9 Tbio Non-IDG -0.42429 2.33 98