Development Level

Tbio 22 | 10,625
Tdark 6 | 7,003
Tchem 2 | 1,890
Tclin 2 | 602

Collection

Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

increased circulating calcium ... 32 | 32
preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

medulloblastoma, large-cell 20 | 6,234
ovarian cancer 19 | 8,492
psoriasis 19 | 6,685
osteosarcoma 18 | 7,933
atypical teratoid / rhabdoid tumor 16 | 4,369
glioblastoma 14 | 5,572
lung cancer 13 | 4,473
non-small cell lung cancer 13 | 2,798
pilocytic astrocytoma 12 | 3,086
primitive neuroectodermal tumor 12 | 3,031
lung adenocarcinoma 11 | 2,714
oligodendroglioma 11 | 2,849
ependymoma 10 | 2,514
lung carcinoma 10 | 2,844
Breast cancer 9 | 3,099
astrocytic glioma 9 | 2,241
subependymal giant cell astrocytoma 9 | 2,287
ulcerative colitis 9 | 2,087
Pick disease 8 | 1,893
colon cancer 8 | 1,475
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
malignant mesothelioma 8 | 3,163
pediatric high grade glioma 8 | 2,712
tuberculosis 8 | 1,563
adrenocortical carcinoma 7 | 1,427
cutaneous lupus erythematosus 7 | 1,056
ductal carcinoma in situ 7 | 1,745
group 4 medulloblastoma 7 | 1,875
interstitial cystitis 7 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
invasive ductal carcinoma 7 | 2,950
medulloblastoma 7 | 1,524
pancreatic cancer 7 | 2,300
pancreatic carcinoma 7 | 567
pituitary cancer 7 | 1,972
Cancer 6 | 2,346
adult high grade glioma 6 | 2,148
breast carcinoma 6 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
spina bifida 6 | 1,064
Atopic dermatitis 5 | 944
group 3 medulloblastoma 5 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Carcinoma 4 | 2,147
Intellectual disability 4 | 573
astrocytoma 4 | 1,493
cystic fibrosis 4 | 1,670
hepatocellular carcinoma 4 | 550
posterior fossa group A ependymoma 4 | 1,511
Hyperglycemia 3 | 120
Kidney disease 3 | 397
Multiple myeloma 3 | 1,328
Obesity 3 | 616
acute myeloid leukemia 3 | 785
diabetes mellitus 3 | 1,663
esophageal adenocarcinoma 3 | 737
fibroadenoma 3 | 557
nasopharyngeal carcinoma 3 | 1,056
primary Sjogren syndrome 3 | 789
sarcoidosis 3 | 368
Cleft palate 2 | 125
Down syndrome 2 | 548
Hypertension 2 | 293
IGA Glomerulonephritis 2 | 454
Infertility 2 | 163
Posterior polymorphous corneal dystrophy 2 | 24
Sengers syndrome 2 | 17
Vascular disease 2 | 281
active Crohn's disease 2 | 918
aldosterone-producing adenoma 2 | 664
dermatomyositis 2 | 967
gastric cancer 2 | 436
gastric carcinoma 2 | 832
glioblastoma multiforme 2 | 347
juvenile dermatomyositis 2 | 1,189
mucosa-associated lymphoid tissue lymphoma 2 | 480
non primary Sjogren syndrome sicca 2 | 840
posterior fossa group B ependymoma 2 | 1,530
progressive supranuclear palsy 2 | 674
tuberculosis and treatment for 3 months 2 | 327
urothelial carcinoma 2 | 318
Calcinosis 1 | 63
Cholera 1 | 33
Diabetic Nephropathy 1 | 37
Fibrous dysplasia 1 | 15
Gestational Diabetes 1 | 17
Gilles de la Tourette syndrome 1 | 47
Goodpasture syndrome 1 | 6
HYPOCALCIURIC HYPERCALCEMIA, FAMILIAL, TYPE II (disorder) 1 | 1
Hyperlipidemia 1 | 25
Hypertensive disorder 1 | 58
Hypocalcemia, autosomal dominant 2 1 | 1
Hypocalciuric hypercalcemia, familial 2 1 | 1
Hypokalemia 1 | 40
McCune Albright syndrome 1 | 19
Ocular cancer 1 | 5
Pertussis 1 | 17
Pseudohypoparathyroidism 1 | 17
Sepsis 1 | 21
Uveal melanoma 1 | 18

Tissue

Blood and immune system 32 | 17,995
Digestive Tract 32 | 18,473
Female tissues 32 | 18,647
Liver and Pancreas 32 | 18,136
Male tissues 32 | 17,969
Nervous System 32 | 18,561
Urinary Tract 32 | 18,444
Cardiovascular System 31 | 17,958
Endocrine System 31 | 18,512
Respiratory system 31 | 17,484
Skin and soft tissues 31 | 18,115

Target Family

Non-IDG 17 | 11,969
Enzyme 8 | 4,146
GPCR 3 | 408
Transporter 2 | 473
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NEDD4 family-interacting protein 2 NDFIP2 Tbio Non-IDG -0.60179 4.85 31
Transmembrane protein 100 TMEM100 Tbio Non-IDG -0.82355 7.27 72
C-X-C chemokine receptor type 2 CXCR2 Tchem GPCR -2.84060 671.4 536
Solute carrier family 12 member 1 SLC12A1 Tclin Transporter -2.34899 171.5 155
Glycogen [starch] synthase, liver GYS2 Tbio Enzyme -1.56596 34.7 62
Relaxin receptor 2 RXFP2 Tbio GPCR -1.95653 81.2 200
LON peptidase N-terminal domain and RING finger protein 3 LONRF3 Tdark Enzyme 0.00000 90
Kaptin KPTN Tbio Non-IDG -1.39649 23.8 120
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.79576 564.2 147
Leptin receptor LEPR Tclin Non-IDG -2.99987 751.7 530