Development Level

Tbio 26 | 11,651
Tdark 4 | 6,593
Tclin 3 | 612
Tchem 1 | 1,388

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

increased circulating calcium ... 34 | 34
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 24 | 11,493
ovarian cancer 21 | 8,520
psoriasis 21 | 6,694
medulloblastoma, large-cell 20 | 6,241
osteosarcoma 20 | 7,950
atypical teratoid / rhabdoid tumor 17 | 5,112
ependymoma 17 | 4,679
glioblastoma 16 | 5,792
lung cancer 14 | 4,740
primitive neuroectodermal tumor 14 | 3,035
group 3 medulloblastoma 13 | 4,104
non-small cell lung cancer 12 | 2,890
Astrocytoma, Pilocytic 11 | 3,081
oligodendroglioma 11 | 2,850
Breast cancer 10 | 3,578
adult high grade glioma 10 | 3,801
lung adenocarcinoma 10 | 2,716
lung carcinoma 10 | 2,843
subependymal giant cell astrocytoma 10 | 2,287
tuberculosis 10 | 2,010
Kidney cancer 9 | 2,613
astrocytic glioma 9 | 2,597
malignant mesothelioma 9 | 3,232
Pick disease 8 | 1,894
ulcerative colitis 8 | 1,819
Cancer 7 | 2,499
pancreatic cancer 7 | 2,398
Autosomal recessive predisposition 6 | 1,442
Intellectual disability 6 | 1,016
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
ductal carcinoma in situ 6 | 1,745
interstitial cystitis 6 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
invasive ductal carcinoma 6 | 2,951
pancreatic carcinoma 6 | 562
pituitary cancer 6 | 1,972
spina bifida 6 | 1,074
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
adrenocortical carcinoma 5 | 1,428
cystic fibrosis 5 | 1,696
gastric carcinoma 5 | 807
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
breast carcinoma 4 | 1,638
nasopharyngeal carcinoma 4 | 1,058
Atopic dermatitis 3 | 952
Down syndrome 3 | 499
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Hyperglycemia 3 | 137
Hypertension 3 | 396
Kidney disease 3 | 430
Mood swings 3 | 77
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Pediatric failure to thrive 3 | 365
Progressive disorder 3 | 142
Seizures 3 | 596
Sensorineural Hearing Loss (disorder) 3 | 284
Short stature 3 | 531
active Crohn's disease 3 | 922
astrocytoma 3 | 1,146
diabetes mellitus 3 | 1,728
esophageal adenocarcinoma 3 | 737
hepatocellular carcinoma 3 | 547
juvenile dermatomyositis 3 | 1,187
pediatric high grade glioma 3 | 1,064
progressive supranuclear palsy 3 | 676
sarcoidosis 3 | 370
Acidosis, Lactic 2 | 97
Crohn's disease 2 | 321
Endometriosis 2 | 540
Hypoglycemia 2 | 152
Impaired exercise tolerance 2 | 42
Infertility 2 | 188
Lactic acidemia 2 | 95
Liver cancer 2 | 604
Melanoma 2 | 711
Nephrocalcinosis 2 | 35
Rheumatoid arthritis 2 | 1,191
Skin cancer 2 | 469
Strabismus 2 | 270
Vascular disease 2 | 319
Vomiting 2 | 116
acute quadriplegic myopathy 2 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
dermatomyositis 2 | 966
fibroadenoma 2 | 559
primary Sjogren syndrome 2 | 735
urothelial carcinoma 2 | 318

Tissue

Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Blood and immune system 33 | 16,909
Digestive Tract 33 | 17,369
Liver and Pancreas 33 | 16,750
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Male tissues 32 | 17,142
Nervous System 31 | 16,725
Respiratory system 31 | 16,393
Cardiovascular System 29 | 15,192

Target Family

Non-IDG 17 | 12,091
Enzyme 9 | 4,145
GPCR 2 | 408
Transcription Factor 2 | 1,400
Transporter 2 | 473
Epigenetic 1 | 242
Kinase 1 | 634

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycogen [starch] synthase, liver GYS2 Tbio Enzyme -1.61077 38.6 69
KICSTOR complex protein kaptin KPTN Tbio Non-IDG -1.45875 26.8 153
Ninjurin-2 NINJ2 Tbio Non-IDG -1.26697 18.9 55
Podoplanin PDPN Tbio Non-IDG -3.34579 2142.9 847
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207
SLIT and NTRK-like protein 4 SLITRK4 Tbio Non-IDG -0.13951 1.24 181
Urocortin-3 UCN3 Tbio Non-IDG -1.86551 74.1 120
Thioredoxin-interacting protein TXNIP Tbio Non-IDG -2.47583 365.2 216
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 Tclin Enzyme -2.71218 475.2 197
Protein FAM234B FAM234B Tdark Non-IDG 1.00 0.10 21