Development Level

Tbio 10 | 11,445
Tchem 5 | 1,598
Tclin 1 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

increased circulating bilirubi... 16 | 16
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

osteosarcoma 12 | 7,950
ovarian cancer 10 | 8,520
psoriasis 10 | 6,694
Carcinoma 9 | 11,493
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
medulloblastoma, large-cell 8 | 6,241
Autosomal recessive predisposition 7 | 1,442
non-small cell lung cancer 7 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
lung cancer 6 | 4,740
Breast cancer 5 | 3,578
colon cancer 5 | 1,478
glioblastoma 5 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
invasive ductal carcinoma 5 | 2,951
Atopic dermatitis 4 | 952
Cancer 4 | 2,499
Multiple myeloma 4 | 1,332
adrenocortical carcinoma 4 | 1,428
atypical teratoid / rhabdoid tumor 4 | 5,112
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 4,679
group 3 medulloblastoma 4 | 4,104
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Astrocytoma, Pilocytic 3 | 3,081
Kidney cancer 3 | 2,613
Obesity 3 | 678
Seizures 3 | 596
adult high grade glioma 3 | 3,801
breast carcinoma 3 | 1,638
interstitial cystitis 3 | 2,312
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
nephrosclerosis 3 | 333
non primary Sjogren syndrome sicca 3 | 891
ulcerative colitis 3 | 1,819
Acquired metabolic disease 2 | 336
Alopecia 2 | 115
Alzheimer's disease 2 | 658
Cardiovascular system disease 2 | 246
Cerebrovascular disease 2 | 238
Chemical and Drug Induced Liver Injury 2 | 195
Cognitive delay 2 | 608
Coronary artery disease 2 | 268
Disease Progression 2 | 136
Dyslipidemias 2 | 27
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Fatty liver disease 2 | 103
Gaucher disease type 1 2 | 180
Global developmental delay 2 | 608
Hepatomegaly 2 | 285
Hyperglycemia 2 | 137
Hyperlipidemia 2 | 43
Hyperlipidemias 2 | 17
Hypertension 2 | 396
Hypertensive disease 2 | 292
Hypertriglyceridemia result 2 | 37
Infantile onset 2 | 238
Kidney disease 2 | 430
Liver disease 2 | 237
Mental and motor retardation 2 | 608
Multiple Sclerosis 2 | 540
Muscle hypotonia 2 | 571
Neurodegenerative disease 2 | 414
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Pick disease 2 | 1,894
Primary hypogonadism 2 | 37
Primary physiologic amenorrhea 2 | 55
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
cutaneous lupus erythematosus 2 | 1,057
esophageal adenocarcinoma 2 | 737
gastric carcinoma 2 | 807
malignant mesothelioma 2 | 3,232
nasopharyngeal carcinoma 2 | 1,058
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
Blepharitis 1 | 23
Cellulitis of eyelid 1 | 17
Familial hyperlipidemia 1 | 6
Femoral bowing 1 | 20
Fibular bowing 1 | 5
Increased serum parathyroid hormone 1 | 14
Normal pressure hydrocephalus 1 | 11
Perrault syndrome 1 | 19
Tibial bowing 1 | 19

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Cardiovascular System 13 | 15,192

Target Family

Non-IDG 7 | 12,091
Enzyme 6 | 4,145
GPCR 1 | 408
Kinase 1 | 634
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit DDOST Tchem Enzyme -1.60313 44.1 140
Adhesion G protein-coupled receptor F5 ADGRF5 Tbio GPCR -0.93250 10.8 161
Leptin receptor LEPR Tclin Non-IDG -3.01833 782.6 615
ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP Tbio Enzyme -2.67803 471.0 188
Canalicular multispecific organic anion transporter 1 ABCC2 Tchem Transporter -2.90204 834.9 234
Phosphoserine phosphatase PSPH Tbio Enzyme -1.56433 55.8 252
F-box only protein 7 FBXO7 Tbio Non-IDG -2.07231 118.6 100
Mitochondrial fission 1 protein FIS1 Tbio Non-IDG -2.19572 143.4 224
Centromere protein O CENPO Tbio Non-IDG -0.67552 5.22 124