Development Level

Tbio 20 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

increased circulating amylase ... 25 | 25
preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 19 | 11,493
psoriasis 13 | 6,694
Kidney cancer 10 | 2,613
osteosarcoma 10 | 7,950
ovarian cancer 10 | 8,520
glioblastoma 7 | 5,792
lung cancer 7 | 4,740
atypical teratoid / rhabdoid tumor 6 | 5,112
ependymoma 6 | 4,679
invasive ductal carcinoma 6 | 2,951
malignant mesothelioma 6 | 3,232
medulloblastoma, large-cell 6 | 6,241
Astrocytoma, Pilocytic 5 | 3,081
Autosomal recessive predisposition 5 | 1,442
Epilepsy 4 | 792
Intellectual disability 4 | 1,016
Obesity 4 | 678
Pick disease 4 | 1,894
active Crohn's disease 4 | 922
cystic fibrosis 4 | 1,696
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung carcinoma 4 | 2,843
Atopic dermatitis 3 | 952
Autism spectrum disorder 3 | 101
Breast cancer 3 | 3,578
Cancer 3 | 2,499
Diarrhea 3 | 253
Endometrial cancer 3 | 311
Failure to gain weight 3 | 365
Liver cancer 3 | 604
Melanoma 3 | 711
Multiple myeloma 3 | 1,332
Neurodegenerative disease 3 | 414
Pediatric failure to thrive 3 | 365
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
Severe mental retardation (I.Q. 20-34) 3 | 99
Skin cancer 3 | 469
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung adenocarcinoma 3 | 2,716
non primary Sjogren syndrome sicca 3 | 891
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Athetosis 2 | 16
Autistic Disorder 2 | 364
Bipolar Disorder 2 | 666
Cholestasis 2 | 155
Constipation 2 | 181
Curvature of spine 2 | 282
Depressive disorder 2 | 409
Down syndrome 2 | 499
Dysarthria 2 | 192
Dyschezia 2 | 135
Fever 2 | 138
Gamma chain deficiency 2 | 7
Generalized muscle weakness 2 | 57
Global developmental delay, severe 2 | 47
Kidney disease 2 | 430
Large intestine cancer 2 | 126
Leukemia 2 | 104
MYELODYSPLASTIC SYNDROME 2 | 53
Motor neuron disease 2 | 49
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Osteoporosis 2 | 363
Radioulnar synostosis 2 | 35
Respiratory Failure 2 | 104
Seizures 2 | 596
Severe psychomotor retardation 2 | 47
Skeletal muscle atrophy 2 | 139
Strabismus 2 | 270
Systemic lupus erythematosus 2 | 194
Vascular disease 2 | 319
Waldenstrons macroglobulinemia 2 | 765
X-linked dominant 2 | 57
active ulcerative colitis 2 | 764
acute myeloid leukemia 2 | 783
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
cutaneous lupus erythematosus 2 | 1,057
diabetes mellitus 2 | 1,728
fibroadenoma 2 | 559
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
muscle degeneration 2 | 139
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
posterior fossa group B ependymoma 2 | 416
ulcerative colitis 2 | 1,819

Tissue

Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Liver and Pancreas 22 | 16,750
Skin and soft tissues 22 | 17,230
Blood and immune system 21 | 16,909
Female tissues 21 | 17,400
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Urinary Tract 19 | 16,678
Cardiovascular System 18 | 15,192
Respiratory system 18 | 16,393

Target Family

Non-IDG 15 | 12,091
Enzyme 5 | 4,145
TF/Epigenetic 2 | 38
Transporter 2 | 473
Transcription Factor 1 | 1,400

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
PR domain zinc finger protein 4 PRDM4 Tbio TF/Epigenetic -0.87918 7.84 221
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
Solute carrier family 12 member 1 SLC12A1 Tclin Transporter -2.37125 226.3 178
ER membrane protein complex subunit 10 EMC10 Tbio Non-IDG -1.41680 25.5 60
Cell cycle progression protein 1 CCPG1 Tbio Non-IDG -0.85752 6.11 52
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.21106 157.2 307
Insulin-degrading enzyme IDE Tchem Enzyme -2.57779 392.8 331
MDS1 and EVI1 complex locus protein MDS1 MECOM Tbio Non-IDG -1.84060 124.5 0
Cytochrome b561 CYB561 Tbio Non-IDG -1.41422 21.1 62
Phosphatidylcholine:ceramide cholinephosphotransferase 1 SGMS1 Tchem Enzyme -1.61164 41.6 0